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Extracellular matrix-evoked angiostasis and autophagy within the tumor microenvironment represent two critical, but unconnected, functions of the small leucine-rich proteoglycan, decorin. Acting as a partial agonist of vascular endothelial growth factor 2 (VEGFR2), soluble decorin signals via the energy sensing protein, AMP-activated protein kinase (AMPK), in the autophagic degradation of intracellular vascular endothelial growth factor A (VEGFA). Here, we discovered that soluble decorin evokes intracellular catabolism of endothelial VEGFA that is mechanistically independent of mTOR, but requires an autophagic regulator, paternally expressed gene 3 (PEG3). We found that administration of autophagic inhibitors such as chloroquine or bafilomycin A1, or depletion of autophagy-related 5 (ATG5), results in accumulation of intracellular VEGFA, indicating that VEGFA is a basal autophagic substrate. Mechanistically, decorin increased the VEGFA clearance rate by augmenting autophagic flux, a process that required RAB24 member RAS oncogene family (RAB24), a small GTPase that facilitates the disposal of autophagic compartments. We validated these findings by demonstrating the physiological relevance of this process in vivo. Mice starved for 48 h exhibited a sharp decrease in overall cardiac and aortic VEGFA that could be blocked by systemic chloroquine treatment. Thus, our findings reveal a unified mechanism for the metabolic control of endothelial VEGFA for autophagic clearance in response to decorin and canonical pro-autophagic stimuli. We posit that the VEGFR2/AMPK/PEG3 axis integrates the anti-angiogenic and pro-autophagic bioactivities of decorin as the molecular basis for tumorigenic suppression. These results support future therapeutic use of decorin as a next-generation protein therapy to combat cancer.

Magician Roy Horn, who was one half of the German duo "Siegfried & Roy," has died after contracting Covid-19, his spokesman says.

Roy Horn, famed tiger handler and co-star of the magic duo known as Siegfried and Roy, died of complications from the coronavirus in a hospital in Las Vegas on Friday. He was 75 years old. "Today, the world has lost one of the greats of magic, but I have lost my best friend," Siegfried Fischbacher said in a statement. "From the moment we met, I knew Roy and I, together, would change the world." "There could be no Siegfried without Roy, and no Roy without Siegfried." This is a developing story. Please check back for updates.

The invention relates to quinazoline derivatives of formula (I), wherein m is an integer from 1 to 3; R1 represents halogeno or C1-3alkyl; X1 represents —O—; R2 is selected from one of the following three groups: 1) C1-5alkylR3, wherein R3 is piperidinyl-4-yl which may bear one or two substituents selected from hydroxy, halogeno, C1-4alkyl, C1-4hydroxyalkyl and C1-4alkoxy; 2) C2-5alkenylR3, wherein R3 is as defined herein; 3) C2-5alkynylR3, wherein R3 is as defined herein; and wherein any alkyl, alkenyl or alkynyl group may bear one or more substituents selected from hydroxy, halogeno and amino; and salts thereof; processes for their preparation; pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.

A molecule comprising a lipid, a peptide and a linker to bind the lipid to the peptide which have specific amino acid sequence to bind to Epidermal Growth Factor Receptor (EGFR) of tumor cells, and a liposomal composition which is targeted by the molecule, and method for preparing thereof is disclosed.

The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.

The present invention relates to in vitro methods of assessing the susceptibility or responsiveness of a subject to the treatment with an epidermal growth factor receptor (EGFR) inhibitor/antagonist, wherein the subject has been diagnosed or suspected of suffering from inflammation-associated. These methods comprise determining the level of expression of EGFR in myeloid cells in a sample from the subject, wherein an expression of EGFR in the myeloid cells is indicative of the subject being susceptible to the treatment with an EGFR inhibitor/antagonist. The invention also relates to EGFR inhibitors/antagonists for use in the treatment or amelioration of inflammation-associated cancer. The invention furthermore provides in vitro methods of prognosing the survival time, progression-free survival time or disease course of a subject that has been diagnosed or suspected of suffering from from inflammation-associated cancer. In addition thereto, the invention relates to in vitro diagnostic methods of assessing the proneness of a subject to develop inflammation-associated cancer in which the expression of EGFR is determined in myeloid cells from the subject.

