A team of researchers report findings from a Phase I/II gene therapy clinical trial for patients with Leber congenital amaurosis, which found that the gene

A team of researchers report findings from a Phase I/II gene therapy clinical trial for patients with Leber congenital amaurosis, which found that the gene

Toronto, ON — Imagine telling a patient suffering from age-related (type-II) osteoporosis that a single injection of stem cells could restore their normal bone structure. This week, with a publication in STEM CELLS Translational Medicine, a group of researchers from the University of Toronto and The Ottawa Hospital suggest that this scenario may not be […]

Psychotherapy: Three approaches evaluated- Institut national de la sant� et de la recherche m�dicale.

Evidence-based psychotherapy resources for psychologists and mental health practitioners.

Custom designing proteins — a breakthrough recognized by the latest Nobel Prize in chemistry — could yield treatments that stop the worst of COVID-19 before it begins.

The post Stanford Medicine experts help Nobel winner custom design proteins for COVID-19 therapy appeared first on Scope.

Conformance of ITU-T H.810 personal health system: Personal Health Devices interface Part 5O: Sleep apnoea breathing therapy equipment

The international technology group Körber is driving the integration of supply chain and data orchestration platforms into its Werum PAS-X Manufacturing Execution System (MES).

Carl Rogers, the founder of the person-centered approach, revolutionized early psychotherapy. Learn how his methods continue to change the world today.

A growing body of evidence points to MDMA’s therapeutic potential for managing an array of hard-to-treat conditions like PTSD and depression.

Location: Electronic Resource- 

Location: Electronic Resource- 

Location: Engineering Library- R857.P6P599 2016

The danger of toxic side effects for two common chemotherapy drugs could be mitigated with a simple genetic test.

MERT is being marketed to families of children with autism. Providers suggest the treatment has been thoroughly studied, but there is little evidence to date of its efficacy.

Here are the key takeways from The Times' yearlong investigation into the science behind magnetic resonance therapy, or MERT, as a therapy for autism.

Transcranial magnetic stimulation sounds like — and looks like — something you'd find in a science fiction movie, but it's a real treatment option…

In this episode, Ida introduces us to Pride Counseling, an iOS app that provides access to the company's online therapy platform specifically designed for the LGBTQ+ community. She discusses the app's features, such as live chat and video calls with licensed professionals who specialize in LGBTQ+ issues. Ida explains how Pride Counseling provides personalized therapy that is convenient and discreet.

Logic’s new album, College Park, is his first record as an independent artist after parting ways with Def Jam. He tells Tom Power about the ups and downs of major labels, his turbulent early life and how he has prevailed in spite of setbacks.

WHEN you meet Peter Chalouhy it is hard to imagine the bubbly little boy may not make it to his 14th birthday. A stem cell gene therapy trial is his only hope but funds are needed to bring it here.

Anyone seeking to become part of Colorado’s psychedelics industry by growing mushrooms, operating a healing center, or manufacturing psilocybin edibles now has guidance on how to do so legally.

When psychedelic-assisted therapy becomes available in Colorado next year, the state will be just the second in the U.S. to regulate the production and use of psilocybin mushrooms.

On October 27, Bermuda will join the global community in celebrating World Occupational Therapy Day, recognizing the vital contributions of Occupational Therapists [OTs] who empower individuals to engage fully in daily life and promoting the 2024 theme, “Occupational Therapy for All.” A Government spokesperson said, “World Occupational Therapy Day will be celebrated on October 27th, […]

Systematic review produced by the EPPI-Centre in 2015.This systematic review aimed to evaluate the effect of HAART and ARV monotherapy on liver disease progression and liver-related mortality in individuals co-infected with HIV and hepatitis C, including in patients with haemophilia.

Give yourself an extra relaxation boost with an aromatherapy pillow that you’ll customize with fabric and essential oils of your own choosing. The pillow can be hand-stitched or you can use a Makerspace-provided sewing machine. All supplies will be provided. Drop-ins welcome! Come for the entire time or only part of the session. Registration is optional, but if you know you’ll be attending please register so we can anticipate the number of people to expect.

