A method for producing fatty acid alkyl esters from biolipids through transesterification and/or esterification reactions uses a flow-through cavitation device for generating cavitation bubbles in a fluidic reaction medium. The fluidic medium is passed through sequential compartments in the cavitation device having varying diameters and inner surface features to create localized reductions in fluid pressure thus vaporizing volatile alcohols and creating an increased surface area and optimized conditions for the reaction to occur at the gas-liquid interface around the bubbles.

Provided is an oxide sintered body suitably used for the production of an oxide semiconductor film for a display device, wherein the oxide sintered body has both high conductivity and relative density, and is capable of depositing an oxide semiconductor film having high carrier mobility. This oxide sintered body is obtained by mixing and sintering powders of zinc oxide, tin oxide and indium oxide, and when an EPMA in-plane compositional mapping is performed on the oxide sintered body the percentage of the area in which Sn concentration is 10 to 50 mass % in the measurement area is 70 area percent or more.

Provided are an oxide sintered body and a sputtering target that are ideal for the production of an oxide semiconductor film for a display device. The oxide sintered body and sputtering target that are provided have both high conductivity and high relative density, are capable of forming an oxide semiconductor film having a high carrier mobility, and in particular, have excellent direct-current discharge stability in that long-term, stable discharge is possible, even when used by the direct-current sputtering method. The oxide sintered body of the invention is an oxide sintered body obtained by mixing and sintering zinc oxide, tin oxide, and an oxide of at least one metal (M metal) selected from the group consisting of Al, Hf, Ni, Si, Ga, In, and Ta. When the in-plane specific resistance and the specific resistance in the direction of depth are approximated by Gaussian distribution, the distribution coefficient σ of the specific resistance is 0.02 or less.

Embodiments provide methods, apparatus, systems, and computer readable media associated with predicting predicates and branch targets during execution of programs using combined branch target and predicate predictions. The predictions may be made using one or more prediction control flow graphs which represent predicates in instruction blocks and branches between blocks in a program. The prediction control flow graphs may be structured as trees such that each node in the graphs is associated with a predicate instruction, and each leaf associated with a branch target which jumps to another block. During execution of a block, a prediction generator may take a control point history and generate a prediction. Following the path suggested by the prediction through the tree, both predicate values and branch targets may be predicted. Other embodiments may be described and claimed.

A single software project in an integrated development environment (IDE) may be built for multiple target environments in a single build episode. Multiple different output artifacts may be generated by the build process for each of the target environments. The output artifacts are then deployed to the target environments, which may be homogeneous or heterogeneous environments. The same source project may be used to generate multiple output artifacts for the same target environment.

An automated process uses a local positioning system to acquire location (i.e., position and orientation) data for one or more movable target objects. In cases where the target objects have the capability to move under computer control, this automated process can use the measured location data to control the position and orientation of such target objects. The system leverages the measurement and image capture capability of the local positioning system, and integrates controllable marker lights, image processing, and coordinate transformation computation to provide tracking information for vehicle location control. The resulting system enables position and orientation tracking of objects in a reference coordinate system.

This invention relates to extend the benefits of using hypochlorite compounds such as sodium hypochlorite to clean and disinfect articles while reducing or eliminating the side effects of treating an article with a strong oxidant material. The invention relates to a single step process involving mixing of precursor compositions of a suitable hypohalite or hypohalous acid with a solution of a reducing agent. Optionally a buffer may be present in either or both precursor compositions, such that at time of use such active hypohalous acid concentration in the resulting aqueous mixture remains at a sufficient activity level to effect one or more desired benefits against a target substrate for a desired period of time. The oxidant is substantially consumed by reaction with the reducing agent after the time needed for achieving the desired benefit has passed.

The present invention concerns a TCTP antagonist, in particular a nucleic acid targeting an m RNA encoding Translationally-Controlled Tumor Protein (TCTP), wherein said nucleic acid is capable of reducing the amount of TCTP in cells, for use in the treatment or prevention of hormone-independent cancer or chemo-resistant cancer, such as an androgen-independent prostate cancer.

