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Grilled calamari, watermelon, olives, goat's curd and crispy vine leaves

This recipe was featured on Foodie Tuesday, a weekly segment with Raf Epstein on Drive, 774 ABC Melbourne, 3:30 PM, courtesy of George Calombaris. George's new book is called "Greek."




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Coorong Angus Beef Pie with Red Wine, Fennel and Green Olives

This recipe featured on Foodie Tuesday, a weekly segment with Raf Epstein on Drive, 774 ABC Melbourne, 3.30PM, courtesy of Maggie Beer. Maggie's new book is "Autumn Harvest".




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Buckwheat polenta with roasted vegetables, blue cheese, pine nuts and thyme

As the cold weather sets in, this nourishing winter dish is perfect to warm hands, feet and heart. The addition of buckwheat flour to polenta gives it a delicious smoky earth flavour and adds to the nutrition level of this dish. Rich in fibre and silica, gluten free buckwheat contain rutin, a bioflavonoid that is know to increase blood circulation and reduce high blood pressure. Perfect for winter!





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Jerusalem artichokes cooked overnight with hazelnut praline

This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by Dan Hunter, chef and owner of Otways' restaurant Brae.




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Medallions of Beef, with pan juice sauce, wilted cherry tomatoes, wine and basil

Medallions of Beef, with pan juice sauce, wilted cherry tomatoes, any old wine and basil. Really nice with a potato salad, with fresh spring peas and crispy bacon pieces. Something I do very often is knock up quick tasty dinner utilising your favourite heavy-based frying pan.




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Pakistan shines on pitch with series win

Pakistan highlighted its talent on the pitch to draw the third and final Test against Sri Lanka in Sharjah and win the series 1-0, just days after three former team-mates were jailed for spot-fixing.




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Myocardial Ischemic Burden and Differences in Prognosis Among Patients With and Without Diabetes: Results From the Multicenter International REFINE SPECT Registry

OBJECTIVE

Prevalence and prognostic impact of cardiovascular disease differ between patients with or without diabetes. We aimed to explore differences in the prevalence and prognosis of myocardial ischemia by automated quantification of total perfusion deficit (TPD) among patients with and without diabetes.

RESEARCH DESIGN AND METHODS

Of 20,418 individuals who underwent single-photon emission computed tomography myocardial perfusion imaging, 2,951 patients with diabetes were matched to 2,951 patients without diabetes based on risk factors using propensity score. TPD was categorized as TPD = 0%, 0% < TPD < 1%, 1% ≤ TPD < 5%, 5% ≤ TPD ≤ 10%, and TPD >10%. Major adverse cardiovascular events (MACE) were defined as a composite of all-cause mortality, myocardial infarction, unstable angina, or late revascularization.

RESULTS

MACE risk was increased in patients with diabetes compared with patients without diabetes at each level of TPD above 0 (P < 0.001 for interaction). In patients with TPD >10%, patients with diabetes had greater than twice the MACE risk compared with patients without diabetes (annualized MACE rate 9.4 [95% CI 6.7–11.6] and 3.9 [95% CI 2.8–5.6], respectively, P < 0.001). Patients with diabetes with even very minimal TPD (0% < TPD < 1%) experienced a higher risk for MACE than those with 0% TPD (hazard ratio 2.05 [95% CI 1.21–3.47], P = 0.007). Patients with diabetes with a TPD of 0.5% had a similar MACE risk as patients without diabetes with a TPD of 8%.

CONCLUSIONS

For every level of TPD >0%, even a very minimal deficit of 0% < TPD < 1%, the MACE risk was higher in the patients with diabetes compared with patients without diabetes. Patients with diabetes with minimal ischemia had comparable MACE risk as patients without diabetes with significant ischemia.




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Genetic Susceptibility Determines {beta}-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76)

OBJECTIVE

Previous studies suggested that childhood prediabetes may develop prior to obesity and be associated with relative insulin deficiency. We proposed that the insulin-deficient phenotype is genetically determined and tested this hypothesis by longitudinal modeling of insulin and glucose traits with diabetes risk genotypes in the EarlyBird cohort.

