Disclosed is a process for converting a reactant composition comprising H2 and CO to a product comprising at least one aliphatic hydrocarbon having at least about 5 carbon atoms, the process comprising: flowing the reactant composition through a microchannel reactor in contact with a Fischer-Tropsch catalyst to convert the reactant composition to the product, the microchannel reactor comprising a plurality of process microchannels containing the catalyst; transferring heat from the process microchannels to a heat exchanger; and removing the product from the microchannel reactor; the process producing at least about 0.5 gram of aliphatic hydrocarbon having at least about 5 carbon atoms per gram of catalyst per hour; the selectivity to methane in the product being less than about 25%. Also disclosed is a supported catalyst comprising Co, and a microchannel reactor comprising at least one process microchannel and at least one adjacent heat exchange zone.

The present invention features compounds having the Formula (Ia) and (Ib) (e.g., a compound of any of Formulas ((Ia-2)-(Ia-21)), including other tautomers, stereoisomers, E/Z stereoisomers, prodrugs, pharmaceutically acceptable salts, and compositions thereof. The invention also features methods for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient by administering an effective amount of a compound of Formula (Ia) or (Ib). The invention also features a method for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient that includes administering to a patient in need thereof an effective amount of a compound of Formula (IIa) or (IIb) (e.g., a compound of any of Formulas ((IIa-2)-(IIa-6)). The compounds described herein (e.g., a compound of Formulas (Ia), (Ib), (IIa), or (IIb)) can also be used as anticonvulsants.

The present invention is concerned with a process for preparing 5-(2{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one or a pharmaceutically acceptable salt thereof.

A molecule possessing a primary or secondary amino group and an additional functionality capable of providing a novel or improved property to a cellulose material has been permanently attached to the cellulose material in aqueous media using a water-soluble carbodiimide as the coupling agent/activator. One such molecule is 5-aminofluorescein (abbreviated as “A-fluo”) and one such cellulose material is a papermaking pulp. Papers made from a pulp furnish containing, for example, 0.01 wt. % of the “A-fluo”-attached pulp show an embedded marker feature authenticable upon UV or visible light excitation. The “A-fluo”-attached pulp can also be used for the marking and identification of a pulp furnish.

Thermoplastic composition and articles containing UV absorbers that protect the articles contents from harmful UV radiation are disclosed as well as methods for making the thermoplastic articles and methods for using the articles to contain and protect materials sensitive to UV radiation. The UV absorbers contain oxazolone and/or azine functional groups that absorb UV radiation and prevent its transmission into the article. Many of the compounds are novel compositions of matter. The generally clear thermoplastic articles of this disclosure are particularly useful for containing a variety of UV sensitive consumer products that would otherwise have to be packaged in opaque containers.

A TMR sensor that includes a free layer having at least one B-containing (BC) layer made of CoFeB, CoFeBM, CoB, COBM, or CoBLM, and a plurality of non-B containing (NBC) layers made of CoFe, CoFeM, or CoFeLM is disclosed where L and M are one of Ni, Ta, Ti, W, Zr, Hf, Tb, or Nb. One embodiment is represented by (NBC/BC)n where n≧2. A second embodiment is represented by (NBC/BC)n/NBC where n≧1. In every embodiment, a NBC layer contacts the tunnel barrier and NBC layers each with a thickness from 2 to 8 Angstroms are formed in alternating fashion with one or more BC layers each 10 to 80 Angstroms thick. Total free layer thickness is

Type composing apparatus is disclosed as including means for representing its binary code a series of characters, means for generating a relative width value for each character, means for representing a succession of point size factors, one for each character, and means for multiplying a relative width value assigned to each character by a point size factor for that character. The means for multiplying associated pairs of relative width values and point size factors is disclosed as comprising a memory having stored therein products of relative width values and point size factors. Means are shown for addressing and extracting from the memory an adjusted width value and point size factor. The means for generating a relative width value for each character is depicted as including a read-only integrated circuit memory having permanently stored therein at mutually exclusive addresses a relative width value for each of the characters. One embodiment of a photocomposing machine is disclosed.

Novel photoactive polymers, as well as related photovoltaic cells, articles, systems, and methods, are disclosed.

An ultra-fine nepheline syenite powder produced from a pre-processed nepheline syenite powder feedstock. The powder having a “controlled” maximum grain size D95 or D99 of less than about 20 microns and a “controlled” minimum grain size D5 in the range of 2-8 microns with a particle size spread D5-D95 of less than about 12 microns.

