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Graybar Targets Ways to Make Business Strong and Sustainable

At Graybar, sustainability is an expression of the company’s core values and its long-term view. The company’s sustainability plan includes acting as a responsible steward of its resources, reducing its impact on the environment, and providing sustainable solutions in the marketplace.




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Target Price Raised 69% on SMR Developer

This New York-based company has made large strides in building out its nuclear reactor program, noted a Benchmark Co. report.




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Target Price Raised 69% on SMR Developer

Source: Michael Legg 11/12/2024

This New York-based company has made large strides in building out its nuclear reactor program, noted a Benchmark Co. report.

Nano Nuclear Energy Inc. (NNE:NASDAQ) saw a 69% raise in its target price to US$66 per share from US$39 by The Benchmark Co. in light of the nuclear energy company's robust internal development, reported analyst Michael Legg in a November 7 research note. Nano Nuclear is developing 1–2 megawatt small modular reactors (SMRs).

"Nano Nuclear's balance sheet has been bolstered by capital raises placing over US$65 million (US$65M) on [the] balance sheet, allowing [the company] to continue to execute on its strategy," Legg wrote.

As the company was trading at the time of the report at about US$19.05 per share, the new target price implies a 246% return, noted Legg.

Nano Nuclear remains a Buy.

Strengthened Financial Status

This New York-headquartered company improved its balance sheet to the point of having US$65M in cash and no debt, which allowed Nano Nuclear to keep working its strategy.

"We have lowered our discount rate on our net present value analysis to 20% from 25% to reflect reduced risk," Legg wrote.

Company's Recent Efforts

The analyst reported Nano Nuclear's newest achievements and progress. They include:

1) Advancing development of its ZEUS and ODIN SMRs to the physical test work phase from the design stage and starting initial rig construction. The company also did external design audits on its SMRs.

2) Expanding its team, adding advisers and engineers, to expedite program development. Nano Nuclear appointed John Vonglis as chairman of its Executive Advisory Board for Strategic Initiatives. Vonglis is a former chief financial officer of the U.S. Department of Energy (DOE) and Acting Director of DOE’s Advanced Research Projects Agency-Energy.

The energy company appointed Lieutenant General Terry G. Robling, USMC (Ret.), as chair of its Executive Advisory Board for Federal and Defense Appropriations and Requirements. It appointed Carlos Maidana as head of its Thermal Hydraulics and Space Program and added six engineers to its Nuclear Technology and Engineering team.

3) Acquiring for US$1.71M in August a 14,000-square-foot, two-story building in Oak Ridge, Tenn., to be its Nuclear Technology Center location.

4) Signing a memorandum of understanding with the Rwanda Atomic Energy Board, which could result in deployment of SMRs and microreactors in the African country.

5) Starting its pre-application review with the Nuclear Regulatory Commission (NRC). Nano Nuclear provided the NRC and DOE the status of its microreactor designs and the estimated development timelines, so the NRC may line up the personnel needed to oversee the related licensing. Nano Nuclear is in the process of identifying places for a test bed reactor site.

6) Winning a DOE Gateway for Accelerated Innovation in Nuclear (GAIN) voucher, which provides it with funding for 80% of a winning proposal, the remaining 20% to be covered by Nano Nuclear. This increases its chances of being awarded additional vouchers in the future, purported Legg.

Nuclear Power Demand Grows

Momentum in the clean energy sector, particular nuclear power, being sought out for artificial intelligence data centers, bitcoin mining and electric vehicles, also is benefitting Nano Nuclear, Legg wrote.

A string of recent events exemplify the demand. Amazon.com announced it will buy power from SMRs, and Google partnered with Kairos for nuclear power. Sam Altman and Bill Gates invested in nuclear. President-Elect Donald Trump had noted while campaigning that he would expand nuclear power were he elected.

Further, the U.S. federal government passed the Accelerating Deployment of Versatile, Advanced Nuclear for Clean Energy (ADVANCE) Act, aimed at ramping up development of advanced nuclear technology and preserving existing nuclear power generation.

