60,000 students participate virtually from 900 schools in Tirupati district

Unwanted crystals could adversely affect drug stability and shelf life

Study shows how stopping one enzyme could help drugs treat an important class of cancers more effectively

Given the rapid spread of COVID-19 and its relatively high mortality, filling the gap for coronavirus-specific drugs is urgent.

CALVINIA - A 56-year-old Johannesburg man was arrested by South African Police Service (SAPS) officers during a roadblock at Calvinia this past week after drugs with an estimated street value of almost R4 million...

A 56-year-old Johannesburg man was arrested during a roadblock at Calvinia in the Northern Cape this week for storing drugs in his spare tyre.

ISLAMABAD: The Asian Development Bank (ADB) under its ‘Supply Chain Finance Programme’ has dedicated $200 million to support companies that make and distribute medicines and other items needed to combat coronavirus in the developing member countries of the Bank.

The programme aims to stabilise the supply chain for products such as N95 marks, test kits, gloves, personal protective equipment (PPE) for healthcare providers, ventilators, hygiene items, and other critical goods.

The ADB assistance is targeted at channeling fund to manufacturers, their suppliers, and the distributors of critical goods through post-shipment post-acceptance finance, pre-shipment loans, and distributor financing.

Export bans of key materials have worsened the shortage of face masks in 22 economies, including Pakistan, Bangladesh, Canada, Czech Republic, Egypt, France, Germany, India, Indonesia, Iran, Japan, Jordan, Kazakhstan, Kenya, Malaysia, Poland, China, the Russian Federation, the Republic of Korea, Taipei, Thailand and Ukraine. The export bans are in place in these economies since March 18.

Pakistan among nations that faced shortage of masks due to ban on export

A $800m increase in ADB’s Trade Finance Programme will also be mobilised and along with the increase in capital comes flexibility to support domestic and cross-border trade in times of emergency. The programme is an effective crisis response vehicle because it has strong relationships with many banks, both inside developing Asia and globally, the latter particularly helpful to mobilise co-financing, involving private sector resources to leverage the impact of ADB’s direct support.

An ADB report says that surging demand, partly joined with panic buying, hoarding, and misuse of PPE amid the Covid-19 pandemic, is disrupting global supplies and putting lives at risk. Demand has surged, overwhelming global production capacity.

The dramatic rise in demand for surgical masks, goggles, gloves, and gowns has depleted stockpiles, prompted significant price increases, and led to production backlogs of 4 to 6 months in fulfilling orders.

The most significant challenge is to ensure that critical PPE products are sourced and allocated to frontline health workers and other responders in affected countries, especially those most vulnerable to the spread of coronavirus.

The global market for PPE in the health sector was estimated to be worth $2.5 billion in 2018. Gloves have the highest share of sales revenues at 25 per cent, followed by suits or coveralls at 22pc. Face masks and hats came in third with a share of 14pc.

By region, the United States had the largest market share (33pc), followed by Asia and the Pacific (28pc), and Europe (22pc) in 2018.

The PPE supply chain has not been properly functioning to meet a surge in demand due to the constraints in production and logistics. Prices of PPE products have risen dramatically since the beginning of the Covid-19 outbreak: a six-fold increase for surgical masks; threefold for respirators; and a doubling in the price of gowns.

Among the major sources of the identified backlogs in the production and distribution of PPE, with a focus on face masks, are transport and shipping constraints caused by roadblocks and quarantine measures, and lower availability of transportation and freight containers, hoarding, profiteering, and limited workforce capacity due to illness, also contribute to the shortage.

Published in Dawn, May 10th, 2020

High-resolution pictures or atomic-level detail of chikungunya virus interacting with a protein found on the cell surface in the joints was snapped by

Jessica Ennis-Hill has not given up hope of becoming a three-time world champion as she waits for the gold medal she was denied in 2011 by a drugs cheat.

Berlin, May 5: Several drugs approved for the treatment of hepatitis C viral infection have been identified as potential candidates against COVID-19 caused by the SARS-CoV-2 coronavirus, according to a study based on extensive calculations using supercomputer simulations.

