Some nominally high-risk individuals may have a lower chance of developing dementia than once thought

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The NCAA men's college basketball championship game was on the line. People in office pools around the country were holding their breath. Louisville was down by four points with a few minutes left on the clock. A UCLA player stole a pass and raced down the court where, after being bumped by a...

In the year 65, the Roman emperor Nero discovered that a group of nobles had hatched a conspiracy to kill him. The tyrant captured the suspects one by one and threatened them with torture; most confessed and implicated others. One of the conspirators, Epicharis, was publicly tortured -- her bones...

Long before word recently broke that white referees in the National Basketball Association were calling fouls at a higher rate on black athletes than on white athletes, and long before studies found racial disparities in how black and white applicants get called for job interviews, researchers no...

If you were Barack Obama, you would be scratching your head, too.

According to conventional wisdom, front-runners win presidential nominations. Democrats and Republicans who start the race for a presidential nomination with the largest amount of money and the best poll numbers are supposed to be the ones most likely to walk away with victory months later.

Last year, as the financial meltdown was getting underway, a scientist named Yaneer Bar-Yam developed a computer model of the economy. Instead of the individuals, companies and brokers that populate the real economy, the model used virtual actors. The computer world allowed Bar-Yam to do what...

As maritime arrivals climbed in 2015, EU policymakers struggled to mount a coordinated response. A range of ad hoc crisis-response tools emerged, but many officials worry that if another migration emergency were to hit Europe, the European Union may still be unprepared. This report traces the evolution of the EU response to the 2015–16 crisis and lays out recommendations to lock in progress and shore up weaknesses.

Over the last several years it has become clear that higher order assemblies on membranes, exemplified by signalosomes, are a paradigm for the regulation of many membrane signaling processes. We have recently combined two-color direct stochastic optical reconstruction microscopy (dSTORM) with the (Clus-DoC) algorithm that combines cluster detection and colocalization analysis to observe the organization of 5-lipoxygenase (5-LO) and 5-lipoxygenase–activating protein (FLAP) into higher order assemblies on the nuclear envelope of mast cells; these assemblies were linked to leukotriene (LT) C4 production. In this study we investigated whether higher order assemblies of 5-LO and FLAP included cytosolic phospholipase A2 (cPLA2) and were linked to LTB4 production in murine neutrophils. Using two- and three-color dSTORM supported by fluorescence lifetime imaging microscopy we identified higher order assemblies containing 40 molecules (median) (IQR: 23, 87) of 5-LO, and 53 molecules (62, 156) of FLAP monomer. 98 (18, 154) molecules of cPLA2 were clustered with 5-LO, and 77 (33, 114) molecules of cPLA2 were associated with FLAP. These assemblies were tightly linked to LTB4 formation. The activation-dependent close associations of cPLA2, FLAP, and 5-LO in higher order assemblies on the nuclear envelope support a model in which arachidonic acid is generated by cPLA2 in apposition to FLAP, facilitating its transfer to 5-LO to initiate LT synthesis.

BRUSSELS — While the European Union has called on Member States to expand channels for foreign workers as a way to meet labour market needs and potentially tackle spontaneous migration, they have struggled to deliver on this pledge. To date, policies have focused more on attracting high-skilled workers, but less attention has been paid to admission of low- or middle-skilled nationals. Policymakers would do well not to overestimate the potential of legal channels to reduce irregular migration.

This is the biscuit base to sprinkle in top of the cake Make enough to accomodate 22 cm round tin 50 g Unsalted Butter 50 g Raw Sugar 50 g Almond Meal 8 g of Coco Powder Pinch of Salt 40 g plain Flour Beat all ingredients together in machine with k beater Roll into oblong wrap in glad and freeze Cake mix 250 g eggs or 5 x large eggs 75 g of local honey 125 g castor sugar beat all ingredients together 75 g Almond Meal 120 g plain Flour 25 g coco powder 8 g Baking powder sieve ingredients Add to egg mix then add 120 ml of double Cream Melt together 70 g 70% best quality chocolate 75 g unsalted butter

400g ripe roma (plum) or pomodorino (baby plum) tomatoes 1 1/2 tablespoons chopped mint 1 teaspoon dried oregano 90g plain flour 1 teaspoon baking powder 1 teaspoon salt Light olive oil, or sunflower oil for pan-frying 250g Greek-style yogurt 1 tablespoon finely chopped dill Lemon wedges, to serve

Responsables de políticos principales y partes interesadas de América Latina, así como representantes de instituciones internacionales claves, ofrecen sus puntos de vista sobre los desafíos futuros mientras gobiernos latinoamericanos buscan establecer las estrategias para responder a flujos migratorios forzados a gran escala, como los de Venezuela y Nicaragua.

OBJECTIVE

Previous studies suggested that childhood prediabetes may develop prior to obesity and be associated with relative insulin deficiency. We proposed that the insulin-deficient phenotype is genetically determined and tested this hypothesis by longitudinal modeling of insulin and glucose traits with diabetes risk genotypes in the EarlyBird cohort.

OBJECTIVE

The Diabetes Control and Complications Trial (DCCT) and its observational follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) demonstrated the dominant role of glycemia, second only to age, as a risk factor for a first cardiovascular event in type 1 diabetes (T1D). We now investigate the association between established risk factors and the total cardiovascular disease (CVD) burden, including subsequent (i.e., recurrent) events.