"We believe this passing is further justification that nuclear is needed to reach climate initiatives, as nuclear is the only large-scale, reliable, emission-free energy source," Legg wrote.

Foreseen Benefits to the Stock

Legg noted that ongoing operational success could positively impact Nano Nuclear's share price.

Other catalysts, he wrote, include increased knowledge about and demand for SMRs, expected to happen as climate change efforts favor emission-free energy and the public accepts safety and use cases.

Sign up for our FREE newsletter at: www.streetwisereports.com/get-news

Important Disclosures:

  1. Doresa Banning wrote this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor.
  2. This article does not constitute investment advice and is not a solicitation for any investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Each reader is encouraged to consult with his or her personal financial adviser and perform their own comprehensive investment research. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company.

For additional disclosures, please click here.

Disclosures for The Benchmark Co., Nano Nuclear Energy Inc., November 7, 2024

The Benchmark Company, LLC. (“Benchmark” or “the Firm”) compensates research analysts, like other Firm employees, based on the Firm’s overall revenue and profitability, which includes revenues from the Firm’s institutional sales, trading, and investment banking departments. No portion of the analyst’s compensation is based on a specific banking transaction. Analyst compensation is based upon a variety of factors, including the quality of analysis, performance of recommendations and overall service to the Firm’s institutional clients.

This publication does not constitute an offer or solicitation of any transaction in any securities referred to herein. Ratings that use the “Speculative” risk qualifier are considered higher risk. Any recommendation contained herein may not be suitable for all investors. The Benchmark Company, LLC makes every effort to use reliable, comprehensive information, but we make no representation that it is accurate or complete. We have no obligation to disclose when information in this report changes apart from when we intend to discontinue research coverage of a subject company. Although the information contained in the subject report has been obtained from sources, we believe to be reliable, its accuracy and completeness cannot be guaranteed. This publication and any recommendation contained herein speak only as of the date hereof and are subject to change without notice. The Benchmark Company, LLC and its affiliated companies and employees shall have no obligation to update or amend any information herein. This publication is being furnished to you for informational purposes only and on the condition that it will not form a primary basis for any investment decision. Each investor must make its own determination of the appropriateness of an investment in any securities referred to herein based on the legal, tax and accounting considerations applicable to such investor and its own investment strategy. By virtue of this publication, none of The Benchmark Company, LLC or any of its employees shall be responsible for any investment decision. This report may discuss numerous securities, some of which may not be qualified for sale in certain states and may therefore not be offered to investors in such states. The “Recent Price” stated on the cover page reflects the nearest closing price prior to the date of publication. For additional disclosure information regarding the companies in this report, please contact The Benchmark Company, LLC, 150 East 58th Street, New York, NY 10155, 212-312-6770. The Benchmark Company, LLC is not in any way affiliated with or endorsed by the Menlo Park, California venture capital firm Benchmark Capital. This report may not be reproduced, distributed, or published without the prior consent of The Benchmark Company, LLC. Copyright © 2024. All rights reserved by The Benchmark Company, LLC.

( Companies Mentioned: NNE:NASDAQ, )




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Strong Investor Demand Pushes Oversubscribed Private Placement Beyond Target

Source: Streetwise Reports 11/07/2024

Tectonic Metals Inc. (TSXV: TECT; OTCQB: TETOF; FSE: T15B) announced the successful closing of its private placement, which was significantly oversubscribed, raising CA$5,349,171. Read more to find out how this oversubscribed funding round exceeded expectations and what it means for Tectonic's future projects.

Tectonic Metals Inc. (TSXV: TECT; OTCQB: TETOF; FSE: T15B) announced the successful closing of its private placement, which was significantly oversubscribed, raising CA$5,349,171. This amount surpassed the company's initial target. Initially announced on October 4, 2024, this extension raised an additional CA$1,691,712 through the issuance of 28,195,200 units priced at CA$0.06 per unit. This total combined the funds from the second tranche with those from the initial tranche and previous offering rounds.

