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HitPaw Edimakor Revolutionizes Video Editing with Advanced AI Subtitle Generator

Edimakor provides an AI subtitle generator to support multiple languages and enables accurate subtitling with hardly any human involvement.




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SubTropolis

With a depth of up to 160 feet, the temperature inside the network of tunnels and chambers hovers between 68 and 72 degrees all year round, with humidity sitting at a comfortable 40 percent. Thanks to the miners' use of an extraction technique called the "room and pillar method," the enormous underground cavities left behind are supported by 16-foot pillars; the space is open, regular, and, expansive enough to accommodate nearly anything that can fit through its above-ground, drive-in entrance ramps. from Since the '60s, Ford Has Stored Cars Underground in a Kansas City Cave [Hagerty]




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What to Do with Doubt, Pt. #1

Average reading time is about 2 and a half minute(s)

Shall any teach God knowledge? seeing he judgeth those that are high. Job 21:22

Many, especially those who are young in the Christian life, are at times troubled with the suggestions of skepticism. There are in the Bible many things which they cannot explain, or even understand, and Satan employs these to shake their faith in the Scriptures as a revelation from God. They ask, "How shall I know the right way? If the Bible is indeed the word of God, how can I be freed from these doubts and perplexities?"

God never asks us to believe, without giving sufficient evidence upon which to base our faith. His existence, His character, the truthfulness of His word, are all established by testimony that appeals to our reason; and this testimony is abundant. Yet God has never removed the possibility of doubt. Our faith must rest upon evidence, not demonstration. Those who wish to doubt will have opportunity; while those who really desire to know the truth will find plenty of evidence on which to rest their faith.

It is impossible for finite minds fully to comprehend the character or the works of the Infinite One. To the keenest intellect, the most highly educated mind, that holy Being must ever remain clothed in mystery. "Canst thou by searching find out God? canst thou find out the Almighty unto perfection? It is as high as heaven; what canst thou do? deeper than hell; what canst thou know?" Job 11:7, 8.

The apostle Paul exclaims, "O the depth of the riches both of the wisdom and knowledge of God! how unsearchable are His judgments, and His ways past finding out!" Romans 11:33. But though "clouds and darkness are round about Him," "righteousness and judgment are the foundation of His throne." Psalm 97:2, R.V. We can so far comprehend His dealings with us, and the motives by which He is actuated, that we may discern boundless love and mercy united to infinite power. We can understand as much of His purposes as it is for our good to know; and beyond this we must still trust the hand that is omnipotent, the heart that is full of love.

The word of God, like the character of its divine Author, presents mysteries that can never be fully comprehended by finite beings. The entrance of sin into the world, the incarnation of Christ, regeneration, the resurrection, and many other subjects presented in the Bible, are mysteries too deep for the human mind to explain, or even fully to comprehend. But we have no reason to doubt God's word because we cannot understand the mysteries of His providence. In the natural world we are constantly surrounded with mysteries that we cannot fathom. The very humblest forms of life present a problem that the wisest of philosophers is powerless to explain.

Everywhere are wonders beyond our ken. Should we then be surprised to find that in the spiritual world also there are mysteries that we cannot fathom? The difficulty lies solely in the weakness and narrowness of the human mind. God has given us in the Scriptures sufficient evidence of their divine character, and we are not to doubt His word because we cannot understand all the mysteries of His providence.



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Onyx Collective's Sexy Legal Drama "Reasonable Doubt" Renewed for Season Three on Hulu

"Reasonable Doubt" centers on Los Angeles-based high-powered criminal defense attorney Jacqueline "Jax" Stewart (Emayatzy Corinealdi) as she deals with past traumas, a struggling marriage, motherhood and a murder case, all while trying to keep her life together.




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Inflation Needs Subtlety Right Now. It’s Getting Trump




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Nicole Kidman's subtle dig at THIS legendary director for masculine movies

Nicole Kidman reveals she wants to work with THIS movie-makerNicole Kidman has recently taken a subtle dig at one of the iconic directors in Hollywood for his male-centered movies.In a new interview with Vanity Fair, the Stoker actress responded to a question about any notable movie-maker...




