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Government retains borrowing target, to raise ₹6.61 lakh crore in H2 to fund revenue gap

The gross market borrowing of ₹6.61 lakh crore shall be completed through 21 weekly auctions.




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Fiscal deficit in April-August at 27% of full-year target: Govt data

In absolute terms, the fiscal deficit was at ₹4,35,176 crore as of August-end




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China's economy grew 4.6% in July-September quarter, falling short of 5% target

The latest data show the world's second largest economy slowing from 4.7% annual growth in the previous quarter and falling short of the official target of “about 5%” growth for 2024,




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GST receipts’ growth rebounds in October, but still off target

Collections surpass ₹1.87 lakh crore in October, marking the second highest monthly collections on record, with growth mounting to 8.9% in October from September’s 40-month low uptick of 6.5%




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Australian curriculum debuts in India, targets 10 schools by next academic year

This K-12 curriculum, which emphasises balanced assessment with a 50 per cent school-based evaluation and 50 per cent external exam split, has been piloted in a school in Punjab to adapt it for Indian students 




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India-European Free Trade Association deal | $100-billion investment target was breakthrough moment: Swiss official

EFTA negotiator cautions that actual investment can only come from European private sector, not guaranteed by governments, and hopes FTA will be ratified by 2024-end




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UCC does not target live-in couples: CM Pushkar Singh Dhami

“This election is not for the election of a particular MP but to elect the Prime Minister; and there is no doubt that the country wants to see Modi ji return as PM once again,” Mr. Dhami said




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Charge target collection from different triboelectrification domains by electrostatic induction and polarization enabled air discharges

Energy Environ. Sci., 2024, 17,8942-8953
DOI: 10.1039/D4EE04035J, Paper
Kaixian Li, Siqi Gong, Shaoke Fu, Hengyu Guo, Chuncai Shan, Huiyuan Wu, Jian Wang, Shuyan Xu, Gui Li, Qionghua Zhao, Xue Wang, Chenguo Hu
New channels of dynamic dielectric polarization enabled discharges (DPD) are proposed and combined with electrostatic induction enabled discharges (EID) to achieve charge target collection from different triboelectrification domains.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Target fixed to provide education loans for 7,000 students in Salem, says Collector




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Integrated transcriptomics and untargeted metabolomics reveal bone development and metabolism of newly weaned mice in response to dietary calcium and boron levels

Food Funct., 2024, 15,10853-10869
DOI: 10.1039/D4FO03657C, Paper
Shuo Li, Xuehai Cao, Tiande Zou, Zirui Wang, Xingping Chen, Jun Chen, Jinming You
Boron supplementation in diets with varying calcium levels modulates bone development and bone parameters in mice by regulating calcium signaling, lipid metabolism, and neural signaling and inflammatory signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A novel method for exploration and prediction of the bioactive target of rice bran-derived peptide (KF-8) by integrating computational methods and experiments

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02493A, Paper
Rui Liang, Fangliang Song, Ying Liang, Yanpeng Fang, Jianqiang Wang, Yajuan Chen, Zhongxu Chen, Xiaorong Tan, Jie Dong
The diagram of the strategy to explore peptide targets based on model predictions and experiments.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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India will fail to meet 2025 TB ‘elimination’ target




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Folic acid-targeted redox responsive polylactic acid-based nanoparticles co-delivering pirarubicin and salinomycin suppress breast cancer tumor growth in vivo

Nanoscale, 2024, 16,20131-20146
DOI: 10.1039/D4NR02365J, Paper
Priya Gupta, Ankushi Bansal, Harshdeep Kaur, Mohd Anees, Neetu Singh, Harpal Singh
Schematic illustration of design, administration, and mechanism of action of Pira/Sal dual-loaded FA-conjugated redox responsive [S-(PLA-b-PEG-CONH)]2 block copolymeric nanoparticles.
The content of this RSS Feed (c) The Royal Society of Chemistry




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DON encapsulated carbon dot–vesicle conjugate in therapeutic intervention of lung adenocarcinoma by dual targeting of CD44 and SLC1A5

Nanoscale, 2024, Advance Article
DOI: 10.1039/D4NR00426D, Paper
Afreen Zaman, Aparajita Ghosh, Anup Kumar Ghosh, Prasanta Kumar Das
HACD–TMAV, a carbon dot–vesicle conjugate, selectively delivered glutamine inhibitor DON to CD44-enriched cancer cells, inducing ROS triggered apoptosis by dual targeting CD44 and SLC1A5 through downregulation of PI3K/AKT/mTOR signalling cascade.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Tailored peptide nanomaterials for receptor targeted prostate cancer imaging

