According to the Q3 2024 Europe Hotel Construction Pipeline Trend Report from Lodging Econometrics (LE), analysts report that the region’s total pipeline stands at 1,645 projects/244,548 rooms.

In the Q3 2024 China Hotel Construction Pipeline Trend Report by Lodging Econometrics (LE), at the end of the quarter, China’s total hotel construction pipeline reached a record high project count of 3,853 projects with 703,312 rooms, up 4% by projects and 3% by rooms year-over-year (YOY).

Mickey Surfs Pipeline by Trevor Mezak is a(n) Limited Edition. The Edition is Limited to Limited Edition Of 95 pcs

The growing incidents of ransomware attacks like the Colonial Pipeline breach highlight the need for automated anti-malware remediation solutions such as SpyHunter.

Yuan LI,Tingting HU,Ryuji FUCHIKAMI,Takeshi IKENAGA, Vol.E107-D, No.11, pp.1396-1407
1 millisecond (1-ms) vision systems are gaining increasing attention in diverse fields like factory automation and robotics, as the ultra-low delay ensures seamless and timely responses. Superpixel segmentation is a pivotal preprocessing to reduce the number of image primitives for subsequent processing. Recently, there has been a growing emphasis on leveraging deep network-based algorithms to pursue superior performance and better integration into other deep network tasks. Superpixel Sampling Network (SSN) employs a deep network for feature generation and employs differentiable SLIC for superpixel generation. SSN achieves high performance with a small number of parameters. However, implementing SSN on FPGAs for ultra-low delay faces challenges due to the final layer’s aggregation of intermediate results. To address this limitation, this paper proposes an aggregated to pipelined structure for FPGA implementation. The final layer is decomposed into individual final layers for each intermediate result. This architectural adjustment eliminates the need for memory to store intermediate results. Concurrently, the proposed structure leverages decomposed layers to facilitate a pipelined structure with pixel streaming input to achieve ultra-low latency. To cooperate with the pipelined structure, layer-partitioned memory architecture is proposed. Each final layer has dedicated memory for storing superpixel center information, allowing values to be read and calculated from memory without conflicts. Calculation results of each final layer are accumulated, and the result of each pixel is obtained as the stream reaches the last layer. Evaluation results demonstrate that boundary recall and under-segmentation error remain comparable to SSN, with an average label consistency improvement of 0.035 over SSN. From a hardware performance perspective, the proposed system processes 1000 FPS images with a delay of 0.947 ms/frame.
Publication Date: 2024/11/01

.Progress on the TAPI pipeline has been repeatedly delayed because of security issues in conflict-ravaged Afghanistan

The floodwater washed away SSGC supply gas pipeline near Bolan district

Washington — New online training from the National Volunteer Fire Council is intended to help fire departments better respond to pipeline emergencies.

Washington — The Pipeline and Hazardous Materials Safety Administration is providing more than $41 million in grants for hazardous materials safety programs and hazmat training for firefighters.

Washington — Approximately 18,000 miles of decommissioned oil and gas pipelines in the Gulf of Mexico pose safety and environmental risks, according to a new report from the Government Accountability Office.

Calgary, Alberta – Oil-carrying pipeline workers have a lower injury risk than workers transporting oil on railroads or roadways, according to a new study from public policy think tank Fraser Institute.

Washington – Crude oil shipped from the Bakken Formation – located in North Dakota, Montana and nearby Canadian provinces – may be more flammable than “traditional” heavy crude oil, the Pipeline and Hazardous Materials Safety Administration warned shippers, sellers and emergency responders in a Jan. 2 safety advisory.

Washington – A new advisory bulletin from the Pipeline and Hazardous Materials Safety Administration recounts one of the largest pipeline spills in the past five years and encourages pipeline owners and operators to take new preventive measures against leaks.

Washington – The Pipeline and Hazardous Materials Safety Administration must make improvements to its oversight of state pipeline safety programs, concludes an audit released May 7 by the Department of Transportation Office of Inspector General.

Washington – The House has approved an amendment to fund pipeline safety measures as part of the 2015 Transportation, Housing and Urban Development Appropriations Act.

Washington – Pipeline operators may be required to notify the National Response Center no later than one hour after an incident involving natural gas and hazardous liquid pipelines, under a recently proposed rule from the Pipeline and Hazardous Materials Safety Administration.

Washington — The Pipeline and Hazardous Materials Safety Administration recently published a set of FAQs on training requirements.

Washington — Prompted by a reported cyberattack that has resulted in a disruption of service along a major petroleum pipeline, the Federal Motor Carrier Safety Administration on May 9 issued a temporary hours-of-service exemption to commercial motor vehicle operators transporting gasoline, diesel, jet fuel and other refined petroleum products to 17 states and the District of Columbia, as part of emergency relief efforts.