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Doubt in Form AOC 4

For the first year of filing after Incorporation of a company do we need to provide the subscribed capital details at time of incorporation In Form AOC 4 , tab " Share capital raised during the reporting period ". Or its only meant for additional capital raised




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Pick up a right wedding dress subtly to hide your excessive fat

Gorgeous Cathedral Train Beaded Ruffled Plus Size Wedding Dress



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The Subtle Power of Spiritual Abuse By David Johnson and Jeff Vanvonderen (Bethany House, 1991, 2005) 235 pages -- The Subtle Power of Spiritual Abuse discusses unhealthy spiritual patterns in a constructive and helpful way - There are many books that att

But this book by Johnson and Vanvonderen is different. Drawing upon years of ministry experience as pastor and counselor (respectively), they examine the fine line between Biblical leadership and abuse. Without mentioning groups or demonizing those involved, they discuss how well-intentioned leadership can have abusive effects. This "high road" approach is highly helpful in identifying some of the critical factors that have led to harsh and harmful leadership in churches. -- Marks of a Spiritually Unhealthy Environment: For example, the authors identify the marks of a spiritually unhealthy system. I'd like to include these here as a sample of how the authors address these issues. (The following consists of verbatim citations of copyrighted material from Chapter 5,6 of "The Subtle Power of Spiritual Abuse.") -- 1. Power-Posturing: Power-posturing simply means leaders spend a lot of time focused on their own authority and reminding others of it, as well. They spend a lot of energy posturing about how much authority they have and how much everyone else is supposed to submit to it. The fact that they are eager to place people under them-- under their word, under their "authority"-- is one easy-to-spot clue that they are operating in their own authority. -- 2. Performance Preoccupation: In abusive spiritual systems, power is postured and authority is legislated. Therefore, these systems are preoccupied with the performance of their members. Obedience and submission are two important words often used. The way to tell if someone is doing the right thing for the wrong reason is if they are keeping track of it. Let's say that another way. If obedience and service is flowing out of you as a result of your own dependence on God alone, you won't keep track of it with an eye toward reward, you'll just do it. But if you're preoccupied with whether you've done enough to please God, then you're not looking at Him, you're looking at your own works. And you're also concerned about who else might be looking at you, evaluating you. What would anyone keep track of their godly behavior unless they were trying to earn spiritual points because of it? For many reasons, followers sometimes obey or follow orders to avoid being shamed, to gain someone's approval, or to keep their spiritual status or position intact. This is not true obedience or submission, it is compliant self-seeking. When behavior is simply legislated from the outside, instead of coming from a heart that loves God, it cannot be called obedience. It is merely weak compliance to some form of external pressure. -- 3. Unspoken Rules: In abusive spiritual systems, people's lives are controlled from the outside in by rules, spoken and unspoken. Unspoken rules are those that govern unhealthy churches or families but are not said out loud. Because they are not said out loud, you don't find out that they're there until you break them. The most powerful of all unspoken rules in the abusive system is what we have already termed the "can't talk" rule. The "can't talk" [rule] has this thinking behind it: "The real problem cannot be exposed because then it would have to be dealt with and things would have to change; so it must be protected behind walls of silence (neglect) or by assault (legalistic attack). If you speak about the problem, you are the problem. -- 4. Lack of Balance: The fourth characteristic of a spiritual abusive system is an unbalanced approach to living out the truth of the Christian life. This shows itself in two extremes: Extreme Objectivism - The first extreme is an empirical approach to life, which elevates objective truth to the exclusion of valid subjective experience. This approach to spirituality creates a system in which authority is based upon the level of education and intellectual capacity alone, rather than on intimacy with God, obedience and sensitivity to His Spirit. Extreme Subjectivism - The other manifestation of lack of balance is seen in an extremely subjective approach to the Christian life. What is true is decided on the basis of feelings and experiences, giving more weight to them than what the Bible declares. In this system, people can't know or understand truths (even if they really do understand or know them) until the leaders "receive them by spiritual revelation from the Lord" and "impart" them to the people. In such systems, it is more important to act according to the word of a leader who has "a word" for you than to act according to what you know to be true from Scripture, or simply from your spiritual growth-history. As with the extreme objective approach, Christians who are highly subjective also