The National Highway Traffic Safety Administration (NHTSA) lists drug and alcohol use as a common cause of car accidents.

Sea snails stun their prey with toxins that mimic glucose-regulating hormones.

Liam Payne dies at the age of 31 after falling from the balcony of hotel in Buenos AiresLiam Payne’s girlfriend Kate Cassidy opened up about the 'ultimatum' she gave to the singer before his tragic death.A close source revealed that, Liam’s excessive use of drugs constantly created a...

The wide range of drugs were seized from 155 cases registered under the NDPS Act

The drug war under the administration of President Marcos has netted P40.32 billion worth of illegal drugs, the Philippine National Police reported yesterday.

MANILA, Philippines — Northern Police District officers arrested two individuals and seized drugs worth a total of P146,440 in Caloocan City early Wednesday morning, Nov. 13. The suspects were identified by police as “Budoy”, 18; and “Buknoy”, 24, both of whom are Caloocan residents. NPD’s District Drugs Enforcement Unit made the arrest in a buy-bust operation at 4:12 a.m. on Wednesday along Libis Espina Street in Barangay 18, Caloocan City. Twenty grams of a white substance suspected to be shabu (crystal meth), estimated to be worth P136,000, were seized from the suspects. Additionally, police said they recovered 17 grams of […]...

Keep on reading: Nearly P150,000 worth of drugs seized in Caloocan buy-bust op

MANILA, Philippines — Parañaque City police arrested three foreign nationals for shooting a Chinese man and for possessing drugs worth P1.2 million during their arrest on Wednesday, Nov. 13. The victim was identified as “Li”, a 35-year-old Chinese national who works as a money changer employee in Parañaque City. He was shot at a residential complex in Barangay Don Galo on Wednesday morning and was taken to Juan De Dios Hospital in Pasay City for treatment. According to the Southern Police District’s (SPD) report, alias “Syncell”, a 32-year-old Filipino online agent who also lives in the complex, witnessed the incident. […]...

Keep on reading: Chinese man shot in Parañaque; suspects with P1.2-M in drugs nabbed

In this article, Beldeu Singh highlights some of the gross inconsistencies in our current approach to what is called the "AIDS epidemic". There has never, to this date, been a proper isolation and purification of the human immunodeficiency virus, and one might be justified in saying that there is no AIDS epidemic, but rather an iatrogenic (doctor caused) epidemic of drug-induced deaths and a lot of unnecessary fear and suffering, all based on very wonky science... but it all seems to make excellent business sense, if you are a drug company shareholder or one of the thousands of researchers who work "to find a cure" for AIDS. by Beldeu Singh INTRODUCTION In the early days neutropenia was one of the key parameters of AIDS. The clinical course of severe neutropenia, as described in the basic pathology textbook, “Pathologic Basis of Disease” by Robbins (5th Ed.), which is used in most medical schools to study pathology, describes what happens to people with severe neutropenia. The symptoms and signs of neutropenias are those of bacterial infections... Robbins also states, in italics, that "the most severe forms of neutropenias are produced by drugs." In severe agranulocytosis with virtual absence of neutrophils, "these infections may become so overwhelming as to cause death within a few days," (Robbins, p 631). This sounds disturbingly similar to a description of AIDS. Dr. Michael Lange, associate chief of infectious diseases at St. Luke's-Roosevelt Hospital in New York and one of the doctors the FDA consulted when evaluating AZT in 1987, says even he sometimes had trouble differentiating between AZT's toxic effects and AIDS itself. An article in the New England Journal of Medicine describes the muscle wasting caused by AZT and compared it to muscle wasting, called "myopathy", presumed to be caused by HIV. Their comments in the abstract are shocking: "We conclude that long-term therapy with Zidovudine can cause a toxic mitochondrial myopathy, which... is indistinguishable from the myopathy associated with primary HIV infection..." So, there is drug-induced immune suppression and drug-induced AIDS, and AZT can cause AIDS. Yet 5000 scientists signed a declaration that HIV is the sole cause of AIDS. The AIDS industry is built on paradoxes and misguided beliefs....