Hyperbaric Oxygen Therapy (HBOT) is a medical treatment that involves breathing pure oxygen in a pressurized environment. This unique treatment method has shown effectiveness in healing various conditions, from complex wound healing to treating decompression sickness in divers. HBOT works on the principle of increasing oxygen concentration in the body, which can enhance the body’s ... Read more

The post How Much Does Hyperbaric Oxygen Therapy Cost? Price Tips appeared first on Star Two.

Jet lag is a common issue for anyone crossing multiple time zones. While various remedies exist, massage therapy stands out as an effective, natural method to help the body adjust and recover. This guide explores how this therapy can be utilized to alleviate the symptoms of jet lag, offering practical tips and techniques that can ... Read more

The post Massage Therapy for Frequent Travelers – Tips for Reducing Jet Lag appeared first on Star Two.

The genetic testing company 23andMe announced it will cut 40% of its workforce, or 200 jobs, and halt the work on therapies it was developing. As the BBC notes, the company is fighting for survival after hackers gained access to personal information of millions of its users, causing the stock to crater by more than 70%. All seven of its independent directors also resigned in September, following a protracted negotiation with founder and Chief Executive Anne Wojcicki over her plan to take the company private. The BBC reports: On Tuesday, the company warned investors of "substantial doubt" about its ability to continue operating, as it reported that revenue had fallen to $44 million between July and September compared to $50 million in the same period last year. Losses fell to $59 million from $75 million. The job cuts are expected to lead to one-off costs of $12 million, including severance pay, for the plan that will result in savings of $35 million. "We are taking these difficult but necessary actions as we restructure 23andMe and focus on the long-term success of our core consumer business and research partnerships," Ms Wojcicki said. The company also said it is considering what to do with the therapies it had in development, including licensing or selling them. 23andMe is a giant of the growing ancestor-tracing industry. It offers genetic testing from DNA, with ancestry breakdown and personalised health insights. Its customers include famous names, from rapper Snoop Dogg to multi-billionaire investor Warren Buffett. The company was valued at roughly $3.5 billion when it listed on the Nasdaq stock exchange in 2021 and its share price peaked at $17.65. But they have since tumbled and are currently trading at less than $5.

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Visual Abstract

Visual Abstract

Visual Abstract

Visual Abstract

Visual Abstract

Renal Cell Carcinoma (RCC) is one of the most commonly diagnosed cancers worldwide with research efforts dramatically improving understanding of the biology of the disease. To investigate the role of the immune system in treatment-naïve clear cell Renal Cell Carcinoma (ccRCC), we interrogated the immune infiltrate in patient-matched ccRCC tumor samples, benign normal adjacent tissue (NAT) and peripheral blood mononuclear cells (PBMCs isolated from whole blood, focusing our attention on the myeloid cell infiltrate. Using flow cytometric, MS, and ExCYT analysis, we discovered unique myeloid populations in PBMCs across patient samples. Furthermore, normal adjacent tissues and ccRCC tissues contained numerous myeloid populations with a unique signature for both tissues. Enrichment of the immune cell (CD45⁺) fraction and subsequent gene expression analysis revealed a number of myeloid-related genes that were differentially expressed. These data provide evidence, for the first time, of an immunosuppressive and pro-tumorigenic role of myeloid cells in early, clinically localized ccRCC. The identification of a number of immune proteins for therapeutic targeting provides a rationale for investigation into the potential efficacy of earlier intervention with single-agent or combination immunotherapy for ccRCC.