The invention provides a new method for preparing ultra-small polymeric-lipidic delivery nanoparticles (USDNs) that were synthesized by a nanoprecipitation method followed by a layer-by-layer nanodeposition. The USDNs particle size can be controlled between 5-25 mn and provides loading capacities of 22.12% to 72.08%. Moreover, the USDNs platform provides pH controlled drug release, within a terminal release ratio of 68% at pH 5.0 and almost no release to pH of 7.5. Furthermore, based on their small sizes (5-25 nm) and unique composition, the USDNs penetrates the skin strata efficiently, release the payload at the target site as topical or transdermal treatment of a variety of skin disorders. Additionally the USDNs system can be used to treat and diagnoses other crucial diseases (Cancer, Alzheimer, etc) can be combined with various micro-needles or needles free array technologies for special application.

The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing whether PD has progressed in a subject afflicted with PD, assessing whether a neurological disorder is developing in a subject who has been identified as being at risk of developing the neurological disorder, assessing whether a subject afflicted with a neurological disorder is likely to benefit from a therapy, assessing whether a subject afflicted with a neurological disorder has benefited from a therapy, treating a subject afflicted with a neurological disorder, and prophylactically treating a subject who has been identified as being at risk of developing a neurological disorder. The present invention also provides epitopes, compounds and compositions relating to these methods.

The present invention is directed to novel organoleptic compounds, a process of augmenting, enhancing or imparting taste to a material selected from the group consisting of a foodstuff, a chewing gum, a dental product, an oral hygiene product and a medicinal product comprising the step of incorporating an olfactory acceptable amount of such novel organoleptic compounds, and a process of improving, enhancing or modifying a fragrance composition through the addition of an olfactory acceptable amount of such novel organoleptic compounds.

A formulation consisting of a food-grade dye and a plant aroma cocktail is uptaken by plants and flowers and fruit. The improved aroma profile and color make the plant or it's flowers or it's fruit more desirable for consumption or viewing with an enhanced aroma.

A three-dimensional (3D) scanner device for generating a three dimensional (3D) surface model of shaped objects, such as dental structures, applicable for use in the field of dentistry, particularly to dental prosthetics manufacturing is described. The scanning device can include a probe head having a particular configuration and utility. Methods and systems relating to the device and components thereof are also disclosed.

A configurable container-support frame is disclosed. The frame includes at least two sections, each section including at least three substantially parallel telescoping members, each connected to two other members by a cross member that is substantially perpendicular to the telescoping members. The telescoping members of one section telescopically engage with the telescoping members of at least one other section and the engaged sections define a configurable volume. The frame may be disposed within an existing container, such as a bag or a box, to improve the protective capabilities of that container. Or the frame may be integrated with a surface, such as a fabric, to create a configurable container with improved protective capabilities over the surface alone.

A novelty apparel includes multiple attached conformable, selectable and viewable occupational role playing indicia. A baseball cap includes a dome shaped crown of compound curves and a forward facing sun visor brim portion, a display region in a central front face portion of the dome shaped crown, where the display region displays a first permanent occupational status identifier and a mounting region for a secondary occupational status identifier selectable from a number of different indicia carried on a display surface conformable to said dome shaped crown. The selected indicium is displayed centered above the brim. The display surface conforms to the curved exterior of the dome shaped crown, wherein the baseball cap does not deviate substantially from the look of a typical baseball cap with a single permanent indicium.

The present invention mainly provides a novel microchannel structure comprising a plurality of first fluid-guiding channels, a plurality of micro fluid-guiding channels and a plurality of second fluid-guiding channels. Particularly, the first fluid-guiding channel has an arc-shaped fluid-guiding end corner communicating with a first channel opening of the micro fluid-guiding channel, and the second fluid-guiding channel has an arc-shaped fluid-guiding start corner communicating with a second channel opening of the micro fluid-guiding channel. Therefore, when a refrigerant fluid flows in the heat sink, the flow speed of the refrigerant fluid would be changed because the cross sectional area of an U-shaped fluid-guiding channel constructed by the arc-shaped fluid-guiding end corner, the micro fluid-guiding channel and the arc-shaped fluid-guiding start corner varies along the flow direction of the refrigerant fluid, such that the heat dissipating ability of the heat sink is enhanced without increasing the power of circulation pump.

The invention is drawn to novel nanostructures comprising hollow nanospheres and nanotubes for use as chemical sensors, conduits for fluids, and electronic conductors. The nanostructures can be used in microfluidic devices, for transporting fluids between devices and structures in analytical devices, for conducting electrical currents between devices and structure in analytical devices, and for conducting electrical currents between biological molecules and electronic devices, such as bio-microchips.

