Jeremy Roenick nous a offert le moment le plus touchant de l’intronisation des membres de la cuvée 2024 du Temple de la renommée du hockey.

L’ex-premier ministre de la Colombie-Britannique John Horgan est décédé à l’âge de 65 ans après une bataille contre le cancer.

Une ancienne boîte de poulet St-Hubert, retrouvée par hasard dans l’entretoit d’un chalet, a été remise à la famille Martin en échange d'un don.

As people gather to remember those who fought and died to protect this country in past wars, a new poll suggests many Canadians know little about their country's history.

Thousands of veterans, military personnel and their supporters gathered at Canada's National War Memorial in Ottawa to remember those who have fought and died to protect this country and its freedoms.

Ontario Premier Doug Ford appears to be dipping his toe into new territory — talking about removing Mexico from the North American trade agreement.

Former B.C. premier John Horgan has died at the age of 65, CBC News has confirmed. In June this year, Horgan told CBC that he had been diagnosed with cancer for the third time during a routine followup appointment for his previous throat cancer.

Gros succès en France, le drame biographique est présenté samedi au Festival Cinemania.

Un premier spectacle d’humour en solo, intitulé «Après seulement 32 ans d’absence sur scène».

Asahi Kasei Medical has launched the Planova FG1, a next-generation virus removal filter featuring higher flux for the manufacture of biotherapeutics, in October 2024.

A research team at the University of California San Diego have developed a smartphone attachment that can provide information on changes in pupil size, which can be used to assess neurological phenomena, such as traumatic brain injury and Alzheimer’s disease. Such changes in pupil size have been difficult to characterize in the past in those […]

The General Pharmaceutical Council has said most candidates living in countries with a two-hour or more time difference from the UK will be able to apply to sit the registration assessment at home.

Maybe those pesky sites are good for something after all. 

It's been six years since Pfizer boldly announced the launch of its "clinical trial in a box". The REMOTE trial was designed to be entirely online, and involved no research sites: study information and consent was delivered via the web, and medications and diaries were shipped directly to patients' homes.

Despite the initial fanfare, within a month REMOTE's registration on ClinicalTrials.gov was quietly reduced from 600 to 283. The smaller trial ended not with a bang but a whimper, having randomized only 18 patients in over a year of recruiting.

Still, the allure of direct to patient clinical trials remains strong, due to a confluence of two factors. First, a frenzy of interest in running "patient centric clinical trials". Sponsors are scrambling to show they are doing something – anything – to show they have shifted to a patient-centered mindset. We cannot seem to agree what this means (as a great illustration of this, a recent article in Forbes on "How Patients Are Changing Clinical Trials" contained no specific examples of actual trials that had been changed by patients), but running a trial that directly engages patients wherever they are seems like it could work.

The less-openly-discussed other factor leading to interest in these DIY trials is sponsors' continuing willingness to heap almost all of the blame for slow-moving studies onto their research sites. If it’s all the sites’ fault – the reasoning goes – then cutting them out of the process should result in trials that are both faster and cheaper. (There are reasons to be skeptical about this, as I have discussed in the past, but the desire to drop all those pesky sites is palpable.)

However, while a few proof-of-concept studies have been done, there really doesn't seem to have been another trial to attempt a full-blown direct-to-patient clinical trial. Other pilots have been more successful, but had fairly lightweight protocols. For all its problems, REMOTE was a seriously ambitious project that attempted to package a full-blown interventional clinical trial, not an observational study.

In this context, it's great to see published results of the TAPIR Trial in vasculitis, which as far as I can tell is the first real attempt to run a DIY trial of a similar magnitude to REMOTE.

TAPIR was actually two parallel trials, identical in every respect except for their sites: one trial used a traditional group of 8 sites, while the other was virtual and recruited patients from anywhere in the country. So this was a real-time, head-to-head assessment of site performance.

And the results after a full two years of active enrollment?

• Traditional sites: 49 enrolled
• Patient centric: 10 enrolled

Sudan's civil war has displaced 10 million citizens. Here are profiles of two young people from the most vulnerable groups: an unaccompanied minor caring for twin brothers, a woman who was raped.

The FDA has proposed removing oral phenylephrine from its guidelines for over-the-counter drugs due to inefficacy as a decongestant. Use of this ingredient in cold and allergy medicines grew after a federal law required that pseudoephedrine-containing products be kept behind pharmacy counters.

The post FDA Takes Step Toward Removal of Ineffective Decongestants From the Market appeared first on MedCity News.

Denzel Washington has confirmed he will star in Black Panther 3 before his retirement. The 69-year-old actor is the first to talk about the existence of a third film in the blockbuster Marvel franchise — which will follow the 2018 original and 2022 sequel Black Panther: Wakanda Forever — and has also revealed the film will be among a handful of roles he will take on before he bows out of acting after a career spanning four decades. Confirming director Ryan Coogler has written a role just for the Oscar-winner for the third instalment, Denzel told Australia's Today show: "At this point in my career, I'm only interested in working with the best, I don't know how many more films I will make, probably not that many. I want to do things that I haven't done." Sharing the roles he has lined up before he bids farewell to his Hollywood career, he said: "I played Othello at 22, I'm now going to play it at 70. After that, I'm playing Hannibal. After that, I've been talking with Steve McQueen about a film. After that, Ryan Coogler is writing a part for me in the next Black Panther.

