Rabindranath Tagore, a popular Bengali-poet, artist, musician, Ayurveda researcher and polymath was born on 7 May 1861. He is often referred to as Gurudev, Kabiguru and Biswakabi by his admirers. During the late 19th century and early 20th century, he extensively

β-1,3-d-Glucan is a ubiquitous glucose polymer produced by plants, bacteria, and most fungi. It has been used as a diagnostic tool in patients with invasive mycoses via a highly-sensitive reagent consisting of the blood coagulation system of horseshoe crab. However, no method is currently available for measuring β-1,6-glucan, another primary β-glucan structure of fungal polysaccharides. Herein, we describe the development of an economical and highly-sensitive and specific assay for β-1,6-glucan using a modified recombinant endo-β-1,6-glucanase having diminished glucan hydrolase activity. The purified β-1,6-glucanase derivative bound to the β-1,6-glucan pustulan with a KD of 16.4 nm. We validated the specificity of this β-1,6-glucan probe by demonstrating its ability to detect cell wall β-1,6-glucan from both yeast and hyphal forms of the opportunistic fungal pathogen Candida albicans, without any detectable binding to glucan lacking the long β-1,6-glucan branch. We developed a sandwich ELISA-like assay with a low limit of quantification for pustulan (1.5 pg/ml), and we successfully employed this assay in the quantification of extracellular β-1,6-glucan released by >250 patient-derived strains of different Candida species (including Candida auris) in culture supernatant in vitro. We also used this assay to measure β-1,6-glucan in vivo in the serum and in several organs in a mouse model of systemic candidiasis. Our work describes a reliable method for β-1,6-glucan detection, which may prove useful for the diagnosis of invasive fungal infections.

Al Arabian Novel Factory is the sequel to Jasmine Days, the story of young radio jockey Sameera Parvin, an immigrant in the city from Pakistan, and her guitar-playing colleague Ali Fardan.

This Metasploit module exploits a code execution flaw in Novell ZENworks Configuration Management 10 SP3 and 11 SP2. The vulnerability exists in the ZEnworks Control Center application, allowing an unauthenticated attacker to upload a malicious file outside of the TEMP directory and then make a second request that allows for arbitrary code execution. This Metasploit module has been tested successfully on Novell ZENworks Configuration Management 10 SP3 and 11 SP2 on Windows 2003 SP2 and SUSE Linux Enterprise Server 10 SP3.

A major fruit crop of temperate regions, APPLE is consumed worldwide as fresh fruit, juice and other food products. This consensus document provides science-based key insights for the regulatory assessment of the environmental safety of genetically-engineered products: taxonomy, reproductive biology, genetics, hybridisation and introgression, and ecology.

Zoa shared photographs from the hospital clicked during and after her blood donation.

The bacterial type VI secretion system (T6SS) secretes many toxic effectors to gain advantage in interbacterial competition and for eukaryotic host infection. The cognate immunity proteins of these effectors protect bacteria from their own effectors. PldB is a T6SS trans-kingdom effector in Pseudomonas aeruginosa that can infect both prokaryotic and eukaryotic cells. Three proteins, PA5086, PA5087 and PA5088, are employed to suppress the toxicity of PldB-family proteins. The structures of PA5087 and PA5088 have previously been reported, but the identification of further distinctions between these immunity proteins is needed. Here, the crystal structure of PA5086 is reported at 1.90 Å resolution. A structural comparison of the three PldB immunity proteins showed vast divergences in their electrostatic potential surfaces. This interesting phenomenon provides an explanation of the stockpiling mechanism of T6SS immunity proteins.

A novel monoclinic phase of human insulin co-crystallized with m-cresol was structurally characterized by means of powder and single-crystal X-ray diffraction.

Two novel crystal forms of bis­(oxonium) ethane-1,2-di­sulfonate, 2H3O−·C2H4O6S22−, are reported. Polymorph II has monoclinic (P21/n) symmetry, while the symmetry of form III is triclinic (Poverline{1}). Both structures display extensive networks of O—H⋯O hydrogen bonds. While this network in Form II is similar to that observed for the previously reported Form I [Mootz & Wunderlich (1970). Acta Cryst. B26, 1820–1825; Sartori et al. (1994). Z. Naturforsch. 49, 1467–1472] and extends in all directions, in Form III it differs significantly, forming layers parallel to the ab plane. The sulfonate mol­ecule in all three forms adopts a nearly identical geometry. The other observed differences between the forms, apart from the hydrogen-bonding network, are observed in the crystal density and packing index.