have a view of education-- most often, that education is bad or unnecessary. There is almost a pride in not being educated, and a disdain for those who are. Everything that is needed is taught through the Holy Spirit. ("After all, Peter and Timothy didn't go to college or seminary...") -- 5. Paranoia: In the church that is spiritually abusive, there is a sense, spoken or unspoken, that "others will not understand what we're all about, so let's not let them know-- that way they won't be able to ridicule or persecute us." There is an assumption that (1) what we say, know, or do is a result of our being more enlightened that others; (2) others will not understand unless they become one of us; and (3) others will respond negatively. In a place where authority is grasped and legislated, not simply demonstrated, persecution sensitivity builds a case for keeping everything within the system. Why? Because of the evil, dangerous, or unspiritual people outside of the system who are trying to weaken or destroy "us." This mentality builds a strong wall or bunker around the abusive system, isolates the abusers from scrutiny and accountability, and makes it more difficult for people to leave-- because they will then be outsiders too. While it is true that there is a world of evil outside of the system, there is also good out there. But people are misled into thinking that the only safety is in the system. Ironically, Jesus and Paul both warned that one of the worst dangers to the flock was from wolves in the house (Matthew 10:16, Acts 20:29-30). -- 6. Misplaced Loyalty: The next characteristic of spiritually abusive systems is that a misplaced sense of loyalty is fostered and even demanded. We're not talking about loyalty to Christ, but about loyalty to a given organization, church, or leader. Once again, because authority is assumed or legislated (and therefore not real), following must be legislated as well. A common way this is accomplished is by setting up a system where disloyalty to or disagreement with the leadership is construed as the same thing as disobeying God. Questioning leaders is equal to questioning God. "We Alone Are Right" There are three factors that come into place here, adding up to a misplaced loyalty. First, leadership projects a "we alone are right" mentality, which permeates the system. Members must remain in the system if they want to be "safe," or to stay "on good terms" with God, or not be viewed as wrong or "backslidden." - Scare Tactics - The second factor that brings about misplaced loyalty is the use of "scare tactics." We're already seen this in some of the paranoia described in the last section. Scare tactics are more serious. This is more than just the risk of being polluted by the world. We have counseled many Christians who, after deciding to leave their church, were told horrifying things. "God is going to withdraw His Spirit from you and your family." "God will destroy your business." "Without our protection, Satan will get your children." "You and your family will come under a curse." This is spiritual blackmail and it's abuse. And it does cause people to stay in abusive places. - Humiliation - The third method of calling forth misplaced loyalty is the threat of humiliation. This is done by publicly shaming, exposing, or threatening to remove people from the group. Unquestionably, there is a place for appropriate church discipline. In the abusive system, it is the fear of being exposed, humiliated or removed that insures your proper allegiance, and insulates those in authority. You can be "exposed" for asking too many questions, for disobeying the unspoken rules, or for disagreeing with authority. People are made public examples in order to send a message to those who remain. Others have phone campaigns launched against them, to warn their friends and others in the group about how "dangerous" they are. -- 7. Secretive: When you see people in a religious system being secretive-- watch out. People don't hide what is appropriate; they hide what is inappropriate. One reason spiritual abusive families and churches are secretive is because they are so image conscious. People in these systems can't even live up to their own performance standards, so they have to hide what is real. Some believe they must do this to protect God's good name. So how things look and what others think becomes more important than what's real. They become God's "public relations agents." The truth is, He's not hiring anyone for this position. Another reason for secrecy in a church is that the leadership has a condescending, negative view of the laity. This results in conspiracies on the leadership level. They tell themselves, "People are not mature enough to handle truth." This is patronizing at best. Conspiracies also develop among the lay people. Since it is not all right [sic] to notice or talk about problems, people form conspiracies behind closed doors and over the telephone as they try to solve things informally. But since they have no authority, they solve, and solve, and solve-- but nothing really gets solved. And all the while, building God's true kingdom is put on hold. -- Conclusion: I hope that what I have cited gets your attention and motivates you to read this book. The subtle patterns of unhealthy characteristics are discussed in a way that actually helps people identify them, resist them, and recover from them. Copyright © 2000 John Engler. All rights reserved. The Barnabas Ministry