Magician and animal trainer Roy Horn, of the legendary Las Vegas duo Siegfied and Roy, died Friday from complications related to COVID-19. Horn tested positive last week. He was 75. "The world has lost one of the greats of magic, but I have lost my best friend," Siegfried Fischbacher said of his partner in a statement. "Roy was a fighter his whole life including during these final days. I give my heartfelt appreciation to the team of doctors, nurses and staff at Mountain View Hospital who worked heroically against this insidious virus that ultimately took Roy's life." Roy Horn was born in Germany in 1944. He and Siegfried began their act in Las Vegas in 1967. In 1989 they began a 14-year run at the Mirage Resort performing illusions with exotic animals, making tigers, lions, even elephants vanish and reappear. In October of 2003, Roy Horn was performing with a 400-pound white tiger named Mantecore when the great cat grabbed him by the throat before a stunned audience and dragged him

Magician and animal trainer Roy Horn, of the legendary Las Vegas duo Siegfied and Roy, died Friday from complications related to COVID-19. Horn tested positive last week. He was 75. "The world has lost one of the greats of magic, but I have lost my best friend," Siegfried Fischbacher said of his partner in a statement. "Roy was a fighter his whole life including during these final days. I give my heartfelt appreciation to the team of doctors, nurses and staff at Mountain View Hospital who worked heroically against this insidious virus that ultimately took Roy's life." Roy Horn was born in Germany in 1944. He and Siegfried began their act in Las Vegas in 1967. In 1989 they began a 14-year run at the Mirage Resort performing illusions with exotic animals, making tigers, lions, even elephants vanish and reappear. In October of 2003, Roy Horn was performing with a 400-pound white tiger named Mantecore when the great cat grabbed him by the throat before a stunned audience and dragged him

Stage partner Siegfried Fischbacher has since paid tribute to the Las Vegas entertainer and offered his heartfelt appreciation to the doctors, nurses and staff that have worked heroically against COVID-19.

Stage partner Siegfried Fischbacher has since paid tribute to the Las Vegas entertainer and offered his heartfelt appreciation to the doctors, nurses and staff that have worked heroically against COVID-19.

Magician and animal trainer Roy Horn, of the legendary Las Vegas duo Siegfied and Roy, died Friday from complications related to COVID-19. Horn tested positive last week. He was 75. "The world has lost one of the greats of magic, but I have lost my best friend," Siegfried Fischbacher said of his partner in a statement. "Roy was a fighter his whole life including during these final days. I give my heartfelt appreciation to the team of doctors, nurses and staff at Mountain View Hospital who worked heroically against this insidious virus that ultimately took Roy's life." Roy Horn was born in Germany in 1944. He and Siegfried began their act in Las Vegas in 1967. In 1989 they began a 14-year run at the Mirage Resort performing illusions with exotic animals, making tigers, lions, even elephants vanish and reappear. In October of 2003, Roy Horn was performing with a 400-pound white tiger named Mantecore when the great cat grabbed him by the throat before a stunned audience and dragged him

Magician and animal trainer Roy Horn, of the legendary Las Vegas duo Siegfied and Roy, died Friday from complications related to COVID-19. Horn tested positive last week. He was 75. "The world has lost one of the greats of magic, but I have lost my best friend," Siegfried Fischbacher said of his partner in a statement. "Roy was a fighter his whole life including during these final days. I give my heartfelt appreciation to the team of doctors, nurses and staff at Mountain View Hospital who worked heroically against this insidious virus that ultimately took Roy's life." Roy Horn was born in Germany in 1944. He and Siegfried began their act in Las Vegas in 1967. In 1989 they began a 14-year run at the Mirage Resort performing illusions with exotic animals, making tigers, lions, even elephants vanish and reappear. In October of 2003, Roy Horn was performing with a 400-pound white tiger named Mantecore when the great cat grabbed him by the throat before a stunned audience and dragged him

Magician and animal trainer Roy Horn, of the legendary Las Vegas duo Siegfied and Roy, died Friday from complications related to COVID-19. Horn tested positive last week. He was 75. "The world has lost one of the greats of magic, but I have lost my best friend," Siegfried Fischbacher said of his partner in a statement. "Roy was a fighter his whole life including during these final days. I give my heartfelt appreciation to the team of doctors, nurses and staff at Mountain View Hospital who worked heroically against this insidious virus that ultimately took Roy's life." Roy Horn was born in Germany in 1944. He and Siegfried began their act in Las Vegas in 1967. In 1989 they began a 14-year run at the Mirage Resort performing illusions with exotic animals, making tigers, lions, even elephants vanish and reappear. In October of 2003, Roy Horn was performing with a 400-pound white tiger named Mantecore when the great cat grabbed him by the throat before a stunned audience and dragged him