The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules. The present invention further relates to methods for generating, for example, functional biomolecules, particularly to functional nucleic acids, that bind with functional activity to another biomolecule, such as a receptor molecule. More than one or multiple targets as used herein may generally include different types of targets, and/or may also include a multitude of a singular type of targets at different conditions, such as, for example, temperature, pH, chemical environment, and/or any other appropriate conditions.

Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.

The present invention relates to oligomer compounds (oligomers) for the treatment and prevention of acute myeloid leukemia, which target GLI2 mRNA in a cell, leading to reduced expression of GLI2.

Techniques are described to transmit commands to a display device. The commands can be transmitted in header byte fields of secondary data packets. The commands can be used to cause a target device to capture a frame, enter or exit self refresh mode, or reduce power use of a connection. In addition, a request to exit main link standby mode can cause the target enter training mode without explicit command to exit main link standby mode.

The disclosed technology provides a manufacturing method of a target comprising obtaining an initial mass and a residual mass of the target sample, and calculating an etching mass; determining a relative etching depth of the target sample; calculating a relative etching mass based on the etching mass and the relative etching depth; determining a utilization parameter of the target sample based on the relative etching mass and the initial mass of the target sample before being used; and performing a simulation and optimization process on the utilization parameter of the target sample, obtaining target parameters corresponding to a preset value of the utilization parameter, and outputting the target parameters to a manufacturing control center for manufacturing a target. The disclosed technology also provides a manufacturing system of a target.

One or more temporal stimulation parameters of vagus nerve stimulation (VNS) are selected to substantially modulate one or more target physiological functions without substantially modulating one or more non-target physiological functions. In one embodiment, a stimulation duty cycle is selected such that VNS is delivered to the cervical vagus nerve trunk to modulate a cardiovascular function without causing laryngeal muscle contractions.

Embodiments of the present invention disclose a method and a device for determining a target cell. The method includes: acquiring information about a candidate cell for a mobile terminal; and determining the candidate cell as a target cell for the mobile terminal if the candidate cell is a preferred cell determined according to cell statistic information, where the cell statistic information includes: specific information about a cell having served the mobile terminal and specific information about the mobile terminal in the cell having served the mobile terminal. According to the solutions provided in the embodiments of the present invention, a proper target cell may be determined for a mobile terminal, thereby avoiding a large number of handovers and reselections and saving network resources.

Lubrication additives of the current invention require formation of emulsions in base lubricants, created with an aqueous salt solution plus a single-phase compound such that partitioning within the resulting emulsion provides thermodynamically targeted compounds for boundary layer organization thus establishing anti-friction and/or anti-wear. The single-phase compound is termed “boundary layer organizer”, abbreviated BLO. These emulsion-contained compounds energetically favor association with tribologic surfaces in accord with the Second Law of Thermodynamics, and will organize boundary layers on those surfaces in ways specific to the chemistry of the salt and BLO additives. In this way friction modifications may be provided by BLOs targeted to boundary layers via emulsions within lubricating fluids, wherein those lubricating fluids may be water-based or oil-based.

This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a processing vessel, such as an Eppendorf tube, a syringe or a test tube, and a collector. The collector is sized and shaped to fit into a primary vessel, such as a test tube. The collector funnels the target material from the suspension through a cannula and into the processing vessel. The cannula extends into a cavity at a first end of the collector that holds the processing vessel. The collector includes a funnel at a second end in fluid communication with the cannula. In one implementation, the processing vessel includes at least one displacement fluid to be expelled, such that the at least one displacement fluid pushes the target material into the collector.

The invention relates to compounds and methods for targeting radionuclide-based imaging agents to cells having receptors for a vitamin, or vitamin receptor binding derivative or analog thereof, by using such a vitamin as the targeting ligand for the imaging agent. The vitamin-based compounds can be used to target radionuclides to cells, such as a variety of tumor cell types, for use in diagnostic imaging of the targeted cells.

