As the Coronavirus continues to spread, Josh Spiegel expresses his frustration with hygiene warnings from the government.

Confused about Coronavirus? You’re not alone. Josh Spiegel gives many examples of the mixed messages that have been circulating.

What's it like for Josh Spiegel to be ordered to stay at home during the coronavirus crisis? You might think it would be a dream come true for him. It's actually quite the opposite.

For the first time since the coronavirus crisis began, Josh Spiegel left home to go shopping. He was uneasy with the world he found.

In today's Commentary, Josh Spiegel shares his latest observations on the pandemic including the overwhelming number of cliches that he says have overwhelmed him.

The ability of political cartoonists to point out the absurdity of the news with a beautiful line and a pithy comment never ceases to amaze and they’ve been doing it for over 200 years as Comedy & Commentary at Mottisfont Abbey shows.

The economic shock caused by the coronavirus is accelerating a tech-industry shift from prioritizing growth to profitability, meaning rank-and-file workers will no longer be immune to the forces confronting so many workers throughout America.

The South Sydney Rabbitohs hold off Brisbane's late charge in a spiteful clash at Lang Park, while the North Queensland Cowboys comfortably account for Penrith.

On the 17th day of our lockdown, I sat on an empty barstool at my 3-year-old, all-day fine-dining eatery, which had essentially been converted to a fast food, to-go joint.  It was a bitter cold, miserable, snowy spring night, and I said to myself, “the hell with it." (Actually, I used stronger words, but can't use them in a family newspaper.)

The Board of Regents had to appeal the ruling in the lawsuit. To not do so would cede the authority not only of this board, but all future boards, to be able to select the best president of CU.

The first time I smoked a cigarette, I was 14 years old. By the time I was an adult, I was smoking two packs a day. I tried the nicotine patch, gum, and even Chantix, the pharmaceutical drug, to quit smoking cigarettes. None of these worked. I’m embarrassed to say that I even tried hypnosis. It wasn’t until I tried vaping as an adult that I was able to find a solution and quit smoking those dreadful cigarettes. Vaping was so effective, I quit smoking cigarettes in one weekend after 20 years of addictive cigarette smoking. I’m one of the 350,000 Coloradans and one of approximate 13 million responsible adults in America who have used vaping products to quit smoking more harmful cigarettes.

As RTD scatters the homeless, many are likely to crowd into the few areas where they are still allowed during the lockdown, possibly exacerbating this public health crisis.

Sixty years ago, a young president urged us to ask what we could do for our country. We have not heard that challenge since. But now our health and economic threats require us to renew that challenge and recover the ideal of service.

How strong is our economy if it can’t absorb shocks? If growth comes at a great expense to future generations? And where is the scorecard that tells us how we are actually doing?

As RTD scatters the homeless, many are likely to crowd into the few areas where they are still allowed during the lockdown, possibly exacerbating this public health crisis.

Sixty years ago, a young president urged us to ask what we could do for our country. We have not heard that challenge since. But now our health and economic threats require us to renew that challenge and recover the ideal of service.

How strong is our economy if it can’t absorb shocks? If growth comes at a great expense to future generations? And where is the scorecard that tells us how we are actually doing?

I started 132 books this year and finished 127. New this year: a twitter thread of everything I read in...

Melissa John and Frankie got together last month and watched the final Deathly Hallows film and recorded a DVD commentary! Instructions on how to listen are included in the first 3 minutes. Enjoy!

Find the latest episode and explore PotterCast interviews, discussions and more at PotterCast.com

Visit the-leaky-cauldron.org for the latest and greatest from Harry Potter's Wizard World.

The Lakers and Clippers forfeited their draft futures for a chance to chase the NBA title this season. Have their hopes been derailed by the coronavirus?

If possible, Major League Baseball should start the season with the All-Star game at Dodger Stadium to give to give fans the chance to embrace the sport again.

The $2.2 trillion CARES Act was designed for small businesses like MOCA. Using relief funds would help to keep the staff at full employment.

Legacy buildings of Los Angeles County Museum of Art are being torn apart for a new Peter Zumthor design. The planned gallery interiors remain a mystery.

Hospitals built in two weeks. Freeways with few cars. Which innovations and changes could, or should, stick with us in a post-coronavirus world?

Glenn Gould's "Solitude Trilogy" uses dialogue as though it were musical counterpoint and explores a kind of isolation familiar in our coronavirus era.

Painter Antoine-Jean Gros made the French general into a military hero, turning troublesome truth into feel-good fiction.

A DAC, or digital to analog converter, makes all the difference when streaming on a phone or laptop. You don't have to spend a ton, our music critic says.

Pop music critic Mikael Wood and TV critic Lorraine Ali debate the merits of Apple TV's new documentary 'Beastie Boys Story,' directed by Spike Jonze.

Jacob Oleck
Aug 1, 2016; 29:180-184
Pharmacy and Therapeutics

(University of California - Santa Cruz) Restoration ecologist Karen Holl has a simple message for anyone who thinks planting 1 trillion trees will reverse the damage of climate change: 'We can't plant our way out of climate change.'

For more than two decades naturally presented, human leukocyte antigen (HLA)-restricted peptides (immunopeptidome) have been eluted and sequenced using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Since, identified disease-associated HLA ligands have been characterized and evaluated as potential active substances. Treatments based on HLA-presented peptides have shown promising results in clinical application as personalized T cell-based immunotherapy. Peptide vaccination cocktails are produced as investigational medicinal products under GMP conditions. To support clinical trials based on HLA-presented tumor-associated antigens, in this study the sensitive LC-MS/MS HLA class I antigen identification pipeline was fully validated for our technical equipment according to the current US Food and Drug Administration (FDA) and European Medicines Agency (EMA) guidelines.

The immunopeptidomes of JY cells with or without spiked-in, isotope labeled peptides, of peripheral blood mononuclear cells of healthy volunteers as well as a chronic lymphocytic leukemia and a bladder cancer sample were reliably identified using a data-dependent acquisition method. As the LC-MS/MS pipeline is used for identification purposes, the validation parameters include accuracy, precision, specificity, limit of detection and robustness.

Henry J. Pownall
May 1, 2020; 61:595-597
Commentary

Larry Shover, SFG Alternatives

Bob Iaccino, Path Trading Partners

Larry Shover, SFG Alternatives

Dan Deming, KKM Financial

Dan Deming, KKM Financial

Larry Shover, SFG Alternatives

Bob Iaccino, Path Trading Partners

Larry Shover, SFG Alternatives

Bob Iaccino, Path Trading Partners

Bob Iaccino, Path Trading Partners

Bob Iaccino, Path Trading Partners

Larry Shover, Efficient Advisors