Tourists stayed away from western North Carolina this year after Helene swept through the area, and towns that depend on leaf lookers are bracing for big losses.

Montana not only went enthusiastically for Trump for a third time, but took the last statewide seat held by a Democrat. Senator Jon Tester's defeat caps a years-long quest to erase purple from Montana's map.

Canada's second failure in a row to win a Security Council seat was a blow to the Trudeau government's prestige. But how much will it matter to this country in the long run?

In 1919, Canadian artist Mary Riter Hamilton embarked on a solo mission to paint the World War One battlefields of France and Belgium. A century later, documentary maker Alisa Siegel speaks to the artist's biographer, historians, and art historians to resuscitate Mary Riter Hamilton's art, life, and legacy.

"If you take politics as a game, you have to play underneath the rules. You can't appear to be disagreeable; you have to appear to voters as someone who’s getting things done."

Gut-wrenching because of how the Broncos (5-5) found themselves on victory’s doorstep.

Broncos' loss sure does feed into NFL fans' conspiracy theories about the Kansas City Chiefs.

Boeing reported a loss of more than $6 billion in the third quarter and immediately turned its attention to union workers who will vote Wednesday on a contract.

Sloane Stephens also revealed she’s been receiving threats.

She says it’s “exhausting and never ending.”

Miami lost to the Jacksonville Jaguars in London.

Former accountant Jeffrey Bevan, “who stole nearly £2m from the Bermuda government” is facing a hearing to determine if he will lose his pension. A BBC story said, “A former Welsh government and BBC accountant who stole nearly £2m from the Bermuda government faces a hearing to decide if he will lose his pension. “Jeffrey […]

Bermudian rugby player Jamin Hodgkins kicked a penalty in Bridgend Ravens’ 62-13 defeat away to league champions Llandovery in their final Welsh Indigo Group Premiership game of the season last Thursday [April 25]. The former Bermuda Under-19 fly-off joined Bridgend, who finished ninth in the 13-team table, from second-tier side Glamorgan Wanderers in January. Hodgkins […]

The following article, Democrats Preparing for Massive Losses, was first published on The Black Sphere.

Trump goes into Alvin Braggs' and Letitia James' backyard, and takes a piss. And Chuck Schumer, Hillary Clinton, Kirsten Hillebrand...

Continue reading Democrats Preparing for Massive Losses ...

By Jason Cohen Former MSNBC host Chris Matthews on Wednesday criticized Democrats for their “open border” policy following Vice President Kamala Harris’ loss to former President Donald Trump. Trump clinched the required 270 electoral votes early Wednesday, winning Georgia, North Carolina and Pennsylvania, according to multiple forecasters. Matthews, on “Morning Joe,” argued that Democrats’ lenient […]

The post ‘A Lot Of People Are Very Angry’: Chris Matthews Unloads On Dems Over ‘Open Border’ Policy After Harris Loss appeared first on Liberty Unyielding.

In the 2024 election, Donald Trump easily carried many predominantly Hispanic rural areas like Hidalgo County, Texas, and some mostly non-white precincts, such as mostly Asian areas of Brooklyn. As journalist Josh Kraushaar noted, “Trump carried PASSAIC County, New Jersey. Majority/Hispanic electorate and home to a sizable Orthodox Jewish constituency. Was a Dem stronghold for […]

The post Prominent law professor blames Harris loss on ‘white supremacy’ and ‘toxic masculinity’ appeared first on Liberty Unyielding.

The appeal is clear - but should we be turning to appetite-suppressing injections?

Experts call for an urgent review of obesity treatment services amid booming demand for weight loss jabs.

The rise of these treatments has major implications for how we think about obesity, says James Gallagher.

NHS experts report unprecedented demand for the new generation of obesity treatments.

England prop Ellis Genge admits last year's World Cup semi-final defeat by South Africa is something he will carry for the rest of his career.