RESEARCH DESIGN AND METHODS

EarlyBird is a nonintervention prospective cohort study that recruited 307 healthy U.K. children at 5 years of age and followed them throughout childhood. We genotyped 121 single nucleotide polymorphisms (SNPs) previously associated with diabetes risk, identified in the adult population. Association of SNPs with fasting insulin and glucose and HOMA indices of insulin resistance and β-cell function, available from 5 to 16 years of age, were tested. Association analysis with hormones was performed on selected SNPs.

RESULTS

Several candidate loci influenced the course of glycemic and insulin traits, including rs780094 (GCKR), rs4457053 (ZBED3), rs11257655 (CDC123), rs12779790 (CDC123 and CAMK1D), rs1111875 (HHEX), rs7178572 (HMG20A), rs9787485 (NRG3), and rs1535500 (KCNK16). Some of these SNPs interacted with age, the growth hormone–IGF-1 axis, and adrenal and sex steroid activity.

CONCLUSIONS

The findings that genetic markers influence both elevated and average courses of glycemic traits and β-cell function in children during puberty independently of BMI are a significant step toward early identification of children at risk for diabetes. These findings build on our previous observations that pancreatic β-cell defects predate insulin resistance in the onset of prediabetes. Understanding the mechanisms of interactions among genetic factors, puberty, and weight gain would allow the development of new and earlier disease-management strategies in children.




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Predicting 10-Year Risk of End-Organ Complications of Type 2 Diabetes With and Without Metabolic Surgery: A Machine Learning Approach

OBJECTIVE

To construct and internally validate prediction models to estimate the risk of long-term end-organ complications and mortality in patients with type 2 diabetes and obesity that can be used to inform treatment decisions for patients and practitioners who are considering metabolic surgery.

RESEARCH DESIGN AND METHODS

A total of 2,287 patients with type 2 diabetes who underwent metabolic surgery between 1998 and 2017 in the Cleveland Clinic Health System were propensity-matched 1:5 to 11,435 nonsurgical patients with BMI ≥30 kg/m2 and type 2 diabetes who received usual care with follow-up through December 2018. Multivariable time-to-event regression and random forest machine learning models were built and internally validated using fivefold cross-validation to predict the 10-year risk for four outcomes of interest. The prediction models were programmed to construct user-friendly web-based and smartphone applications of Individualized Diabetes Complications (IDC) Risk Scores for clinical use.

RESULTS

The prediction tools demonstrated the following discrimination ability based on the area under the receiver operating characteristic curve (1 = perfect discrimination and 0.5 = chance) at 10 years in the surgical and nonsurgical groups, respectively: all-cause mortality (0.79 and 0.81), coronary artery events (0.66 and 0.67), heart failure (0.73 and 0.75), and nephropathy (0.73 and 0.76). When a patient’s data are entered into the IDC application, it estimates the individualized 10-year morbidity and mortality risks with and without undergoing metabolic surgery.

CONCLUSIONS

The IDC Risk Scores can provide personalized evidence-based risk information for patients with type 2 diabetes and obesity about future cardiovascular outcomes and mortality with and without metabolic surgery based on their current status of obesity, diabetes, and related cardiometabolic conditions.




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The Digital Transformation Playbook: Rethink Your Business for the Digital Age

Every business begun before the Internet now faces the same challenge: How to transform to compete in a digital economy? This is the leadership challenge examined by BRITE founder and Columbia Business School faculty member David Rogers in his newest book, The Digital Transformation Playbook (April 5, 2016; Columbia Business School Publishing). In the book, […]




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Reflections on Business, Leadership, and Branding: Shelly Lazarus ’70

Much has changed in the world of advertising from the picture painted by Mad Men. Shelly Lazarus ’70, Chairman Emeritus, Ogilvy & Mather, was one of the women helping pioneer these changes. Making the journey from ‘the only woman in the room’ to CEO and Chairman of Ogilvy gives Lazarus a lot to reflect on […]




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Therapeutic Inertia is a Problem for All of Us

Stephen Brunton
Apr 1, 2019; 37:105-106
Editorials




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Genesis for Engineers

Technology has come a long way since Australopithecus first bruised their fingers chipping flint to make knives and scrapers. We are blessed to fruitfully multiply, to fill the world and to master it (Genesis 1:28). And indeed the trend of technological history is towards increasing mastery over our world. Inventors deliberately invent, but many inventions are useless or even harmful. Why is there progress and how certain is the process? Part of the answer is that good ideas catch on and bad ones get weeded out. Reality, however, is more complicated: what is 'good' or 'bad' is not always clear; unintended consequences cannot be predicted; and some ideas get lost while others get entrenched. Mastering the darkness and chaos of creation is a huge engineering challenge. But more than that, progress is painful and uncertain and the challenge is not only technological.