Radiolabeled small-molecule DOTA-haptens can be combined with antitumor/anti-DOTA bispecific antibodies (BsAbs) for pretargeted radioimmunotherapy (PRIT). For optimized delivery of the theranostic - and β-emitting isotope ¹⁷⁷Lu with DOTA-based PRIT (DOTA-PRIT), bivalent Gemini (DOTA-Bn-thiourea-PEG4-thiourea-Bn-DOTA, aka (3,6,9,12-tetraoxatetradecane-1,14-diyl)bis(DOTA-benzyl thiourea)) was developed. Methods: Gemini was synthesized by linking 2 S-2-(4-isothiocyanatobenzyl)-DOTA molecules together via a 1,14-diamino-PEG4 linker. [¹⁷⁷Lu]Lu-Gemini was prepared with no-carrier-added ¹⁷⁷LuCl₃ to a molar-specific activity of 123 GBq/μmol and radiochemical purity of more than 99%. The specificity of BsAb-¹⁷⁷Lu-Gemini was verified in vitro. Subsequently, we evaluated biodistribution and whole-body clearance for [¹⁷⁷Lu]Lu-Gemini and, for comparison, our gold-standard monovalent [¹⁷⁷Lu]Lu-S-2-(4-aminobenzyl)-DOTA ([¹⁷⁷Lu]Lu-DOTA-Bn) in naïve (tumor-free) athymic nude mice. For our proof-of-concept system, a 3-step pretargeting approach was performed with an established DOTA-PRIT regimen (anti-GPA33/anti-DOTA IgG-scFv BsAb, a clearing agent, and [¹⁷⁷Lu]Lu-Gemini) in mouse models. Results: Initial in vivo studies showed that [¹⁷⁷Lu]Lu-Gemini behaved similarly to [¹⁷⁷Lu]Lu-DOTA-Bn, with almost identical blood and whole-body clearance kinetics, as well as biodistribution and mouse kidney dosimetry. Pretargeting [¹⁷⁷Lu]Lu-Gemini to GPA33-expressing SW1222 human colorectal xenografts was highly effective, leading to absorbed doses of [¹⁷⁷Lu]Lu-Gemini for blood, tumor, liver, spleen, and kidneys of 3.99, 455, 6.93, 5.36, and 14.0 cGy/MBq, respectively. Tumor–to–normal tissue absorbed-dose ratios (i.e., therapeutic indices [TIs]) for the blood and kidneys were 114 and 33, respectively. In addition, we demonstrate that the use of bivalent [¹⁷⁷Lu]Lu-Gemini in DOTA-PRIT leads to improved TIs and augmented [¹⁷⁷Lu]Lu-Gemini tumor uptake and retention in comparison to monovalent [¹⁷⁷Lu]Lu-DOTA-Bn. Finally, we established efficacy in SW1222 tumor-bearing mice, demonstrating that a single injection of anti-GPA33 DOTA-PRIT with 44 MBq (1.2 mCi) of [¹⁷⁷Lu]Lu-Gemini (estimated tumor-absorbed dose, 200 Gy) induced complete responses in 5 of 5 animals and a histologic cure in 2 of 5 (40%) animals. Moreover, a significant increase in survival compared with nontreated controls was noted (maximum tolerated dose not reached). Conclusion: We have developed a bivalent DOTA-radiohapten, [¹⁷⁷Lu]Lu-Gemini, that showed improved radiopharmacology for DOTA-PRIT application. The use of bivalent [¹⁷⁷Lu]Lu-Gemini in DOTA-PRIT, as opposed to monovalent [¹⁷⁷Lu]Lu-DOTA-Bn, allows curative treatments with considerably less administered ¹⁷⁷Lu activity while still achieving high TIs for both the blood (>100) and the kidneys (>30).

The therapy helps the brain work more efficiently and lifts depression.

Many people who want to be healthy often try to eat a balanced diet and get regular exercise. However, most foods today simply do not contain the nutrition they did in the past. If your goal is to improve your physical and mental health, your body may still require essential nutrients. IV nutrition therapy is […]

The post Exploring the Impact of IV Nutrition Therapy on Mental Health first appeared on What is Psychology?.