Nanoporous anodic aluminium oxide (AAO) membranes are promising host systems for confinement of condensed matter. Characterizing their structure and composition is thus of primary importance for studying the behavior of confined objects. Here a novel methodology to extract quantitative information on the structure and composition of well defined AAO membranes by combining small-angle neutron scattering (SANS) measurements and scanning electron microscopy (SEM) imaging is reported. In particular, (i) information about the pore hexagonal arrangement is extracted from SEM analysis, (ii) the best SANS experimental conditions to perform reliable measurements are determined and (iii) a detailed fitting method is proposed, in which the probed length in the fitting model is a critical parameter related to the longitudinal pore ordering. Finally, to validate this strategy, it is applied to characterize AAOs prepared under different conditions and it is shown that the experimental SANS data can be fully reproduced by a core/shell model, indicating the existence of a contaminated shell. This original approach, based on a detailed and complete description of the SANS data, can be applied to a variety of confining media and will allow the further investigation of condensed matter under confinement.

A portable small-angle X-ray scattering instrument with geometrical dimensions suitable for installation at the D22 instrument was designed and constructed for simultaneous small-angle X-ray and neutron scattering experiments at ILL.

The structure of the Pseudomonas aeruginosa T6SS PldB immunity protein PA5086 is reported at 1.9 Å resolution. Comparison of PA5086 with its homologs PA5087 and PA5088 showed great similarities in sequence and structure, but vast divergences in electrostatic potential surfaces.

The crystallization of amidase, the ultimate enzyme in the Trp-dependent auxin-biosynthesis pathway, from Arabidopsis thaliana was attempted using protein samples with at least 95% purity. Cube-shaped crystals that were assumed to be amidase crystals that belonged to space group I4 (unit-cell parameters a = b = 128.6, c = 249.7 Å) were obtained and diffracted to 3.0 Å resolution. Molecular replacement using structures from the PDB containing the amidase signature fold as search models was unsuccessful in yielding a convincing solution. Using the Sequence-Independent Molecular replacement Based on Available Databases (SIMBAD) program, it was discovered that the structure corresponded to dihydrolipoamide succinyltransferase from Escherichia coli (PDB entry 1c4t), which is considered to be a common crystallization contaminant protein. The structure was refined to an Rwork of 23.0% and an Rfree of 27.2% at 3.0 Å resolution. The structure was compared with others of the same protein deposited in the PDB. This is the first report of the structure of dihydrolipo­amide succinyltransferase isolated without an expression tag and in this novel crystal form.

In the first volume of the Secret Smithsonian Adventures graphic-novel series from Smithsonian Books, The Wrong Wrights, four middle-school kids visit the Smithsonian’s National Air […]

The post ‘The Wrong Wrights’: A Graphic Novel from Smithsonian Books appeared first on Smithsonian Insider.

Stephen Kershaw, David J. Morgan, James Boyd, David G. Spiller, Gareth Kitchen, Egor Zindy, Mudassar Iqbal, Magnus Rattray, Chris M. Sanderson, Andrew Brass, Claus Jorgensen, Tracy Hussell, Laura C. Matthews, and David W. Ray

Glucocorticoids (GCs) act through the glucocorticoid receptor (GR) to regulate immunity, energy metabolism, and tissue repair. Upon ligand binding, activated GR mediates cellular effects by regulating gene expression, but some GR effects can occur rapidly without new transcription. We show GCs rapidly inhibit cell migration, in response to both GR agonist and antagonist ligand binding. The inhibitory effect on migration is prevented by GR knockdown with siRNA, confirming GR specificity, but not by actinomycin D treatment, suggesting a non-transcriptional mechanism. We identified a rapid onset increase in microtubule polymerisation following glucocorticoid treatment, identifying cytoskeletal stabilisation as the likely mechanism of action. HDAC6 overexpression, but not knockdown of αTAT1, rescued the GC effect, implicating HDAC6 as the GR effector. Consistent with this hypothesis, ligand-dependent cytoplasmic interaction between GR and HDAC6 was demonstrated by quantitative imaging. Taken together, we propose that activated GR inhibits HDAC6 function and thereby increases the stability of the microtubule network to reduce cell motility. We therefore report a novel, non-transcriptional mechanism whereby GCs impair cell motility through inhibition of HDAC6 and rapid reorganization of the cell architecture.

Native soils are thought to take up more of the greenhouse gas methane than land used for farming. This study shows that, while agriculture can exert an adverse impact on soil methane uptake, the application of soil conditioners like compost may compensate for loss of the methane sink function. The researchers propose new land management strategies based on this finding

As the threat of novel corona virus COVID-19 spreads through the world, we live in an increasingly anxious time. While healthcare workers fight the virus in the front line, we do our part by practicing social distancing to slow the pandemic. Today's guest blogger, Toshi Takeuchi, would like to share how he spends his time by analyzing data in MATLAB.... read more >>

Groups of chemicals used as flame retardants were present in the bodies of Antarctic rock cod (Trematomus bernacchii), young gentoo penguin (Pygoscelis papua), and brown skua seabird (Stercorarius antarcticus) collected from King George Island, Antarctica. This study is the first to find some of these chemicals in Antarctica, confirming that they undergo long-range transport and can reach isolated areas where they are not widely produced or used.