The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity.

The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates to a method for producing such a mutein. Furthermore, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.

The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.

The present disclosure relates to a Co-029 inhibitor for inhibiting the migration of cancer cells which express Co-029. The disclosure relates to a Co-029 inhibitor for the treatment of cancer and/or the prevention of cancer metastasis and pharmaceutical compositions comprising said inhibitor and provides Co-029 antibodies. The disclosure provides a method for predicting the response of a patient afflicted with or susceptible to be afflicted with cancer to a medical treatment with a Co-029 inhibitor, a method for diagnosing a cancer in a patient and a method for predicting the survival in a cancer patient.

A method for controlling a transmission of a powertrain system includes executing a single source shortest path search to identify a preferred shift path originating with an initial powertrain state and terminating at a target powertrain state, wherein the single source shortest path search employs transition-specific costs and situational costs to identify the preferred shift path. The preferred shift path is executed to achieve the target powertrain state.

The present invention relates to fusion proteins comprising an antibody, functional fragment or functional derivative thereof having specific binding affinity to either the extracellular domain of oncofetal fibronectin (ED-B) or at least one of the extracellular domains of oncofetal tenascin fused to a cytokine selected from the group consisting of IL-10, IL15, IL-24 and GM-CSF, functional fragments and functional derivatives thereof. The invention is also directed to the use of at least one of said fusion proteins for the manufacture of a medicament. In particular, the invention concerns the use of said medicament for the treatment of tumors or chronic inflammatory diseases such as atherosclerosis, arthritis and psoriasis.

A targeting jig apparatus for targeting interlocking holes of an intramedullary nail. The targeting jig includes a support-arm extending substantially parallel to the intramedullary nail. A targeting mechanism including a pair of targeting mechanism drill-guide orifices is adjustably disposed on the support arm for aligning the targeting mechanism drill-guide orifice with the interlocking holes of the intramedullary nail. The targeting mechanism includes a saddle having a U-shape including a base and parallel legs that are slidable along the support-arm. A connection mechanism includes a horizontal slot on the support-arm aligned with a vertical slot on the targeting mechanism and a pivot screw extending through the slots for facilitating adjustment of the targeting mechanism relative to the support arm.

According to one embodiment, a target tracking apparatus acquires a first determination result by determining which combination of N-dimensional tracks is for the real target, acquires a second determination result by determining which combination of N-dimensional angular observation values is for the real target, selects the first determination result when an observation environment is an environment other than a dense environment, selects the second determination result when the observation environment is a dense environment, and calculates distance information to thereby generate an (N+1)-dimensional track for each target.

Devices for attaching a sheet-like implant to a target tissue include a sheath and a staple push rod. The sheath has a distal end configured to be pressed against the target tissue. The staple push rod is disposed within at least a portion of the sheath and is slidable relative thereto. The staple push rod includes a pair of stakes. Each stake is dimensioned to abut a surface of a staple to apply pushing forces thereto. The stakes are biased to assume a bow-like shape such that an intermediate portion of a staple extends tautly between the first stake and the second stake when the stakes are extending beyond the distal end of the tubular member. Methods for attaching a sheet-like implant to a target tissue are also disclosed.

A device for attaching a sheet-like implant to a target tissue. The device includes a fastener push rod including a first portion, a second portion and a force limiting mechanism operably coupled between the first portion and the second portion. A fastener is carried by the second portion of the fastener push rod. The force limiting mechanism transmits longitudinal movement of the first portion to the second portion while the forces applied to the fastener by the fastener push rod are less than a predetermined value such that longitudinal movement of the first portion of the fastener push rod causes substantially equivalent longitudinal movement of the second portion. The force limiting mechanism allows relative longitudinal motion between the first and second portions while the forces applied to the fastener are equal to or greater than the predetermined value such that the application of undue forces to the fastener is prevented.