EMDR therapy, also known as Eye Movement Desensitization and Reprocessing therapy, is an integrative and all-inclusive psychotherapy model used to treat mental conditions and trauma. This approach has been researched extensively in recent years and confirmed to be an effective way to tackle mental challenges. EMDR therapy was reportedly developed in the 1980’s by an […]

The post What are The Different Phases of EMDR Therapy? first appeared on What is Psychology?.

Are you a clinician looking to master CBT for Perfectionism? Or, learn more about the CBT model of perfectionism below. CBT Model of Perfectionism Perfectionism is not the same thing as conscientiousness. For example, in a recent study of older adults, perfectionism was both associated with increased risk of mortality whereas conscientiousness was associated with […]

The post Cognitive Behavioral Therapy Model of Perfectionism appeared first on Dr Alice Boyes.

The core beliefs that cause the most common problems fall into the following 3 categories. These core beliefs commonly underlie depression and anxiety. Helpless Core Beliefs such as: “I’m incompetent” “I’m needy” “I’m weak” “I’m defective, I don’t measure up” “I’m a failure” Unlovable Core Beliefs such as: “I’m unlovable” “I’m different” “I’m bound to […]

The post How To Change Negative Core Beliefs: A Straightforward Guide to Cognitive Behavioral Therapy (CBT) appeared first on Dr Alice Boyes.

We recently demonstrated that transient attenuation of Toll-like receptor 4 (TLR4) in dorsal root ganglion (DRG) neurons, can both prevent and reverse pain associated with chemotherapy-induced peripheral neuropathy (CIPN), a severe side effect of cancer chemotherapy, for which treatment options are limited. Given the reduced efficacy of opioid analgesics to treat neuropathic, compared with inflammatory pain, the cross talk between nociceptor TLR4 and mu-opioid receptors (MORs), and that MOR and TLR4 agonists induce hyperalgesic priming (priming), which also occurs in CIPN, we determined, using male rats, whether (1) antisense knockdown of nociceptor MOR attenuates CIPN, (2) and attenuates the priming associated with CIPN, and (3) CIPN also produces opioid-induced hyperalgesia (OIH). We found that intrathecal MOR antisense prevents and reverses hyperalgesia induced by oxaliplatin and paclitaxel, two common clinical chemotherapy agents. Oxaliplatin-induced priming was also markedly attenuated by MOR antisense. Additionally, intradermal morphine, at a dose that does not affect nociceptive threshold in controls, exacerbates mechanical hyperalgesia (OIH) in rats with CIPN, suggesting the presence of OIH. This OIH associated with CIPN is inhibited by interventions that reverse Type II priming [the combination of an inhibitor of Src and mitogen-activated protein kinase (MAPK)], an MOR antagonist, as well as a TLR4 antagonist. Our findings support a role of nociceptor MOR in oxaliplatin-induced pain and priming. We propose that priming and OIH are central to the symptom burden in CIPN, contributing to its chronicity and the limited efficacy of opioid analgesics to treat neuropathic pain.

Two of the preeminent researchers of gene therapy hope to improve their patients' sight in an experimental operation (Stephen Voss/WPN)

Cardiac MRI of an animal that has undergone photosynthetic therapy. CREDIT: Stanford University School of Medicine, Department of Cardiothoracic Surgery

Monarch250 to bring affordable cancer treatment option to more cancer centers

A physical therapy clinic — staffed by students supervised by licensed professionals and offering free services to volunteer community participants in need — is planned for fall 2025 at Pennsylvania College of Technology.

The FDA estimates that between 45 and 50 students at a Massachusetts school for students with autism, emotional disturbances, and intellectual disabilities are subjected to electrical shocks through electrodes attached to their skin.

Pamela Pologruto has received the F.A. Davis Award for Outstanding Physical Therapist Assistant Educator. The American Physical Therapy Association recognized her achievement with this national award, only given to one recipient annually, at their honors and awards reception ceremony in Kansas City, Missouri.