Each unit in the placement includes one common share and one-half of a common share purchase warrant, with each full warrant exercisable at CA$0.10 until two years from the offering's close. LIFE units from the offering are freely tradeable, while non-LIFE units are subject to a four-month hold period. In this latest tranche, CA$591,708 was generated through LIFE units, with 9,861,800 common shares and 4,930,900 warrants issued, while HOLD units contributed CA$1,100,004, resulting in the issuance of 18,333,400 common shares and 9,166,700 warrants.

Finder's fees in cash totaling CA$98,143 were paid to Canaccord Genuity Corp., Haywood Securities Inc., Ventum Financial Corp., Roche Securities Ltd., Gerhard Merkel, and Black Oak Ventures Ltd. Additionally, Tectonic issued 1,635,714 non-transferable common share purchase warrants to these finders, each exercisable at CA$0.10 until November 1, 2026. The cumulative finder's fees for both the extended and initial offerings amount to CA$226,029, with 3,767,153 finder's warrants issued. This private placement was approved by the TSX Venture Exchange (TSXV).

Why Gold?

On October 29, Kitco Media's Gary Wagner reported on gold nearing US$2,800, attributing this surge to a mix of "geopolitical conflicts, Federal Reserve interest rate normalization, and strong demand from global central banks." This combination, which Wagner referred to as a "perfect storm," has pushed gold prices up by approximately 35% this year. Emerging market central banks have notably increased their gold reserves as part of a strategic shift away from the U.S. dollar, adding further support to the metal's robust price performance.

Further insights from LiveMint on October 30 revealed a strong performance in the gold sector, with MCX gold rates surging in India. This was partly fueled by cultural factors and a rise in retail demand. Chintan Mehta, CEO of Abans Holdings, emphasized gold's safe-haven appeal, stating, "Gold stands out in times of uncertainty . . . a complete safe-haven unlike silver." Despite potential near-term dips, Mehta suggested that such declines would present valuable buying opportunities amid continued demand for gold.

In a November 4 report, Egon von Greyerz, founder of VON GREYERZ AG, highlighted the consistent historical role of gold as a protective asset. He took particular note of gold's rise in times of financial instability. He observed, "Gold doesn't lie…an ounce of gold in 1923 was worth 87 trillion Marks," underscoring gold's resilience during currency devaluations. He further anticipated that gold's journey was "only starting now," driven by the ongoing devaluation of fiat currencies.

Tectonic's Catalysts

The capital raised through Tectonic's private placement aims to support exploration and development at the company's Flat Gold Project in Alaska, a promising district-scale opportunity for open-pit heap leach gold mining. As outlined in the company's October 2024 investor update, Tectonic has prioritized "economic mine" criteria, highlighting heap leach processing potential, high gold recovery rates, and infrastructure access through on-site airstrips and nearby river barge routes, which reduce logistical costs.

The company's exploration strategy benefits from strong partnerships and technical expertise, particularly its milestone partnership with Doyon Limited, Alaska's largest private landholder, and Crescat Capital, which together hold significant ownership in Tectonic. Additionally, Tectonic's technical team has established a 100% drill success rate at the Chicken Mountain target, identifying zones of gold mineralization and potential higher-grade starter pits. According to Tectonic's October 2024 presentation, the company's "disciplined, upfront de-risking strategy" aims to secure long-term value and sustainable operational progress at the Flat Gold Project.

Analysts Talk Tectonic

*Technical analyst Clive Maund strongly endorsed Tectonic Metals Inc., rating it an "Immediate Strong Buy" on October 4. Maund emphasized the potential for "spectacular gains" as Tectonic's stock showed clear signs of a bullish reversal. He noted a "giant Double Bottom base pattern," indicating a rally from lows, supported by an "exceptionally positive volume pattern" and a strengthening Accumulation line, both bullish signals. [OWNERSHIP_CHART-10225]

Maund also highlighted Tectonic's Flat Project, noting its substantial scale and favorable mining conditions, especially within the Chicken Mountain Intrusion, where all 74 drill holes intersected gold mineralization, hinting at a "big resource." Additionally, Maund remarked on Tectonic's strategic partnerships. These include Doyon Ltd., which holds nearly 10% of the company's stock, underscoring strong local support and shareholder stability. These factors contributed to his confidence in the stock's growth potential, concluding that the current price represented a strong entry point.

