Considera que las demoras en la atención a pacientes no son constitutivas de delito Leer

El Ejecutivo foral prorroga el acuerdo firmado por los nacionalistas Urkullu y Uxue en 2016 para que los tres canales de la televisión vasca se capten en toda Navarra. UPN y PP critican la "gota malaya" de los contenidos elaborados desde Bilbao que el Gobierno de Navarra no puede controlar. El PNV asimila el convenio con el de Andalucía con Ceuta y Melilla Leer

Óscar Sánchez fue detenido la semana pasada en el marco de una operación dirigida por la Audiencia Nacional contra el narcotráfico Leer

Tarancón era el fundador de la marca deportiva Luanvi; Burdeos, de la empresa que elabora los productos con marca Bosque Verde y Deliplus; y Marín, fundador de Colegios del Siglo XXI, cuyo buque insignia es el conocido centro privado Mas Camarena. Leer

The new system, nearly a decade in the making, is crucial to agencies managing an ever-growing store of digital records.

The post National Archives prepares to ramp up work in new federal records system first appeared on Federal News Network.

Location: Main Library- HV5840.M3B57 2004

I’m using the Outlook app on my mobile device but it doesn’t seem to support the Online Archive as I can’t find it anywhere.

I tried to work around it by using Outlook on the Web in my browser, but that doesn’t show the Online Archive either even though it does show it when I use Outlook on the Web on my Desktop.

How do I access the Online Archive when I’m on my mobile?

The Hellenic Genocide in the Danish Archives

Re-release; Norris, D K. no. 58-5, 1958, 25 pages (1 sheet), https://doi.org/10.4095/101214

A £1 million project to digitise BT’s historical collection of photos and documents is set to bring 165 years of UK telecoms heritage to the public’s fingertips today

Esta y más ofertas laborales en La Luciérnaga.

I really gotta get off Twitter/X, but I'd like to have all my data on one service. Have any of the alternate federated services implemented an importer for archived data yet? If not, are there any good third-party ways to do this now?

I looked into this a couple years ago, before I set up my mefi.social Mastodon account. But I only found some GitHub repos with scripts to do things like this, and it looked like doing it on Mastodon, for instance, if you'd already created an account would run the risk of flooding the server you're on with your old posts.

But people have been leaving Twitter/X for a couple years now, and the services have had some time to catch up after the flood of initial interest. Is there a way to import this data? Especially is there a way to do this on Mastodon that won't spam mefi.social? Heh.

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En Caracol Radio estuvo Cathy Juvinao, representante a la Cámara, conversando sobre proyectos del Congreso

6AM Hoy por Hoy, José Camilo Guzmán, Director Seccional de Administración Judicial de Bogotá, informó sobre la suspensión del contrato para la construcción de la nueva bodega del archivo judicial.

The American musician and storyteller spoke with Eleanor Wachtel about her book All the Things I Lost in the Flood.

The Bermuda Archives is inviting the public to their upcoming 2nd Annual Open House on June 7, 2024, for International Archives Day, themed “Digitize It.” A Government spokesperson said, “The Bermuda Archives formally invites the public to visit us, get a rare glimpse of our repository and collection, and learn more about the Bermuda Archives […]

The Roddenberry Archive has begun a “multi-decade collaboration between The Gene Roddenberry Estate and OTOY...

Contributors this month include 2cross2affliction, dronon, earthfurst, GreenReaper, and Rakuen Growlithe.

read more

As you all know, I continue to use WordStar for DOS 7.0 as my word-processing program. It was last updated in December 1992, and the company that made it has been defunct for decades; the program is abandonware. There was no proper archive of WordStar for DOS 7.0 available online, so I decided to create […]

I’ve updated my WordStar for DOS 7.0 archive, based on feedback from the thousands of people who downloaded the initial public release (which was version 1.4, dated July 30, 2024).This new version is 1.5, dated August 12, 2024. The new version has the file size of the PDF manuals reduced (which cuts the archive size […]

If you'd like to subscribe to the newsletter, follow this link. You'll get around one newsletter per month. The newsletters have something about British–American linguistic relations (often linking to blog posts here), a bit about what I've been up to in my Lynneguist life (as well as things in the works), and links to things I've found interesting. 

Click here for the newsletter archive.

Twitter has been my main internet stomping ground since 2009, but I've been withdrawing my labo(u)r from it since October, when it became much more volatile for some reason. 