Washington — Enhancing first responders’ education and training on hazardous materials is the focus of more than $30 million in recent Pipeline and Hazardous Materials Safety Administration grant funding.

Washington — OSHA has scheduled a virtual public meeting for Nov. 16 in advance of the 43rd session of the United Nations Sub-Committee of Experts on the Globally Harmonized System of Classification and Labeling of Chemicals.

The post NIHR launches pipeline of Mental Health Research Groups across England [ £27 million to support mental health research teams in nine regions ] was curated by information for practice.

Electron cryo-microscopy image-processing workflows are typically composed of elements that may, broadly speaking, be categorized as high-throughput workloads which transition to high-performance workloads as preprocessed data are aggregated. The high-throughput elements are of particular importance in the context of live processing, where an optimal response is highly coupled to the temporal profile of the data collection. In other words, each movie should be processed as quickly as possible at the earliest opportunity. The high level of disconnected parallelization in the high-throughput problem directly allows a completely scalable solution across a distributed computer system, with the only technical obstacle being an efficient and reliable implementation. The cloud computing frameworks primarily developed for the deployment of high-availability web applications provide an environment with a number of appealing features for such high-throughput processing tasks. Here, an implementation of an early-stage processing pipeline for electron cryotomography experiments using a service-based architecture deployed on a Kubernetes cluster is discussed in order to demonstrate the benefits of this approach and how it may be extended to scenarios of considerably increased complexity.

Data acquisition and processing for cryo-electron tomography can be a significant bottleneck for users. To simplify and streamline the cryo-ET workflow, Tomo Live, an on-the-fly solution that automates the alignment and reconstruction of tilt-series data, enabling real-time data-quality assessment, has been developed. Through the integration of Tomo Live into the data-acquisition workflow for cryo-ET, motion correction is performed directly after each of the acquired tilt angles. Immediately after the tilt-series acquisition has completed, an unattended tilt-series alignment and reconstruction into a 3D volume is performed. The results are displayed in real time in a dedicated remote web platform that runs on the microscope hardware. Through this web platform, users can review the acquired data (aligned stack and 3D volume) and several quality metrics that are obtained during the alignment and reconstruction process. These quality metrics can be used for fast feedback for subsequent acquisitions to save time. Parameters such as Alignment Accuracy, Deleted Tilts and Tilt Axis Correction Angle are visualized as graphs and can be used as filters to export only the best tomograms (raw data, reconstruction and intermediate data) for further processing. Here, the Tomo Live algorithms and workflow are described and representative results on several biological samples are presented. The Tomo Live workflow is accessible to both expert and non-expert users, making it a valuable tool for the continued advancement of structural biology, cell biology and histology.

A systematic procedure is introduced for modeling charge-neutral non-polar surfaces of ionic minerals containing polyatomic anions. By integrating distance- and charge-based clustering to identify chemical species within the mineral bulk, our pipeline, PolyCleaver, renders a variety of theoretically viable surface terminations. As a demonstrative example, this approach was applied to forsterite (Mg2SiO4), unveiling a rich interface landscape based on interactions with formaldehyde, a relevant multifaceted molecule, and more particularly in prebiotic chemistry. This high-throughput method, going beyond techniques traditionally applied in the modeling of minerals, offers new insights into the potential catalytic properties of diverse surfaces, enabling a broader exploration of synthetic pathways in complex mineral systems.

In addressing the challenges faced by laboratories and universities with limited (or no) cryo-electron microscopy (cryo-EM) infrastructure, the ESRF, in collaboration with the Grenoble Institute for Structural Biology (IBS), has implemented the cryo-EM Solution-to-Structure (SOS) pipeline. This inclusive process, spanning grid preparation to high-resolution data collection, covers single-particle analysis and cryo-electron tomography (cryo-ET). Accessible through a rolling access route, proposals undergo scientific merit and technical feasibility evaluations. Stringent feasibility criteria demand robust evidence of sample homogeneity. Two distinct entry points are offered: users can either submit purified protein samples for comprehensive processing or initiate the pipeline with already vitrified cryo-EM grids. The SOS pipeline integrates negative stain imaging (exclusive to protein samples) as a first quality step, followed by cryo-EM grid preparation, grid screening and preliminary data collection for single-particle analysis, or only the first two steps for cryo-ET. In both cases, if the screening steps are successfully completed, high-resolution data collection will be carried out using a Titan Krios microscope equipped with a latest-generation direct electron counting detector coupled to an energy filter. The SOS pipeline thus emerges as a comprehensive and efficient solution, further democratizing access to cryo-EM research.

