[Object] To provide a method of manufacturing a sputtering target and a sputtering target that are capable of achieving refinement and uniformity of crystal grains. [Solving Means] A method of manufacturing a sputtering target according to an embodiment of the present invention includes forging an ingot formed of metal by applying a stress in a first axis direction (z-axis direction) and a plane direction (xy-plane direction) orthogonal to the first axis direction. The ingot is additionally forged by applying a stress in a second axis direction (axial directions c11, c12, c21, c22) obliquely intersecting with a direction parallel to the first axis direction. The ingot is heat-treated at a temperature equal to or higher than a recrystallization temperature thereof. In such a manner, since slip deformation can be caused not only in the first axis direction and the plane direction orthogonal thereto but also in the second axis direction, the high density and uniformity of an internal stress can be achieved.

In various embodiments, planar sputtering targets are produced by forming a billet at least by pressing molybdenum powder in a mold and sintering the pressed powder, working the billet to form a worked billet, heat treating the worked billet, working the worked billet to form a final billet, and heat treating the final billet.

A knit sock includes a foot portion having an upper instep area and a lower sole area integrally knit of a body yarn in circumferential courses and axial wales. The lower sole area defines inner and outer arch regions. The inner arch region incorporates a targeted compression zone adapted to reside generally adjacent an inner arch of a wearer's foot. The compression zone includes axially extending compression ridges of variable length spaced apart from a top of the compression zone to a bottom of the compression zone. When the sock is worn, a compression force applied by the foot portion within the targeted compression zone is greater than the compression force in directly adjacent areas of said foot portion.

A molecule comprising a lipid, a peptide and a linker to bind the lipid to the peptide which have specific amino acid sequence to bind to Epidermal Growth Factor Receptor (EGFR) of tumor cells, and a liposomal composition which is targeted by the molecule, and method for preparing thereof is disclosed.

The present invention relates to methods and compositions for treating, preventing, and diagnosing Alzheimer's Disease or other tauopathies in a subject by administering an immunogenic tau peptide or an antibody recognizing the immunogenic tau epitope under conditions effective to treat, prevent, or diagnose Alzheimer's Disease or other tauopathies. Also disclosed are methods of promoting clearance of aggregates from the brain of the subject and of slowing progression of tau-pathology related behavioral phenotype in a subject.

The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant.

Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

The present invention relates to the use of the miRNA expression profile, particularly of miR-199a-5p, and the target genes regulated thereby for the diagnosis, prognosis and use of miR-199a-5p inhibitors for treating fibroproliferative disorders.

The invention relates to polynucleotide agents targeting the complement component C5 gene, and methods of using such polynucleotide agents to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria.

Provided herein are compositions and methods for modifying a predetermined nucleic acid sequence. A programmable nucleoprotein molecular complex containing a polypeptide moiety and a specificity conferring nucleic acid (SCNA) which assembles in-vivo, in a target cell, and is capable of interacting with the predetermined target nucleic acid sequence is provided. The programmable nucleoprotein molecular complex is capable of specifically modifying and/or editing a target site within the target nucleic acid sequence and/or modifying the function of the target nucleic acid sequence.

A binary exploding target package, a process of forming an exploding target from the contents of the binary exploding target package, and the exploding target formed therefrom. The binary exploding target package includes a first, target container and a second container. An oxidizer composition is contained within one of the containers and a catalyst composition is contained within the other container. An exploding target is formed by mixing the oxidizer and catalyst compositions, and introducing the mixture into the target container to form an exploding target just prior to using the exploding target as a target for a shooting exercise.

Systems, apparatus and methods to create a database by a device (such as a server) and to use the database by a mobile device for detecting a planar target are presented. The database allows recognition of a planar target by a mobile device from steeper angles with minimum impact on runtime. The database is created from at least one warped view of the planar target. For example, a database may contain keypoints and descriptors from a non-warped view and also from one or more warped views. The database may be pruned by removing keypoints and corresponding descriptors of one image (e.g., a warped image) overlapping with similar or identical keypoints and descriptors of another image (e.g., a non-warped image).