An example of the weeding-out process, by which our mastery improves, comes to us in Hammurabi's code of law from 38 centuries ago:

"If a builder build a house for some one, and does not construct it properly, and the house which he built fall in and kill its owner, then that builder shall be put to death. If it kill the son of the owner the son of that builder shall be put to death." (Articles 229-230)

Builders who use inferior techniques, or who act irresponsibly, will be ruthlessly removed. Hammurabi's law doesn't say what techniques to use; it is a mechanism for selecting among techniques. As the level of competence rises and the rate of building collapse decreases, the law remains the same, implicitly demanding better performance after each improvement.

Hammurabi's law establishes negative incentives that weed out faulty technologies. In contrast, positive incentives can induce beneficial invention. John Harrison (1693-1776) worked for years developing a clock for accurate navigation at sea, motivated by the Royal Society's 20,000 pound prize.

Organizations, mores, laws and other institutions explain a major part of how good ideas catch on and how bad ones are abandoned. But good ideas can get lost as well. Jared Diamond relates that bow and arrow technologies emerged and then disappeared from pre-historic Australian cultures. Aboriginal mastery of the environment went up and then down. The mechanisms or institutions for selecting better tools do not always exist or operate.

Valuable technologies can be "side-lined" as well, despite apparent advantages. The CANDU nuclear reactor technology, for instance, uses natural Uranium. No isotope enrichment is needed, so its fuel cycle is disconnected from Uranium enrichment for military applications (atom bombs use highly enriched Uranium or Plutonium). CANDU's two main technological competitors - pressurized and boiling water reactors - use isotope-enriched fuel. Nuclear experts argue long (and loud) about the merits of various technologies, but no "major" or "serious" accidents (INES levels 6 or 7) have occurred with CANDU reactors but have with PWRs or BWRs. Nonetheless, the CANDU is a minor contributor to world nuclear power.

The long-run improvement of technology depends on incentives created by attitudes, organizations and institutions, like the Royal Society and the law. Technology modifies those attitudes and institutions, creating an interactive process whereby society influences technological development, and technology alters society. The main uncertainty in technological progress arises from unintended impacts of technology on mores, values and society as a whole. An example will make the point.

Early mechanical clocks summoned the faithful to prayer in medieval monasteries. But technological innovations may be used for generations without anyone realizing their full implications, and so it was with the clock. The long-range influence of the mechanical clock on western civilization was the idea of "time discipline as opposed to time obedience. One can ... use public clocks to summon people for one purpose or another; but that is not punctuality. Punctuality comes from within, not from without. It is the mechanical clock that made possible, for better or for worse, a civilization attentive to the passage of time, hence to productivity and performance." (Landes, p.7)

Unintended consequences of technology - what economists called "externalities" - can be beneficial or harmful. The unintended internalization of punctuality is beneficial (maybe). The clock example illustrates how our values gradually and unexpectedly change as a result of technological innovation. Environmental pollution and adverse climate change are harmful, even when they result from manufacturing beneficial consumer goods. Attitudes towards technological progress are beginning to change in response to perceptions of technologically-induced climate change. Pollution and climate change may someday seriously disrupt the technology-using societies that produced them. This disruption may occur either by altering social values, or by adverse material impacts, or both.

Progress occurs in historical and institutional context. Hammurabi's Code created incentives for technological change; monastic life created needs for technological solutions. Progress is uncertain because we cannot know what will be invented, and whether it will be beneficial or harmful. Moreover, inventions will change our attitudes and institutions, and thus change the process of invention itself, in ways that we cannot anticipate. The scientific engineer must dispel the "darkness over the deep" (Genesis 1:2) because mastery comes from enlightenment. But in doing so we change both the world and ourselves. The unknown is not only over "the waters" but also in ourselves.