Presented and discussed here is the implementation of a software solution that provides prompt X-ray diffraction data analysis during fast dynamic compression experiments conducted within the dynamic diamond anvil cell technique. It includes efficient data collection, streaming of data and metadata to a high-performance cluster (HPC), fast azimuthal data integration on the cluster, and tools for controlling the data processing steps and visualizing the data using the DIOPTAS software package. This data processing pipeline is invaluable for a great number of studies. The potential of the pipeline is illustrated with two examples of data collected on ammonia–water mixtures and multiphase mineral assemblies under high pressure. The pipeline is designed to be generic in nature and could be readily adapted to provide rapid feedback for many other X-ray diffraction techniques, e.g. large-volume press studies, in situ stress/strain studies, phase transformation studies, chemical reactions studied with high-resolution diffraction etc.

Source: Streetwise Reports 11/08/2024

Vertex Pharmaceuticals Inc. (VRTX:NASDAQ) has reported a robust financial performance for the third quarter of 2024. The report has demonstrated the company's continued revenue growth and the strengthening of its innovative pipeline. For Q3 2024, Vertex's product revenue reached US$2.77 billion, a 12% increase from the previous year. This was primarily driven by strong demand for its TRIKAFTA®/KAFTRIO® therapies. Based on this momentum, Vertex raised its full-year product revenue guidance to a range of US$10.8 billion to US$10.9 billion, citing a solid trajectory in its cystic fibrosis (CF) portfolio and expected future launches.

In Q3, the company made notable advancements in its pipeline. Three programs have begun moving into Phase 3 clinical development: suzetrigine in diabetic peripheral neuropathy (DPN), povetacicept in IgA nephropathy (IgAN), and VX-880 in type 1 diabetes (T1D). Vertex is also preparing for the launch of two potential treatments in early 2025, with PDUFA dates set for January 2 for the vanzacaftor triple therapy for CF and January 30 for suzetrigine, the latter being a pain medication in a new therapeutic class aimed at reducing reliance on opioids.

GAAP and Non-GAAP net income both reached US$1.0 billion, largely driven by increased product revenue, which offset rising R&D and SG&A expense. This was s due to investments in global commercialization and late-stage clinical development. For Q3, Vertex's combined R&D and SG&A expenses were US$1.2 billion and US$1.1 billion, respectively, an increase from last year attributed to new global program advancements and upcoming launch support.

Vertex's cash position remained strong, with US$11.2 billion in cash, cash equivalents, and marketable securities as of September 30. The decline from US$13.7 billion at the end of 2023 primarily reflects the acquisition of Alpine Immune Sciences and share repurchases under the company's buyback program.

A Look At Biotechnology and Pharma

The U.S. Pharmaceuticals Report for 2024 by Nova One Advisor detailed the size and growth trajectory of the U.S. pharmaceutical market. Valued at US$602.19 billion in 2023, the sector is projected to exceed US$1 trillion by 2033. The report pointed to a "high healthcare expenditure provided by government bodies" as a primary growth driver, further bolstered by the aging population's demand for advanced treatments.

In an October 24 article, The Investing News Network reported on a dynamic landscape within the biotechnology sector. The report highlighted advancements in AI-powered drug discovery. Despite a cautious investment climate, interest remained strong in AI's potential to reshape healthcare, with venture capital investment reaching US$6.59 billion. At the HealthTech Ignite conference, Susie Roberts from Relay Therapeutics expressed confidence, noting, "We will definitely see AI design drugs in the next 10 years."

On November 4, Yahoo! Finance shared insights from MIT professors Andrew Lo and Dennis Whyte. They emphasized that biotechnology's rapid advancement over the past five decades offers valuable lessons for future innovation. In their research paper, Lo and Whyte proposed initiatives to accelerate biotechnology's growth, underscoring the importance of "reducing risk and uncertainty" to foster a robust investment ecosystem that supports groundbreaking discoveries.

Catalysts Driving Vertex Pharma

According to Vertex's November 2024 investor presentation, the company sees multiple growth catalysts over the next few years. Vertex aims to meet its goal of achieving "five launches in five years," focusing on expanding the treatable patient base in CF with vanzacaftor triple, addressing critical needs in sickle cell disease (SCD) and beta thalassemia (TDT) with CASGEVY, and launching suzetrigine for acute pain management.

Additionally, Vertex expects its expansive R&D pipeline to support long-term growth. This includes pivotal clinical trials for VX-880 in T1D, povetacicept in IgAN, and NaV1.8 pain inhibitors like suzetrigine, indicating a commitment to treating a range of chronic and life-threatening conditions with limited therapeutic options.