Hey, it’s been quite some time without updates on this front, but our latest updates to our Android and iOS…

OBJECTIVE

To assess the efficacy and safety of MK-0941, a glucokinase activator (GKA), when added to stable-dose insulin glargine in patients with type 2 diabetes.

Responsables de políticos principales y partes interesadas de América Latina, así como representantes de instituciones internacionales claves, ofrecen sus puntos de vista sobre los desafíos futuros mientras gobiernos latinoamericanos buscan establecer las estrategias para responder a flujos migratorios forzados a gran escala, como los de Venezuela y Nicaragua.

“I’m a confused Mexican Jew.” So says Daniel Lubetzky, Founder and CEO of KIND Snack, in his very personal interview with Columbia faculty member David Rogers at BRITE ’16. Their discussion touched on the many ideas behind KIND Snacks, from the beginnings of the company, to the strategic thinking that forces Lubetzky to stay away […]

Margaret A. Powers
Apr 1, 2016; 34:70-80
Position Statements

Edward C. Chao
Jan 1, 2014; 32:4-11
Feature Articles

Evan M. Benjamin
Jan 1, 2002; 20:
Practical Pointers

James Chamberlain
Jul 1, 2013; 31:106-109
Feature Articles

The June 2020 issue of History of Psychiatry is now online. Full details follow below: “Wild melancholy. On the historical plausibility of a black bile theory of blood madness, or hæmatomania,” Jan Verplaetse. Abstract: Nineteenth-century art historian John Addington Symonds coined the term hæmatomania (blood madness) for the extremely bloodthirsty behaviour of a number of … Continue reading New History of Psychiatry: Melancholy, Madness, Chinese Psychiatry, Psychedelic Therapy, and More →

AHP readers may be interested in a recent piece on “History of Spanish Psychology, 1800–2000” in the Oxford Research Encyclopedia of Psychology. Full details below. “History of Spanish Psychology, 1800–2000,” by Javier Bandrés. Abstract: In the history of Spanish psychology in the 19th century, three stages can be distinguished. An eclectic first stage was defined … Continue reading History of Spanish Psychology, 1800–2000 →

Photographs of John Watson (left) and Rosalie Rayner (right) via Ben Harris. The May 2020 issue of History of Psychology is now online. The issue includes a special section on “Who Was Little Albert? The Historical Controversy.” Full details follow below. Special Section: Who Was Little Albert? The Historical Controversy“Journals, referees, and gatekeepers in the … Continue reading May HoP, including a Special Section: Who Was Little Albert? The Historical Controversy →

The clitoris is an organ that has been wildly misunderstood and mischaracterized for most of human history. The last three decades have dramatically changed the way that scientists think and talk about the clitoris; however, many myths and misconceptions remain.

In much of the world, gender is viewed as binary: man or woman, each assigned characteristics and traits designated by biological sex. But that's not the case everywhere, says France Villarta. In a talk that's part cultural love letter, part history lesson, he details the legacy of gender fluidity and inclusivity in his native Philippines -- and emphasizes the universal beauty of all people, regardless of society's labels.

Historian Elizabeth Stordeur Pryor leads a thoughtful and history-backed examination of one of the most divisive words in the English language: the N-word. Drawing from personal experience, she explains how reflecting on our points of encounter with the word can help promote productive discussions and, ultimately, create a framework that reshapes education around the complicated history of racism in the US.

The common thinking on biological sex goes like this: females have two X chromosomes in their cells, while males have one X and one Y. In this myth-busting talk, science writer and podcaster Molly Webster shows why the so-called "sex chromosomes" are more complicated than this simple definition -- and reveals why we should think about them differently.

Indigenous languages across North America are under threat of extinction due to the colonial legacy of cultural erasure, says linguist Lindsay Morcom. Highlighting grassroots strategies developed by the Anishinaabe people of Canada to revive their language and community, Morcom makes a passionate case for enacting policies that could protect Indigenous heritage for generations to come.

Health care workers are under more stress than ever before. How can they protect their mental health while handling new and complex pressures? TED Fellow Laurel Braitman shows how writing and sharing personal stories helps physicians, nurses, medical students and other health professionals connect more meaningfully with themselves and others -- and make their emotional well-being a priority.

A lovely short video about a mother who goes through the forensic mental health care system and recovers and regains custody of her son.

By Emily Reynolds. People are often required to adjust their behaviour to meet demands of apps, rather than technology being designed to meet our needs, researchers say.

Research findings on the implementation of a new teacher candidate performance assessment in Massachusetts inform the development of additional supports for educator preparation programs.

A collection of short news stories from this week.

Watch a discussion between three educators who ran for their state legislatures about their experiences on the campaign trail.

Lawmakers effectively killed the controversial education bill that had prompted the second statewide strike in two years.

A West Virginia official turns up the heat on financial disclosure for the state’s beleaguered schools, and ruffles feathers in the process.

In Arkansas, Ohio, and Wisconsin, educators and advocates will be on this year's ballot for governor, a position that will inevitably have an outsized role in shaping education policy.

Any discussion in politics of the future of education in Ohio inevitably turns to the Electronic Classroom of Tomorrow.

Watch a discussion between three educators who ran for their state legislatures about their experiences on the campaign trail.

Despite a $6,100 teacher pay raise this spring, school districts report that they're starting the new academic year with nearly 500 teaching vacancies.

"Teaching is a political act," argues teacher-turned-politician John Waldron. And it's going to take more organizing to rescue public education.