The New York Times Spelling Bee has been my morning-coffee activity for some of those years, and since November 2020 I've been jokingly tweeting the BrE words that it hasn't accepted. These go in a thread of posts that always start: 

Perfectly Common BrE Words the @NYTimesGames Spelling Bee Has Denied Me: An Occasional Series

Twitter has really degraded this week, which is making me feel a bit sad that perhaps that thread will have to die. (I'm also sad that the thread has frayed along the way—it's very difficult to read it all the way to the beginning because it splits here and there.) So as a clearly procrastinatory measure, I'm putting the list of "perfectly common BrE words" here, with a little more explanation than they tended to get on Twitter.

For those who don't know the Bee: it's an anagram game where one must use the middle letter. The twist—and what makes it a superior anagram game—is that you can use any of the letters as many times as you like. Here's what it looked like on the 5th of April when I hadn't yet got to Genius level.  (My goal every day is 'make it to Genius before breakfast'. It's nice to be called 'Genius' before you've started work.) 

The game, of course, has its own word list, which is suitably American for its New York Times home. Still, some not-usually-AmE words are playable, like FLATMATE, LORRY and PRAM. But many words that are part of my everyday vocabulary in England are not playable. And non-AmE spellings are generally not playable. 

There's been a lot of attention to AmE words that (orig. AmE) stump non-American players in Wordle. (Here's Cambridge Dictionary's 2022 Word of the Year post, which covers some—and includes a video in which I talk about why HOMER was a great choice for Word of the Year.) Not as much attention has been paid to the Spelling Bee, which you need to subscribe to. I'm sure British players have their own (mental) lists of American words they've had to learn in order to get "Queen Bee" status (finding all the day's words) in the game. If you're one of them, do use the comments to tell us about those weird words.

So, after all that preamble, here are the "Perfectly Common BrE Words the @NYTimesGames Spelling Bee Has Denied Me" words in alphabetical order, with translations or links to other blog posts. But first, a bit more preamble. The disclaimers! 

• Words in the puzzle must be at least four letters long, so some of these are suffixed forms for which the three-letter base word was unplayable. If there's an -ED form but not an -ING form (etc.), that'll be because the other one's letters weren't in the puzzle. 
• Some of these would not have been allowable—regardless of their dialectal provenance—on the basis that they are "naughty" words. I include them anyway. 
• I have checked questionable cases against the GloWbE corpus to ensure that the word really is more common in BrE than AmE.
• Some are Irish or Australian by origin, but they are still more common in BrE than in AmE.
• Sometimes my spelling is a bit liberal here. If I could find one British dictionary that allowed me the word with the given spelling, I included it.  
• Also the phrase "perfectly common" is not meant to be taken too seriously!
• These words were not playable at the time when I tried to play them. The word list may have changed and some of them may be playable now. 
• Red ones are ones that have been unsuccessfully played/tweeted about since I first started this blog list. Green ones have been added to the blog since the original post, but were tweeted-about earlier than that—I just missed them in the tangled Twitter threads when I was writing the blog post. 

AGGRO aggression, aggressive behavio[u]r

AITCH  the letter. Less need to spell it as a word in AmE. See this old post.

ANAEMIA / ANAEMIC  AmE anemia/anemic

ANNEXE  minority spelling in BrE; usually, as in AmE, it's annex

APNOEA  AmE apnea

APPAL   AmE appall; old post on double Ls

ARDOUR   old post on -or/-our

ARMOUR    -or/-our

BALLACHE   something annoying or tedious (usually hyphenated, but some dictionaries include the closed-up version)

BIBBED  I don't know why this shows up more in BrE data, but it does, just meaning 'wearing a bib'

BINMAN / BINMEN  AmE garbage man (among other terms); old post on bin

BINT  derogatory term for a woman

BITTY having lots of unconnected parts, often leaving one feeling unsatisfied; for example, this blog post is a bit bitty

BLAG covered in this old post

BLUB / BLUBBING to sob (= general English blubbering)

BOAK retch, vomit, throw up a bit in the mouth. That was gross. Sorry.

BOBBLY having bobbles 

BOBBY  I think this one might be playable now. Informal term for police officer. In AmE, found in bobby pins. 

BODGE / BODGED make or fix something badly

BOFFIN  see this old post

BOLLOCK / BOLLOCKED  reprimand severely

BOLLOX  This one's more common in Irish English than BrE. To screw something up.

BOKE   see BOAK 

BONCE  the head (informal)

BOYO a boy/man (Welsh informal)

BRILL  short for brilliant, meaning 'excellent'; also a kind of European flatfish

BROLLY  umbrella (informal)

BUNG / BUNGING to put (something) (somewhere) quickly/carelessly. People cooking on television are always bunging things in the oven. 