Loss and damage: Where are we now and what happens next? 25 January 2022 — 1:00PM TO 2:00PM Anonymous (not verified) 17 January 2022 Online

This event discusses the progress of the loss and damage agenda within climate negotiations. 

Loss and damage refers to harms and destruction caused by climate change impacts that cannot be avoided through mitigation or adaptation.

While it has gained increasing recognition in international climate change negotiations, turning the concept of loss and damage into tangible action for climate-vulnerable countries has been contentious.

Loss and damage is interwoven with issues of fairness and equity. The issue is highly disputed due to its connection with the historical responsibility of developed countries in causing climate change, as well as associated calls for compensation from developing countries.

At COP26, Scotland became the first government to pledge funds for loss and damage for countries in the Global South. However, most climate-vulnerable countries left disappointed by the failure of the Glasgow Climate Pact to secure the establishment of a dedicated loss and damage financing facility.

Developing countries have made it clear that they will continue to push for a new financing facility in the Glasgow Dialogue, a set of international discussions on loss and damage kicking off in June.

The Environment and Society Discussion Series is hosting two events on loss and damage ahead of that date. This first event outlines the key debates and discuss what progress has been made on advancing the loss and damage agenda within climate negotiations to date.

The second event focuses on solutions and possible ways forward, looking ahead to the COP27 negotiations in Egypt later in 2022, where loss and damage is expected to be a high-profile agenda item.

A deep dive into loss and damage solutions 8 February 2022 — 1:00PM TO 2:15PM Anonymous (not verified) 31 January 2022 Online

This second event of our loss and damage series cuts through polarized debate by bringing together international experts to discuss innovative legal and financial approaches.

This event will focus on a deep dive into constructive solutions and progress made to address loss and damage.

Following the first event of this two-part series, ‘Loss and Damage – where are we now and what happens next’, this event focuses on a deep dive into constructive solutions and progress made to address loss and damage.

Loss and damage refers to harms and destruction caused by climate change impacts that cannot be avoided through mitigation or adaptation. While it has gained increasing recognition in international climate change negotiations, turning the concept of loss and damage into tangible action for climate-vulnerable countries has been contentious.

Loss and damage is interwoven with issues of fairness and equity. The issue is highly disputed due to its connection with the historical responsibility of developed countries in causing climate change, as well as associated calls for compensation from developing countries.

At COP26, Scotland became the first government to pledge funds for loss and damage for countries in the Global South. However, most climate-vulnerable countries left disappointed by the failure of the Glasgow Climate Pact to secure the establishment of a dedicated loss and damage financing facility.

Developing countries have made it clear that they will continue to push for a new financing facility in the Glasgow Dialogue, a set of international discussions on loss and damage kicking off in June. The Environment and Society Discussion Series is hosting two events on loss and damage ahead of that date.

This second event convenes a deep dive into the progress and potential on loss and damage solutions, while also examining the hurdles that are still to overcome to make loss and damage support a reality.

We have observed overexpression of PACS-1, a cytosolic sorting protein in primary cervical tumors. Absence of exonic mutations and overexpression at the RNA level suggested a transcriptional and/or posttranscriptional regulation. University of California Santa Cruz genome browser analysis of PACS-1 micro RNAs (miR), revealed two 8-base target sequences at the 3' terminus for hsa-miR-34a and hsa-miR-449a. Quantitative RT-PCR and Northern blotting studies showed reduced or loss of expression of the two microRNAs in cervical cancer cell lines and primary tumors, indicating dysregulation of these two microRNAs in cervical cancer. Loss of PACS-1 with siRNA or exogenous expression of hsa-miR-34a or hsa-miR-449a in HeLa and SiHa cervical cancer cell lines resulted in DNA damage response, S-phase cell cycle arrest, and reduction in cell growth. Furthermore, the siRNA studies showed that loss of PACS-1 expression was accompanied by increased nuclear γH2AX expression, Lys382-p53 acetylation, and genomic instability. PACS-1 re-expression through LNA-hsa-anti-miR-34a or -449a or through PACS-1 cDNA transfection led to the reversal of DNA damage response and restoration of cell growth. Release of cells post 24-h serum starvation showed PACS-1 nuclear localization at G1-S phase of the cell cycle. Our results therefore indicate that the loss of hsa-miR-34a and hsa-miR-449a expression in cervical cancer leads to overexpression of PACS-1 and suppression of DNA damage response, resulting in the development of chemo-resistant tumors.