Psychotropic drugs seized in city

The non-steroidal anti-inflammatory drugs mefenamic acid (MFA) and tolfenamic acid (TFA) have a close resemblance in their molecular scaffold, whereby a methyl group in MFA is substituted by a chloro group in TFA. The present study demonstrates the isomorphous nature of these compounds in a series of their multicomponent solids. Furthermore, the unique nature of MFA and TFA has been demonstrated while excavating their alternate solid forms in that, by varying the drug (MFA or TFA) to coformer [4-di­methyl­amino­pyridine (DMAP)] stoichiometric ratio, both drugs have produced three different types of multicomponent crystals, viz. salt (1:1; API to coformer ratio), salt hydrate (1:1:1) and cocrystal salt (2:1). Interestingly, as anticipated from the close similarity of TFA and MFA structures, these multicomponent solids have shown an isomorphous relation. A thorough characterization and structural investigation of the new multicomponent forms of MFA and TFA revealed their similarity in terms of space group and structural packing with isomorphic nature among the pairs. Herein, the experimental results are generalized in a broader perspective for predictably identifying any possible new forms of comparable compounds by mapping their crystal structure landscapes. The utility of such an approach is evident from the identification of polymorph VI of TFA from hetero-seeding with isomorphous MFA form I from acetone–methanol (1:1) solution. That aside, a pseudopolymorph of TFA with di­methyl­formamide (DMF) was obtained, which also has some structural similarity to that of the solvate MFA:DMF. These new isostructural pairs are discussed in the context of solid form screening using structural landscape similarity.

Although the immediate side effects of antimalarial drugs are widely recognized, few studies were designed specifically to examine health problems that might occur or persist months or years after people stopped taking them.

Constructed wetlands can effectively remove veterinary drugs from wastewater, preventing contamination of the environment, research suggests. A recent study has demonstrated that laboratory-scale constructed wetlands were able to remove between 94 and 98% of two commonly used antibiotics from pig farm wastewater.

A recent report raises awareness of the impact of pharmaceuticals in the environment. Experts from science, industry and the state sector have drawn up a series of proposals for actions that need to be taken at the European level to increase understanding and improve management of the risks.

Aeration is an effective means of eliminating antidepressants from landfill leachate, a new study finds. The concentrations of five different drugs were reduced by this treatment process, which could be an effective means of tackling the growing problem of pharmaceutical infiltration into aquatic environments.

Up to 90% of consumed drugs enter the environment. This may have negative effects on wildlife, especially when the drugs take long periods to break down. This study assessed the breakdown of sulphonamides — a class of antibacterials — in samples from two rivers in Poland. The results showed that sulphamethoxazole, a common veterinary antibiotic, was the most persistent and that various factors inhibit degradation, including low temperatures, heavy metal pollution and low pH.

From ginger to exercise, natural methods may help beat cramps, bloating and other monthly symptoms.

Brazen raccoon bandits may be trying to trying to send Toronto a message. They have been showing up in all sorts of places.

People should be cautions about using two new weight-loss drugs because it's not clear whether they increase the risk for heart problems.

A study from UC Berkeley reveals that information stimulates our dopamine-producing reward system — just like food and money.

Anxiety Do you often find yourself stressed out because of certain misfortunes of the past or uncertainty of future? How frequently do you feel a pang of an unpleasant emotion in anticipation of some ill- defined calamity? If very often it is time for you to realize that you are suffering from some anxiety disorder that causes innumerable psychological and physical tribulations.

The Corporate Whistleblower Center says, "We are urging an honest pharmacist to call us anytime if they have proof a pharmacy chain is gouging Medicare, Medicaid or TRICARE in anyway. Sometimes these types of people can make millions."

The Corporate Whistleblower Center says, "We are appealing to a pharmacist or pharmacy manager to call us anytime at 800-714-0303 if their employer is overcharging Medicare and Medicaid. The rewards for this type of information can be substantial."

Mandatory testing of fatal crash drivers a national priority. "Probable Cause" used as an excuse for not testing must no longer be allowed. Join our NATIONAL COALITION! madtests.com. Mandatory Alcohol/Drug testing of all fatal crash driver.