This invention provides recombinant DNA constructs and methods for manipulating expression of a target gene that is regulated by a small RNA, by interfering with the binding of the small RNA to its target gene. More specifically, this invention discloses recombinant DNA constructs encoding cleavage blockers, 5-modified cleavage blockers, and translational inhibitors useful for modulating expression of a target gene and methods for their use. Further disclosed are miRNA targets useful for designing recombinant DNA constructs including miRNA-unresponsive transgenes, miRNA decoys, cleavage blockers, 5-modified cleavage blockers, and translational inhibitors, as well as methods for their use, and transgenic eukaryotic cells and organisms containing such constructs.

Aspects of the invention relate to several methods to deposit and regenerate target materials in neutron generators and similar nuclear reaction devices. In situ deposition and regeneration of a target material reduces tube degradation of the nuclear reaction device and covers impurities on the surface of the target material at the target location. Further aspects of the invention include a method of designing a target to generate neutrons at a high efficiency rate and at a selected neutron energy from a neutron energy spectrum.

A thermal signal generating device, including at least two parallel buss bars operable for carrying a current and a heating element having at least a first region and a second region. The heating element includes a plurality of horizontal traces and a plurality of vertical traces. Widths of each of the plurality of horizontal and vertical traces may be greater in a first region of the heating element than in a second region of the heating element, allowing for a gradient heat differential to be emitted by the heating element.

A portable target comprising: (a) a complaint, energy-absorbing backer; (b) a target on a surface of said backer; and (c) a support mechanism for holding said surface of said backer in a vertical position.

The system includes a rotation disengagement mechanism configured to disengage a rotatable shaft from a powered drive unit such that upon disengagement the powered drive unit is no longer able to rotate the shaft. After disengagement, the rotatable shaft may reengage the powered drive unit at only one rotational position relative to the rotation disengagement mechanism. A target coupled to the shaft is thus always in a known home position. The systems and methods further comprise smart positioning logic that assigns a number designation to four rotational orientations spaced 90° from one another.

According to one aspect of the present invention, a projectile target is disclosed comprising a target having a substantially sealed chamber having a front face and a rear face with an enclosing side wall disposed intermediate. The front and rear faces are formed by membranes configured to allow a projectile to pass therethrough and then substantially seal to maintain the substantially sealed chamber. Pressure wave sensors are disposed within the chamber and are configured to detect pressure waves created by the projectile. A target controller receives signals from the pressure sensors indicative of the pressure sensed by the sensors and determines an impact point of the projectile on the front face of the target.

A target and object receiving device that includes a base portion having an outer edge and a lower coupling area disposed on a top surface of the base portion. An upper portion is spaced vertically from the base portion and includes an outer edge and an upper coupling area disposed on a bottom surface of the upper portion. A separator extends vertically from the lower coupling area to the upper coupling area. Either: (a) the top surface of the base portion approaches the bottom surface of the upper portion as the top surface extends from the outer edge of the base portion toward the lower coupling area; or (b) the bottom surface of the upper portion approaches the top surface of the base portion as the bottom surface of the upper portion extends from the outer edge of the base portion toward the upper coupling area.

Shooters must presently take their firearms out of their hands to then manually actuate a new target into shooting position. This Target Apparatus will allow the shooter to shine his laser light, infrared light, flashlight, or multi-spectrum light onto a Target Apparatus-mounted sensor that engages a drive means mounted upon the target frame that then forwards a new target into position without removing the firearm from its' shooting position. The unit also uses a unique target backing material that does not require targets to be made of rolls of coated or heavy material stock. The system can utilize rolls of cash register paper, cut sections of gift wrapping paper, hand towel rolls, or even paper towels as target materials without snagging and preventing the next target from being presented.

A portable fabric target for ball sports has at least: a) three fabric panels, comprising a top first panel, a middle second panel; and a bottom third panel;b) the top first panel having i) a first bottom edge attached to at top edge of the second middle panel and ii) a second outside top edge;c) the top first panel having a support element extending away from the second outside top edge;d) the support element having a self-latching system that connects the second outside top edge to itself to form a loop or to a section of the top first panel to form a loop;e) the support element when locked around a pole supporting all weight of the portable fabric target without unlocking; andf) the bottom third panel having a stabilizing component thereon.