Ownership and Share Structure

Institutions hold around 32.3%. Doyon Ltd has 9.9% and Crescat Capital has 22.3%. 15% of Tectonic is held by insiders and other institutions.The rest is retail.

Tectonic has a market cap of US$16.92 Million with 342.61 Million Free Float Shares. Their 52-week range is US$0.045 - 0.17

Sign up for our FREE newsletter at: www.streetwisereports.com/get-news

Important Disclosures:

  1. Tectonic Metals Inc. is a billboard sponsor of Streetwise Reports and pays SWR a monthly sponsorship fee between US$4,000 and US$5,000.
  2. As of the date of this article, officers and/or employees of Streetwise Reports LLC (including members of their household) own securities of Tectonic Metals Inc.
  3. James Guttman wrote this article for Streetwise Reports LLC and provides services to Streetwise Reports as an employee.
  4. This article does not constitute investment advice and is not a solicitation for any investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Each reader is encouraged to consult with his or her personal financial adviser and perform their own comprehensive investment research. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company.

For additional disclosures, please click here.

* Disclosure for the quote from the Clive Maund article published on October 4, 2024

  1. For the quoted article (published on October 4, 2024), the Company has paid Street Smart, an affiliate of Streetwise Reports, US$2,500.
  2. Author Certification and Compensation: [Clive Maund of clivemaund.com] is being compensated as an independent contractor by Street Smart, an affiliate of Streetwise Reports, for writing the article quoted. Maund received his UK Technical Analysts’ Diploma in 1989. The recommendations and opinions expressed in the article accurately reflect the personal, independent, and objective views of the author regarding any and all of the designated securities discussed. No part of the compensation received by the author was, is, or will be directly or indirectly related to the specific recommendations or views expressed

Clivemaund.com Disclosures

The quoted article represents the opinion and analysis of Mr. Maund, based on data available to him, at the time of writing. Mr. Maund's opinions are his own, and are not a recommendation or an offer to buy or sell securities. As trading and investing in any financial markets may involve serious risk of loss, Mr. Maund recommends that you consult with a qualified investment advisor, one licensed by appropriate regulatory agencies in your legal jurisdiction and do your own due diligence and research when making any kind of a transaction with financial ramifications. Although a qualified and experienced stock market analyst, Clive Maund is not a Registered Securities Advisor. Therefore Mr. Maund's opinions on the market and stocks cannot be only be construed as a recommendation or solicitation to buy and sell securities.

( Companies Mentioned: TSXV: TECT;OTCQB: TETOF;FSE: T15B, )




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Warner Brothers job cuts determined by financial target

We reported last week that layoffs were coming soon to Warner Brothers, but how many positions will be cut is still unknown.  

A spokesman for Warner Brothers Entertainment, Paul McGuire, told KPCC there's no exact number yet. "There is no headcount reduction target, but there is a substantial financial target," Maguire said. 

“This is a budget issue, not a head count issue,” Dee Dee Myers, Warner Brothers Vice President of Corporation Communications told Variety.  The trade publication reports that Warner Brothers is expected to eliminate as many as 1,000 positions worldwide - or about 10 percent of its workforce:

Senior managers are currently assessing their businesses to come up with ways to trim overhead. Only at the end of that process will an exact reduction figure be known. It could be somewhat lower than the current numbers being speculated, but cuts are expected to be substantial.  

News of coming layoffs became public two weeks ago, when KPCC and other media outlets obtained an internal memo written by Warner Bros. Chairman and Chief Executive Officer Kevin Tsujihara.   

"It pains me to say this, positions will be eliminated—at every level—across the Studio," Tsujihara wrote in the memo. 

