siRNNs could enable RNAi knockdown of therapeutic targets in a broader range of cells and tissue types than siRNA.

Rubens Barrichello hopes that his fourth place in the European Grand Prix will provide a springboard for the team to improve further for the remainder of the season

Renault team principal Eric Boullier is targeting race victories in the next three years and fourth place in the championship next season

When inflation targeting came to Canada, it was the government not the Bank of Canada that proposed it. Why? Three possible explanations come to mind. First, perhaps the government thought it was a fundamentally good idea. Second, the government was in the process of introducing a new goods and services tax, which would boost headline…

The right to practice religion free of fear is one of our nation’s most indelible rights. But over the last few years, the United States has experienced a significant increase in mass casualty attacks targeting houses of worship and their congregants. Following a string of attacks on synagogues, temples, churches, and mosques in 2019, the…

Speaking recently at Georgetown University, Mark Zuckerberg told an audience “I’ve focused on building services to do two things: give people voice, and bring people together.” He later said “More people being able to share their perspectives has always been necessary to build a more inclusive society.” The speech anointed Facebook as the “Fifth Estate”…

Summary Craig Garthwaite, John Graves, Tal Gross, Zeynal Karaca, Victoria Marone, and Matthew J. Notowidigdo study the effect of the Affordable Care Act Medicaid expansion on hospital services, with a focus on the geographic variations of its impact, finding that it increased Medicaid visits, decreased uninsured visits, and lead the uninsured to consume more hospital…

Summary Philippe Andrade, Jordi Galí, Hervé Le Bihan, and Julien Matheron study how changes in the steady-state natural interest rate affect the optimal inflation target, finding that starting from pre-crisis values, a 1 percentage point decline in the natural rate should be accommodated by an increase in the optimal inflation target of about 0.9 to…

The right to practice religion free of fear is one of our nation’s most indelible rights. But over the last few years, the United States has experienced a significant increase in mass casualty attacks targeting houses of worship and their congregants. Following a string of attacks on synagogues, temples, churches, and mosques in 2019, the…

The current crisis reveals two major flaws in the world’s crisis-resolution mechanisms: (i) funds available to launch credible rescue operations are insufficient, and (ii) national crisis responses have negative spillovers. One solution is to emulate the EU’s enhanced cooperation solution at the global level, with the IMF ensuring that the rules are respected. Big global…

Abstract Surprisingly little theoretical attention has been devoted to the final step of the public policy implementation chain: understanding why the targets of public policies do or do not “comply” — that is, behave in ways that are consistent with the objectives of the policy. This paper focuses on why program “targets” frequently fail to…

Traditionally, defense in cyberspace has been based on the “Risk equation,” a loosely calculated product of Vulnerability, Asset value and Threat. Vulnerability means the degree to which computing infrastructure is exposed to intruders. Asset value represents the importance of information to an organization and its constituents. Threat is a subjective assessment of the danger posed…

The following is part of the Series on Counterterrorism and American Statutory Law, a joint project of the Brookings Institution, the Georgetown University Law Center, and the Hoover Institution Introduction It is a slight exaggeration to say that Barack Obama is the first president in American history to have run in part on a political…

Photo credit: What Rhymes with Nicole Target may finally be feeling the heat from consumer, health, and environmental groups such as the Center for Health, Environment and Justice (CHEJ), which has been vociferous in its campaign to get the nation's

Short design-life products made of PVC have been a common, inexpensive, and functional choice for almost 50 years. But, vinyl can also be a risky choice of material for objects often handled by consumers, posing a risk of lead exposure, especially if

News Corporation, parent company of Fox, the Wall Street Journal, and most recently of The Daily for the iPad, was the first global media company to commit to and then achieve the goal of becoming carbon neutral.

If you don't subscribe to the print version of Mother Jones you may have missed what seems to be a really sort of creepy story about how the US beef industry is not so subtly waging war against sustainable and slow

George Monbiot says you don't set targets in an emergency, you act.

It's not revising up its official targets, but the government is hinting that it may now achieve 225 GW by 2022.

For those who say it's too difficult...

If a hurricane is headed your way, you surely have a lot on your mind. Knowing the energy infrastructure risks in your area may be one more thing to throw in there.

