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This episode is about compile-time metaprogramming, and specifically, about implementing DSLs via compile-time metaprogramming. Our guest, Laurence Tratt, illustrates the idea with his (research) programming language called Converge.

We started by talking about the importance of a custom syntax for DSL and took a brief look at the definition of DSLs by a chap called Paul Hudak. We then briefly covered the disctinction between internal and external DSLs.

More to the point of this episode, we discussed the concept of compile-time metaprogramming, and the language features necessary to achieve it: in converge, these concepts are called splice, quasi-quote and insertion. We then looked at how the Converge compiler works, and at the additional features that are required to implement DSLs based on the metaprogramming features mentioned above. Using an example, we then walked through how to implement a simple DSL.

Looking at some of the more technical details, we discussed the difference between the parse tree and the abstract syntax tree and at different kinds of parsers - specifically, the Earley parser used by Converge. In multi-stage languages (i.e. languages that execute programs and meta programs) error reporting is important, but non trivial. We discussed how this is done in Converge. We finally looked at how to integrate Converge's expression language into your DSL and how to package DSL definition for later use.

The last segment look at the process of implementing a DSL in converge and about some of the history and practical experience with Converge. Lessons learned from building Converge wrap up the episode.

Recent efforts in gut microbiome studies have highlighted the importance of explicitly describing the ecological processes beyond correlative analysis. However, we are still at the early stage of understanding the organizational principles of the gut ecosystem, partially because of the limited information provided by currently used analytical tools in ecological modeling practices. Proteomics and metaproteomics can provide a number of insights for ecological studies, including biomass, matter and energy flow, and functional diversity. In this Mini Review, we discuss proteomics and metaproteomics-based experimental strategies that can contribute to studying the ecology, in particular at the mucosal-luminal interface (MLI) where the direct host-microbiome interaction happens. These strategies include isolation protocols for different MLI components, enrichment methods to obtain designated array of proteins, probing for specific pathways, and isotopic labeling for tracking nutrient flow. Integration of these technologies can generate spatiotemporal and site-specific biological information that supports mathematical modeling of the ecosystem at the MLI.

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