Magician and animal trainer Roy Horn, of the legendary Las Vegas duo Siegfied and Roy, died Friday from complications related to COVID-19. Horn tested positive last week. He was 75. "The world has lost one of the greats of magic, but I have lost my best friend," Siegfried Fischbacher said of his partner in a statement. "Roy was a fighter his whole life including during these final days. I give my heartfelt appreciation to the team of doctors, nurses and staff at Mountain View Hospital who worked heroically against this insidious virus that ultimately took Roy's life." Roy Horn was born in Germany in 1944. He and Siegfried began their act in Las Vegas in 1967. In 1989 they began a 14-year run at the Mirage Resort performing illusions with exotic animals, making tigers, lions, even elephants vanish and reappear. In October of 2003, Roy Horn was performing with a 400-pound white tiger named Mantecore when the great cat grabbed him by the throat before a stunned audience and dragged him

LAS VEGAS (AP) — Roy Horn of Siegfried & Roy, the duo whose extraordinary magic tricks astonished millions until Horn was critically injured in 2003 by one of the act’s famed white tigers, has died. He was 75. Horn died of complications from the coronavirus on Friday in a Las Vegas hospital, according to a […]

LAS VEGAS (AP) — Roy Horn of Siegfried & Roy, the duo whose extraordinary magic tricks astonished millions until Horn was critically injured in 2003 by one of the act’s famed white tigers, has died. He was 75. Horn died of complications from the coronavirus on Friday in a Las Vegas hospital, according to a […]

LAS VEGAS (AP) — Roy Horn of Siegfried & Roy, the duo whose extraordinary magic tricks astonished millions until Horn was critically injured in 2003 by one of the act’s famed white tigers, has died. He was 75. Horn died of complications from the coronavirus on Friday in a Las Vegas hospital, according to a […]

In een ziekenhuis in Las Vegas is de Duitse dompteur en illusionist Roy Horn overleden aan de gevolgen van het coronavirus. Hij was 75 jaar.

Horn werd wereldberoemd met de extravagante leeuwen- en tijgershows die hij jarenlang met partner Siegfried Fischbacher maakte. Aan het succes van Siegfried & Roy kwam abrupt een einde toen Horn in 2003 tijdens een optreden werd aangevallen door een van zijn dieren. Hij raakte zwaargewond en worstelde sindsdien met zijn gezondheid. Vorige week werd een coronabesmetting bij hem vastgesteld.

"De wereld is een van de grote goochelaars kwijtgeraakt en ik mijn beste vriend", reageert Siegfried Fischbacher op het overlijden van Horn. "Vanaf het moment dat we elkaar troffen, wist ik dat Roy en ik de wereld zouden veranderen. Er is geen Siegfried zonder Roy en geen Roy zonder Siegfried."

In 1999 kregen Siegfried & Roy een ster op de Hollywood Walk of Fame:

Als kind was Horn al gefascineerd door exotische dieren en had een jachtluipaard als huisdier. Deze Chico nam hij ook mee toen hij ging werken op een cruiseschip, eind jaren 50. Het was daar dat hij Fischbacher ontmoette, die naast zijn werk op het schip ook kleine goocheltrucs deed om de gasten te vermaken. Roy ging hem daarbij helpen en zo ontstond 's wereld bekendste illusionistenduo.

Na optredens overal ter wereld kwamen Horn en Fischbacher in 1967 met hun goochelshow in Las Vegas terecht. De Siegfried & Roy Show waarmee ze uiteindelijk in het hotelcasino The Mirage stonden, was bij aanvang in 1990 met een productiebudget van 30 miljoen dollar verreweg de grootste en duurste show in de gokstad.

Illusionist Hans Klok reageert geschrokken op het overlijden van de beroemde dompteur en illusionist. Hij had pas eerder deze week gehoord dat Roy met corona in het ziekenhuis lag, maar had erop gerekend dat hij er weer bovenop zou komen. "Hij had immers ook een aanval van een tijger overleefd", zei Klok in het NOS Radio 1 Journaal.