  • Christian Church History Study
  • 4. 1881 A.D. to Present (2012) - Corrupt modern bible translations and compromised Seminaries and Universities

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The CalvaryChapelAbuse.com website - Sue says -- January 4, 2012 at 7:48 pm, 4 years ago I read "Pagan Christianity" by Frank Viola and it was a very freeing book - Also another book that's really helped me heal is "The Subtle Power of

Reaching4Truth says: January 3, 2012 at 3:01 pm -- Hanna, you said: "I still keep my hopes up that we will find a church, but as I have said before..in our town it is all about who can have the biggest church, who can draw the largest crowd, who can own more hotels and claim more territory on the monopoly board. People have no idea what the Pastor is purchasing in terms of real estate and investments, and they don't really even care because they trust him completely." -- This is not just a phenomenon in your town, but is widespread everywhere. Because in this era, pastors have been given celebrity status and encouraged to build their kingdoms, their resume, on ideas borrowed from the business realm. Over time they've been seduced by numerous voices from without and within the evangelical world, to produce measurably "effective" and "successful" ministries.. Pursuing and inculcating worldly business values and methodologies and wrongly applying them to the church and the realm of ministry. And basically it turns out to be an abandonment of their allegiance to the Lord in exchange for the approval of men and the respect of men, both in the church and in the world. -- Pastors and ministry leaders have been seduced by things appealing to their pride to pursue accomplishments and a measure of renown - respectability - for themselves. To be someone that others in the community (church and beyond) look up to and speak well of. -- Through many avenues and means, Christian pastors and ministry leaders have received worldly advice dressed up in acceptable Christian language, and coming from trusted "christian" sources. I employ the quotes because to look at the nature of what has come to be accepted as wise Christian insight and counsel, through resources such as Leadership Journal and Christianity Today, just to name two among a plethora of resources with a large readership among pastors, is to find, if one compares the "wisdom" offered from such sources, they wander quite a distance from sound spiritual wisdom or true compatibility with the word of God. -- Our pastors have been drinking from poisoned wells, even from what have been in the past trusted Christian sources. But, minus the requisite discretion and discernment that is expected of those we trust, a scourge has set upon the churches. Having listened to and consulted the voices of so many Pied Pipers in the business realm, there is very little left now of truly Holy Spirit-inspired leadership. We have been in the business of exchanging the truth of God for a lie for so long that we can barely distinguish the difference. Church and ministry leaders, in their efforts to win the worldly (yes I mean "worldly") to Christ through clever means, have drunk deeply from the wells of "vain philosophy and empty deceit". And we are sadly observing the results of that exchange. -- Clever wolves have entered in, and/or risen up from our midst, and had their effect upon the churches. I have observed with great sadness and sobriety the Christian establishment being given over to a host of clever lies and the spirit of the world. -- And hero worship has had a lot to do with it. A WHOLE lot to do with it. I think it's for lack of (or for need of) a hero in our lives that we (pastors and their flocks) have become worshippers of admired Christian men, inclined to enshrine them in a sort of "holy glow" - a sort of spiritual 'static' where we assume they will always and forever continue in a faithful path, as if they can do no wrong and, like their Lord, were immaculately conceived of the Holy Spirit. -- We have been, the whole lot of us - pastors and others alike - led onto deceptive paths because of having given our unquestioning trust to men with feet of clay. I believe we have entered a time of the Lord cleaning house, and waking His people up from a long slumber, a longer slumber than we would guess, wherein the enemy has now effectively infiltrated the mustard tree and overspread the churches. -- Jesus was careful to warn us that these days would come, and tremendous deception all around us was given as a key sign of the nearness of His return. He led with "See to it THAT NO MAN DECEIVES YOU." It was much more a matter of having our eyes/hearts exercised to recognize cleverly cloaked deception and delusion than it was ever a call to make an idol of earthly Jerusalem, for instance. JESUS is to be our focus; ALWAYS JESUS. We were instructed not to put our trust in man, but only IN HIM. -- So… pastors are to blame, for having wandered from the scriptures as their sole source of spiritual light, life and guidance, and succumbing to spiritual blindness… but so are we. We are living in a time of strong hero worship, leading to strong delusion, with sobering effect. The sooner we return our affection to the LORD and away from faulty leaders, the better for all of us. -- Chuck Smith is simply one example of what hero worship - the desire to elevate a hero in our midst (besides Jesus) can lead to. By giving our indiscriminate trust to men we admire, we forget that they can be just as prone to sin and error as the rest of us. The mercy of God is a great need in all of our lives, and our relationship with Him is to be first and foremost. I need these reminders as much as the next person. --- Lord, I'm thankful for your MERCY and your GREAT, GREAT kindness to us. Help us wind our way out of this mess we find ourselves in and into singlehearted allegiance to You and affection for your word. Clean us up and restore the broken places? and rekindle our love for YOU.