Researchers have published a paper providing evidence that a ‘cooling-off effect’ can lead to increased public acceptance of new environmental technologies over time. The scientists analysed survey results from over 1 000 respondents in Germany, using solar radiation management (SRM), a controversial climate-engineering technique, as a test case. They found that, following a cooling-off period of either one month, 12 months, or 18 months, acceptance of SRM increased significantly — and that the longer the cooling-off period, the larger the increase. These findings have far-reaching implications, both for the deployment of SRM and for climate policymakers seeking to more accurately measure the public acceptability of novel interventions.

People across the globe are trying to write 50,000 words for National Novel Writing Month, but only one man has asked the Internet to help him do it.

The online retailer's new 'Election Heat Map' uses book-sales data to reveal a widespread Republican streak among its American customers.

The downloadable romance novel "Tender Wings of Desire" from KFC is free. But how does Rob Lowe fit into all of this?

The new process may provide a revolutionary, all-purpose flu vaccine.

4-Ever-in-My Heart is an enchanting of blend action, drama and the Lakota culture and as a bonus, readers can download free Native flute music by acclaimed musician, Randy McGinnis.

Readers declare Wind in the Grasses Dancing"Mesmerizing," "Exciting," "A Jewel"

Crow writes meticulously researched, entertaining novels of romance, history and mystery in an engaging you-are-there style that allows readers to live the history.

If you think America is prepared for a major disaster, think again. Yellowstone, the new Madrid Fault, a nuclear terrorist attack with a dirty bomb! Hurricane Katrina was nothing compared to these.

Athena's Home Novelties' ambitious charitable endeavor, The Athena's Cup began linking their 200,527 donated bras to create their record-busting chain on October 4th.

Unification and Integration is key in the fragmented digital health ecosystem

A high-tech executive turned entrepreneur, Ms. Novello has dedicated her career to saving animals

Pure Health, the largest laboratory operator in the Middle East, has taken immediate response to the threat of 2019 Novel Coronavirus.

During this time of crisis, many people are beginning to experience the strain a worldwide pandemic can have on our collective financial wellbeing. Knowing what options are available and where one can find emergency funding is a must.

The app stratifies users as high, moderate or low risk based on their complication rate from a potential COVID-19 infection.

Crow writes meticulously researched, entertaining novels of romance, history and mystery in an engaging you-are-there style that allows readers to live the history.

Iafrate's sweeping, extraordinary story lines reveal the richness of the human experience told through the eyes of finely drawn characters.

Crow writes meticulously researched, entertaining novels of romance, history and mystery in an engaging you-are-there style that allows readers to live the history.

Crow writes meticulously researched, entertaining novels of romance, history and mystery in an engaging you-are-there style that allows readers to live the history.

Woolf's novel has received rave reviews from readers and reviewers alike. One reviewer called it "better than Harry Potter".

You walk down one aisle of the grocery store to get your favorite cereal. On the dairy aisle, someone sick from COVID-19 coughs. Did your decision to grab your cereal before your milk possibly keep you healthy? How can these unpredictable, near-random choices be included in complex models?

Understanding the types of statistical bias that pop up in popular media and reporting is especially important during this pandemic where the data -- and our global response to the data -- directly impact peoples' lives.

Introduction of spectrum-sharing in 5G and subsequent generation networks demand base-station(s) with the capability to characterize the wideband spectrum spanned over licensed, shared and unlicensed non-contiguous frequency bands. Spectrum characterization involves the identification of vacant bands along with center frequency and parameters (energy, modulation, etc.) of occupied bands. Such characterization at Nyquist sampling is area and power-hungry due to the need for high-speed digitization. Though sub-Nyquist sampling (SNS) offers an excellent alternative when the spectrum is sparse, it suffers from poor performance at low signal to noise ratio (SNR) and demands careful design and integration of digital reconstruction, tunable channelizer and characterization algorithms. In this paper, we propose a novel deep-learning framework via a single unified pipeline to accomplish two tasks: 1)~Reconstruct the signal directly from sub-Nyquist samples, and 2)~Wideband spectrum characterization. The proposed approach eliminates the need for complex signal conditioning between reconstruction and characterization and does not need complex tunable channelizers. We extensively compare the performance of our framework for a wide range of modulation schemes, SNR and channel conditions. We show that the proposed framework outperforms existing SNS based approaches and characterization performance approaches to Nyquist sampling-based framework with an increase in SNR. Easy to design and integrate along with a single unified deep learning framework make the proposed architecture a good candidate for reconfigurable platforms.