Morningstar Analyst Neil Macker told KPCC that management at Warner Brothers is trying to protect the company from another takeover play by Rupert Murdoch.  In July, Murdoch offered to buy parent company Time Warner for $80 billion. He withdrew the offer in August. 

 




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Wanted Posters Targeting Jewish Faculty at NY Campus

Hundreds of "Wanted" posters targeting members of the University of Rochester community were found glued to campus buildings and classrooms, according to the Department of Public Safety.




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Australia builds on its strengths as a top 10 foreign investment target

Australia remains a top 10 global destination for foreign direct investment (FDI) for a third straight year after attracting US$50 billion in foreign direct investment in 2013, according to the UN Conference on Trade and Development’s (UNCTAD) World Investment Report 2014. Over the three years to 2013, FDI flows to Australia rose nearly 55 per cent to US$171 billion from US$110 billion over the previous three years. This impressive growth has expanded Australia’s share of global FDI inflows to 3.8 per cent in 2011-13 from 2.5 per cent in 2008-10. In contrast, developed economies’ share of world FDI inflows fell to 44 per cent in 2011-13 from 53 per cent in 2008-10.




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Bio blog: New therapy targeting the malaria parasite’s Achilles’ heel

Malaria is a devastating disease, affecting 200 million people worldwide and causing more than 600 000 deaths each year. In the past decade, great inroads have been made in reducing the number of infections, primarily through the implementation of insecticide-laced bed nets, and also reducing the death rate with combination therapies. However the emergence of drug-resistant malaria is rendering these therapies less effective, and there is an urgent need to develop novel therapies to cure malaria.




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UBS maintain a US$2900 target for gold

UBS is sticking to its bullish gold forecast.

  • says the move higher for equities and lower for gold is a 'highly optimistic' view for lower policy and political risk, this is premature
  • expect US yields and US dollar to move into downtrend, which will support gold
  • gold fundamentals, as a hedge and diversity play, are intact
This article was written by Eamonn Sheridan at www.forexlive.com.




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High Commissioner Thors, in her OSCE Permanent Council address, discusses country engagement and highlights the increase in hate speech targeting national minorities

Addressing the OSCE Permanent Council in Vienna on 2 June 2016, OSCE High Commissioner on National Minorities Astrid Thors described country engagement and highlighted the disturbing increase in hate speech.

The statement covered the High Commissioner’s activities since her last statement to the Permanent Council in November 2015. During this period Thors visited Kyrgyzstan, Serbia, Ukraine, Bosnia and Herzegovina, Georgia, Croatia, Hungary, Slovakia and Moldova.

The High Commissioner expressed concern about the increase in hate speech targeting national minorities. Thors called for renewed efforts to tackle hate speech in order to prevent tensions and to promote integration with respect for diversity.

Thors also informed the Permanent Council about the work her institution is doing together with researchers to identify best practices that highlight the bridge building potential of national minorities in diverse societies.

The full statement can be found here.

Related Stories



  • High Commissioner on National Minorities
  • Conflict prevention and resolution
  • Minority rights
  • News

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High Commissioner Thors, in her OSCE Permanent Council address, discusses country engagement and highlights the increase in hate speech targeting national minorities

Addressing the OSCE Permanent Council in Vienna on 2 June 2016, OSCE High Commissioner on National Minorities Astrid Thors described country engagement and highlighted the disturbing increase in hate speech.

The statement covered the High Commissioner’s activities since her last statement to the Permanent Council in November 2015. During this period Thors visited Kyrgyzstan, Serbia, Ukraine, Bosnia and Herzegovina, Georgia, Croatia, Hungary, Slovakia and Moldova.

The High Commissioner expressed concern about the increase in hate speech targeting national minorities. Thors called for renewed efforts to tackle hate speech in order to prevent tensions and to promote integration with respect for diversity.

Thors also informed the Permanent Council about the work her institution is doing together with researchers to identify best practices that highlight the bridge building potential of national minorities in diverse societies.

The full statement can be found here.