Embodiments of the present disclosure provide a method and an apparatus for determining a similar document set to a target document from a plurality of documents. Each of the multiple documents and the target document may include a plurality of words, and each of words corresponds to a different integer. The method comprises: for each document among the plurality of documents and the target document, obtaining a set of integers associated with a document based on a set of words associated with the document, converting the set of integers associated with the document into a vector with a same dimension based on a predefined conversion rule; and determining the similar document set based on differences between the corresponding vectors for the multiple documents and the vector for the target document.

Provided is an apparatus for capturing a target component from a gas including a rotating packed bed and a packed bed. The rotating packed bed has a first absorbent inlet, a first absorbent outlet, a first gas inlet and a first gas outlet. The packed bed has a second absorbent inlet, a second absorbent outlet, a second gas inlet and a second gas outlet. The first absorbent outlet is in connection with the second absorbent inlet to form an absorbent flow path that sequentially passes through the rotating packed bed and the packed bed. The second gas outlet is in connection with the first gas inlet to form a gas flow path that sequentially passes through the packed bed and the rotating packed bed.

The present disclosure relates to a method and apparatus for detecting a target object by a radar device for a vehicle. The method includes recognizing the situation that causes the deterioration in the function of a radar, and preventing the performance from deterioration through a signal processing technology. The apparatus includes: a signal transmitting unit that transmits a transmission signal for detecting a target object; a signal receiving unit that receives a reception signal generated by a reflection of the transmission signal; a signal analyzing unit that calculates frequency spectrum information of the reception signal, and extracts periodicity information for determining a periodicity of the frequency spectrum information; a determining unit that determines whether a clutter structure exists; and a target detecting unit that detects a target object by deleting a peak value component of the periodicity information when it is determined that the clutter structure exists.

An apparatus for providing a target for a projectile comprises an elongate member extending between first and second ends, sized to span a playing surface. The apparatus further comprises first and second support legs extending from the first and second ends of the elongate member, each of the first and second support legs having a length selected to position the elongate member above and outside of a possible path of the projectile and a plurality of lights located on the elongate member selectable by a user to provide a visual target for a user. After the elongate member is positioned above and outside a possible path of the projectile a desired path for the projectile is selected and one of a plurality of lights on the elongate member to provide a visual target for a user expected to produce the desired path in the projectile is illuminated.

This invention relates in general to target games and methods for animating a target game and playing an animated target game. In the present invention, a game with an animated component comprises a target structure having a first target surface and a second target surface. In some embodiments, the first target surface is separated from the second target surface by a joint. An animation mechanism is provided for moveably connecting the first target surface to the second target surface at the joint.

A multi-contact type position detection apparatus for a target board includes a first membrane board having a plurality of first signal lines formed in a first direction, a second membrane board having a plurality of second signal lines formed in a second direction, and a plurality of dots which are formed on the first membrane board or the second membrane board such that the first membrane plate and the second membrane plate are spaced at a predetermined distance from each other, wherein the plurality of dots can be arranged at a distance of “k/2±A (A is 1%˜2% of k)” when a magnetic body diameter of a pin attached on the target board is “kmm”.

Using traceable target plates triggering a LED flashing controller to make different color of LED lights flashing different patterns corresponding to shooting results. The invention can be used in airsoft gun target, archery target, or dart target.

A kit and a method of playing a game with a kit having: (a) a plurality of stackable objects including one or more images thereon; (b) one or more target selectors including one or more images thereon which correspond to the one or more images of the plurality of stackable objects; and (c) one or more aiming objects.

A ballistic picture frame for holding two dimensional paper targets, photographs or print art used for dry-fire training. The ballistic picture frame holds paper targets, photographs, or other two dimensional graphics or prints like conventional picture frames, but also provides a ballistic barrier for enhanced safety during dry-fire training. The ballistic frame includes a back panel constructed of ballistic materials that prevent projectile penetration through the frame in the event of a negligent discharge.