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New History of Psychiatry: Melancholy, Madness, Chinese Psychiatry, Psychedelic Therapy, and More

The June 2020 issue of History of Psychiatry is now online. Full details follow below: “Wild melancholy. On the historical plausibility of a black bile theory of blood madness, or hæmatomania,” Jan Verplaetse. Abstract: Nineteenth-century art historian John Addington Symonds coined the term hæmatomania (blood madness) for the extremely bloodthirsty behaviour of a number of … Continue reading New History of Psychiatry: Melancholy, Madness, Chinese Psychiatry, Psychedelic Therapy, and More




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New JHBS: Mind-Body Medicine Before Freud, Psychology and Biography, Jung and Einstein

The Spring 2020 issue of the Journal of the History of the Behavioral Sciences is now online. Full details about contributions to this issue follow below. “Practicing mind-body medicine before Freud: John G. Gehring, the “Wizard of the Androscoggin”” by. Ben Harris and Courtney J. Stevens. Abstract: This article describes the psychotherapy practice of physician … Continue reading New JHBS: Mind-Body Medicine Before Freud, Psychology and Biography, Jung and Einstein




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This Essential Mineral Linked To COVID-19 Recovery

An essential mineral in the body have been linked to recovery of COVID-19 patients.

Support PsyBlog for just $5 per month. Enables access to articles marked (M) and removes ads.

→ Explore PsyBlog's ebooks, all written by Dr Jeremy Dean:




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What Loneliness Does To Your Immune System (M)

Five natural ways to boost the immune system.

Support PsyBlog for just $5 per month. Enables access to articles marked (M) and removes ads.

→ Explore PsyBlog's ebooks, all written by Dr Jeremy Dean:




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Online Therapy: A Powerful Tool in the Fight Against Covid 19

The coronavirus pandemic is affecting billions of people around the world today. Coronavirus, now called covid 19, is a type of virus that is usually found in animals and is rarely transmitted to humans. According to reports from the World Health Organization, covid 19 likely originated from a seafood and meat market in Wuhan, China, […]




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“Mandate-Schmandate,” Rick Perry and the HPV vaccine – by Richard Thaler

Nudge blog note: Last night’s Republican debate prompted Richard Thaler to weigh in on Rick Perry’s handling of an HPV vaccine executive order, but not the policy itself. Also, Thaler recently started tweeting. Follow him. By Richard Thaler In the Republican Presidential debate last night at the Reagan library a question emerged about Rick Perry’s [...]




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The Paradox of Online Dating: Too Many Options Makes It Harder to Invest in a Relationship

In any relationship, you’re bound to discover that your partner has one or two (or maybe ten or twenty) quirks that eventually come to annoy you. In these situations, it's tempting to think that you might be happier with someone else—someone who doesn’t have the same set of peccadillos. However, according to behavioral economist Dr. Dan Ariely, this kind of thinking can set you up for a lifetime of disappointment.




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What are the Most Effective Pick-Up Lines? Here’s What the Science Says

For decades, researchers have been studying the effectiveness of different kinds of pick-up lines in order to better understand the psychology of attraction. What they’ve found is that certain types of lines definitely seem to work better than others—and the results have been surprisingly consistent over the years.




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The gender-fluid history of the Philippines | France Villarta

In much of the world, gender is viewed as binary: man or woman, each assigned characteristics and traits designated by biological sex. But that's not the case everywhere, says France Villarta. In a talk that's part cultural love letter, part history lesson, he details the legacy of gender fluidity and inclusivity in his native Philippines -- and emphasizes the universal beauty of all people, regardless of society's labels.




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2 questions to uncover your passion -- and turn it into a career | Noeline Kirabo

What's your passion? Social entrepreneur Noeline Kirabo reflects on her work helping out-of-school young people in Uganda turn their passions into profitable businesses -- and shares the two questions you can ask yourself to begin doing the same.