This is another installment of research into the biochemistry of HIV and Aids by Cal Crilly, an Australian who finds himself fascinated with the intricacies of biology. Crilly analyzes the seemingly unconnected studies that show the biochemical changes that accompany the presence of numerous retroviruses - one of them called HIV - in humans. The mechanism that makes retroviruses appear is hypomethylation, and it is the same mechanism that accompanies pregnancy and inflammation. Those retroviruses are produced in the course of normal biological activity and they are not infectious. There are many different types (ever heard of HIV 'mutating'?). As an aside, we declare pregnant mothers to be "HIV positive" as pregnancy causes the presence of retroviruses in the course of normal biological activity, and those harmless endogenous retroviruses react with what's generally called an "HIV" test. Certain basic nutrients - Selenium, Folate, B12, B6, Choline are the most important - counteract hypomethylation of the cells and thereby calm the production of human endogenous retroviruses. The toxic Aids drug AZT causes hypermethylation but it is so destructive of normal cell processes that most patients die. The 'life prolonging' effect of HAART, the drug cocktail that is prescribed to Aids patients today is due to a sharp decrease in the dosage of deadly AZT in the cocktail. Cal demonstrates those facts and more with reference to studies you can find as well, if you're interested in the details. Meanwhile we continue to treat immune compromised people with drugs that further compromise the immune system and - in many cases - kill the patient. When is medicine going to start treating those people by insisting on better eating and supplementation supplying the correct nutrients? How long will it take until the toxic drugs are phased out in favor of real prevention?...

A pizzeria in Germany was recently busted for selling more than just pizza. A major undercover operation revealed that customers who asked for secret item number 40 received a side of cocaine with their pizza. The investigation led to a major drug ring bust where several homes and properties were raided, which led to several […]

The post 10 Restaurants Busted for Selling Drugs appeared first on Listverse.

Three men, two women and a teenage girl are due to appear in court charged with drug offences.

KUCHING: Sarawak police seized 10.4 kilograms (kg) of syabu estimated to be worth RM332,800 in a raid conducted at an apartment in Matang on Monday.

Sarawak Police Commissioner Datuk Mancha Ata said during the raid, a 57-year-old local man who tested positive for methamphetamine and amphetamine was also arrested.

“The total amount of drugs seized could be used by 52,000 addicts and a Kawasaki Z900 motorcycle estimated to be worth RM50,000 was also seized.

“Initial investigations by the police also found that the suspect had a record of past offences under Section 12(2) of the Dangerous Drugs Act 1952,“ he said in a statement here today.

Mancha said the suspect would be remanded for seven days from today until Nov 19 to assist in investigations under Section 39B of the Dangerous Drugs Act 1952.

At least 10 suspects, including a woman, arrested as ANF seizes drugs worth more than Rs 80 million

Taking prescription medicines known as “Z-drugs” for insomnia may lead to complex sleep behaviors, overdose, injury and – in rare cases – death, the Food and Drug Administration cautions in a recent alert.

Founded in 1901 and visited by more than 6.1 million customers daily, Walgreens leads the chain drugstore industry in sales and profit.

The post Antipsychotic Drugs: A Concise Review of History, Classification, Indications, Mechanism, Efficacy, Side Effects, Dosing, and Clinical Application was curated by information for practice.

The post CfP | Psychoactives: Recreational drugs repurposed as novel therapies (Submission Deadline: 27 June) was curated by information for practice.

Fatty acid-derivative prodrugs have been utilized extensively to improve the physicochemical, biopharmaceutical and pharmacokinetic properties of active pharmaceutical ingredients. However, to our knowledge, the crystallization behavior of prodrugs modified with different fatty acids has not been explored. In the present work, a series of paliperidone aliphatic prodrugs with alkyl chain lengths ranging from C4 to C16 was investigated with respect to crystal structure, crystal morphology and crystallization kinetics. The paliperidone derivatives exhibited isostructural crystal packing, despite the different alkyl chain lengths, and crystallized with the dominant (100) face in both melt and solution. The rate of crystallization for paliperidone derivatives in the melt increases with alkyl chain length owing to greater molecular mobility. In contrast, the longer chains prolong the nucleation induction time and reduce the crystal growth kinetics in solution. The results show a correlation between difficulty of nucleation in solution and the interfacial energy. This work provides insight into the crystallization behavior of paliperidone aliphatic prodrugs and reveals that the role of alkyl chain length in the crystallization behavior has a strong dependence on the crystallization method.

The structures of three multicomponent crystals formed with imidazole-based drugs, namely metronidazole, ketoconazole and miconazole, in conjunction with tri­thio­cyanuric acid are characterized. Each of the obtained adducts represents a different category of crystalline molecular forms: a cocrystal, a salt and a cocrystal of salt. The structural analysis revealed that in all cases, the N—H⋯N hydrogen bond is responsible for the formation of acid–base pairs, regardless of whether proton transfer occurs or not, and these molecular pairs are combined to form unique supramolecular motifs by centrosymmetric N—H⋯S interactions between acid molecules. The complex intermolecular forces acting in characteristic patterns are discussed from the geometric and energetic perspectives, involving Hirshfeld surface analysis, pairwise energy estimation, and natural bond orbital calculations.