  • Christian Church History Study
  • 4. 1881 A.D. to Present (2012) - Corrupt modern bible translations and compromised Seminaries and Universities

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Holiness Movement at a Crossroads - By the late 19th century, the Wesleyan-Holiness Movement floundered at the edge of a sectarian snakepit, divided by race, region, and national boundaries - Yet from this doubtful setting, the Church of the Nazarene aros

Early in the 19th century, Sarah Lankford combined the women's prayer groups of two Methodist in New York City to create the Tuesday Meeting for the Promotion of Holiness. That action, coupled with the publication of Boston pastor Timothy Merritt's Guide to Christian Perfection, marked the Holiness Movement's advent. ... John Inskip, J.A. Wood, and other Methodist clergy initiated a new phase of the movement after the Civil War. The National Camp Meeting Association for the Promotion of Holiness fostered specialized meetings throughout the United States. But Inskip was dead by 1890, while Wood had retired to California and preached occasionally from Phineas Bresee's pulpit. A democratic spirit pervaded the Holiness Movement. Bishops could control Methodist clergy but not the laity who led many local, county, and state Holiness associations. Some were headed by women excluded from leadership in other areas. Independent-minded evangelicals defied the Methodist Discipline and used a local preacher's license as authority to conduct revivals, even competing with local pastors. By century's end, the Wesleyan-Holiness Movement included sectarian "come-outers," "put-outers" dismissed from their churches, and Methodist loyalists. The fragmenting Holiness revival posed daunting questions: would anyone--could anyone--gather the pieces?



  • Christian Church History Study
  • 4. 1881 A.D. to Present (2012) - Corrupt modern bible translations and compromised Seminaries and Universities

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The Dark Ages - Early Middle Ages (DVD $16.99) {In case you have ever wondered if Satan is raging a relentless war against the Christian Church and against mankind in general this History documentary will lay aside all doubts.}

Between the Fall of Rome and the dawn of the Renaissance, Europe plunged into a dark night of constant war, splintered sovereignties, marauding pagans, rabid crusaders and devastating plague. That anything of value arose from this chaotic muck - much less the Renaissance - is nothing short of miraculous. Through masterful cinematography and ground-breaking research, THE DARK AGES brings to life this amazing and mysterious time. Relive in striking detail critical turning points in the Early Middle Ages including the fall of Rome to the Visigoths, the horrors of Bubonic Plague, the rise of Charlemagne and the launching of the First Crusade.



  • Christian Church History Study
  • 2. 313 A.D. to 1521 A.D. - Revised Rome and the Holy Roman Empire
  • Christian Videos

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CDC issues health alert to U.S. doctors over subtype of monkeypox spreading in Congo that kills one in ten and is more infectious

CDC issues health alert to U.S. doctors over subtype of monkeypox spreading in Congo that kills one in ten and is more infectious –Alert warned clinicians to test patients traveling from the Congo for the virus | 7 Dec 2023 | Doctors in the US are being told to look out for a more deadly […]




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Coping with Thoughts of Doubt

Frederica shares a reply on the subject of doubt to a visitor to her website.




