Scientists have used computational tools, including machine learning, to differentiate between subtypes of rheumatoid arthritis.

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles  Nature.com

A signed version of Newsround is available to watch every weekday for children who use British Sign Language.

The New York-based company reportedly last year captioned and subtitled more than 15 million minutes in video on-demand, processed more than 500,000 minutes of content with speech recognition, and live-captioned more than 300,000 minutes of events.

Improved accuracy, wider language choices, and real-time options are among the benefits.

As agencies look deeper into 2024 FEVS results, they may want to analyze the intersection between two key indices: employee engagement, and employee experience.

The post The subtle difference between engagement and experience in 2024 FEVS first appeared on Federal News Network.

Robert Griffin III continued to throw during practice; he continued to run and he continued to be optimistic about his chances for being ready at the start of the season. That’s why, when asked if the start of training camp was a realistic possibility for his return, Griffin didn’t hestitate.

Laurence Inman is not in a hopeful mood, despite receiving good news

En 10AM Hoy por Hoy de Caracol Radio estuvo Edgar Enrique Sandoval, economista y primer gerente general de Transmilenio, hablando sobre el tema del metro de Bogotá y el debate que se lleva a cabo sobre este tema.

It pits the best young shire cricketers against each other - but with an average age of just 18, Roseville are out to show they’re no pushover.

1. Kate Middleton sparks doubts whether she even had cancer?  Geo News
2. ‘Played us all’: Vicious Kate theory takes hold  news.com.au
3. Kate Middleton Yet Again Trapped In Conspiracy Theories While Battling Cancer? Find Out As Royal Reporter Questions Princess’ Diagnosis  PINKVILLA

Self-love is a topic we hear about often, but putting it into practice can feel elusive, like trying to hold onto something that keeps slipping away. You know it’s there, but it’s hard to hold on to. The concept of self-love involves valuing oneself and letting go of toxic influences. It’s about stepping back from ... Read more

The post A Guide to Self-Love: From Overcoming Doubt to System-Based Growth appeared first on LifeHack.

Springbok team doctor Jerome Mampane says that injured utility back Sacha Feinberg-Mngomezulu is recovering well.

Alright! The Muses sing, drawing you to the desk, pump your veins with hot blood and fill your mind with combustible imagination. You’re on fire and ready to write. The idea once tumbling in your mind is bucking with life and wants to breath words on your screen. It’s awesome. You’re awesome. All is good.

Then the passions temper under the cool, steady light of your computer screen. The process of fleshing out your idea with words demands time. So much so, you feel the vibrant energy of your story suffocate under the process. Now you’re using the logical, analytical side of your brain. Each scene or circumstance demands continuity and must fit into the internal logic of your world. Everything must make sense; else the reader will dismiss this pile of junk for amateur hubris.

With logic comes the questions. A train of them, each rumbling down the tracks uncaring of the idea which once bucked in the stables of your mind, eager for freedom, now tied to the rails. All of the doubts can easily be summarized into “Can I?”

Of course, this isn’t the real question haunting the halls of your mind.

Continue reading Can I? When Doubt Kills Your Ideas at Mythic Scribes.

Jan Draisma and Thomas Karam
Proc. Amer. Math. Soc. 152 (), 5083-5093.
Abstract, references and article information

Juntuo Zhou
Nov 30, 2020; 0:RA120.002384v1-mcp.RA120.002384
Research

The histopathological subtype of lung adenocarcinoma (LUAD) is closely associated with prognosis. Micropapillary or solid predominant LUAD tends to relapse after surgery at an early stage, whereas lepidic pattern shows a favorable outcome. However, the molecular mechanism underlying this phenomenon remains unknown. Here, we recruited 31 lepidic predominant LUADs (LR: low-risk subtype group) and 28 micropapillary or solid predominant LUADs (HR: high-risk subtype group). Tissues of these cases were obtained and label-free quantitative proteomic and bioinformatic analyses were performed. Additionally, prognostic impact of targeted proteins was validated using The Cancer Genome Atlas databases (n=492) and tissue microarrays composed of early-stage LUADs (n=228). A total of 192 differentially expressed proteins were identified between tumor tissues of LR and HR and three clusters were identified via hierarchical clustering excluding eight proteins. Cluster 1 (65 proteins) showed a sequential decrease in expression from normal tissues to tumor tissues of LR and then to HR and was predominantly enriched in pathways such as tyrosine metabolism and ECM-receptor interaction, and increased matched mRNA expression of 18 proteins from this cluster predicted favorable prognosis. Cluster 2 (70 proteins) demonstrated a sequential increase in expression from normal tissues to tumor tissues of LR and then to HR and was mainly enriched in pathways such as extracellular organization, DNA replication and cell cycle, and high matched mRNA expression of 25 proteins indicated poor prognosis. Cluster 3 (49 proteins) showed high expression only in LR, with high matched mRNA expression of 20 proteins in this cluster indicating favorable prognosis. Furthermore, high expression of ERO1A and FEN1 at protein level predicted poor prognosis in early-stage LUAD, supporting the mRNA results. In conclusion, we discovered key differentially expressed proteins and pathways between low-risk and high-risk subtypes of early-stage LUAD. Some of these proteins could serve as potential biomarkers in prognostic evaluation.