A bag target and a method of manufacturing the bag target configured to substantively decrease in size for storage, shipment and/or display. The bag target is further configured to absorb and dissipate essentially all of the kinetic energy of a high energy projectile such as an arrow or a crossbow bolt.

A portable control module autonomously positions a target deployed in a combat simulation course. The module chassis is bullet-resistant and angled to deflect errant shots, and encloses a control circuit having an adjustable target exposure delay, an adjustable target exposure duration, means for receiving a trigger signal representing movement of a human body, means for revealing the target when the exposure delay lapses after triggering, means for enabling, only when the target is revealed, hit detection means detecting a shot striking the target, and means for concealing the target responsive to earliest occurrence of the shot detection or lapse of the target exposure duration. The module may include means for relaying the trigger signal to other modules within a cooperative decentralized target control system. A method for the autonomous position control is also disclosed.

The Archery Target Having a Replaceable Cube Core includes a replaceable cube core, a target frame, and a support base. The target frame houses the replaceable cube core at the center of the target frame. The support base is attached to the target frame and the replaceable cube core abuts the support base. The replaceable cube core provides a visual target display for archers to aim and shoot. The support base ensures that the cube core is firmly held within the confines of the target frame and the support base to prevent the replaceable cube core from shifting or moving under impact from the arrows. The replaceable cube core is formed as a cube having six (6) useable target surfaces. Each target surface provides a consistent penetration depth on each surface for predictable results, regardless of the face that is used for the target surface.

A target may allow target practice and/or simulate the shape of one or more animals. In various implementations, a target may include a target body and/or stand. The target body may be capable of receiving shots from arrows and/or ammunition. A target body may include a first aiming zone and a second aiming zone on an opposing surface. In some implementations, the first aiming zone and/or the second aiming zone may be off center. The orientation of the target body may be altered to select an aiming zone of the target body based upon user preference, in some implementations. The overlay may have shape similar to a predetermined animal. The overlay may be replaceable. The stand may support the target body. In various implementations, an overlay may be coupled to the target body and/or stand.

A method and system for suspending a target above a surface that provides for supporting a support member above the surface. A hanger is used to suspend a target from the support member. When the target is hanging from the support member, it is induced into an angle so that its top portion is closer to a shooter. When the target is struck by an incoming projectile, it is allowed to pivot downward from its initial position and the target is also restrained from rotating about the axis of suspension.

The purpose of the present invention is to provide an In—Cu alloy sputtering target member having high compositional homogeneity in the thickness direction. The present invention provides a sputtering target member having a composition containing from 1 to 70 at. % of Cu relative to a total number of atoms of In and Cu, the balance being In and inevitable impurities, wherein the target member fulfills 0.95≦A/B≦1, where A represents a Cu atomic concentration relative to the total number of atoms of In and Cu in one half of a thickness direction; B represents a Cu atomic concentration relative to the total number of atoms of In and Cu in the other half of the thickness direction; and B≧A; and wherein a number of pores having a size of 100 μm or more is less than 10/cm2 on average.

An Al—Te—Cu—Zr alloy sputtering target, comprising 20 at % to 40 at % of Te, 5 at % to 20 at % of Cu, 5 at % to 15 at % of Zr and the remainder of Al, wherein a Te phase, a Cu phase and a CuTe phase are not present in a structure of the target. An object of the present invention is to provide an Al—Te—Cu—Zr alloy sputtering target capable of effectively reducing particle generation, nodule formation and the like upon sputtering and further capable of reducing oxygen contained in the target.

There is provided an insulator target which, when mounted on a sputtering apparatus and supplied with AC power, is capable of preventing the discharging from occurring in a clearance between a shield and the target. The insulator target for the sputtering apparatus according to this invention, around which is disposed a shield at the time of assembling the insulator target on the sputtering apparatus, is made up of: a plate-shaped target material to be enclosed by the shield; and, suppose that one surface of the target material is defined as a sputtering surface to be subjected to sputtering, an annular supporting material coupled to an outer peripheral portion of the opposite surface of the target material. The supporting material has an extended portion which is extended outward from a peripheral surface of the target material and which keeps a predetermined clearance to the shield.