The U.S. Supreme Court has ruled that low-level crack cocaine offenders cannot benefit from a 2018 federal law.; Credit: J. Scott Applewhite/AP

The U.S. Supreme Court ruled Monday that some crack cocaine offenders sentenced to harsh prison terms more than a decade ago cannot get their sentences reduced under a federal law adopted with the purpose of doing just that.

At issue in the case was the long and now notorious history of sentencing under the 1986 Anti-Drug Abuse Act, which established harsh mandatory prison sentences based on the amount of drugs that the defendant possessed or sold. The triggering amount, however, was different for crack cocaine used most often by Black people, and powder cocaine, used most often by whites.

Indeed, the ratio was 100-to-1, so that a five-year mandatory minimum penalty, for instance, was triggered by possession of 5 grams of crack, whereas the same penalty was triggered by 500 grams of powder cocaine.

Nine years after enactment of these mandatory penalties, the U.S. Sentencing Commission found these disparities unjustified, and by 2010 Congress passed new legislation to reduce the disparity to from 100-to-1 to 18-to-1. But that left everyone previously sentenced under the old regime stuck with the harsher penalties. And in 2018, Congress passed and then-President Donald Trump signed into law a bipartisan bill to make the new ratios retroactive.

That allowed thousands of crack offenders who were serving prison sentences to be resentenced under the new law and new sentencing guidelines, with an average reduction of six years in their sentences. But while the new law allowed even drug kingpins to be resentenced, some prisoners were left out — a number now in the low hundreds, according to the Biden administration.

One of those was the prisoner at the center of Monday's case, Tarahrick Terry, sentenced to nearly 16 years in prison for possession with intent to distribute 3.9 grams of crack cocaine, less than the weight of four paper clips.

He claimed that his sentence, like others, should be revised in light of the 2018 law, but the Supreme Court rejected that argument. Writing for the court, Justice Clarence Thomas noted that Terry had been sentenced under a section of the law that applied to "career criminals," those who had two previous drug or violent convictions. Terry did, in fact, have two previous drug convictions as a teenager — for which he spent 120 days in jail.

So, as Thomas observed, Terry was sentenced under the provision of the law that was not included in the 2018 revision.

Democratic Sens. Dick Durbin and Cory Booker and Republican Sens. Charles Grassley and Mike Lee — the sponsors and drafters of the act — warned in a friend of the court brief filed in the case that excluding low-level offenders from the act's reforms would mean ignoring its purpose. "Had Congress intended to exclude individuals with low-level crack offenses from relief," they wrote, "Congress of course could have done so."

Thomas and the rest of the court rejected that argument. "We will not convert nouns to adjectives and vice versa," wrote Thomas, which is what he said Congress was asking the court to do. The 2018 law, he said, did not change the section of the law under which Terry was sentenced, so the argument that the revision modified the whole law just wouldn't wash.

Although the decision was unanimous, it included an interesting back-and-forth about race between Thomas, the only African American on the court and arguably its most conservative member, and Justice Sonia Sotomayor, its only Hispanic and arguably most liberal member. Specifically, their disagreement was about the role race played in the adoption of mandatory minimum sentences that were wildly more harsh for possession or sale of crack cocaine than for powder cocaine.

As Thomas saw it, the 100-to-1 ratio for crack cocaine was enacted "with near unanimity" by Congress, because of two concerns expressed by Black leaders at the time: First, that crack "was fueling crime against residents in the inner cities who were predominantly black," and second that "prosecutors were not taking these kinds of crimes seriously enough because the victims were disproportionately black." Moreover, he quoted a 1995 U.S. Sentencing Commission report that concluded the 100-to-1 ratio created "a perception of unfairness," even though there was no reason to believe that "racial bias or animus undergirded the initiation of the federal sentencing law."

In a concurring opinion, Sotomayor declined to join that part of Thomas' opinion, because "it includes an unnecessary, incomplete, and sanitized history of the 100-to-1 ratio," including "race-based myths" about crack cocaine.

"The full history is far less benign," she said. It ignores the fact that Black leaders were promised federal investment in longer term solutions — including in job training and education programs — but that help never arrived. Nor, she noted, did the majority opinion mention that the bill containing the 100-to-1 ratio was "rush[ed] through to pass dramatic drug legislation before the midterm elections," and that the legislative history of the bill offered no justification for the 100-to-1 ratio, "save that it was the highest ratio proposed."

"Most egregiously, the Court barely references the ratio's real-world impact" — one so profound and unjustified, as demonstrated by subsequent research — "that the [Congressional Black Caucus] came together in unanimous and increasingly vocal opposition to the law."

