Bongo Boy Records' The Corridors Delivers Music To A Powerful Video Series To Make People Aware Of The Need To Improve The Child’s Medical Environment In Taiwan.

As Drag For All Ages reaches its anniversary, it and its queens are thriving.

The ABA Journal recently published an article entitled Bar Exam Does Little to Ensure Attorney Competence, Say Lawyers in Diploma Privilege State, describing the experience in Wisconsin, the only state that currently has the “diploma privilege.”  Under the Wisconsin rules, in-state law school graduates can become licensed without taking a bar exam.  These graduates must … Continue reading The Coronavirus Crisis Provides an Opportunity to Adopt Better Systems for Licensing Lawyers than the Bar Exam →

Billy Liptrot is making the transition from prison to life on the outside just as one of the nation's hottest economic streaks has imploded in the face of a global pandemic. But the 38-year-old husband and father is optimistic as he undertakes training for what he hopes will lead to a career as a carpenter in the home building industry. And the industry says years of "under building" could help the industry bounce back as the economy improves.

The plans need to be approved by the U.S. Forest Service.

U.S. withdrawal from the international agreement to combat global warming, along with rule rollbacks, have slowed momentum that once inspired emulators abroad.

Billy Liptrot is making the transition from prison to life on the outside just as one of the nation's hottest economic streaks has imploded in the face of a global pandemic. But the 38-year-old husband and father is optimistic as he undertakes training for what he hopes will lead to a career as a carpenter in the home building industry. And the industry says years of "under building" could help the industry bounce back as the economy improves.

Tech Pals is pairing volunteers with seniors who want to learn more about technology, giving them someone to talk to and a chance to learn something new.

Which Yeezus look would the RHOH allow their girls to wear?

The ratchetness is real on the red carpet.

No class,” Kenya said about her castmate.

The duo have a long history of charitable endeavors.

Beat your face like Cookie, Boo Boo Kitty and the rest.

Riri can work-work-work any carpet she sets foot upon.

How he's helping Michigan city will move you.

Bey's uplifting Chloe & Halle in more ways than one.

Really, though?

Exploring Crowdsourced Monitoring Data for Safety , released by the Virginia Tech Transportation Institute

Barriers, berms, buildings, and natural terrain may affect the propagation of aircraft noise by shielding or reflecting sound energy. If terrain and manmade structures obstruct the line‐of‐sight between the source and the receiver, then sound energy will be attenuated at the receiver. This attenuation increases with the terrain and structures’ size and proximity to either the source or the receiver. If gaps exist in the terrain or structures, then the potential benefits of acoustical shielding will be su...

Rozvolňování opatření proti šíření koronaviru v Česku zdárně pokračuje podle plánu. Otevírají se obchody a instituce, firmy obnovují svoji činnost a zanedlouho otevřou zahrádky u hospod. Lidé už začali plánovat dovolenou a nervózně sledují vývoj zpráv, jestli budou moct letos k moři či nikoliv. Vše by mohlo nasvědčovat tomu, že se všechno brzy vrátí do starých kolejí. Ale to je omyl, česká společnost se vrátí do poněkud odlišnějšího světa. Protože u toho už nebude řada firem a desítky či možná stovky tisíc lidí budou pracně zajišťovat svoji existenci.

Arterial cardiovascular events are the leading cause of death in patients with JAK2V617F myeloproliferative neoplasms (MPNs). However, their mechanisms are poorly understood. The high prevalence of myocardial infarction without significant coronary stenosis or atherosclerosis in patients with MPNs suggests that vascular function is altered. The consequences of JAK2V617F mutation on vascular reactivity are unknown. We observe here increased responses to vasoconstrictors in arteries from Jak2V617F mice resulting from a disturbed endothelial NO pathway and increased endothelial oxidative stress. This response was reproduced in WT mice by circulating microvesicles isolated from patients carrying JAK2V617F and by erythrocyte-derived microvesicles from transgenic mice. Microvesicles of other cellular origins had no effect. This effect was observed ex vivo on isolated aortas, but also in vivo on femoral arteries. Proteomic analysis of microvesicles derived from JAK2V617F erythrocytes identified increased expression of myeloperoxidase as the likely mechanism accounting for their effect. Myeloperoxidase inhibition in microvesicles derived from JAK2V617F erythrocytes suppressed their effect on oxidative stress. Antioxidants such as simvastatin and N-acetyl cysteine improved arterial dysfunction in Jak2V617F mice. In conclusion, JAK2V617F MPNs are characterized by exacerbated vasoconstrictor responses resulting from increased endothelial oxidative stress caused by circulating erythrocyte-derived microvesicles. Simvastatin appears to be a promising therapeutic strategy in this setting.

Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, the impact of vascular permeability on neutrophil trafficking is unknown. Here, through the application of confocal intravital microscopy, we report that vascular permeability–enhancing stimuli caused a significant frequency of neutrophil reverse transendothelial cell migration (rTEM). Furthermore, mice with a selective defect in microvascular permeability enhancement (VEC-Y685F-ki) showed reduced incidence of neutrophil rTEM. Mechanistically, elevated vascular leakage promoted movement of interstitial chemokines into the bloodstream, a response that supported abluminal-to-luminal neutrophil TEM. Through development of an in vivo cell labeling method we provide direct evidence for the systemic dissemination of rTEM neutrophils, and showed them to exhibit an activated phenotype and be capable of trafficking to the lungs where their presence was aligned with regions of vascular injury. Collectively, we demonstrate that increased microvascular leakage reverses the localization of directional cues across venular walls, thus causing neutrophils engaged in diapedesis to reenter the systemic circulation. This cascade of events offers a mechanism to explain how local tissue inflammation and vascular permeability can induce downstream pathological effects in remote organs, most notably in the lungs.

BACKGROUND Beige adipose tissue is associated with improved glucose homeostasis in mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this study was intended to determine whether the treatment of obese, insulin-resistant humans with the β3-AR agonist mirabegron, which stimulates beige adipose formation in subcutaneous white adipose tissue (SC WAT), would induce other beneficial changes in fat and muscle and improve metabolic homeostasis.METHODS Before and after β3-AR agonist treatment, oral glucose tolerance tests and euglycemic clamps were performed, and histochemical analysis and gene expression profiling were performed on fat and muscle biopsies. PET-CT scans quantified brown adipose tissue volume and activity, and we conducted in vitro studies with primary cultures of differentiated human adipocytes and muscle.RESULTS The clinical effects of mirabegron treatment included improved oral glucose tolerance (P < 0.01), reduced hemoglobin A1c levels (P = 0.01), and improved insulin sensitivity (P = 0.03) and β cell function (P = 0.01). In SC WAT, mirabegron treatment stimulated lipolysis, reduced fibrotic gene expression, and increased alternatively activated macrophages. Subjects with the most SC WAT beiging showed the greatest improvement in β cell function. In skeletal muscle, mirabegron reduced triglycerides, increased the expression of PPARγ coactivator 1 α (PGC1A) (P < 0.05), and increased type I fibers (P < 0.01). Conditioned media from adipocytes treated with mirabegron stimulated muscle fiber PGC1A expression in vitro (P < 0.001).CONCLUSION Mirabegron treatment substantially improved multiple measures of glucose homeostasis in obese, insulin-resistant humans. Since β cells and skeletal muscle do not express β3-ARs, these data suggest that the beiging of SC WAT by mirabegron reduces adipose tissue dysfunction, which enhances muscle oxidative capacity and improves β cell function.TRIAL REGISTRATION Clinicaltrials.gov NCT02919176.FUNDING NIH: DK112282, P30GM127211, DK 71349, and Clinical and Translational science Awards (CTSA) grant UL1TR001998.

IBM's Smarter Cities Challenge program (@CitiesChallenge) will be sending teams of company experts to five municipalities through 2018 to provide pro bono consultative advice on issues such as affordable housing, economic development, immigration, and public safety.

ENGIE, a global leader in energy transition, today announced a new initiative with IBM. This nonexclusive, technological and commercial alliance is designed to improve the management of cities by looking at patterns, event correlation, anomaly detection and real-time data across all parts of cities.

Sci-Tech Daresbury and IBM today announced the opening of a new building for the collaborative research facility at The Hartree Centre in Daresbury. The building, opened by the Duke of York, is the latest evolution of the long-running collaboration between Sci-Tech Daresbury and IBM.

IBM today announced that Vissensa, a UK-based managed service provider (MSP), has taken delivery of the IBM Enterprise Cloud System, which will help the company offer new and improved cloud services to its customers.

IBM announced today that Southern Connecticut State University (SCSU) has integrated IBM Watson Analytics to help create new services and programs based on data-driven insights to improve students’ academic achievement and development.

Grinding out a living behind the wheel

A.P. Moller –Maersk and IBM today announced their intent to establish a joint venture to provide more efficient and secure methods for conducting global trade using blockchain technology.

The IBM board of directors today declared a regular quarterly cash dividend of $1.50 per common share, payable December 9, 2017 to stockholders of record November 10, 2017.

The IBM board of directors today declared a regular quarterly cash dividend of $1.50 per common share, payable March 10, 2018 to stockholders of record February 9, 2018. IBM has paid consecutive quarterly dividends every year since 1916.

IBM today announced a research collaboratory in Singapore, where researchers from IBM intend to collaborate with scientists and engineers from public agencies in Singapore to improve the quality of its urban services. The focus of this research effort will be to use sensor networks to more effectively model, predict and manage the use of natural and physical infrastructure resources – water, transport and energy.