My first editor, Rukun Advani, once described himself as ‘a composite hybrid of the Indian and the Anglo-European’, who sought to reconcile ‘within himself those varying cultural influences which chauvinistic nationalists could only see as contradictions.’ This self-characterization I might avow as my own. One mark of the Anglo-European in me is that, unlike members [...]

During recent trips to southern Punjab, Principal Officer was repeatedly told that a sophisticated jihadi recruitment network had been developed in the Multan, Bahawalpur, and Dera Ghazi Khan Divisions.

Though the Northwest Frontier Province (NWFP) and Federally Administered Tribal Areas (FATA) continue to grab headlines for terrorist violence, poor and underdeveloped regions in the rest of "settled" Pakistan are increasingly the recruiting and training ground for extremism and militancy.

Jun 14, 2024

Owen R. Coté Jr., who exerted a profound influence on security studies as Co-Editor and later Editor of the Belfer Center journal International Security, died on June 8, 2024. He was 63. Owen was also the Principal Research Scientist and Associate Director of the Security Studies Program (SSP) at the Massachusetts Institute of Technology (MIT).

“All of us at the Belfer Center are saddened to learn of the passing of Owen Coté,” said Belfer Center Director Meghan O’Sullivan. “While he was based at MIT, he has been an integral part of our Center through his decades-long work with our signature publication, the journal International Security. Our hearts go out to his family, friends, and colleagues.”
 

Dec 15, 2017

To ministers and heads of state, he was a sought-after adviser, pointing the way toward reforms that boosted farm yields, educational standards, and economic prosperity. To the scientific community, he was an unstinting champion of innovation and rigorous evidence. To his students, he was a passionate teacher and mentor. To thousands of his fans on social media, he was a fount of insight, optimism, and good humor. To us, he was a dear friend and extraordinary colleague.

Dec 18, 2017

Our colleague Calestous Juma—who passed away on December 15 at age 64 after a long illness—was a pioneering, prolific, and influential scholar/practitioner in science and technology policy for sustainable well-being. He joined Harvard Kennedy School (HKS) in 1999 as Director of the Science, Technology, and Innovation Project (a joint venture of the Belfer Center for Science and International Affairs and the Center for International Development) and became Professor of the Practice of International Development in 2002, a position in which he maintained his exceptional productivity and engagement with policy, despite illness, up to the time of his death.

Dec 21, 2023

Artificial intelligence is poised to remove human limitations inherent in many systems, including information and logistical bottlenecks in decision-making.

May 6, 2024

Joseph S. Nye advocates for identifying areas for cooperation between the United States and China such as climate change and public health.

May 24, 2024

We must avoid the successor to the grand reapers of the past century: World War I and World War II. We must avoid World War III. We should reflect on this during this Memorial Day.

Jim Poolman on the Changing Face of Retirement

Preparations for a live screening of the Fight of the Century on a remote island in the Philippines

European Business Award Teaser 2015

Interview Jean Jouzel, Pr�sident du jury

HGTV Dream Home 90-second Tour

Flatbed Cider Co. offers two all new hand-crafted ciders made from the apples and pears that made the Northwest famous. Look for our Crisp Apple Cider and Pear Cider at restaurants and retailers throughout Washington State and Oregon.

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Los artistas m�s grandes llegan a los Premios Billboard de la M�sica Latina �Billboard Duets� que se transmitir� en vivo por TELEMUNDO el jueves 28 de abril a las 8pm/7c

Conoce a la familia Méndez, pionera en la transformación extrema de camiones. Texas Trocas, nueva serie de Discovery en Español. Estreno 15 de septiembre a las 10PM E/P.

Los prestigiosos Premios Billboard de la Música Latina tendrán lugar el jueves 30 de abril a las 7pm/6c por Telemundo

La segunda temporada de Texas Trocas llega a Discovery en Español con nuevas historias y transformaciones aún más extremas.

WebMD�s Future of Health with Robin Roberts presents stories about cutting-edge medical breakthroughs, inspiring individuals working to improve people�s lives, and the people that are benefiting from their efforts.

REMWorks is a new sleep store concept like no other. Relieve sleeplessness, sleep apnea, snoring and insomnia with products and custom solutions from our sleep experts.

March of Dimes volunteer ambassador and world famous photographer Anne Geddes is featured in a PSA to raise awareness about preventing preterm birth and give more babies a healthy start in life.

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Ryan Lochte explains the feeling of Gentle Laser Hair Removal

Donald Trump has been reelected president of the United States. Ahead of Kamala Harris’s expected concession speech, we speak to professors Carol Anderson and Michele Goodwin to discuss Harris’s historic campaign — and historic loss. “The Confederacy won,” says Anderson, a professor of African American studies at Emory University. “It paints a picture of what Americans are willing to embrace,” says Goodwin, a professor of constitutional law at Georgetown and an expert on healthcare law, who warns of the public health dangers of a second Trump administration and discusses the election’s implications for reproductive rights.

New materials would help the cars of the future survive cold snaps and other climate disruptions

In a wetland on the south coast of England, archaeologists dug up one of the oldest and most complete wooden tools ever found in Britain, which is around 3500 years old