Related Stories



  • High Commissioner on National Minorities
  • Conflict prevention and resolution
  • Minority rights
  • News

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PRC Targeting of Commercial Telecommunications Infrastructure

Comments




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Beats Studio Buds have dropped to under $100 at Target

As of Nov. 13, the Beats Studio Buds are on sale for $99.99 at Target. Normally they retail for $149.99.




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Target is dropping daily and weekly doorbusters ahead of its weeklong Black Friday sale

Target is offering daily and weekly holiday deals in the lead-up to its Black Friday sale, which will run from Nov.




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to understand the coordinated anti-Arab, anti-Muslim and anti-immigrant campaigns run with huge amounts of money targeting Europe




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Kia sees near-term market challenges but sticks to 1.6 mln annual EV sales target by 2030

South Korean car maker Kia expects challenging market conditions in the near term due in part to governments' policies but will stick to its target of selling 1.6 million electric vehicles annually by 2030, a senior executive said.




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ASML targets €60 billion revenue with AI, EUV growth

ASML Holding NV stated on Thursday that it predicts annual revenue of €44 to €60 billion by 2030, with gross margins between 56% and 60%.The Dutch semiconductor equipment leader emphasized in a report...




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US Attacks Iranian Targets In Syria

The United States is incapable of ceasing the advancement of war. The ruling class has now attacked what it called “Iranian targets” within Syria. If this continues, we will see a third world war. Eventually, those countries being bombed will fight back against the aggression of the U.S. military-industrial complex. The U.S. military has carried …




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'I was targeted by gangs when I was eight'

There are key warning signs parents should watch out for, police officer say.




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FBI Involved After Homes of Travis Kelce and Patrick Mahomes Are Targeted Hours Apart

It’s not easy being a two-time, defending Super Bowl champion who happens to be undefeated and with one of the most famous fans in the world. (However one may feel […]

The post FBI Involved After Homes of Travis Kelce and Patrick Mahomes Are Targeted Hours Apart appeared first on The Western Journal.




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K.C. Chiefs' Patrick Mahomes 'frustrated' after home burglars target him, Travis Kelce

Police are investigating burglaries that occurred at the homes of Kansas City Chiefs players Patrick Mahomes and Travis Kelce.




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Blue Jackets Should Target Maple Leafs Forward

The Blue Jackets should be target David Kampf from the Maple Leafs.




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Edmonton fails to meet climate targets 2 years after launching carbon budget

The City of Edmonton is falling short of its greenhouse gas emissions targets, two years after the municipality introduced its first carbon budget. 



  • News/Canada/Edmonton

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Three Rivers councillor feels unjustly targeted by some residents, but won't be bullied into leaving

A councillor in Three Rivers, P.E.I., says the vitriol in the town has become so bad that she has trouble sleeping at night, worries what her family will hear on the streets, and can't even go to the grocery store without plotting an exit strategy.



  • News/Canada/PEI

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Vancouver officer sexually assaulted colleague, but police group chat targeted victim: investigation

The decision against Narinder Dosanjh, obtained by The Canadian Press, includes the running commentary on the woman's testimony — apparently written by someone inside the courtroom — that calls her a "bad drunk" and says there was "no way" her case would be proved.



  • News/Canada/British Columbia

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AirPods Pro crackling issue target of new class-action lawsuit

A class-action lawsuit is accusing Apple of false advertising, claiming the crackling issue of the first-gen AirPods Pro go against Apple's marketing promises.


AirPods Pro

Filed on November 1 in the United States District Court for the Northern District of California, the proposed class action lawsuit titled "LaBella et al v. Apple" claims that Apple was incorrect in marketing the high-quality audio of the AirPods Pro. Across 51 pages, the lawsuit alleges that the audio issues of the personal audio accessories go directly against the quality claims.

The lawsuit, first reported by ClassAction.org, discusses how consumers complained about audio problems when using the AirPods Pro within months of release. The issues were significant enough for Apple to launch a service program for affected units made before October 2020.


Continue Reading on AppleInsider | Discuss on our Forums




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Nelson Mandela Bay Mayor Targets Immigrant-Owned Spaza Shops

[GroundUp] "These are politically motivated actions against us. There are many more pressing issues facing this city."