By driving advancements in CF therapies, diversifying its portfolio with novel pain treatments, and pursuing accelerated approvals for renal and blood-related disorders, Vertex is strategically positioning itself to sustain growth and achieve several near-term milestones.

What Are Experts Saying About Vertex?

In a November 5, 2024, H.C. Wainwright & Co. update, the analysts highlighted promising data from Vertex's recent Phase 2 trial for suzetrigine, which showed encouraging reductions in pain intensity. [OWNERSHIP_CHART-4085]

The analysts noted that suzetrigine's peripheral nervous system-specific mechanism could potentially address "a significant, unmet medical need worldwide" in non-opioid pain management. They set a price target of US$600.00, projecting Vertex's continued growth from its strong cystic fibrosis franchise and pipeline expansion.

From the November 7 Kingswood Capital Partners report, analysts noted Vertex Pharmaceuticals' "sustained execution" in advancing product development programs and achieving robust operating margins, enabling "continued, significant investments" in both its pipeline and commercial capabilities. The firm maintained a "Buy" rating with a 12-month target price of US$550.00, attributing this outlook to Vertex's deep cash resources and historical successes in clinical trials.

Ownership and Share Structure

According to Refinitiv, 95.44% of Vertex Pharmaceuticals is held by Institutions. The top among them are Capital World Investors at 10.37%, The Vanguard Group at 8.88%, BlackRock Institutional Trust with 5.49%, State Street Global Advisors (US) with 4.55%, and Fidelity Management and Research with 4.11%. Strategic Investors hold .12%. The rest is retail.

The company's market cap is US$129,395.59 million with 257.07 million free float shares. The 52 week range is US$341.90–$510.64.

Sign up for our FREE newsletter at: www.streetwisereports.com/get-news

Important Disclosures:

1) James Guttman wrote this article for Streetwise Reports LLC and provides services to Streetwise Reports as an employee.

2) This article does not constitute investment advice and is not a solicitation for any investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Each reader is encouraged to consult with his or her personal financial adviser and perform their own comprehensive investment research. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company.

For additional disclosures, please click here.

( Companies Mentioned: VRTX:NASDAQ, )

Safe, effective antimicrobial medicines are essential to modern medical procedures and pandemic preparedness. A new National Academies report recommends a range of policy, regulatory, and financial actions to tackle antimicrobial resistance, spanning human, animal, and environmental health.

With optimized metal detection sensitivity and high hygiene standards, the updated detector protects productivity whilst providing consumers with safe, uncontaminated products.

Drain cleaning and inspection services offer lucrative opportunities for plumbing contractors, especially with aging infrastructure. New technology makes these services easier than ever.

quantms: a cloud-based pipeline for quantitative proteomics enables the reanalysis of public proteomics data  Nature.com

Olympus now distributes Creaform’s Pipecheck Analyze software.

Sean Knapp of Ascend.io talks to Robert Blume about data pipeline automation with an orchestration layer.

Nir Valtman, co-Founder and CEO at Arnica, discusses pipelineless security with SE Radio host Priyanka Raghavan. They start by defining pipelines and then consider how to add security. Nir lays out the key challenges in getting good code coverage with the pipeline-based approach, and then describes how to implement a pipelineless approach and the advantages it offers. Priyanka quizzes him on the concept of "zero new hardcoded secrets," as well as some ways to protect GitHub repositories, and Nir shares examples of how a pipelineless approach could help in these scenarios. They then discuss false positives and handling developer fatigue in dealing with alerts. The show ends with some discussion around the product that Arnica offers and how it implements the pipelineless methodology.

Deadline reports that Marv Films (Matthew Vaughn's UK-based production company) "is plotting 'something like seven more Kingsman films' as part of the company’s expansion plans." That's... ambitious! But other spy franchises have certainly sustained that many or more. At least one of those seven films is expected to be a spinoff centered on the American spies (including Channing Tatum and Jeff Bridges) introduced in the second movie, Statesman. If previous plans mooted by Vaughn are still in effect, another is likely to be a third and supposedly final movie about the characters from the first two films, Eggsy (Taron Edgerton) and Harry Hart (Colin Firth), said to close out that trilogy. 

The next Kingsman movie we see will definitely be the WWI-set prequel The King's Man, long in the can and delayed by the global pandemic. That's currently slated for February, but likely to change again. It stars Harris Dickinson, Ralph Fiennes, Gemma Arterton, Rhys Ifans, Tom Hollander, and Daniel Brühl. With a cast like that an an exciting new time period less well mined by other spy franchises (and even a more serious tone judging from the trailers), I'm hopeful some more of these upcoming Kingsman films are sequels to The King's Man. Perhaps Dickinson and Fiennes will get as many movies as Edgerton and Firth.

