Boris Schlossberg, BK Asset Management

Todd Colvin, Ambrosino Brothers

Todd Colvin, Ambrosino Brothers

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Dan Deming, KKM Financial

Dan Deming, KKM Financial

Bob Iaccino, Path Trading Partners

Bob Iaccino, Path Trading Partners

Scott Shellady, TJM Investments

Scott Shellady, TJM Investments

Scott Bauer, Prosper Trading Academy

Dan Deming, KKM Financial

Bob Iaccino, Path Trading Partners

Eddie Tofpik, Adm Investor Services International Limited

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Larry Shover, Efficient Advisors

Larry Shover, Efficient Advisors

Todd Colvin, Ambrosino Brothers

Bob Iaccino, Path Trading Partners

Bob Iaccino, Path Trading Partners

Virginia McGathey, www.VirginiaMcGathey.com

Virginia McGathey, www.VirginiaMcGathey.com

Todd Colvin, Ambrosino Brothers

Dan Deming, KKM Financial

Bob Iaccino, Path Trading Partners

Bob Iaccino, Path Trading Partners

Finding antivirals to reduce coronavirus disease 2019 (COVID-19) morbidity and mortality has been challenging. Large randomized clinical trials that aimed to test four repurposed drugs, hydroxychloroquine, lopinavir-ritonavir, interferon beta 1a, and remdesivir, have shown that these compounds lack an impact on the COVID-19 course. Although the phase III COVID-19 vaccine trial results are encouraging, the search for effective COVID-19 therapeutics should not stop. Recently, plitidepsin (aplidin) demonstrated highly effective preclinical activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its antiviral activity was 27.5-fold more potent than that of remdesivir (K. M. White, R. Rosales, S. Yildiz, T. Kehrer, et al., Science, 2021, https://science.sciencemag.org/content/early/2021/01/22/science.abf4058). Plitidepsin, a repurposed drug developed for the treatment of multiple myeloma, targets the host translation cofactor eEF1A. Plitidepsin has shown efficacy in animal models and phase I/II human trials. Although plitidepsin is administered intravenously and its toxicity profile remains to be fully characterized, this compound may be a promising alternative COVID-19 therapeutic.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

The National Center for Complementary and Integrative Health (NCCIH), which is part of the US National Institutes of Health (NIH), has a broad interest in studying the biologic activities of natural products, especially those for which compelling evidence from preclinical research suggests biologic activities that may be beneficial to health or have a potential role in disease treatment, as well as products used extensively by the American public. As of 2023, use of cannabis for medical purposes is legal in 38 states and Washington, D.C. Such use continues to climb generally without sufficient knowledge regarding risks and benefits. In keeping with NCCIH’s natural product research priorities and recognizing this gap in knowledge, NCCIH formally launched a research program in 2019 to expand research on the possible benefits for pain management of certain substances found in cannabis: minor cannabinoids and terpenes. This Viewpoint provides additional details and the rationale for this research priority at NCCIH. In addition, NCCIH’s efforts and initiatives to facilitate and coordinate an NIH research agenda focused on cannabis and cannabinoid research are described.

Cannabis and its products have been used for centuries for both medicinal and recreational purposes. The recent widespread legalization of cannabis has vastly expanded its use in the United States across all demographics except for adolescents. Meanwhile, decades of research have advanced our knowledge of cannabis pharmacology and particularly of the endocannabinoid system with which the components of cannabis interact. This research has revealed multiple targets and approaches for manipulating the system for therapeutic use and to ameliorate cannabis toxicity or cannabis use disorder. Research has also led to new questions that underscore the potential risks of its widespread use, particularly the enduring consequences of exposure during critical windows of brain development or for consumption of large daily doses of cannabis with high content ⁹-tetrahydrocannabinol. This article highlights current neuroscience research on cannabis that has shed light on therapeutic opportunities and potential adverse consequences of misuse and points to gaps in knowledge that can guide future research.

Indianapolis : Hackett Publishing Company, Inc., [2006]

[Place of publication not identified] : [eBookIt.com], [1996]

Albany : State University of New York Press, [1991]

Eugene, Oregon : Wipf and Stock, 2022.

Once while eating dinner in Montreal, our friendly, intoxicated waitress plopped herself in my lap and proceeded to tell us about how obsessed she was with the CD that was playing - singing out the lyrics at an ungodly volume and flinging her arms about. Wow, I thought to myself, people who listen to Morcheeba sure seem to have a lot of fun, and promised to check them out.

Several CDs later, they are firmly one of my favorites. And their trip hop meditation, 2003’s Charango remains one of my most played CDs.

Morcheeba (Mor = more, Cheeba = pot) are brothers Ross and Paul Godfrey with singer Skye Edwards (who has since been replaced). Part trance, part ambience, Charango is full of smooth, snogworthy jams. And just as you surrender to its seductive groove, Slick Rick shows up with a rap called “Women Lose Weight”.

Lamenting his wife putting on weight after having kids and stalled by his mistress who wants a clean break before she shacks up with him, he decides the easiest way out of it all is to kill the spouse. Considering different ways to do the deed, he finally rams his car into her Chevy over a long lunch break one fine day. It is an unexpected, stunning, tongue-in-cheek social commentary that makes it a CD you won’t forget easily.

Rave Out © 2007 IndiaUncut.com. All rights reserved.
India Uncut * The IU Blog * Rave Out * Extrowords * Workoutable * Linkastic

Aussie sports commentator Tim Lane has revealed he “felt sick” in the moment he realised his employer had double crossed him on the eve of the AFL season.

This commentary is one of a series of country reports on postsecondary vocational education and training (VET) in OECD countries, prepared as part of an OECD study. The series includes reviews, involving an in-depth analysis of a country system leading to a set of policy recommendations backed by analysis.

Ramu Gorai utilizes both local American and Indian talent in his movies to address a variety of social issues.

Ramu Gorai encourages both local American and Indian talent in his production, which deal with a variety of social issues. Production appreciates the Star Indian American Model Prakash Patil for his extraordinary talent and contribution to the fashio

Ramu Gorai encourages both local American and Indian talent in his production, which deal with a variety of social issues. Production appreciates the Star Indian American Model Prakash Patil for his extraordinary talent and contribution to the fashion and entertainment arena.

Some of you might have read the USA Today Network story about horse racing this week. The piece highlighted some pretty impressive statistics related to the broadcast and marketing of the limited racing calendar we've all been experiencing. One quote caught my eye: “NYRA chief revenue officer Tony Allevato said it had signed up seven […]

The post Commentary: Racing Has A New Set Of Wagering Customers, But Now What? appeared first on Horse Racing News | Paulick Report.

Josh Spiegel shares a special poem for Ravens fans who are still dealing with the loss to the Titans.

Josh Spiegel talks about the Coronavirus and unleashes a torrent of blame on China and its eating habits.

While Democrats and Republicans have been divided for years, Josh Spiegel says, during the State of the Union speech, it was clear there's bipartisan support for despising each other.

In a week that saw the release of former Baltimore Mayor Catherine Pugh's apology video and Pugh being sentenced to federal prison for conspiracy and tax evasion, Josh Spiegel offers his wrap up on the Healthy Holly saga.