drugs

Clinical trial enrollment plummets as volunteers are scared off coronavirus drugs promoted by Trump


One of the hottest debates in the coronavirus pandemic is whether the malaria drugs promoted as possible treatments by President Donald Trump really work. But Americans don’t seem overly eager to help answer the question. Enrollment in several clinical trials of chloroquine and hydroxychloroquine — including two by the University of Washington — has been […]




drugs

Mogelijk drugsafval gedumpt midden in woonwijk Arnhem

In een woonwijk in Arnhem zijn vanochtend ten minste veertig vaten met chemisch afval aangetroffen. De politie vermoedt dat het gaat om drugsafval van een illegaal laboratorium.

Vaten met drugsafval worden vaker gedumpt, vooral in Brabant en Limburg, maar ook in Gelderland. Meestal gebeurt dat buiten de bebouwde kom. Maar nu lagen de vaten aan de Randweg in Arnhem, midden in een groene woonwijk ten zuiden van de Rijn.

"Dat het zo midden in een woonwijk ligt, zien we vaker. Daar maken wij ons wel zorgen over", zegt politiewoordvoerder Marèl van Steenbergen bij Omroep Gelderland.

De vaten zijn inmiddels geruimd door een gespecialiseerd bedrijf.

Derde vondst in korte tijd

Het is het derde incident met drugsafval deze week in Arnhem-Zuid en het nabijgelegen Elst. In de nacht van woensdag op donderdag werden vaten met chemisch afval gevonden in het buitengebied bij Elst.

Donderdagochtend trof de politie op de Drielsedijk een aantal tonnen en jerrycans aan. De politie onderzoekt of er een verband is tussen de drie dumpingen, meldt dagblad De Gelderlander.




drugs

Bunbury prison in full lockdown as raid nets 'significant quantity' of drugs

A prison in WA's South West remains in full lockdown as a three-day raid uncovers a significant haul of drugs and syringes.




drugs

Yacht carrying tonne of drugs hits Abrolhos Islands reef, alleged smugglers found on island

Two men are charged with trying to smuggle more than a tonne of cocaine and ecstasy into WA, after their yacht hit a reef and they were found on an island in the Houtman Abrolhos allegedly hiding the drugs with seaweed.





drugs

Drugs found in Australia Post parcels leads to investigation by Limestone Coast police

A routine car search by Limestone Coast police has led to an investigation into whether south-east drug users are using Australia Post as a courier service to send and receive illegal drugs.




drugs

Albany man charged over drugs package

Police have charged an Albany man who allegedly attempted to import hundreds of thousands of dollars worth of methylamphetamine from Mexico.




drugs

Savages: Sex, drugs and Oliver Stone

Director Oliver Stone turns Don Winslow's tale of drugs, deception and decapitation into his latest gift for the big screen, Savages.




drugs

Police allege man had six drugs in system after being caught on NT highway

A man is allegedly found with six prohibited substances in his system after being pulled over on a highway in the Northern Territory yesterday morning.




drugs

Why are there so many drugs to kill bacteria, but so few to tackle viruses?

Why are there so few antivirals? The answer boils down to biology, and specifically the fact viruses use our own cells to multiply. This makes it hard to kill viruses without killing our own cells in the process.




drugs

Port Augusta Prison death inquest hears drugs are 'coming through the front door'

Drugs including ice are readily available and "coming through the front door" of a South Australian jail, an inquest into a fatal overdose of a prisoner finds.





drugs

South Gippsland council sacked: One councillor on drugs charges, another accused of misusing position

The Victorian Government said ongoing conflict between councillors had reduced the respect for, and standing of, the council in the community.




drugs

Greg Fisher spent seven years and 10 months in jail for dealing drugs. He's now heading up the charity Threaded Together, a charity that aims to diver




drugs

Prison drugs under investigation in death of NT's first contract killer Christopher Malyschko

The Northern Territorys first known contract killer may have accidentally died in his prison cell after using drugs, investigators believe.




drugs

State Crime detective stood down after drugs go missing from evidence room

A State Crime Detective Senior Constable is stood down after police discover a dangerous drug, believed to be cocaine, has been stolen from an evidence room.




drugs

Man, 20, charged with supplying drugs that police believe led to FOMO Festival death

A man is charged with supplying the drugs police believe 19-year-old Alex Ross-King took before she died from a suspected fatal overdose at a dance festival in western Sydney at the weekend.