Nanoscale, 2024, Advance Article
DOI: 10.1039/D4NR03273J, Paper
Fátima Santillán, Carlie L. Charron, Betty C. Galarreta, Leonard G. Luyt
This study reports on a cancer targeted nanomaterial created from cyclic octapeptides that is tailored for the optical imaging of prostate cancer. The strategy focuses on the co-assembly of four specific templates into cyclic peptide nanotubes.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Applications of peptide-based nanomaterials in targeting cancer therapy

Biomater. Sci., 2024, 12,1630-1642
DOI: 10.1039/D3BM02026F, Review Article
Beilei Sun, Limin Zhang, Mengzhen Li, Xin Wang, Weizhi Wang
To meet the precise diagnosis and treatment as well as reduce systemic toxicity and side effects, self-assembled peptides are applied to the targeting therapy, including targeting theranostics, nanocarrier delivery, immunotherapy, and combination therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Sorafenib and tetrakis (4-carboxyphenyl) porphyrin assembled nanoparticles for synergistic targeted chemotherapy and sonodynamic therapy of hepatocellular carcinoma

Biomater. Sci., 2024, 12,1864-1870
DOI: 10.1039/D3BM01994B, Paper
Yongzhi Chen, Qiuxia Tan, Yuanyu Tang, E. Pang, Rui Peng, Minhuan Lan, Dousheng Bai
Hepatocellular carcinoma (HCC) is characterized by a high degree of malignancy and mortality.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Dynamic monitoring of the fibrosis disease by a collagen targeting near infrared probe

Biomater. Sci., 2024, 12,1924-1931
DOI: 10.1039/D3BM01926H, Paper
Xiaoke Zhang, Qianwen Yang, Sensen Zhou, Cheng Li, Xiqun Jiang
A H2O2-sensitive macromolecular optical probe which can effectively bind to collagen was developed for real time noninvasive visualization of fibrotic tissues.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A mitochondria-targeting heptamethine cyanine-chlorambucil formulated polymeric nanoparticle to potentiate native tumor chemotherapeutic efficacy

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00003J, Paper
Jing Liu, Jie Zhang, Yongteng Zhang, Wei Wei, Meixiao Zhan, Zhiren Zhang, Bing Liu, Xianglong Hu, Weiling He
Facile conjugation of chlorambucil with IR775 chloride can afford IR775-Cbl with mitochondria-targeting potency for tumor cells, exhibiting distinct “1 + 1 > 2” tumor inhibition.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Beyond Nanoparticle-based Oral Drug Delivery: Transporter-mediated Absorption and Disease Targeting

Biomater. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4BM00313F, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hana Cho, Kang Moo Huh, Hyun Ji Cho, Bogeon Kim, Min Suk Shim, Yong-Yeon Cho, Joo Young Lee, Hye Suk Lee, Young Jik Kwon, Han Chang Kang
Various strategies in the microscale/nanoscale have been developed to improve oral absorption of therapeutics. Among them, gastrointestinal (GI)-transporter/receptor-mediated nanosized drug delivery systems (NDDSs) have drawn attention due to their many...
The content of this RSS Feed (c) The Royal Society of Chemistry




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YSRCP women’s wing president questions selective targeting of social media activists in Andhra Pradesh




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Shooting star Manu Bhaker is new target of brands

From aerated drinks to cosmetics to nutrition brands, everyone wants to ally with the ace markswoman




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Today’s top tech news: Apple’s labour challenges; Russian trolls target U.S. elections; Microsoft’s AI users in India




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Escient launches to tackle itching and anaphylactoid drug targets

The startup raised $40 million to target a class of GPCRs called Mas-related G-protein receptors, to treat neuroimmune and inflammatory conditions




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Can single-cell genomics lead to a new wave of drug targets? Celsius Therapeutics thinks so

The start-up, based on the work of Broad Institute scientist Aviv Regev, has raised $65 million to develop therapies for cancer and autoimmune disease




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Accent Therapeutics launches to target the epitranscriptomic RNA code in cancer

With $40 million series A funding, the start-up will develop inhibitors of proteins that make chemical modifications to RNA




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U.S. Congress targets requirements for fluorochemicals in firefighting foams at airports




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Targeting immune cells could relieve chronic pain

Study finds macrophages talk to sensory nerves to elicit chronic pain caused by nerve damage




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Targeting immune cells could relieve chronic pain

Study finds macrophages talk to sensory nerves to elicit chronic pain caused by nerve damage




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STT collection hits ₹36,000 crore, reaching 97% of Budget target amid market rally

Implemented in 2004, STT is designed to combat tax evasion on capital gains and has undergone various adjustments to its rates and structure since its inception.