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The quest for the coronavirus vaccine | Seth Berkley

When will the coronavirus vaccine be ready? Epidemiologist Seth Berkley (head of Gavi, the Vaccine Alliance) takes us inside the effort to create a vaccine for COVID-19. With clarity and urgency, he explains what makes it so challenging to develop, when we can expect it to be rolled out at scale and why we'll need global collaboration to get it done. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 26, 2020)




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How to make pandemics optional, not inevitable | Sonia Shah

What can past pandemics teach us how to tackle the current one? Tracing the history of contagions from cholera to Ebola and beyond, science journalist Sonia Shah explains why we're more vulnerable to outbreaks now than ever before, what we can do to minimize the spread of coronavirus and how to prevent future pandemics. (This virtual conversation is part of the TED Connects series, hosted by science curator David Biello and current affairs curator Whitney Pennington Rodgers. Recorded March 31, 2020)




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A new way to "grow" islands and coastlines | Skylar Tibbits

What if we could harness the ocean's movement to protect coastal communities from rising sea levels? Designer and TED Fellow Skylar Tibbits shows how his lab is creating a dynamic, adaptable system of underwater structures that uses energy from ocean waves to accumulate sand and restore eroding shorelines -- working with the forces of nature to build rather than destroy.




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How American and Chinese values shaped the coronavirus response | Huang Hung

To combat COVID-19, countries have enforced city-wide shutdowns, stay-at-home orders and mask mandates -- but the reaction (and adherence) to these rules has differed markedly in the East and West. In conversation with TED's head of curation Helen Walters, writer and publisher Huang Hung sheds light on how Chinese and American cultural values shaped their responses to the outbreak -- and provides perspective on why everyone needs to come together to end the pandemic. (Recorded April 16, 2020)




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2019 SJDM Conference program available online

SOCIETY FOR JUDGMENT AND DECISION MAKING CONFERENCE PROGRAM: DOWNLOAD AWAY The program for the 2019 SJDM conference (taking place this weekend (Nov 15-19, 2019) in Montreal, Canada) can be found in two places The SJDM home page (program link) The SJDM Newsletter (link) Please get it while it is hot.

The post 2019 SJDM Conference program available online appeared first on Decision Science News.




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Here’s How The Online Status Indicators In Apps Influence Our Behaviour

By Emily Reynolds. People are often required to adjust their behaviour to meet demands of apps, rather than technology being designed to meet our needs, researchers say.




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Online Charter Schools in North Carolina Petition to Go From Pilot to Permanent

The state's two virtual charter schools have earned poor marks from the state's accountability system in the few years they've been operating.




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Coronavirus Is Pushing Teacher Hiring Online. Here's What That Means

Districts that can screen, interview, and select candidates virtually will have less disruption to their hiring, despite how coronavirus is upending every aspect of school operations.




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Educational Opportunities and Performance in Maine

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.




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Educational Opportunities and Performance in Maine

This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.




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Maine to begin reopening; fall plan for schools is to come




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Lion's Share of Ohio Districts Rank No Teachers as 'Ineffective'

About 94 percent of Ohio school districts did not rate a single teacher as "ineffective," the lowest rating on the state's four-rung teacher-evaluation scale, according to the 2016-17 state report card.




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Unimpressed by online classes, college students seek refunds




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Alabama official outlines phased plan to reopen schools




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Barack Obama will headline televised prime-time commencement




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Stop Giving Inexperienced Teachers All the Lower-Level Math Classes, Reformers Argue

“Detracking” math teachers is tough because many educators resist upending their routines or challenging informal hierarchies, and PD initiatives to make it happen are limited.




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Why Troubles Are Mounting for Online Charter Schools in Three States

Officials in Illinois, Nevada, and Pennsylvania are proposing to close online charter schools over concerns that they're producing subpar academic results for students.




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Pointillism in 1st Grade? Teachers Use Unfamiliar Lessons to Mine for Giftedness

Some districts are using new “response lessons” to identify the talented students that traditional assessments miss.




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Teacher Activism Played Prominent Role in Southern Governors' Races

Governors' races in Kentucky and Mississippi took center stage, testing the political muscle of teacher activists and yielding possible policy implications for everything from public employee pensions to teacher pay.




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Alabama official outlines phased plan to reopen schools




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Prominent Literacy Expert Denies Dyslexia Exists; Says to 'Shoot' Whoever Wrote Law on It

A group of teachers and literacy advocates are pushing back after Richard Allington, one of the country's most prominent experts on early literacy, made inflammatory claims about dyslexia at a Tennessee literacy conference this week.




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'I've Had a Lot of Survivor's Guilt': Columbine High's Former Principal on Healing His Community

Frank DeAngelis, who was the principal of Columbine High School from 1996-2014, talks about the steps he took to heal students and staff in the wake of the school shooting.




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Unimpressed by online classes, college students seek refunds




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Alabama official outlines phased plan to reopen schools