BUTTY  see this old post

CAFF  a café, but typically used of the kind that is analogous to an AmE diner (that is to say a café is not as fancy in BrE as it would be in AmE)

CAWL  a soupy Welsh dish (recipe); also a kind of basket

CEILIDH  a Scottish social dance (event)

CHANNELLED   post on double Ls

CHAPPIE  a chap (man)

CHAV / CHAVVY  see this old post and/or this one

CHICANE  a road arrangement meant to slow drivers down; see this old post

CHILLI  see this old post

CHIMENEA / CHIMINEA the 'e' spelling is considered etymologically "correct" but the 'i' spelling seems to be more common in UK; I think these kinds of outdoor fireplaces are just more trendy in UK than in US?

CHIPPIE alternative spelling of chippy, informal for a (fish and) chip shop

CHOLLA  a spelling of challah (the bread) 

CLAG  mud; more common is claggy for 'having a mud-like consistency'

COLOUR    -or/-our

CONNEXION this is a very outdated spelling of connection. Not actually used in UK these days, but wouldn't it be nice to be able to play it?

COOTCH  a hiding place, a shed or similar (from Welsh cwtch)

COUNCILLOR  post on double Ls

CRAIC it's really an Irish one (a 'good time'), but it qualifies here because it's used more in BrE than AmE (and understood pretty universally in UK)

CRIM  criminal

CUTTY  short (in some UK dialects)

DADO  as in dado rail, what's often called a chair rail in AmE (here's a picture)

DEFENCE  AmE defense

DEMOB /DEMOBBED  de-mobilize(d); that is, released from the (BrE) armed forces / (AmE) military

DENE  a valley (esp. a narrow, wooded one) or a low sand dune near the sea (regional)

DEVILLED  post on double Ls

DIALLING  post on double Ls

DIDDY    small (dialectal); see this old post

DOBBED / DOBBING  actually Australian, dob = to inform on someone; see this old post on the BrE equivalent grass (someone) up

DODDLE  it's a doddle  = (orig. AmE) it's a piece of cake (very easy)

DOOLALLY  out of one's mind

EQUALLED   post on double Ls

FAFF / FAFFING  one of the most useful BrE words. See this old post. 

FARL  a kind of (AmE) quick bread, usually cut into triangles; can be made of various things, but here's a recipe for a common kind, the potato farl

FAVOUR   -or/-our

FILMIC cinematic, relating to film

FITMENT = AmE fixture, i.e. a furnishing that is fit(ted) in place

FLANNELETTE = AmE flannel  old post on flannels

FLAVOUR   -or/-our

FLAVOURFUL   -or/-our

FOETAL AmE (and BrE medical) fetal

FOOTMAN a servant or (formerly soldier (of a particular rank)

FUELLED  post on double Ls

FULFIL   post on double Ls

GADGIE / GADGE guy, man, boy (regional)

GAMMON  this post covers the meat meaning, but lately it's also used as an insult for Brexiteers and their political similars

GAMMY  (of a body part) not working well; e.g., I have a gammy knee

GANNET a type of sea bird, but also BrE slang for a greedy person

GAOL  now less common spelling for jail

GIBBET  gallows; to hang (a person) [not really in current use]

GIGGED / GIGGING  to perform at a gig  [playable as of May 2023]

GILET   covered at this clothing post and also at this pronunciation post

GIPPING form of gip, a synonym of BOAK (see above)

GITE French, but used in English for a type of holiday/vacation cottage

GOBBED / GOBBING  form of gob, which as a noun means 'mouth', but as a verb means 'spit'

GOBBIN waste material from a mine

GOBBY mouthy

GOOLY (more often GOOLIE, GOOLEY) a testicle (informal, see GDoS)

GURN / GURNING  see this old post

HAITCH  = AITCH, but pronounced differently See this old post.

HALLO old-fashioned hello 

HENCH strong, fit (like a weightlifter)

HOLDALL  a duffel bag or similar heavy-duty bag; often spelled with a hyphen (hold-all), but at least some places don't. 

HOOPOE a kind of bird (mostly African), which sometimes makes it to England

HOGMANAY it is a proper noun, but I wanted to include it anyway

HOICK / HOIK  to lift/pull abruptly

HOTCHPOTCH  AmE hodgepodge

INNIT invariant tag question: isn't it? 