The present invention relates to a novel method for detecting a detection object in a sample, and a detection device using the same. The detecting method of the present invention uses a “bridge composite” in which gold nanoparticles and an antibody specific to a detection object are coupled in order to induce a sufficient coupling reaction between the antibody and the detection object, thereby improving reactivity. Accordingly, since excellent resolution is provided, the method of the present invention has advantages of enabling accurate concentration measurement of a detection object in a sample, and amplifying a measurement signal. In addition, the method of the present invention can effectively detect small molecules such as hormones, vitamins, etc. having a small molecular weight.

A compound represented by the following formula (1):

Schools are closed, and Zoom is the new classroom for thousands of Bay Area students. We'll discuss how local school districts are handling distance learning, get tips from teachers and hear about what we can do to create equitable learning experiences for all. We'll also get a update on the lastest local pandemic developments and hear a specially composed reflection on life in the coronavirus era by Bay Area novelist Vanessa Hua. And we want to hear from you. Call us during the show with your questions and experiences: 866-798-TALK or send an email anytime to cityvisions@kalw.org . Wednesday, April 15 at 9 PM. Guests : Erin Allday , health reporter, San Francisco Chronicle Peter Chin-Hong , professor of medicine and infectious diseases specialist, UCSF JC Farr , principal, Tamalpais High School in Marin County Lisa Kelly , 6th grade English teacher at the Life Academy in Oakland Jill Tucker, K-12 education reporter, San Francisco Chronicle Vanessa Hua , novelist whose books include

The New Yorker’s fiction editor, Deborah Treisman, talks with Salman Rushdie about “Quichotte,” his apocalyptic quest novel. A few years ago, when the four hundredth anniversary of “Don Quixote” was being celebrated, Rushdie reread Cervantes’s book and found himself newly engaged by a much-improved translation. He immediately began thinking of writing his own story about a “silly old fool,” like Quixote, who becomes obsessed with an unattainable woman and undertakes a quest to win her love. This character became Quichotte (named for the French opera loosely based on “Don Quixote”), who is seeking the love of—or, as she sees it, stalking—a popular talk-show host. As Quichotte journeys to find her, he encounters the truths of contemporary America: the opioid epidemic, white supremacy, the fallout from the War on Terror, and more. “I’ve always really liked the risky thing of writing very close up against the present moment,” Rushdie tells Treisman. “If you do it wrong, it’s a catastrophe. If you do it right, with luck, you somehow capture a moment.” At the same time, the novel gives full rein to Rushdie’s fantastical streak—at one point, for instance, Quichotte comes across a New Jersey town where people turn into mastodons. Treisman talks with the author about the influence of science fiction on his imagination, and about his personal connection to the tragedy of opioids. Rushdie’s much younger sister died from the consequences of addiction, and the book is centrally concerned with siblings trying to reconnect after separation.

NPR's Scott Simon speaks with author Amy Jo Burns about her debut novel, "Shiner," set in the West Virginia mountains.

For nearly 15 years, National Medal of the Arts award-winning poet and author Julia Alvarez has focused on writing picture books and novels for children. But earlier this year, she published her first novel for adults in more than a decade, called Afterlife . The protagonist, Antonia Vega, is a woman in her late 60s reckoning with isolation and her new identity after her husband’s sudden death. In a world upended by the ongoing coronavirus pandemic and wrestling with its own kind of communal grief, the themes of the novel resonate in ways that Alvarez never could have predicted.

In this episode of Free as in Freedom, Karen and Bradley discuss in the first segment recent press coverage of sexist attitudes at Free Software conferences, and in the second segment, discuss the public filings related to the Novell sale.

Show Notes:

Segment 0 (00:40)

• Karen and Bradley discuss an article called The Dark Side of Open Source Conference, which was covered some in the tech press, in press outside of technology. Deb Nicholson wrote a blog post about it, as did Valerie (the original article's author. (01:06)
• Bradley mentioned his blog post where he discussed issues of gender equality across all Computer Science, not just the Free Software community. (05:29)
• Karen mentioned Kirrily “Skud” Robert. (10:27)

Segment 1 (32:18)

• There was an announcement that Novell will be sold (32:15)
• Karen mentioned that Andy Updegrove blogged twice on the subject (32:30)
• Karen talked about the 8K filing that Novell made regarding the purchase. (34:30)
• Karen mentioned a post on groklaw. (42:43)
• Bradley mentioned that the OIN patent license is incredibly narrow and not particularly useful, because the definition of the “Linux system“ is so narrow, and because OIN is a pro-patent, for-profit company that doesn't have the interest of Free Software at its heart. (45:30)
• Karen disagrees with Bradley's comments on OIN and thinks his characterization of the patent pool is a serious exaggeration. (46:00)

These show notes are Copyright © 2010, Karen Sandler and Bradley M. Kuhn of Free as in Freedom, and are licensed under the Creative Commons Attribution-Share-Alike 3.0 Unported license (CC-By-SA-3.0 Unported).