Este año en el mes en que se llevó a cabo el mantenimiento anual de Logos Hope en Uruguay, la tripulante Cecilia* de Argentina se unió a un pequeño equipo que sirve en Asia Central. Mientras estuvo allí, pudo asistir a dos iglesias subterráneas que desbordaban de esperanza y fe.

Coatzacoalcos, Mexico :: Logos Hope's crewmembers encourage a youth group to listen to God's call to serve.

Elementary math specialist Kristin Gray helps her 2nd graders understand different subtraction strategies by talking through their thought processes.

Migration, trade, the defence of democracy, the confrontation with China and the collapse of multilateralism are issues that shed more doubts than certainties on Latin America’s expectations of the imminent presidential elections in the United States. Interest and tension have grown after dozens of polls and bookmakers have shown similar chances of victory for Democrat […]

New archaeological evidence shows that ancient humans ate each other surprisingly often - sometimes for compassionate reasons. The finds give us an opportunity to reassess our views on the practice

Title: Study Casts Doubt on 'Chemical Imbalance' Theory of Depression
Category: Health News
Created: 8/9/2022 12:00:00 AM
Last Editorial Review: 8/9/2022 12:00:00 AM

Researchers have decoded how mutations in the CDK12 gene ignite prostate cancer and revealed a breakthrough treatment-a powerful degrader that targets

In an abrupt move, the Shiv Sena (UBT) has expelled its former Hingoli Lok Sabha MP Subhash Wankhede from the party for alleged 'anti-party' activities

Tiger Woods cast serious doubt on his competitive golf future in his first press conference since a life-threatening February car crash, saying that his ability to compete will never be the same after the devastating leg injuries. Photo: Doug Ferguson/Associated Press

The need of the hour is to produce critical thinkers. One way to ensure this is to encourage questioning.

"We are now aggressively working on spreading awareness about our symbol 'mashaal'," MLA Udaysingh Rajput said, adding that he will also raise farmers' woes as part of his campaign

Suraj Chavan was arrested on January 17, 2024, for his alleged irregularities in distributing khichdi to migrant workers during the COVID-19 pandemic

MVA constituents Congress and NCP (SP) too were gunning for the seats.

The party leader unveils Maharashtra Assembly polls manifesto with promises of free education, stable prices for essential items, and scrapping Dharavi project

Uddhav Thackeray moots new housing policy, vows to scrap cluster development of Koliwadas till the consent of the fishing community is obtained; says joint MVA manifesto to be released by the weekend

'The purest form of love lies in having faith in your beloved, to the point where the need for questioning simply fades away. '

Smith carried his bat with an unbeaten 91 in a losing cause in Brisbane.

Shantanu and Nikhil speak of their 16-year-journey and why they like to keep their style subtle

Rohit along with a large India squad will depart for Perth in two batches – on November 10 and 11 – and the captain may come back home for a while due to personal reasons.

Vasant More had unsuccessfully contested the Pune seat in the recently concluded Lok Sabha election on a VBA ticket after quitting the MNS

Bitcoin lags behind bonds, stocks and gold, signaling a possible slowdown in the crypto market

“I received a lot of phone calls from Gautam bhai and Surya, telling me what to work on,” says the Kerala batter, after his century against South Africa

Hansi Flick said he thought playmaker Dani Olmo would be ready despite feeling unwell overnight, while defender Pau Cubarsi can play despite suffering a cut on his face during the team’s Champions League win over Red Star Belgrade