In a recent survey conducted by Jabil, we discovered that in just over a year, the number of companies utilizing 3D printing as well as the variety of applications rocketed dramatically; the percentage of companies using additive to manufacture production parts…

Standardization terms and trends in energy efficiency

Product development has been a hit sauce for the last two years now. Not participating in this debate seems challenging when all that’s been trending is the widespread hiring of expert product managers to changes in product development aspects. Whether you’re building physical products or a software solution, this comprehensive list of product development trends […]

The post Top 6 Trends in Product Development You Need to Know appeared first on Usability Geek

The 10 Most Important Banking And Financial Technology Trends That Will Shape 2025  Forbes

Microsoft’s Kieran McCorry talks about what the future of tech will look like in Dublin, Ireland and beyond as AI, quantum and more continue to evolve.

Read more: How these tech trends could shape Ireland’s future

The solar industry is rapidly growing, with global revenue projected to reach $241 billion by 2031. The U.S. market alone is estimated to reach $900 million by 2025, driven by improved technology, reduced costs, design and installation enhancements and government tax credits.

RC's annual research initiative focused on capturing the roofing industry's broad perspective on successes and challenges in 2023 while also looking ahead to the year to come.

Owner preferences, new legislation and emerging technologies all need to be on a roofer's radar this year.

Check out what Bone Dry Roofing, RC's 2023 Residential Roofing Contractor of the Year, has its eyes on as a new year approaches.

What strategies and technology are driving data strategy in government?

The post Federal Executive Forum Chief Data Officers Profiles in Excellence in Government 2024: Data Analytics & Artificial Intelligence Trends first appeared on Federal News Network.

The business horizon for MSPs is full of opportunities. But rather than make predictions, it’s wise to look at several trends that are sure to be relevant for managed services in 2021. The MSP industry has reached maturity over the past few years, and providers are more confident in their aptitude to deliver high-quality service. […]

Source: Managed Services Trends of 2021 You Need to Know - Technibble.com

Location: Electronic Resource- 

Location: Electronic Resource- 

Location: Law Library- JZ6369.U55 2016

The Washington State Liquor and Cannabis Board recently released sales and tax data from fiscal 2024 — July 1, 2023, through June 30, 2024…

Titan Company experienced a 15% profit decline in Q2. The company attributes this to losses from a customs duty drop on gold. Despite this, Titan saw strong sales growth in its jewellery and watches segments. The company remains optimistic about the future, particularly the upcoming festive season. Titan is also closely watching the lab-grown diamond market and formulating its strategy.

Record levels all over. Van gebruik tot eigenaren, van politieke aandacht tot prijzen. Cryptovaluta laten op talloze vlakken een mooie groei zien. In dit artikel duik ik in de belangrijkste ontwikkelingen die ik het komende jaar verwacht. Voor veel mensen zijn de afgelopen maanden heel saai geweest in de wondere wereld van cryptovaluta. Een ‘Banana […]

'Pac had swag before swag had swag. Peep his game.

Online gaming has evolved dramatically over the past two decades, shifting from simple web-based games to complex virtual worlds with rich narratives and immersive graphics. This transformation has been driven by technological advancements, changing player preferences, and the growing accessibility... Tagged as:

Tagged as:

It is undeniable that TV has a huge impact on us. It also has a huge impact on how we live! For a long time, TV shows have started interior design movements or made them popular. These TV shows are the reason these interior designs were so famous! Downton Abbey- British Edwardian There is something ... Read more

The post Interior Design Trends – And The Shows That Inspired Them appeared first on Star Two.

When we talk about a house, it’s not just four walls and a roof. Each component adds its distinctive appeal and function, and siding is no exception. An integral part of home design, siding not only safeguards your home but significantly impacts its curb appeal. Did you know that siding dates back to the Roman ... Read more

The post Innovative Trends in Siding: A Comprehensive Overview appeared first on Star Two.

At Ignition Media, as we embrace 2024, we’re keenly aware of the evolving trends in web design that...

The post The Top Website Design Trends for 2024 appeared first on Ignition Media.

2 ‘Moody’ Home Design Trends Generating Buzz

The trends of the Premier League season so far that make for interesting reading.

We recently hosted an engaging live discussion with industry experts from G2Crowd, Instapage and Subscription Insider, covering trends and growth tips for online businesses. Check out what these leaders had to say about what they learned last year in the software industry, where people are missing opportunities and what’s coming next.

July was a big month for model releases: There are new large models from Mistral and Meta, smaller multilingual models from Mistral and DeepL, another Mistral model that specializes in code generation, and a small version of GPT-4o. The security world saw another software supply chain disaster when CrowdStrike released a bad software update that […]

This month, we’ll give AI a rest. Alex Russell has finished an excellent series of posts titled “Reckoning.” It’s a must-read for web developers. If you want to understand why our networks and laptops are much faster than they were 15 or 20 years ago, but the web is slower, it comes down to one […]

The model release train continues, with Mistral’s multimodal Pixtral 12B, OpenAI’s o1 models, and Roblox’s model for building 3D scenes. We also have another important AI-enabled programming tool: Cursor is an alternative to GitHub Copilot that’s getting rave reviews. Security will never cease to be a problem, but this month seems particularly problematic. The Mirai […]

October had many language model releases. The mid-size models, and even the small models, are catching up to frontier models like GPT-4.5o in performance. But the release that blew us all away wasn’t a language model: It was Claude’s computer use API. Computer use allows you to teach Claude how to use a computer: how […]

Who Can Currently Afford to Buy a Home?