Just released data from the National Highway Traffic Safety Agency (NHTSA) shows 67% of all fatal crash drivers were not drug tested and 59% not tested for DUI, For fatally injured drivers, 46% were not tested for drugs and 38% not tested for DUI.

Book Become International Best Seller

A computational study of 4,600 drugs indicates that approved drugs were less effective than non-approved drugs when binding to a COVID-19 protein. In addition, Diosmin, a non-prescription natural supplement bound better than 99% of drugs considered.

The study, published in the journal Pathogens, found that all four drugs were effective in inhibiting, or blocking, the coronavirus' RNA proteins from making genomic copies of the novel coronavirus.

The present invention provides carbonate prodrugs which comprise a carbonic phosphoric anhydride prodrug moiety attached to the hydroxyl or carboxyl group of a parent drug moiety. The prodrugs may provide improved physicochemical properties over the parent drug. Also provided are methods of treating a disease or condition that is responsive to the parent drug using the carbonate prodrugs, as well as kits and unit dosages.

This invention is related to a pharmaceutical combination that contains a Casein kinase 2 (CK2) peptide inhibitor (termed P15) along with the standard chemotherapeutic drugs used in cancer treatment and which are administered together, separated or sequentially. The chemotherapeutic drugs include cisplatin, taxol, alkaloids from Vinca, 5-fluorouracil, doxorubicin, cyclophosphamide, etoposide, mitomicin C, imatinib, iressa and velcade (vortezomib). The synergism between the P15 peptide and the anticancer drugs achieves an efficient concentration of each cytostatic drug in the combination which is from 10- to 100-fold lower than that for each cytostatic drug alone. The pharmaceutical combination described in this invention exhibits lower toxicity compared to that reported by the anticancer therapeutics and therefore, it represents a crucial advantage for its use in cancer therapy. Furthermore, the sequential administration of this pharmaceutical combination through the pretreatment with the P15 peptide leads to the chemo sensibilization of refractory tumors to the anticancer therapeutics.

It is an object of the present invention to provide antimicrobial metallodrugs comprising an antimicrobial peptide (“AMP”) and/or an antibiotic covalently bound to a metal binding moiety. These metallodrugs combine a metal binding domain which typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, with a member of a diverse class of antimicrobial agents currently validated in preclinical and clinical settings for the treatment of a broad spectrum of pathogenic organisms.

The present invention provides assays for detecting and measuring the presence or level of anti-TNFα drug therapeutics and autoantibodies in a sample. The present invention is useful for optimizing therapy and monitoring patients receiving anti-TNFα drug therapeutics to detect the presence or level of autoantibodies (e.g., HACA and/or HAHA) against the drug.

RETIRED engineer Brian Cramp is a medical pioneer.

Microbes are the bacteria that live in our guts. Scientists are learning how they help us process medication.

The so-called evidence collected by fan of the 'Shortie Like Mine' hitmaker's rumored drug abuse confirms an Instagram thot's claim that they were high on whippets during a drug-filled night out in April.

http://www.musicxray.com/xrays/1319824 Luh Guccii - Luh Guccii ft. Kevo - Fix it up(everday off the drugs)

Swami Sivananda who was a medical doctor by profession shares with us simple and cheap remedies for common ailments..

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Prescription drugs can cost a fortune. One reader wonders aloud about saving money on brand-name medicine.

One of the hottest debates in the coronavirus pandemic is whether the malaria drugs promoted as possible treatments by President Donald Trump really work. But Americans don’t seem overly eager to help answer the question. Enrollment in several clinical trials of chloroquine and hydroxychloroquine — including two by the University of Washington — has been […]

One of the hottest debates in the coronavirus pandemic is whether the malaria drugs promoted as possible treatments by President Donald Trump really work. But Americans don’t seem overly eager to help answer the question. Enrollment in several clinical trials of chloroquine and hydroxychloroquine — including two by the University of Washington — has been […]

One of the hottest debates in the coronavirus pandemic is whether the malaria drugs promoted as possible treatments by President Donald Trump really work. But Americans don’t seem overly eager to help answer the question. Enrollment in several clinical trials of chloroquine and hydroxychloroquine — including two by the University of Washington — has been […]