Voor de Nederlandse illusionist golden Siegfried & Roy als "hele grote voorbeelden". Hij kende Siegfried en Roy al tientallen jaren heel goed en voelde zich ook altijd erg gesteund door het Duitse duo. "Ze hebben ongelooflijk veel betekend voor de magic-wereld", aldus Klok.

Na de onaangekondigde show met de cheetah op het cruiseschip werden Siegfried & Roy ontslagen. "De kapitein van het schip was er niet zo erg blij mee", aldus Klok. Ze werden daarna gevraagd voor het Rode Kruis gala in Monte Carlo.

Prins Rainier en prinses Gracia (de voormalige filmster Grace Kelly) zaten vooraan. Grace Kelly droeg een bontjas "en dat ruikt een dier natuurlijk. Dus Siegfried & Roy laten die cheetah verschijnen en die maakt een sprong en vliegt bovenop Grace Kelly. Dat was wereldnieuws."

In de jaren 60 vertrokken Siegfried & Roy naar Las Vegas "en kregen hier te horen 'magic is not gonna work in this city' en de rest is history", zegt Klok. Twintig jaar lang waren ze de best betaalde artiesten in Las Vegas. "Zij, Elvis Presley en Frank Sinatra zijn de mensen die Las Vegas in de afgelopen decennia hebben opgebouwd tot wat het nu is."

Magician Roy Horn, who was one half of the German duo "Siegfried & Roy," has died after contracting Covid-19, his spokesman says.

Roy Uwe Ludwig Horn, half of Las Vegas icons Siegfried & Roy, has died from complications stemming from COVID-19.

Roy Horn, one half of the longtime Las Vegas illusionist duo Siegfried & Roy, has died at the age of 75 after suffering complications from coronavirus.

LAS VEGAS — Roy Horn of Siegfried & Roy, the duo whose extraordinary magic tricks astonished millions until Horn was critically injured in 2003 by one of the act’s famed white tigers, has died. He was 75. Horn died of complications from the coronavirus on Friday in a Las Vegas hospital, according to a statement […]

LAS VEGAS — Roy Horn of Siegfried & Roy, the duo whose extraordinary magic tricks astonished millions until Horn was critically injured in 2003 by one of the act’s famed white tigers, has died. He was 75. Horn died of complications from the coronavirus on Friday in a Las Vegas hospital, according to a statement […]

Roy Horn and his partner Siegfried Fischbacher thrilled audiences for decades doing illusions with big cats. Horn died Friday in Las Vegas of complications from COVID-19.

Roy Horn and his partner Siegfried Fischbacher thrilled audiences for decades doing illusions with big cats. Horn died Friday in Las Vegas of complications from COVID-19.

"Today, the world has lost one of the greats of magic, but I have lost my best friend," Siegfried Fischbacher said in a statement.

Magician Roy Horn, 75, died Thursday after developing symptoms of Covid-19 several days ago. Horn and partner Siegfried Fischbacher ran the most popular stage show in Vegas throughout the 1990s, featuring hundreds of performers, pyrotechnics and a coterie of white tigers at the Mirage hotel. Horn was forced to retire after suffering a stroke before or as a tiger dragged him from the stage by the neck.

TMZ received a statement from Fischbacher:

"Today, the world has lost one of the greats of magic, but I have lost my best friend. From the moment we met, I knew Roy and I, together, would change the world. There could be no Siegfried without Roy, and no Roy without Siegfried."

Siegfried goes on ... "Roy was a fighter his whole life, including during these final days. I give my heartfelt appreciation to the team of doctors, nurses and staff at Mountain View Hospital who worked heroically against this insidious virus that ultimately took Roy's life."

My first visit to the U.S. was a trip to Vegas in 1999. The first thing I remember seeing of America, stepping blearily out of the taxi at the Mirage Hotel after 15 hours in the air, was a colossal fiberglass statue of Siegfried and Roy. God bless America.

Read the rest

Roy Horn of Siegfried & Roy, the duo whose extraordinary magic tricks astonished millions until Horn was critically injured in 2003 by one of the act's famed white tigers, has died. He was 75.