According to Marv Group CEO Zygi Kamasa (per the trade), the company also has a Kingsman TV series in the works. 

TSA's proposed cybersecurity regulation aims to ensure "higher-risk" pipelines and railways are defended from cyber attacks.

The post TSA proposes cybersecurity requirements for pipelines, railroad operators first appeared on Federal News Network.

US recovers most of Colonial Pipeline Bitcoin ransom following cyberattack

Thanks to wide adoption of the Infrastructure as Code (IaC) approach, programmatic provisioning of cloud resources is slowly transforming almost every aspect of computing, with administration of web apps having emerged as a key use case. With IaC, it's possible to streamline resource management tasks, shorten time-to-market, control costs, and scale at will. The adoption of continuous integration and continuous delivery (CICD) pipelines is already making a huge difference in web app deployment and cloud resource management.

In Atlanta today, President Trump will announce big changes to the regulations that govern one of the nation's most significant environmental laws. The aim is to speed up approval for major projects like pipelines and highways, but critics say it could sideline the concerns of poor and minority communities impacted by those projects, and discount their impact on climate change. The 50-year-old National Environmental Policy Act, or NEPA, was signed into law by President Richard Nixon. It requires federal agencies to consider the environmental effects of proposed projects before they are approved. It also gives the public and interest groups the ability to comment on those evaluations. The administration's new regulations are expected to reduce the types and number of projects that will be subject to review under the NEPA. An earlier version of the proposed rules truncated those reviews in an effort to streamline processes that can take years to complete. It also dropped a requirement

When Trump descended the escalator at Trump Tower in 2015 to announce his presidential campaign, he tapped into something that had been brewing in online spaces for years. What made Trump unique wasn’t just his message, but his ability to speak the language of internet culture – his unfiltered tweets, his willingness to be politically […]

The post The Alt-Right Pipeline and the Rise of Trump: How Digital Radicalization Found Its Political Voice appeared first on Feminist Majority Foundation.

Engineers Use 3D CAD and Simulation To Customize Products With Quick Modifications, Testing, and Demonstrations

Hello,

I have been running this `uvm_reg_hw_reset_seq` sequence for the AHB protocol. My UVM Adapter looks like:

Issue: When I use basic reg.write, my write access are working well, as that is managed by the driver i.e. once adapter gives the packet to the driver, the driver supplies the address and the control signals to the DUT on the first clock cycle and then the write data on the next clock cycle. But when I am performing the read operation, somehow the UVM adapter is reading the data at the same clock cycle where read address + Controls are supplied and this is triggering read failure messages from the `uvm_reg_hw_reset_seq` sequence. What should I modify in the driver/sequencer/adapter so that the UVM adapter can read the data on the next cycle instead of the same clock cycle.

Just FYI: The waveforms of the read operation are correct, it is just the Adapter and the `uvm_reg_hw_reset_seq`. The AHB Driver + AHB Monitor is fully proven and verified to be working correctly.

By adopting a contingent workforce model and investing in the right data tools to power better informed decision-making and talent strategy, healthcare organizations can begin to address staffing challenges and turn their talent goals into reality. 

The post Closing Staffing Gaps in Healthcare by Utilizing Diverse Pipelines of Contingent Talent appeared first on MedCity News.

Jul 23, 2024

In the lead up to the October 2021 federal elections, the streets of Baghdad were lined with posters of female candidates. Some were familiar faces with clear political baggage and history, like Sara Iyad Allawi, the daughter of Iraq’s former prime minister. Others were former members of parliament from entrenched political parties. What drew the most excitement from observers, however, were the campaigns of civil activists who had participated in the October protest movement. Locally known as the “Tishreen Movement”, the October protest movement was the largest sustained protest movement in post-2003 Iraq’s history, which took place between October 2019 and February 2020 and involved the participation of hundreds of thousands across multiple cities. The protest movement succeeded in pushing for a new electoral law and in holding early elections, though the elections were only six months ahead of the traditional schedule by the time they were organized. These women represented a new type of female candidate, one without ties to the entrenched elite and who represented. Iraq’s youthful society. Their participation, like the protest movement itself, heralded to many a new era of Iraqi politics, one where younger women were confident enough to run for office and who relied on grassroots campaigning and social media.

Amicus Therapeutics Announces First Quarter 2010 Financial Results and Product Pipeline Advancements

Old pipelines to be connected to newly laid pipelines to facilitate national highway widening