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Makinde presents N678.86bn budget, targets infrastructure, education growth

Oyo State Governor, Seyi Makinde, on Wednesday, presented a proposed budget estimate of N678,086,767,322.18 to the state House of Assembly for legislative consideration and approval. Makinde, while presenting the budget, tagged, “Budget of Economic Stabilisation,” said it was 35 per cent higher compared to the 2024 budget. He said, “Out of the budget, capital expenditure


Read More




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Centre to deliberate on plans to achieve 500 GW green energy target by 2030




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Preventing SARS-CoV-2 infection using Fv-antibodies targeting the proprotein convertase (PPC) cleavage site

RSC Med. Chem., 2024, 15,3704-3710
DOI: 10.1039/D4MD00552J, Research Article
Jaeyong Jung, Jeong Soo Sung, Soonil Kwon, Hyung Eun Bae, Min-Jung Kang, Joachim Jose, Misu Lee, Jae-Chul Pyun
Fv-antibodies targeting the PPC region of SARS-CoV-2 to prevent infection, screened from an Fv-antibody library (displayed on outer membrane of E. coli cell).
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators

RSC Med. Chem., 2024, 15,3800-3816
DOI: 10.1039/D4MD00585F, Research Article
Marwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-Karmalawy
Novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

RSC Med. Chem., 2024, 15,3746-3758
DOI: 10.1039/D4MD00122B, Research Article
Open Access
Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector

P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches




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Flying taxi startup ePlane raises $14 million for eVTOL development, targets commercialisation by 2025

This strategic investment comes from a diverse range of backers, including Micelio Mobility and Naval Ravikant




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Google and Meta Accused of Teen Ad Targeting

Google staff have been accused of exploiting a loophole to target ads at children. The workaround reportedly broke company policy but not any existing laws. According to the Financial Times, the workaround was done in partnership with Meta, which wanted a way to advertise Instagram on YouTube and target 13 to 17 year olds. (Source: ft.com ) Normally that would be impossible under Google's rules for targeting, which don't let advertisers specify ages under 18 when selecting who does and doesn't see an ad. Known Unknowns However, the Financial Times claims Google staff not only knew Meta wanted ... (view more)




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Crustal architecture and evolution of the central Thelon tectonic zone, Nunavut: insights from Sm-Nd and O isotope analysis, U-Pb zircon geochronology, and targeted bedrock mapping

Berman, R G; Taylor, B E; Davis, W J; Sanborn-Barrie, M; Whalen, J B. Canada's northern Shield: new perspectives from the Geoscience for Energy and Minerals Program; Geological Survey of Canada, Bulletin 612, 2024 p. 115-158, https://doi.org/10.4095/332497
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_332497.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_332497.jpg" title="Canada's northern Shield: new perspectives from the Geoscience for Energy and Minerals Program; Geological Survey of Canada, Bulletin 612, 2024 p. 115-158, https://doi.org/10.4095/332497" height="150" border="1" /></a>




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M&amp;Ms Boo-tterscotch (Target Exclusive)

Name: M&Ms Boo-tterscotch Brand: Mars Place Purchased: Target (Eagle Rock) Price: $3.19 Size: 8 ounces Calories per ounce: 148 Type: White Chocolate Rating: 7 out of 10





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Amobee's New Service Optimizes Targeting for Brands Like Del Monte

With Sales Accelerator, Del Monte can 'tweak the levers' during a campaign to boost reach and revenu




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Expert urges Israel to target civilian infrastructure in Lebanon's 'Hezbollah state'


Hezbollah’s drones were “ultimately,” the terrorist organization’s “trump card,” despite rockets being employed as their “main weapons.”




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4 terrorists, including high value target, killed in Kech operation: ISPR

Security forces killed four terrorists, including a “high-value target”, during an exchange of fire in Balochistan’s Kech district, the military’s media wing said on Wednesday.