Send feedback and comments on the cast to <oggcast@faif.us>. You can keep in touch with Free as in Freedom on our IRC channel, #faif on irc.freenode.net, and by following Conservancy on on Twitter and and FaiF on Twitter.

Free as in Freedom is produced by Dan Lynch of danlynch.org. Theme music written and performed by Mike Tarantino with Charlie Paxson on drums.

The content of this audcast, and the accompanying show notes and music are licensed under the Creative Commons Attribution-Share-Alike 4.0 license (CC BY-SA 4.0).

Anyone who stumbled on the tweet sent out by Renard Bell at 2:41 p.m. Friday would understand why the Washington State wide receiver is smiling again. “My grandma is fully recovered from COVID-19,” Bell posted with two emojis – the first depicting a set of hands praying and the second of a heart. My grandma […]

Anyone who stumbled on the tweet sent out by Renard Bell at 2:41 p.m. Friday would understand why the Washington State wide receiver is smiling again. “My grandma is fully recovered from COVID-19,” Bell posted with two emojis – the first depicting a set of hands praying and the second of a heart. My grandma […]

Behind shortages of masks and ventilators is a staggering disruption of the global system of making, assembling and delivering critical products.

The list of events that have been canceled in the Seattle area continues to grow as we head into the third week of the novel coronavirus outbreak. We'll keep this list updated throughout the week.

Due to restrictions on gatherings to slow the spread of COVID-19, many organizations are canceling public gatherings and social events around the city, and are, instead, holding their events, concerts, classes, activities and more online. Submit your events and we will add them to our updating list. Loading…

The list of events that have been canceled in the Seattle area continues to grow as we head into the third week of the novel coronavirus outbreak. We'll keep this list updated throughout the week.

Due to restrictions on gatherings to slow the spread of COVID-19, many organizations are canceling public gatherings and social events around the city, and are, instead, holding their events, concerts, classes, activities and more online. Submit your events and we will add them to our updating list. Loading…

Cut through the misinformation with this visual guide to the new coronavirus, how it spreads, how COVID-19 affects the body, and how to protect yourself and others.

From the godfather of crime fiction to a fresh new voice in the genre, here are three gripping new cases for you to solve from the comfort of your reading chair.

Due to restrictions on gatherings to slow the spread of COVID-19, many organizations are canceling public gatherings and social events around the city, and are, instead, holding their events, concerts, classes, activities and more online. Submit your events and we will add them to our updating list. Loading…

Here's a look at some Seattle-area events that have moved online. We will update this list regularly as we receive more information about online events.

Here's an updated list of local events that have moved online due to the novel coronavirus pandemic and its effects.

Here's an updated list of local events that have moved online due to the novel coronavirus pandemic and its effects.

Here's an updated list of local events that have moved online due to the novel coronavirus pandemic and its effects.

A Seattle expert is estimating about 20,000 people in the U.S. are now infected with the new coronavirus, nearly 10 times more than the roughly 2,300 confirmed cases. Trevor Bedford, a computational biologist at the Fred Hutchinson Cancer Research Center, posted his estimates in a series of 13 tweets Friday night. “I could easily be […]

NPR's Scott Simon speaks with author Amy Jo Burns about her debut novel, "Shiner," set in the West Virginia mountains.

The Debaters have opened the vault and it’s time for a fan-favourite episode from season 10! John Wing and Ivan Decker shoot from the hipster when they discuss millennials. Then, love is in the air when Lori Gibbs and Graham Clark debate romance novels.

The unexpected history of Harlequin romance novels involves a Hudson's Bay fur trader and the Toronto Star.

The award-winning British author spoke with Eleanor Wachtel about amplifying the voices of marginalized people through literature.

Too Much Lip is a raucous family yarn that explores intergenerational trauma, class and the lives of Aboriginal women, and it has just won its author a prestigious $60,000 prize.

Tara June Winch has won three major prizes at the NSW Premier's Literary Awards for her novel of love, family, history and language, The Yield.

Social media posts containing fake quotes from Nobel laureate Tasuku Honjo have spread on Facebook. The posts claimed that Professor Honjo said the novel coronavirus was "manufactured in China".

In the process of becoming Australia's first-ever published Indigenous graphic-novel author and publishing his epic three-volume magnum opus, Brenton E McKenna was battered physically and emotionally.

When your loved ones' murders are turned into a true crime book, what impact does that have on the family left behind and society's insatiable curiosity into the tragedy?