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Apostolic Faith and Apostolic Doubt

Dr. Constaninou takes a break from her series, "Introduction to the Bible," and addresses the very important topic of "doubt."




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Don't Doubt - Believe!

On this St. Thomas the Believer Sunday, we are invited to grow beyond our doubts.




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Doubt and Faith

If we are honest, we will all admit that we struggle from time to time with doubt. Michael reflects on that reality and helps us understand the meaning of doubt as well as faith.




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Don't deny your doubts and your struggles. Be who-you-are before Christ, so He may save who-you-are.

Don't look for the easy way out of pain. Do not deny the reality of your doubts, your struggles and your sins. Be who-you-are before Christ, so that He may save the truth of who-you-are.




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The subtle way of the Antichrist

What has light to do with darkness?




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Are Christians Allowed to Doubt? (Sermon Aug. 21, 2016)

Using the Gospel reading of Peter walking on water, Fr. Andrew talks about the two kinds of doubt in the Christian life and how to address them.




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Fr. Harry Linsinbigler on Dealing with Self Doubt

In this episode, Fr. Anthony and Fr. Harry talk about one of the Demons of Noonday: self doubt. They point out the role that participation in the Divine Liturgy can have in diagnosing and overcoming it and encourage anyone who is suffering from pernicious self doubt to spend more time with their supportive brothers in the priesthood.




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Fear and Doubt and Closed Doors

Fr. Michael shares on Thomas Sunday, "Those who doubt, those who fear, those who hide and shut the doors are not cut off from the One who appears in rooms with closed doors."




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Doubting

The Sunday of St. Thomas reminds us that we are always in danger of losing our faith, even if it is proven to us.




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Doubting Each Other

Fr. Ted explains how our faith in Christ correlates with our willingness to believe in and trust our brother.




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Dare to Doubt

Fr. Theodore Paraskevopoulos explains the significance of St. Thomas' difficulty believing in the resurrection of Jesus for us today.




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Some Doubted

Who were these who doubted in Matthew 28?




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Christ: The Destroyer of Doubt

The Resurrection of Christ destroys death, division, and despair. And though the Lord provides proof of His Resurrection to destroy doubt in us, our hearts must be unlocked from the inside through faith.




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Oh No, It's Doubt




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Doubt Derails Confidence




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Is Doubt Wrong?




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Derail Your Doubts




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OH NO! It's Doubt!




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The Final Outcome is Not in Doubt

In the raising of the son of the widow of Nain, a liturgical parallel to the raising of Lazarus, Luke declares Jesus as Lord and Victor not only over death, but over everything.




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Faith and Doubt

We all struggle with doubt sometimes. Is that a problem, or something that can help our faith?




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Hayden has 'no doubt' Carlisle will turn form around

Carlisle United defender Aaron Hayden is convinced the team is on the right track after they ended a seven-game winless streak.




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Doubts over £10m HGV access work at historic park

Workington Town Council raises concerns about the impact on nearby Hall Park.




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Sotto, Edu doubtful for Gilas in FIBA Asia Cup qualifiers

Gilas Pilipinas may be without two key big men for the November window of the FIBA Asia Cup qualifiers.




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Feed Your Faith, Not Your Doubts

Have you ever noticed that when you focus on one specific prob­lem in your life, the normal things you deal with every day tend to fade into the background? For example, not too long ago, multiple warning lights on my car’s dashboard popped on during a road trip I was taking with my wife and kids, including the dreaded “check engine” light. I couldn’t think about anything else other than the fact that my car needed maintenance as soon as possi­ble. It was difficult to focus on the subject...




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Responses to the Doubts of the Apostates and Anti-Islam Propagandists




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A subtle change may increase disability disclosures

DeKalb, IL — Could altering the language on disability disclosure forms encourage more workers to disclose their conditions? A recent study explored this idea.