An imaging reader reads targets by image capture in both handheld and hands-free modes of operation. Upon detection of the mode of operation, a controller sets the resolution and frame rate of a solid-state imaging sensor to different values in each mode to optimize target reading performance in each mode.

Among other things, one or more systems and/or techniques are described for dynamically adjusting, in a fan-angle direction, attenuation of radiation during an examination of an object such that portions of the object that are not represented in resulting (tilted/targeted) images of the object are exposed to less radiation than portions of the object that are represented in resulting (tilted/targeted) images of the object. As a rotating gantry is rotated, blades of a pre-object collimator are dynamically repositioned to selectively attenuate emitted radiation. A collimator adjustment component may be configured to determine how to reposition the blades based at least in part upon at least one of a desired tilt of the resulting (tilted) image(s), a translational position of the object, and a gantry rotation angle, for example.

The activity monitor (100) includes a basic information acquisition unit (20) that accepts input of basic physical information (BA) of the user's body, a target information acquisition unit (30) that accepts input of the user's target physical expenditure (CS), an activity pattern acquisition unit (40) that acquires pattern information indicating the user's intent on the activity amount (AM), and a target activity calculation unit (50) that determines a target activity amount (TA) on the basis of the basic physical information (BA), the target physical expenditure (CS), and the pattern information acquired by the activity pattern acquisition unit (40).

A target device is usable with a simulation system which includes a weapon simulator having a trigger, a chamber for firing a blank cartridge in response to the trigger, and a transmitter arranged to emit a light signal defining one or more activation codes of prescribed duration in response to the trigger. The target device includes a sensor array of photodiodes and a processor receiving output signals from the photodiodes. The processor determines that the sensor array has been hit by the weapon simulator in response to a first portion of one activation code being received by one of the photodiodes and at least one second portion of the same activation code being received by the same or a different one of the photodiodes when the first portion and the at least one second portion correspond to an entirety of one activation code within the respective prescribed duration.

A device configured to track and capture the movement data of a target as well as shooting and firearm movement activity of a hunter includes a housing, a camera, sensors, a processor, a memory, and a battery. The camera is disposed in close proximity to the housing to capture the movement of a target. One or more sensors are disposed in the housing and interfaced with the processor to capture the velocity and orientation of a gun. A trigger activation sensor is also in communication with the processor. The memory stores camera activity, trigger activity, sensor activities, and also stores an alarm setting on the device. The processor activates the alarm setting when predefined criteria are met. Radar can be incorporated to determine the distance of the target from the user. GPS can also be included to provide precise location and time information.

Provided is a nonmagnetic material particle dispersed ferromagnetic material sputtering target comprising a material including nonmagnetic material particles dispersed in a ferromagnetic material. The nonmagnetic material particle dispersed ferromagnetic material sputtering target is characterized in that all particles of the nonmagnetic material with a structure observed on the material in its polished face have a shape and size that are smaller than all imaginary circles having a radius of 2 μm formed around an arbitrary point within the nonmagnetic material particles, or that have at least two contact points or intersection points between the imaginary circles and the interface of the ferromagnetic material and the nonmagnetic material. The nonmagnetic material particle dispersed ferromagnetic material sputtering target is advantageous in that, in the formation of a film by sputtering, the influence of heating or the like on a substrate can be reduced, high-speed deposition by DC sputtering is possible, the film thickness can be regulated to be thin, the generation of particles (dust) or nodules can be reduced during sputtering, the variation in quality can be reduced to improve the mass productivity, fine crystal grains and high density can be realized, and the nonmagnetic material particle dispersed ferromagnetic material sputtering target is particularly best suited for use as a magnetic recording layer.