Graph convolution network (GCN) have achieved state-of-the-art performance in the task of node prediction in the graph structure. However, with the gradual various of graph attack methods, there are lack of research on the robustness of GCN. At this paper, we will design a robust GCN method for node prediction tasks. Considering the graph structure contains two types of information: node information and connection information, and attackers usually modify the connection information to complete the interference with the prediction results of the node, we first proposed a method to hide the connection information in the generator, named Anonymized GCN (AN-GCN). By hiding the connection information in the graph structure in the generator through adversarial training, the accurate node prediction can be completed only by the node number rather than its specific position in the graph. Specifically, we first demonstrated the key to determine the embedding of a specific node: the row corresponding to the node of the eigenmatrix of the Laplace matrix, by target it as the output of the generator, we designed a method to hide the node number in the noise. Take the corresponding noise as input, we will obtain the connection structure of the node instead of directly obtaining. Then the encoder and decoder are spliced both in discriminator, so that after adversarial training, the generator and discriminator can cooperate to complete the encoding and decoding of the graph, then complete the node prediction. Finally, All node positions can generated by noise at the same time, that is to say, the generator will hides all the connection information of the graph structure. The evaluation shows that we only need to obtain the initial features and node numbers of the nodes to complete the node prediction, and the accuracy did not decrease, but increased by 0.0293.

[IMAGE-1] Before smartphones and Instagram, there were influencers, and they could be as shallow, overconfident and pejorative as they are today. This new adaptation of Jane Austen's Emma — the feature debuts of photographer and music-video director Autumn de Wilde and Man Booker Prize-winning novelist turned screenwriter Eleanor Catton — brings that sort of modern frisson to its retelling of the tale of a very rich young woman who amuses herself by interfering in the romantic lives of those around her.…

The invention concerns a new process for the preparation of crystalline form of agomelatine from a solution of agomelatine in a solvent, characterized in that the agomelatine is crystallized by instantaneous precipitation from said solution, at a temperature equal to or below −10° C.

A platinum complex having the following formula (I) is disclosed, ##STR1## wherein R1 and R2 may be the same or different and each independently represents a methyl group or an ethyl group, and the configuration of 1,2-diaminocyclohexane is either cis-, trans-l-, trans-d-, or trans-dl-.The compound possess excellent antitumor activity with a high therapeutic index and abundant water solubility, and thus are effective as an antitumor agent.

The invention relates 6-acyl-(6H)-dibenz[c,e][1,2]oxaphosphorin-6-oxides of the formula ##STR1## wherein each of R1, R2 and R3 may be present one or more times and R1, R2 and R3 represent halogen having an atomic number of from 9 to 35, alkyl or alkoxy each having from 1 to 6 carbon atoms and wherein Ar represents an aromatic hydrocarbon group having from 6 to 10 carbon atoms.The invention further relates to a process for the preparation of the afore-mentioned compounds and polymerizable compositions containing them as an essential ingredient as a photo-initiator. Finally the invention relates to 6-alkoxy-(6H)-dibenz[c,e][1,2]oxaphosphorin of the formula II ##STR2## wherein each of R1 and R2 may be present once or more times and R1 and R2 represent halogen having an atomic number of from 9 to 35, alkyl or alkoxy each having from 1 to 6 carbon atoms, at least one R1 being, however, halogen and wherein R4 represents alkyl having from 1 to 6 carbon atoms.

A composition comprising an SL0101 [kaempferol 3-O-(3″,4″-di-O-acetyl-α-L-rhamnopyranoside)] derivative compound that has enhanced ability to inhibit RSK activity, relative to the parent compound is provided. The compounds have utility for treating any disease or conditions characterized or associated with excess or undesirable RSK activity. For example the RSK inhibitors of the present invention can be used to reduce the proliferation of neoplastic cells or for inhibiting the establishment or maintenance of an intracellular pathogenic infection by pathogens whose pathogenicity derives in part from the pathogen's ability to impede endosomal/phagosomal maturation in the host cell.

A polyimide demonstrates low coefficient of hygroscopic expansion and low water absorption coefficient when used as an insulation film. The polyimide is derived from a tetracarboxylic acid dianhydride containing ester group expressed by the general formula below, and a polyester imide precursor: wherein R is independent and represents a straight or branched-chain alkyl group with 1 to 6 carbon atoms or straight or branched-chain alkoxyl group with 1 to 6 carbon atoms, n is an integer of 0 to 4, and m is an integer of 2 to 4, but wherein, if m =2, n is an integer of 1 to 4.