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Crystallographic fragment screen of the c-di-AMP-synthesizing enzyme CdaA from Bacillus subtilis

Crystallographic fragment screening has become a pivotal technique in structure-based drug design, particularly for bacterial targets with a crucial role in infectious disease mechanisms. The enzyme CdaA, which synthesizes an essential second messenger cyclic di-AMP (c-di-AMP) in many pathogenic bacteria, has emerged as a promising candidate for the development of novel antibiotics. To identify crystals suitable for fragment screening, CdaA enzymes from Streptococcus pneumoniae, Bacillus subtilis and Enterococcus faecium were purified and crystallized. Crystals of B. subtilis CdaA, which diffracted to the highest resolution of 1.1 Å, were used to perform the screening of 96 fragments, yielding data sets with resolutions spanning from 1.08 to 1.87 Å. A total of 24 structural hits across eight different sites were identified. Four fragments bind to regions that are highly conserved among pathogenic bacteria, specifically the active site (three fragments) and the dimerization interface (one fragment). The coordinates of the three active-site fragments were used to perform an in silico drug-repurposing screen using the OpenEye suite and the DrugBank database. This screen identified tenofovir, an approved drug, that is predicted to interact with the ATP-binding region of CdaA. Its inhibitory potential against pathogenic E. faecium CdaA has been confirmed by ITC measurements. These findings not only demonstrate the feasibility of this approach for identifying lead compounds for the design of novel antibacterial agents, but also pave the way for further fragment-based lead-optimization efforts targeting CdaA.




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STOPGAP: an open-source package for template matching, subtomogram alignment and classification

Cryo-electron tomography (cryo-ET) enables molecular-resolution 3D imaging of complex biological specimens such as viral particles, cellular sections and, in some cases, whole cells. This enables the structural characterization of molecules in their near-native environments, without the need for purification or separation, thereby preserving biological information such as conformational states and spatial relationships between different molecular species. Subtomogram averaging is an image-processing workflow that allows users to leverage cryo-ET data to identify and localize target molecules, determine high-resolution structures of repeating molecular species and classify different conformational states. Here, STOPGAP, an open-source package for subtomogram averaging that is designed to provide users with fine control over each of these steps, is described. In providing detailed descriptions of the image-processing algorithms that STOPGAP uses, this manuscript is also intended to serve as a technical resource to users as well as for further community-driven software development.




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Subtle Love Launches T-Shirt Subscription Service Focused on Spreading Love

Clothing that brings humans closer together.




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The Subtlety of Lowkii Styles – Your Answer to Thinning Hair

This Salon and Spa Galleria salon in Arlington, Texas offers state-of-the-art solutions to hair loss




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The Subtle Art of Saying No

Bruce Tulgan, founder of the management training firm RainmakerThinking, says that the key to career success isn't only embracing opportunities; it's also declining projects, tasks, and requests for help so you create time for the most value-added work. He explains how to evaluate each ask, determine which you should prioritize, and deliver either a strategic "yes" or a well-thought-through no. Tulgan is the author of the HBR article "Learn When to Say No."




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The Subtle Art of Disagreeing with Your Boss

Whether you're someone who enjoys ruffling feathers or the type of person who'd like to challenge the status quo but shies away, you'll benefit from understanding the best, research--backed ways to practice disagreement - even insubordination - while holding onto others' respect at work. Todd Kashdan is a psychology professor at George Mason University and the author of the book The Art of Insubordination: How to Dissent and Defy Effectively. He explains how contrarians, and those with ideas that run counter to the mainstream, can pick their battles, articulate their arguments, and gain allies along the way.




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Scientists Create a Computational Tool That ID's Rheumatoid Arthritis Subtypes

Scientists have used computational tools, including machine learning, to differentiate between subtypes of rheumatoid arthritis.




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Subtype-Dependent Health Disparities Among Breast Cancer Patients

Breast cancer remains the most common invasive cancer diagnosed in women in the United States, accounting for about one in three new female cancers each ye



  • Health & Medicine

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Scientists Create a Computational Tool That ID's Rheumatoid Arthritis Subtypes

Scientists have used computational tools, including machine learning, to differentiate between subtypes of rheumatoid arthritis.



  • Clinical & Molecular DX

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Subtype-Dependent Health Disparities Among Breast Cancer Patients

Breast cancer remains the most common invasive cancer diagnosed in women in the United States, accounting for about one in three new female cancers each ye



  • Clinical & Molecular DX