According to a statement by Inter-Services Public Relations (ISPR), security forces conducted an intelligence-based operation in the general Balgatar area of Kech District on the “reported presence of terrorists”.

“During [the] conduct of the operation, after an intense fire exchange between own troops and the terrorists, four terrorists including a high-value target, terrorist ring leader Sana [alias] Baru were killed,” the statement said.

It added that the killed terrorist was a focal recruitment agent, “especially suicide bombers, for the so-called Majeed Brigade in District Kech and was highly wanted by the law enforcement agencies.”

A sanitisation operation is being conducted to eliminate any other terrorists found in the area.

Pakistan’s security forces “remain determined to thwart attempts of sabotaging peace, stability and progress of Balochistan,” the statement said.

The country has lately witnessed a sharp uptick in the number of attacks targeting security forces, other law enforcement agencies, and security checkpoints, particularly in Balochistan and KP.

Attacks escalated after the TTP broke a fragile ceasefire agreement with the government in 2022 and vowed to target security forces.

Last Sunday, security forces killed 10 terrorists and injured eight others during three different engagements in North Waziristan.

On Nov 7, security forces killed five terrorists during an exchange of fire in South Waziristan, while four soldiers were martyred in the operation.

In another incident on Nov 4, security forces killed seven terrorists in separate operations, with one terrorist killed in Balochistan and the other six killed during two operations in KP.

Likewise, on November 2, four terrorists were killed during an intelligence-based operation in KP’s South Waziristan region.




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New weight loss drug target reduces appetite and burns calories without sickness

The discovery could lead to a new treatment for millions of people with obesity and type 2 diabetes who do not respond well to current treatments.





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France, Italy And Portugal Target Nations League Quarter-Finals

France, Italy and Portugal lead the teams attempting to secure a place in the UEFA Nations League quarter-finals, while England's promotion hopes have been hit by a series of withdrawals.




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Delhi police target hotels as gangs go on overdrive

In response to escalating crime rates in Delhi, including extortion attempts and gang-related violence, the Delhi Police has launched a comprehensive crackdown. This includes stringent checks at hotels and guest houses to verify the identities of guests, as well as verification of local criminals and juveniles. The police have also intensified raids on suspected hideouts of jailed gangsters and their associates. This initiative is being implemented across all 15 police districts and over 180 police stations in Delhi. The decision stems from recent incidents involving out-of-state criminals who used hotels as bases for their criminal activities, highlighting the urgency of proactive measures to curb crime.




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GAMMA Sports Launches Fusion Pickleball Paddles Exclusively at Target

GAMMA Sports, a leading manufacturer of premium pickleball paddles, is excited to announce their collaboration with Target stores nationwide to launch a new line of Fusion pickleball paddles. The paddles will be available at all Target locations nationwide this July.




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Active Directory Change Monitor Will Keep Your Team on Target

Power Admin's Active Directory Change Monitor allows businesses to detect unauthorized alterations to this vital directory service and thereby safeguard system security.




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Changes to our lives are certain if PM meets bold climate target - but a key ingredient is missing for success

Keir Starmer's arrival at COP29, with a promise to drastically cut the UK's carbon emissions by 81%, will be a small ray of sunshine in an otherwise gloomy start to the climate talks.




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Small Business Boot Camp: How to Identify Your Target Market and Create Customer Personas

Having a clear vision of your expected customer base will increase your business chances of success. Clearly defining your target audience — whether it is senior citizens, busy moms or millennials in California — can help answer a lot of questions and overcome obstacles that may be plaguing you as you kick-start your online store. Some of the business questions you will be addressing include:

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How Clever Retargeting Persuades Customers Who Looked But Did not Buy

Did you know that nearly 96 percent of your first-time visitors are not ready to purchase from your website right away? That means in most cases, in order to make a sale, you need to encourage your visitors to return more often to your site.

Retargeting is the best way to target your first-time visitors on different marketing channels and encourage them to return to your site. Since retargeting helps you to target your existing prospects, it will likely boost more engagement than untargeted ads, making your entire campaign cheaper and cost-effective.

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