Oct. 29, 2024 — NVIDIA has announced that xAI’s Colossus supercomputer cluster comprising 100,000 NVIDIA Hopper GPUs in Memphis, Tennessee, achieved this massive scale by using the NVIDIA Spectrum-X Ethernet […]

The post NVIDIA Ethernet Networking Accelerates xAI’s Colossus AI Supercomputer appeared first on HPCwire.

Weight-loss surgery in adolescents with severe obesity can lead to long-term health benefits, such as more frequent remission of type 2 diabetes than in adults who undergo the same treatment, a large, NIH-funded study.

Along with winter vegetables, STEM is blooming in Imperial County. Dennis and Daniel Gibbs are growing young scientists by transplanting the scientific method to the second grade.

Recent Census data finds households in the South and Midwest lagging those in other regions in access to remote learning technologies and learning interactions with teachers and family members.

Recent Census data finds households in the South and Midwest lagging those in other regions in access to remote learning technologies and learning interactions with teachers and family members.

The Pittsburgh Penguins returned home after a three-game road trip only to get blown out by the Dallas Stars 7-1 on Monday night.

The Pittsburgh Penguins traded Lars Eller to the Washington Capitals for two draft picks after a blowout loss dropped them to 6-9-2 on the season.

St. Louis led 2-0 after two periods, was outscored 3-0, allowed game-winner to Pastrnak with 1:47 remaining

The Bulldogs are the first team out of the 12-team playoff after Week 11.

Purdue women's basketball suffered its first defeat of the season on Sunday night as No. 6 Notre Dame came into Mackey Arena and handed the Boilermakers a 102-58 loss. The Boilermakers have now lost nine straight games to the Fighting Irish, since taking a 14-5 lead in the series back in 2005. The in-state rivalry was halted, playing just once between 2012 and 2023, but the Fighting Irish resumed their success over the Boilermakers in each of the last two seasons.

Holly Oakley
Oct 4, 2006; 26:10129-10140
Neurobiology of Disease

Sharon G. Kujawa
Nov 11, 2009; 29:14077-14085
BehavioralSystemsCognitive

Nora D. Volkow
Dec 1, 2001; 21:9414-9418
Behavioral

Holly Oakley
Oct 4, 2006; 26:10129-10140
Neurobiology of Disease

Cochlear hair cells (HCs) sense sound waves and allow us to hear. Loss of HCs will cause irreversible sensorineural hearing loss. It is well known that DNA damage repair plays a critical role in protecting cells in many organs. However, how HCs respond to DNA damage and how defective DNA damage repair contributes to hearing loss remain elusive. In this study, we showed that cisplatin induced DNA damage in outer hair cells (OHCs) and promoted OHC loss, leading to hearing loss in mice of either sex. Cisplatin induced the expression of Brca1, a DNA damage repair factor, in OHCs. Deficiency of Brca1 induced OHC and hearing loss, and further promoted cisplatin-induced DNA damage in OHCs, accelerating OHC loss. This study provides the first in vivo evidence demonstrating that cisplatin mainly induces DNA damage in OHCs and that BRCA1 promotes repair of DNA damage in OHCs and prevents hearing loss. Our findings not only demonstrate that DNA damage–inducing agent generates DNA damage in postmitotic HCs but also suggest that DNA repair factors, like BRCA1, protect postmitotic HCs from DNA damage–induced cell death and hearing loss.

A new exhibition co-presented by the National Portrait Gallery and the Archives of American Art explores the seminal artist’s work

Humans don't just impact the interconnected web of life—we depend on it.