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BJP’s next big target is to form government in Bengal, says Amit Shah

The Union Home Minister accused the Trinamool Congress government of State-sponsored infiltration and referred to R.G. Kar incident, where a doctor was raped and murdered at a State health facility




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Maharashtra Assembly polls: Modi targets Congress over Article 370, steers clear of Sharad Pawar in his speech




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India vs Malaysia Hockey Highlights, Women’s Asian Champions Trophy 2024: Sangita, Preeti, Udita on target; IND beat MAS 4-0




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Japan targets 400,000 coronavirus antigen tests weekly






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Advertisers pull back from targeting US Latinos

Marketers fear ‘racist’ Trump supporters, says head of Hispanic advertising group




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Tottenham join Manchester United and Chelsea as Premier League clubs target Sergej Milinkovic-Savic 

Tottenham have become the latest Premier League club to show interest in signing Lazio star Sergej Milinkovic-Savic,The Serbia international is under contract at the Stadio Olimpico until 2024.




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Tottenham join Manchester United and Chelsea as Premier League clubs target Sergej Milinkovic-Savic 

Tottenham have become the latest Premier League club to show interest in signing Lazio star Sergej Milinkovic-Savic,The Serbia international is under contract at the Stadio Olimpico until 2024.




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M&Ms Boo-tterscotch (Target Exclusive)

Name: M&Ms Boo-tterscotch Brand: Mars Place Purchased: Target (Eagle Rock) Price: $3.19 Size: 8 ounces Calories per ounce: 148 Type: White Chocolate Rating: 7 out of 10




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Viral escape hatch could be treatment target for hepatitis E

Researchers at Princeton and Rutgers universities have found that the hepatitis E virus — an emerging liver virus historically found in developing countries but now on the rise in Europe — uses a technique to spread infection that scientists could in fact exploit to treat the disease.




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Purdue basketball recruiting target Brandon Newman going extra mile for improvement

Brandon Newman's stock rose considerably in the past six months. The 2019 guard from Valparaiso will play at Montverde (Florida) Academy as a senior.

      




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HUL rating: Structural appeal intact, ‘buy’ with target price of Rs 2,650

HUL's investment case rises above this short-term disruption: HUL's structural appeal lies beyond the defensiveness it offers amid Covid-19 disruption, in our view.




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HUL share price slips over 5%; analysts say ‘buy’ post Q4 results, check new target prices

The market share of HUL was up by 50bp in 4QFY20 with 80 per cent of portfolio gaining share in the March quarter, a clear indication of resilient performance in an extraordinarily difficult quarter




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Half of wheat purchase target met despite delayed start

The Food Corporation of India (FCI) has been able to buy half of its wheat procurement target of 40.7 million tonne by Wednesday despite a delayed start this year as Punjab has exceeded expectation by purchasing nearly 75% of its target in only 22 days.




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Coal ministry’s 710 million tonne production target makes CIL stakeholders jittery

The ministry could have set a target of removing the huge burden and could have kept coal at exposed seams. As and when required coal could be extracted out of the seams.




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Jefferies puts ‘Hold’ rating on Strides Arcolab with Rs 1300 target price

Under the scheme, Strides shareholders will get 1 share of SSL for every 6 shares of Strides while Sequent shareholders will get 1 share of SSL for 25 shares of Sequent.




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ACC stock gets rated ‘Buy’ by Edelweiss, says target price revised to Rs 1914

Investors in ACC have reason to cheer as volume posted double digit growth in Q2CY17, up 10% y-o-y, after a gap of >5 years and is set for ~10% jump in CY17, on low base of ~9% dip in H2CY16.




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DLF improves performance in Q3, analysts maintain ‘Buy’ with revised target price of Rs 216

Management continues to focus on liquidating Rs 12,300-crore inventory and scaling up the rental portfolio (DCCDL). We maintain earnings estimates for the erstwhile merged entity (despite demerger of DCCDL) awaiting greater clarity on adjustments/reconciliation between DLF and DCCDL numbers (post-demerger).




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Govt to sell up to 3% stake in Axis Bank to meet Rs 80,000 cr disinvestment target

At the end of December 2018, Suuti held a 9.56% stake in Axis Bank. The OFS is part of the government’s move to meet its disinvestment target of Rs 80,000 crore for FY19.