A sputtering target with low generation of particles in which oxides, carbides, nitrides, borides, intermetallic compounds, carbonitrides, and other substances without ductility exist in a matrix phase made of a highly ductile substance at a volume ratio of 1 to 50%, wherein a highly ductile and conductive metal coating layer is formed on an outermost surface of the target. Provided are a sputtering target capable of improving the target surface in which numerous substances without ductility exist and preventing or inhibiting the generation of nodules and particles during sputtering, and a method of producing such a sputtering target.

Provided is an inorganic-particle-dispersed sputtering target in which inorganic particles are dispersed in a Co base material, wherein the inorganic particles have an electric resistivity of 1×101 Ω·m or less and the volume ratio of the inorganic particles in the target is 50% or less. The sputtering target thus adjusted is advantageous in that, when sputtering is performed using a magnetron sputtering device comprising a DC power source, the inorganic particles are less charged, and arcing occurs less frequently. Accordingly, by using the sputtering target of the present invention, the occurrence of particles attributable to the arcing reduces, and a significant effect of improving the yield in forming a thin film is obtained.

A sputtering target including a sintered body including In, Ga and Mg, the sintered body including one or more compounds selected from a compound represented by In2O3, a compound represented by In(GaMg)O4, a compound represented by Ga2MgO4 and a compound represented by In2MgO4, andhaving an atomic ratio In/(In+Ga+Mg) of 0.5 or more and 0.9999 or less and an atomic ratio (Ga+Mg)/(In+Ga+Mg) of 0.0001 or more and 0.5 or less.

An arrangement for, and a method of, electro-optically reading a target by image capture, employ an aiming assembly for projecting an aiming light pattern on the target that is located within a range of working distances relative to a housing, an imaging assembly for capturing an image of the target and of the aiming light pattern over a field of view, and a controller for determining a distance of the target relative to the housing based on a position of the aiming light pattern in the captured image, for determining a scanning resolution based on the determined distance, for comparing the determined scanning resolution with a scanning resolution setting, and for processing the captured image based on the comparison.

A method and system are presented for enhancing one or more images of an object, so as to increase the visibility within the images of one or more structures within the object. The object may be an anatomical region of a patient, and may include one or more reference structures, for example skeletal structures or vertebral structures, and one or more treatment targets, for example tumors or lesions. An operator, for example a top-hat filter operator, selects at least a first neighborhood and a second neighborhood within the images. The operator selects within each neighborhood one or more pixels having an optimal pixel value, and eliminates the remaining pixels in these neighborhoods. When the operator is applied to the selected neighborhoods, only the pixels having the greatest pixel values remain in the selected neighborhoods, and the remaining pixels are eliminated in the selected neighborhoods. As a result, desired features can be located and enhanced in the images.

The present invention relates to a device for delivering targets (2) comprising at least one column (4) for storing targets (2) capable of receiving a first target (11) at the lowest point of the column (4) and at least a second target (12) stacked on the first target (11), means for delivering the first target (11), and retention means for retaining the second target (12) in the column (4), characterized in that the retention means for retaining comprise a ramp (21) configured to exert a bearing force on the lower face of the second target (12) during the delivery of the first target (11). This invention also relates to a machine for launching targets (2) equipped with a device and a method for distributing the targets (2).

The invention relates to sputter targets and methods for depositing a layer from a sputter target. The method preferably includes the steps of: placing a sputter target in a vacuum chamber; placing a substrate having a substrate surface in the vacuum chamber; reducing the pressure in the vacuum chamber to about 100 Torr or less; removing atoms from the surface of the sputter target while the sputter target is in the vacuum chamber (e.g., using a magnetic field and/or an electric field). The deposited layer preferably is a molybdenum containing alloy including about 50 atomic percent or more molybdenum, 0.5 to 45 atomic percent of a second metal element selected from the group consisting of niobium and vanadium; and 0.5 to 45 atomic percent of a third metal element selected from the group consisting of tantalum, chromium, vanadium, niobium, and titanium.