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drugs

McClain v. Sav-On Drugs

(Supreme Court of California) - Held that customers who had paid sales tax on purchases they believed to be exempt did not have an equitable cause of action to compel the retailers to seek a tax refund from the state, under the facts here. Affirmed a judgment sustaining the retailers' demurrer.




drugs

Featured Centennial Paper - The History of Impaired Driving and the Role of the Transportation Research Board Committee on Alcohol, Other Drugs, and Transportation

The Alcohol and Other Drugs Committee's Centennial Paper to review what it has accomplished since its inception in the early 1970s, how it has evolved along with the field, and what challenges and opportunities it confronts going forward. To learn more about the history of impaired driving and the Standing Technical Committee on Alcohol, Other Drugs, and Transportation (ANB50), check out the Committee's Centennial Paper. As part of TRB's Centennial Celebration, the Technical Activities Council invited al...





drugs

MacMillan illuminates the micro-environment, creating a new path to cancer drugs

A team of Princeton chemists has identified a way to tag a protein's nearest molecular neighbors, enabling the precise mapping of their micro-environment. This could open new avenues to cancer treatment and other drug therapies.




drugs

Pete Davidson asks people to stop bringing drugs to his mom’s house on Staten Island

Pete Davidson, who recently said he quit using drugs, urged people not to drop off any weed or other illegal substances at his mom’s Staten Island house after a stranger did just that a few days ago.




drugs

Two new Ebola drugs dramatically boost survival in a clinical trial

Both treatments rely on infusing patients with antibodies that latch onto the virus and block it from invading cells.




drugs

Pete Davidson asks people to stop bringing drugs to his mom’s house on Staten Island

Pete Davidson, who recently said he quit using drugs, urged people not to drop off any weed or other illegal substances at his mom’s Staten Island house after a stranger did just that a few days ago.




drugs

Pete Davidson asks people to stop bringing drugs to his mom’s house on Staten Island

Pete Davidson, who recently said he quit using drugs, urged people not to drop off any weed or other illegal substances at his mom’s Staten Island house after a stranger did just that a few days ago.




drugs

Pete Davidson asks people to stop bringing drugs to his mom’s house on Staten Island

Pete Davidson, who recently said he quit using drugs, urged people not to drop off any weed or other illegal substances at his mom’s Staten Island house after a stranger did just that a few days ago.




drugs

Malaria drugs aren't the only ones on the shelf that might help coronavirus patients

Treating patients with "moderate" COVID-19 is a way to stop the disease from progressing to a severe stage that would require mechanical ventilation.




drugs

Malaria drugs fail to help coronavirus patients in controlled studies

Hydroxychloroquine, the drug President Trump hailed as a coronavirus killer, had no beneficial effect for COVID-19 patients in two controlled trials.




drugs

Coronavirus: Prostate-cancer men swap chemo for precision drugs

Men with advanced prostate cancer can now take highly targeted hormone therapies at home.




drugs

‘After eight years on drugs, I run a million-dollar firm again'

The US designer who rebuilt his life after destroying it through cocaine and crystal meth addiction.




drugs

Undercurrents: Episode 3 – Duterte’s War on Drugs, and European Security




drugs

Drugs and Organized Crime: The Challenges Facing Southeast Asia




drugs

Coronavirus drugs: Where are we, and what's next? (video)

(American Chemical Society) Antiviral drugs could help us fight the new coronavirus, but currently, we don't have a highly potent, effective antiviral that cures COVID-19. Why not? We called a few virologists to find out: https://youtu.be/AIpeZDR9i3E.




drugs

Bacteria ‘factories’ used to discover potential new malaria drugs

Researchers have engineered bacteria to produce new versions of a potential antibiotic molecule, some with potent antimalarial properties.




drugs

Study to research impact of COVID-19 on people who use drugs

(University of Stirling) Understanding the health impacts of the COVID-19 pandemic on people who use drugs in Scotland is the focus of a new University of Stirling study.




drugs

AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer

D. Grahame Hardie
Jul 1, 2013; 62:2164-2172
Perspectives in Diabetes




drugs

The war on drugs has failed: doctors should lead calls for drug policy reform




drugs

Covid-19: Doctors face shortages of vital drugs, gases, and therapeutics, survey finds




drugs

Covid-19: Allow pharmacists to dispense controlled drugs without prescription, urge specialists




drugs

Talk Evidence - Z drugs, subclinical hypothyroidism and Drazen's dozen

This week on the podcast, (2.02) a listener asks, when we suggest something to stop, should we suggest an alternative instead? (8.24) Helen tells us to stop putting people on treatment for subclinical hypothyroidism, but what does that mean for people who are already receiving thyroxine? (20.55) Carl has a black box warning about z drugs, and...




drugs

Comprehensive Glycomic Analysis Reveals That Human Serum Albumin Glycation Specifically Affects the Pharmacokinetics and Efficacy of Different Anticoagulant Drugs in Diabetes