In the end, however, Sotomayor agreed that "unfortunately," the reading of the law urged by the primary sponsors of the 2018 revision is not born out by the text. "Fortunately," she added, "Congress has numerous tools to right this injustice."

As for prisoner Terry, who brought Monday's case, he is now in the final months of his prison term, and according to the Biden administration is serving his remaining time in home confinement.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Although the immediate side effects of antimalarial drugs are widely recognized, few studies were designed specifically to examine health problems that might occur or persist months or years after people stopped taking them.

Every year, significant amounts of drugs left over and unused from single-dose vials are discarded, but because of the way drugs are priced and paid for in the United States, the cost of the discarded amount cannot be recouped, says a new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

Science academies from the G-7 nations issued statements urging their governments to take action on four global challenges — developing antiviral drugs to prepare for future pandemics, speeding progress on decarbonization, protecting the oceans and sea ice, and implementing a One Health approach to zoonotic disease and antimicrobial resistance.

Grieving mothers seek to raise awareness of a severe, adverse, delayed, and potentially deadly drug reaction — DRESS Syndrome.

Kratom Kava Bar offers a game-changing natural alternative to pre-workouts and enhancers with kratom. With the potential to alleviate muscle soreness and improve mood and energy, kratom empowers athletes to reach new heights.

'We understand the impact of skyrocketing Insulin costs on patients, and we are committed to alleviating this burden,' says NationDrugs.to

Essential guidelines for patients seeking a reputable Canadian pharmacy

NationDrugs.to introduces a reliable solution for patients searching for affordable and high-quality generic cancer drugs.

NationDrugs.to remains a trusted source for affordable medications and continues to serve customers across the globe who are seeking a cost-effective solution to their healthcare needs.

The cost of prescription drugs in the United States continues to rise, making it difficult for many Americans to afford the medications they need to stay healthy.

By Offering Safe and Reliable Access to Low-Cost Medications from Canadian Pharmacies, SaveRxCanada.to Provides Critical Support for Seniors Struggling with High Prescription Costs in the U.S.

Nation's First Lawsuit Asserting that the Affordable Care Act Forbids Exclusion of Obesity Treatment

LOVE DRUGS is a full pop album debut by danish Thyra. Just like the title LOVE DRUGS all 12 pop tracks are full of ironic twists and happy-sad sweet-pain paradoxes.

The California Workers’ Compensation Institute reported that a nearly eightfold increase in migraine drug prescriptions coincided with the emergence of several high-cost drugs that are not included in the formulary. “Although…

Learn about the risks and benefits of these drugs for symptoms of brain injury.

New research reveals that 50% of European and US pharmaceutical manufacturing companies know artificial intelligence (AI) can help bring new drugs to market more rapidly and securely, but 96% face challenges with using leading-edge technology to derive value from their data.

A survey of employers finds that only about a fifth of large companies cover drugs like Wegovy for weight loss. A majority of companies that do cover the medicines have requirements.

There's something strange going on in hospitals. Cheap, common drugs that nurses use every day seem to be constantly hit by shortages. These are often generic drugs that don't seem super complicated to make, things like dextrose and saline (aka sugar water and salt water).

So what's going on? The answer, as with anything in healthcare, is complicated.

On today's show: why hospitals keep running out of generic drugs. The story behind these shortages tells us a lot about how these drugs are made, bought and sold–and, it shows us how these markets can falter without the proper care.

This episode was hosted by Sally Helm and Alexi Horowitz-Ghazi. It was produced by Willa Rubin, with help from James Sneed and Sam Yellowhorse Kesler. It was edited by Martina Castro. Fact-checking by Dania Suleman. Planet Money's executive producer is Alex Goldmark.

Help support Planet Money and hear our bonus episodes by subscribing to Planet Money+ in Apple Podcasts or at plus.npr.org/planetmoney.

As demand for popular weight-loss drugs like Wegovy and Zepbound skyrockets, patients are taking dosage amounts into their own hands.

The woman, who is sued by the member of super group LSD for alleged harassment, is firing back at the DJ, alleging that he's the predator and that his lawsuit is a 'scare tactic.'

The youngest daughter of Ozzy and Sharon Osbourne explains her struggle with weight gain, claiming that she indulged in food after quitting drugs and alcohol.

A new study involving a special group of people shows significant overlap between psychedelic trips and near-death experiences. What does the Bible say about the latter?

Police have arrested three men and “seized two firearms, a quantity of ammunition, as well as a large quantity of controlled drugs with a street value of over $700,000.” A police spokesperson said, “On Monday, September 30, officers from the Specialist Investigations Unit and Task Force conducted an operation that resulted in the arrests of […]