Extracellular matrix-evoked angiostasis and autophagy within the tumor microenvironment represent two critical, but unconnected, functions of the small leucine-rich proteoglycan, decorin. Acting as a partial agonist of vascular endothelial growth factor 2 (VEGFR2), soluble decorin signals via the energy sensing protein, AMP-activated protein kinase (AMPK), in the autophagic degradation of intracellular vascular endothelial growth factor A (VEGFA). Here, we discovered that soluble decorin evokes intracellular catabolism of endothelial VEGFA that is mechanistically independent of mTOR, but requires an autophagic regulator, paternally expressed gene 3 (PEG3). We found that administration of autophagic inhibitors such as chloroquine or bafilomycin A1, or depletion of autophagy-related 5 (ATG5), results in accumulation of intracellular VEGFA, indicating that VEGFA is a basal autophagic substrate. Mechanistically, decorin increased the VEGFA clearance rate by augmenting autophagic flux, a process that required RAB24 member RAS oncogene family (RAB24), a small GTPase that facilitates the disposal of autophagic compartments. We validated these findings by demonstrating the physiological relevance of this process in vivo. Mice starved for 48 h exhibited a sharp decrease in overall cardiac and aortic VEGFA that could be blocked by systemic chloroquine treatment. Thus, our findings reveal a unified mechanism for the metabolic control of endothelial VEGFA for autophagic clearance in response to decorin and canonical pro-autophagic stimuli. We posit that the VEGFR2/AMPK/PEG3 axis integrates the anti-angiogenic and pro-autophagic bioactivities of decorin as the molecular basis for tumorigenic suppression. These results support future therapeutic use of decorin as a next-generation protein therapy to combat cancer.

Yan Zhou Tran
Mar 31, 2020; 0:RA120.002036v1-mcp.RA120.002036
Research

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with very limited therapeutic options. We have recently shown that the combined inhibition of EGFR and ROCK in TNBC cells results in cell death, however, the underlying mechanisms remain unclear. To investigate this, here we applied a mass spectrometry-based proteomic approach to identify proteins altered on single and combination treatments. Our proteomic data revealed autophagy as the major molecular mechanism implicated in the cells' response to combinatorial treatment. We here show that EGFR inhibition by gefitinib treatment alone induces autophagy, a cellular recycling process that acts as a cytoprotective response for TNBC cells. However, combined inhibition of EGFR and ROCK leads to autophagy blockade and accumulation of autophagic vacuoles. Our data show impaired autophagosome clearance as a likely cause of antitumor activity. We propose that the inhibition of the autophagic flux on combinatorial treatment is attributed to the major cytoskeletal changes induced on ROCK inhibition, given the essential role the cytoskeleton plays throughout the various steps of the autophagy process.

Drug resistance is a major obstacle to curative cancer therapies, and increased understanding of the molecular events contributing to resistance would enable better prediction of therapy response, as well as contribute to new targets for combination therapy. Here we have analyzed the early molecular response to epidermal growth factor receptor (EGFR) inhibition using RNA sequencing data covering 13 486 genes and mass spectrometry data covering 10 138 proteins. This analysis revealed a massive response to EGFR inhibition already within the first 24 hours, including significant regulation of hundreds of genes known to control downstream signaling, such as transcription factors, kinases, phosphatases and ubiquitin E3-ligases. Importantly, this response included upregulation of key genes in multiple oncogenic signaling pathways that promote proliferation and survival, such as ERBB3, FGFR2, JAK3 and BCL6, indicating an early adaptive response to EGFR inhibition. Using a library of more than 500 approved and experimental compounds in a combination therapy screen, we could show that several kinase inhibitors with targets including JAK3 and FGFR2 increased the response to EGFR inhibitors. Further, we investigated the functional impact of BCL6 upregulation in response to EGFR inhibition using siRNA-based silencing of BCL6. Proteomics profiling revealed that BCL6 inhibited transcription of multiple target genes including p53, resulting in reduced apoptosis which implicates BCL6 upregulation as a new EGFR inhibitor treatment escape mechanism. Finally, we demonstrate that combined treatment targeting both EGFR and BCL6 act synergistically in killing lung cancer cells. In conclusion, or data indicates that multiple different adaptive mechanisms may act in concert to blunt the cellular impact of EGFR inhibition, and we suggest BCL6 as a potential target for EGFR inhibitor-based combination therapy.