Cross-border conflict, evidence, policy and trends (XCEPT)

This five-year policy-focused research programme seeks to respond to the challenges of long-term cross-border conflicts by exploring the drivers behind them.

dora.popova 26 August 2021

Protracted conflicts in the Middle East and North Africa, Horn of Africa and parts of Asia, although usually arising from intra-state disputes, rarely remain contained within national borders. Their effects reverberate outward and external actors are drawn in.

The longer these wars last, the more difficult they are to resolve as the interests of international actors collide and the web of economic and political interactions which sustain violence and connect conflict across borders expand and deepen.

The Cross-border conflict, evidence, policy and trends (XCEPT) research programme brings together world-leading experts to examine conflict-affected borderlands, how conflicts connect across borders, and the drivers of violent and peaceful behaviour.

Chatham House provides research leadership to the programme, as part of the wider consortium, and our research explores:

• the intersection of conflict supply chains which sustain and embed violence
• coping supply chains for survival-based economic activity which occurs in the context of violence

Three geographic case studies will be supported by cross-cutting workstreams on gender and social inclusion, livelihoods, and border security. Each will produce analysis and recommendations to inform international policy responses to conflict across borders.

These case studies will focus on:

• armed actors and financial flows through Iraq and the Levant
• human smuggling across Libya, East and West Africa
• gold mining and weapons flows across Sudanese borderlands

The consortium is made up of a range of other organizations, including the Asia Foundation, the Malcolm H. Kerr Carnegie Middle East Center, the Rift Valley Institute, Chemonics UK and King’s College London.

XCEPT is funded by UK Aid from the UK government.

Peter Gothen, Margarida Melo and Montserrat Teixidor i Bigas, editors. American Mathematical Society, 2024, CONM, volume 803, approx. 380 pp. ISBN: 978-1-4704-7296-2 (print), 978-1-4704-7646-5 (online). This volume contains the proceedings of the VBAC 2022 Conference on Moduli Spaces and Vector Bundles—New Trends, held in honor of Peter...

Proptech refers to the use of technology and software to assist the real estate market with its needs.

DOVER, DE (Jan. 21, 2022) – The Delaware Division of Public Health (DPH) is providing an update on the most recent statistics related to coronavirus disease 2019 (COVID-19) in Delaware, as of Thursday, Jan 20, 2022. DPH reports a welcomed decrease in new positive cases and hospitalizations over the last week, however, both cases and hospitalizations […]

DOVER, DE (Jan. 28, 2022) – The Delaware Division of Public Health (DPH) is providing an update on the most recent statistics related to coronavirus disease 2019 (COVID-19) in Delaware, as of Thursday, Jan 27, 2022. DPH reports a 57 percent decrease in the seven-day average of new positive cases reported since the peak of the surge […]

Data science continues to be a pivotal force driving innovation across industries. From enhancing customer experiences to optimizing operational efficiencies, the role of data science is expanding, bringing with it new challenges and opportunities. This article explores the emerging trends and technologies that are shaping the future of data science [...]

The future of data science: 7 emerging trends and technologies to watch was published on SAS Voices by Iain Brown

DOVER, DEL. (Oct. 14, 2024) – Delaware’s cancer mortality rate continues to decline, according to the latest data from the Delaware Division of Public Health (DPH). Delaware and the U.S. saw their mortality rates go down by an average of 1.8% and 1.5%, respectively, between 2007 and 2021. In the 2024 report, which looked at the […]

Social protection systems are essential to achieving the 2030 Agenda for Sustainable Development. However, social protection is insufficient across Asia and the Pacific, and the region is at risk from megatrends: climate change, demographic shifts and digitalization. Tens of millions of people have been pushed into extreme poverty since COVID-19, reversing past gains, and many […]

In the coming decades, the Asia-Pacific region faces a series of challenges that threaten to exacerbate poverty. Among these, climate change, demographic shifts, particularly population ageing and the rise of digital technologies stand out as three interconnected global megatrends. A recent technical paper supporting the Social Outlook for Asia and the Pacific 2024 explores various […]

The Beijing Declaration and Platform for Action, adopted in 1995 during the Fourth World Conference on Women, remains a cornerstone in the global pursuit of gender equality and women’s empowerment. With the Asia-Pacific Ministerial Conference on the Beijing+30 Review fast approaching, now is the time to reflect on the progress made and the challenges that […]

South Asia study of foreign direct investments impact in India, Pakistan, Bangladesh, Sri Lanka and Nepal on economic growth, domestic investment, and export; special emphasis on the role of infrastructure.