A new desalination technology company is looking to help clean up and recover some of the trillion gallons of salty wastewater from the oil and gas industry.

Growth Unlocked: Closing the Strategy-to-Execution Gap

Covid-19 has infected 3.7 million people globally, and killed at least 264,111 as of Thursday.

The aspect of the technology that interests Target is its ability to pool multiple orders and route them to a similar place, NBC News reports.

China should still set a growth target this year for the authorities to design a "sensible" stimulus package, says Liu Li-gang, Citigroup's chief economist for China, who adds that the country's unemployment rate risks exceeding 10% without aggressive fiscal stimulus.

With so much money being issued so quickly, the potential for scams and misuse runs rampant.

Matt Maley, chief market strategist at Miller Tabak, and Quint Tatro, chief investment officer at Joule Financial, talk top Thanksgiving trades with CNBC's Mike Santoli.

Industrial materials maker DuPont on Tuesday slashed its capital expenditure by about $500 million and raised its annual cost-savings target to counter global trade uncertainties brought on by the coronavirus outbreak.

Greece might be spared from having to hit strict fiscal targets related to previous bailouts next year, a government official told CNBC, given the ongoing health and economic crises.

CNBC's Dominic Chu reports that San Francisco is targeting May 18 to reopen some businesses.

This May Day, an unprecedented coalition of essential workers from Amazon, Instacart, Whole Foods, Walmart, Target and FedEx are calling out sick or walking out during their lunch break to demand better health and safety conditions, along with hazard pay. Others are joining them for May Day actions that include rent strikes, car caravan protests and online organizing calling for a "People's Bailout" and economic recovery plan that prioritizes workers. We speak with Kali Akuno, co-founder and co-director of Cooperation Jackson, which issued a call for a people's strike starting May 1. "The corporations and the government are willing to sacrifice tens of thousands of us," Akuno says. "We have to put people before profits."

The UK government has set a new target of recruiting an army of 18,000 coronavirus contact tracers by the middle of May, to be in place for the launch of the NHS contact tracing app

People with rheumatoid arthritis often take medicines that can have damaging side-effects, but a system that uses red light to deliver drugs exactly where they are needed could help

Ministers have set targets for testing, medical equipment and hospital beds. Have they delivered?

Pistol ace Manu Bhaker has got a new electronic target installed at the makeshift shooting range at her home in Haryana in place of an archaic manual machine that was breaking down frequently and hampering her Olympics preparation. The old machine was causing her "immense irritation". Delighted by the reboot in her training, the teenaged star has got down to preparing with renewed vigour, sure in her mind that the Olympics will take place next year despite the uncertainty in the world of sports due to the COVID-19 pandemic.

"I have recently got the machine installed at my home and this will be surely more beneficial in my training," Bhaker told PTI from her home at Goria village. Her father set up the range after she showed exceptional skills in the precision sport. Bhaker thanked the Sports Authority of India (SAI) and Olympic Gold Quest (OGQ), the organisation that manages her, for promptly getting the machine -- an avant-garde target -- delivered at her home despite the nationwide lockdown enforced to contain the COVID-19 pandemic.

"I was facing a lot of issues with the old machine as it was manual. The thread would come off and often it would break down on and off. Now it's very different with the new machine," the 18-year-old Bhaker said. "Since I feel there is unlikely to be any outdoor action and competitions for another three-four months, I thought it will be useful to get this installed at this point in time."

A medallist at ISSF World Cup, Commonwealth Games and the Youth Olympics, Bhaker was primed for success at sport's grandest and biggest stage in Tokyo which was to happen this year, but the unprecedented health crisis intervened and forced a postponement of the Games by a year. With the world still far away from bringing the situation under control, there are doubts if the Tokyo Games would be held even next year.

"Yes, the Indian shooters were in great form heading into the Games, but health is a bigger concern," Bhaker said. "I am very hopeful of the Olympics taking place next year and also confident of maintaining my game and hitting peak form there. This is a difficult time for the world but I have no negative thoughts and I am mentally prepared."

The target HS10 machine from Swiss company SIUS Ascor is designed for all air guns for distance ranging from 10 to 20 meters. Some of the salient features of the machine are its accuracy, integrated high-intensity LED target illumination, low operating costs (no paper rolls/rubber rolls) and it is also suitable for outdoor shooting.

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