A Cu—Ga alloy sputtering target includes, as a component composition, Ga: 0.1 to 40.0 at % and a balance including Cu and inevitable impurities, in which a porosity is 3.0% or lower, an average diameter of circumscribed circles of pores is 150 μm or less, and an average crystal grain size of Cu—Ga alloy particles is 50 μm or less.

Provided herein is an apparatus that includes a body with a top surface and a recess in the top surface. The top surface, excluding the recess, is substantially planar. The recess is confined to an area that is defined by an inner diameter of the top surface of the body.

A SOUTHAMPTON home has been pelted with bricks in a series of targeted attacks.

Local schoolboy aims to join world elite.

£25 million awarded in 25 years.

"We believe that a technology-enabled home delivery based solution can promote responsible consumption of alcohol," Mohit Gupta, Zomato's CEO for food delivery, wrote in a business proposal to ISWAI.

"I think we could broaden the product range a bit in our lower price range," Abrahamsson Ring said, adding that new materials, production techniques and distribution methods would help make IKEA "even more affordable".

More than two years after filing for bankruptcy, Toys 'R' Us has managed to make a comeback with the support of a competitor, just in time for the holiday season. The iconic toy brand has relaunched its website, shortly after US retail chain Target announced a partnership with the defunct brand's parent company Tru Kids Brands.

which are high on potential and aspirations.From mix point of.

The company, celebrating its 50th anniversary, has lined up a string of new products for the future.

The Trump administration has revived the debate over "end-to-end encryption" — systems so secure that the tech companies themselves aren't able to read the messages, even when police present them with a warrant. "It is hard to overstate how perilous this is," U.S. Attorney General William Barr said in a speech last fall. "By enabling dangerous criminals to cloak their communications and activities behind an essentially impenetrable digital shield, the deployment of warrant-proof encryption is already imposing huge costs on society." Barr has been concerned about this for years, but he has become more vocal recently as encryption goes mainstream. It's now built into popular services such as Skype and WhatsApp, and even Facebook may soon be encrypted . Republican senator and Trump ally Lindsey Graham recently floated legislation that would strip tech companies of their liability protection under Section 230 of the Communications Decency Act unless they comply with as-of-yet undefined

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The new measures, though, won't affect Seattle-Tacoma International Airport's growing emissions from air traffic or ground transportation — the bulk of the Port's carbon footprint.

The fast food industry has been accused of using marketing strategies to cash in on the pandemic lockdown.

Police hunt two men they believe broke into a Cherrybrook home and assaulted 86-year-old Colin Saliba, who sustained fatal head injuries in the attack, and his wife Josephine, who remains in hospital.

MORNING BRIEFING: People in NSW are warned they should still practice social-distancing as coronavirus restrictions are eased from today, while two men are shot in Merrylands in what is believed to be a targeted attack.

A coronavirus outbreak at Burnie's hospital has prompted a plea for Tasmania's north-west residents to do the right thing over the Easter break, as a drive-through testing station opens in Hobart.

Hundreds of Indigenous people living in communities across the West Australian desert are being signed up to loans by a Gold Coast-based lender they can neither afford nor understand, advocacy groups say.

The Royal Flying Doctor Service is helping launch a mobile testing clinic in a small agricultural town in Victoria to reach an "at risk" population of itinerant farm workers and migrants.

The whitegoods repairman who became the chief suspect in one of Australia's biggest child abduction mysteries reveals for the first time how the ordeal "shattered" his life.

DAILY BRIEFING: The family of three-year-old Eleanor Oakley, which has been fundraising so the young girl can travel to the US to receive cancer treatment, reaches its $300,000 target.