The regulation of drug-metabolizing enzymes and transporters by cytokines has been extensively studied in vitro and in clinic. Cytokine-mediated suppression of cytochrome P450 (CYP) or drug transporters may increase or decrease the systemic clearance of drug substrates that are primarily cleared via these pathways; neutralization of cytokines by therapeutic proteins may thereby alter systemic exposures of such drug substrates. The Food and Drug Administration recommends evaluating such clinical drug interactions during clinical development and has provided labeling recommendations for therapeutic proteins. To determine the clinical relevance of these drug interactions to dose adjustments, trends in steady-state exposures of CYP-sensitive substrates coadministered with cytokine modulators as reported in the University of Washington Drug Interaction Database were extracted and examined for each of the CYPs. Coadministration of cytochrome P450 family 3 subfamily A (CYP3A) (midazolam/simvastatin), cytochrome P450 subfamily 2C19 (omeprazole), or cytochrome P450 subfamily 1A2 (caffeine/tizanidine) substrates with anti-interleukin-6 and with anti-interleukin-23 therapeutics led to changes in systemic exposures of CYP substrates ranging from ~ –58% to ~35%; no significant trends were observed for cytochrome P450 subfamily 2D6 (dextromethorphan) and cytochrome P450 subfamily 2C9 (warfarin) substrates. Although none of these changes in systemic exposures have been reported as clinically meaningful, dose adjustment of midazolam for optimal sedation in acute care settings has been reported. Simulated concentration-time profiles of midazolam under conditions of elevated cytokine levels when coadministered with tocilizumab, suggest a ~six- to sevenfold increase in midazolam clearance, suggesting potential implications of cytokine–CYP drug interactions on dose adjustments of sensitive CYP3A substrates in acute care settings. Additionally, this article also provides a brief overview of nonclinical and clinical assessments of cytokine–CYP drug interactions in drug discovery and development.

SIGNIFICANCE STATEMENT

There has been significant progress in understanding cytokine-mediated drug interactions for CYP-sensitive substrates. This article provides an overview of the progress in this field, including a trend analysis of systemic exposures of CYP-sensitive substrates coadministered with anti-interleukin therapeutics. In addition, the review also provides a perspective of current methods used to assess these drug interactions during drug development and a focus on individualized medicine, particularly in acute care settings.

BackgroundCOVID-19 pandemic restrictions may have influenced behaviours related to weight.AimTo describe patterns of weight change among adults living in England with type 2 diabetes (T2D) and/or hypertension during the pandemic.Design and settingAn observational cohort study using the routinely collected health data of approximately 40% of adults living in England, accessed through the OpenSAFELY service inside TPP.MethodClinical and sociodemographic characteristics associated with rapid weight gain (>0.5 kg/m2/year) were investigated using multivariable logistic regression.ResultsData were extracted on adults with T2D (n = 1 231 455, 43.9% female, and 76.0% White British) or hypertension (n = 3 558 405, 49.7% female, and 84.3% White British). Adults with T2D lost weight overall (median δ = −0.1 kg/m2/year [interquartile range {IQR} −0.7–0.4]). However, rapid weight gain was common (20.7%) and associated with the following: sex (male versus female: adjusted odds ratio [aOR] 0.78 [95% confidence interval {CI} = 0.77 to 0.79]); age (older age reduced odds, for example, aged 60–69 years versus 18–29 years: aOR 0.66 [95% CI = 0.61 to 0.71]); deprivation (least deprived Index of Multiple Deprivation [IMD] quintile versus most deprived IMD quintile: aOR 0.87 [95% CI = 0.85 to 0.89]); White ethnicity (Black versus White: aOR 0.95 [95% CI = 0.92 to 0.98]); mental health conditions (for example, depression: aOR 1.13 [95% CI = 1.12 to 1.15]); and diabetes treatment (non-insulin treatment versus no pharmacological treatment: aOR 0.68 [95% CI = 0.67 to 0.69]). Adults with hypertension maintained stable weight overall (median δ = 0.0 kg/m2/year [IQR −0.6–0.5]); however, rapid weight gain was common (24.7%) and associated with similar characteristics as in T2D.ConclusionAmong adults living in England with T2D and/or hypertension, rapid pandemic weight gain was more common among females, younger adults, those living in more deprived areas, and those with mental health conditions.

James Hicks, healthcare application development and processing engineer at Syensqo explores the latest trends, challenges and solutions in sterilisation.

As regular readers of Drug Channels know, U.S. distribution and dispensing channels for prescription drugs are undergoing significant evolution and consolidation as the changing economics of pharmaceuticals challenge conventional business models.

During this period of volatility, the core business model of the Big Three public pharmaceutical distribution companies—Cardinal Health, Cencora, and McKesson—remains intact. Put simply: Buy low, sell high, collect early, and pay late.

But as I explain below, wholesalers continue to position themselves as essential intermediaries by expanding their industry position and strengthening their economic fundamentals.

Read on for five key pricing, pharmacy, provider, and manufacturer trends that are driving the U.S. drug wholesaling industry.

For even more, check out DCI's new 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors, the fifteenth edition of our deep dive into wholesale distribution channels.Click here to download a free report overview (including key industry trends, the table of contents, and a list of exhibits)
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