Extracellular matrix-evoked angiostasis and autophagy within the tumor microenvironment represent two critical, but unconnected, functions of the small leucine-rich proteoglycan, decorin. Acting as a partial agonist of vascular endothelial growth factor 2 (VEGFR2), soluble decorin signals via the energy sensing protein, AMP-activated protein kinase (AMPK), in the autophagic degradation of intracellular vascular endothelial growth factor A (VEGFA). Here, we discovered that soluble decorin evokes intracellular catabolism of endothelial VEGFA that is mechanistically independent of mTOR, but requires an autophagic regulator, paternally expressed gene 3 (PEG3). We found that administration of autophagic inhibitors such as chloroquine or bafilomycin A1, or depletion of autophagy-related 5 (ATG5), results in accumulation of intracellular VEGFA, indicating that VEGFA is a basal autophagic substrate. Mechanistically, decorin increased the VEGFA clearance rate by augmenting autophagic flux, a process that required RAB24 member RAS oncogene family (RAB24), a small GTPase that facilitates the disposal of autophagic compartments. We validated these findings by demonstrating the physiological relevance of this process in vivo. Mice starved for 48 h exhibited a sharp decrease in overall cardiac and aortic VEGFA that could be blocked by systemic chloroquine treatment. Thus, our findings reveal a unified mechanism for the metabolic control of endothelial VEGFA for autophagic clearance in response to decorin and canonical pro-autophagic stimuli. We posit that the VEGFR2/AMPK/PEG3 axis integrates the anti-angiogenic and pro-autophagic bioactivities of decorin as the molecular basis for tumorigenic suppression. These results support future therapeutic use of decorin as a next-generation protein therapy to combat cancer.

The molecular mechanisms of β-cell compensation to metabolic stress are poorly understood. We previously observed that nutrient-induced β-cell proliferation in rats is dependent on epidermal growth factor receptor (EGFR) signaling. The aim of this study was to determine the role of the EGFR ligand heparin-binding EGF-like growth factor (HB-EGF) in the β-cell proliferative response to glucose, a β-cell mitogen and key regulator of β-cell mass in response to increased insulin demand. We show that exposure of isolated rat and human islets to HB-EGF stimulates β-cell proliferation. In rat islets, inhibition of EGFR or HB-EGF blocks the proliferative response not only to HB-EGF but also to glucose. Furthermore, knockdown of HB-EGF in rat islets blocks β-cell proliferation in response to glucose ex vivo and in vivo in transplanted glucose-infused rats. Mechanistically, we demonstrate that HB-EGF mRNA levels are increased in β-cells in response to glucose in a carbohydrate-response element–binding protein (ChREBP)–dependent manner. In addition, chromatin immunoprecipitation studies identified ChREBP binding sites in proximity to the HB-EGF gene. Finally, inhibition of Src family kinases, known to be involved in HB-EGF processing, abrogated glucose-induced β-cell proliferation. Our findings identify a novel glucose/HB-EGF/EGFR axis implicated in β-cell compensation to increased metabolic demand.

German-born entertainer Roy Uwe Ludwig Horn, one half of the stage duo Siegfried & Roy, has died of complications from the coronavirus. He was 75.

Source: www.timesofisrael.com - Saturday, May 09, 2020
Vegas fixture's work with exotic animals came to violent end in 2003 when he was attacked on stage, critically hurt, by a 400-pound white tiger

Roy Horn was 75.

LAS VEGAS (AP) — Roy Horn of Siegfried & Roy, the duo whose extraordinary magic tricks astonished millions until Horn was critically injured in 2003 by one of the act’s famed white tigers, has died. He was 75. Horn died of complications from the coronavirus on Friday in a Las Vegas hospital, according to a statement released by publicist Dave Kirvin. “Today, the world has lost one of the greats of magic, but I have lost my best friend,” Siegfried Fischbacher said in the statement. “From the moment we met, I knew Roy and I, together, would change the world. There could be no Siegfried without Roy, and no Roy without Siegfried.” He was injured in October 2003 when a tiger named Montecore...

Magician Roy Horn, who alongside Siegfried Fischbacher starred in a popular, long-running Las Vegas act built around rare tigers, died on Friday from of complications of COVID-19, the Las Vegas Review-Journal newspaper reported. He was 75.