Long-term hyperglycemia in patients with diabetes leads to human serum albumin (HSA) glycation, which may impair HSA function as a transport protein and affect the therapeutic efficacy of anticoagulants in patients with diabetes. In this study, a novel mass spectrometry approach was developed to reveal the differences in the profiles of HSA glycation sites between patients with diabetes and healthy subjects. K199 was the glycation site most significantly changed in patients with diabetes, contributing to different interactions of glycated HSA and normal HSA with two types of anticoagulant drugs, heparin and warfarin. An in vitro experiment showed that the binding affinity to warfarin became stronger when HSA was glycated, while HSA binding to heparin was not significantly influenced by glycation. A pharmacokinetic study showed a decreased level of free warfarin in the plasma of diabetic rats. A preliminary retrospective clinical study also revealed that there was a statistically significant difference in the anticoagulant efficacy between patients with diabetes and patients without diabetes who had been treated with warfarin. Our work suggests that larger studies are needed to provide additional specific guidance for patients with diabetes when they are administered anticoagulant drugs or drugs for treating other chronic diseases.




drugs

Combination of HIV, hepatitis C, MS drugs might resolve COVID-19 infection

Combination therapy with interferon beta-1b plus lopinavir-ritonavir and ribavirin appears to improve symptoms and shorten hospital stays for people with mild to moderate COVID-19.




drugs

Efficacy and Safety of 1:1 Fixed-Ratio Combination of Insulin Glargine and Lixisenatide Versus Lixisenatide in Japanese Patients With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs: The LixiLan JP-O1 Randomized Clinical Trial

OBJECTIVE

To assess the efficacy and safety of a 1:1 fixed-ratio combination of insulin glargine and lixisenatide (iGlarLixi) versus lixisenatide (Lixi) in insulin-naive Japanese patients with type 2 diabetes mellitus (T2DM) inadequately controlled on oral antidiabetic drugs (OADs).

RESEARCH DESIGN AND METHODS

In this phase 3, open-label, multicenter trial, 321 patients with HbA1c≥7.5 to ≤10.0% (58–86 mmol/mol) and fasting plasma glucose (FPG) ≤13.8 mmol/L (250 mg/dL) were randomized 1:1 to iGlarLixi or Lixi for 52 weeks. The primary end point was change in HbA1c at week 26.

RESULTS

Change in HbA1c from baseline to week 26 was significantly greater with iGlarLixi (–1.58% [–17.3 mmol/mol]) than with Lixi (–0.51% [–5.6 mmol/mol]), confirming the superiority of iGlarLixi (least squares [LS] mean difference –1.07% [–11.7 mmol/mol], P < 0.0001). At week 26, significantly greater proportions of patients treated with iGlarLixi reached HbA1c <7% (53 mmol/mol) (65.2% vs. 19.4%; P < 0.0001), and FPG reductions were greater with iGlarLixi than Lixi (LS mean difference –2.29 mmol/L [–41.23 mg/dL], P < 0.0001). Incidence of documented symptomatic hypoglycemia (≤3.9 mmol/L [70 mg/dL]) was higher with iGlarLixi (13.0% vs. 2.5%) through week 26, with no severe hypoglycemic events in either group. Incidence of gastrointestinal events through week 52 was lower with iGlarLixi (36.0% vs. 50.0%), and rates of treatment-emergent adverse events were similar.

CONCLUSIONS

This phase 3 study demonstrated superior glycemic control and fewer gastrointestinal adverse events with iGlarLixi than with Lixi, which may support it as a new treatment option for Japanese patients with T2DM that is inadequately controlled with OADs.




drugs

Drug eruptions : a clinical study on the irritant effects of drugs upon the skin / by Prince A. Morrow.

New York : W. Wood, 1887.




drugs

Elements of materia medica : containing the chemistry and natural history of drugs, their effects, doses, and adulterations : with observations on all the new remedies recently introduced into practice, and on the preparations of the British Pharmacopoeia

London : J. Churchill, 1864.




drugs

Young men and drugs : a nationwide survey / by John A. O'Donnell, Harwin L. Voss, Richard R. Clayton, Gerald T. Slatin, Robin G. W. Room.

Rockville, Maryland : National Institute on Drug Abuse, 1976.




drugs

Drugs and driving / editor, Robert E. Willette.

Rockville, Maryland : The National Institute on Drug Abuse, 1977.




drugs

Women and drugs : a new era for research / editors, Barbara A. Ray, Monique C. Braude.

Rockville, Maryland : National Institute on Drug Abuse, 1986.




drugs

Strategies for research on the interactions of drugs of abuse / editors, Monique C. Braude, Harold M. Ginzburg.

Rockville, Maryland : National Institute on Drug Abuse, 1986.




drugs

Urine testing for drugs of abuse / Richard L. Hawks, C. Nora Chiang.

Rockville, Maryland : National Institute on Drug Abuse, 1986.