INVIGILATING AmE proctoring; old post

JAMMY  lucky; old post 

KIRK  church (Scotland)

KIPPING  form of kip, to take a nap

LAIRY  (esp. of a person) unpleasantly loud, garish 

LAMBING  form of to lamb, give birth to lambs. Often heard in lambing time or lambing season

LAMPED  form of to lamp, to hit a person very hard

LARKING  form of to lark,  'to behave in a silly way for fun'

LAYBY  AmE turnout (and other synonyms/regional terms); a place where a car can move out of the flow of traffic (usually has a hyphen lay-by, but I found one dictionary that doesn't require it)

LIDO an outdoor public swimming pool; there's some debate about how to pronounce it 

LILO  a blow-up mattress for floating on in a pool

LINO  short for linoleum

LOLLY  lollipop or (AmE) popsicle (especially in ice lolly)

LOVAGE  a(n) herb that Americans don't see very often  [has been added! Played successfully on 3 May 2023]

LUPIN  AmE lupine, a flower

LURGI / LURGY  see this old post

MEDIAEVAL  the less common spelling of medieval

MILLIARD  (no longer really used) a thousand million, i.e. a billion 

MILORD address term for a nobleman

MINGE  a woman's pubic hair/area (not flattering) 

MINGING  foul, bad smelling, ugly (rhymes with singing!)

MODELLED  post on double Ls

MOGGY  a cat (informal)

MOOB  man boob

MOULT    AmE molt (related to  -or/-our)

MOZZIE  mosquito

MUPPET in its lower-case BrE sense: 'idiot; incompetent person'

NAFF  this has come up in posts about 'untranslatables' and about a study that identified common BrE words Americans don't know

NAPPY AmE diaper

NAVVY  a manual labo(u)rer (old-fashioned)

NEEP  Scottish English for what the English call a swede and what Americans call a rutabaga (old post on the latter two)

NELLY in the BrE phrase not on your nelly (= AmE not on your life)

NIFFY unpleasant-smelling

NOBBLE  to unfairly influence an outcome; steal 

NOBBLY  alternative spelling of knobbly (which is more common in both AmE & BrE)

NONCY  adjective related to nonce (sex offender, p[a]edophile) 

NOWT  nothing (dialectal)

ODOUR    -or/-our

OFFENCE  AmE offense

OFFIE  short for BrE off-licence; AmE liquor store  (discussed a little in this old post) 

ORACY  the speaking version of literacy; in US education, it's called orality

PACY  having a good or exciting pace (e.g. a pacy whodunnit)

PAEDO  short for pa(e)dophile

PANTO see this post

PAPPED / PAPPING  from pap, to take paparazzi pictures

PARLOUR    -or/-our

PARP  a honking noise

PEDALLED   post on double Ls

PELMET  another one from the study that identified common BrE words Americans don't know

PENG  slang for 'excellent' 

PIEMAN / PIEMEN this one is usually two words (pie man), but I was able to find a dictionary that allowed it as a single word, so I added it to the list

PIPPED / PIPPING  pip = to defeat by a small amount; often heard in to be pipped at the post 

PITTA another spelling for pita, more in line with the BrE pronunciation of the word

PLAICE another one from the study that identified common BrE words Americans don't know

PLUMMY  see this post

PODGY  chubby

POMMY another Australian one, but English people know it because it's an insult directed at them, often in the phrase pommy bastard

PONCE / PONCY  see this post

PONGING horrible-smelling

POOED / POOING  see this post for the poo versus poop story

POOTLE to travel along at a leisurely speed

POPPADOM / POPPADUM anything to do with Indian food is going to be found more in UK than US

PORRIDGY  like porridge, which in AmE is oatmeal

PUFFA full form: puffa jacket; a kind of quilted jacket; it is a trademark, but used broadly; I did find it in one dictionary with a lower-case p

PUNNET  see this old post

RAILCARD  you buy one and it gives you discounts on train tickets

RANCOUR    -or/-our

RUMOUR     -or/-our

TANNOY  AmE loudspeaker, public address system  (originally a trademark, but now used generically)

TARTY dressed (etc.) in a provocative manner

TELLY  (orig.) AmE tv

TENCH a Eurasian fish

THALI  another Indian menu word 

THICKO  stupid person

TIDDY  small (dialectal) 

TIFFIN  usually referring to chocolate tiffin (recipe)

TINNING  AmE canning

TITBIT see this post

TITCH  a small person 

TIZZ = tizzy (to be in a tizz[y])

TOFF  an upper-class person (not a compliment)

TOMBOLA  see this post

TOTTED / TOTTING  see this post 

TOTTY  an objectifying term for (usually) a woman

TRUG  a kind of basket; these days, often a handled rubber container  

TUPPENCE  two pence

UNEQUALLED   post on double Ls

UNVETTED related to my 2008 Word of the Year 

VALOUR   -or/-our

VIVA  an oral exam (short for viva voce)

WANK / WANKING  my original Word of the Year (2006!)

WEEING  AmE peeing

WELLIE  / WELLY  a (BrE) wellington boot / (AmE) rubber boot

WHIN a plant (=furze, gorse)

WHINGE  AmE whine (complain)

WILLIE / WILLY  penis

WOAD a plant used to make blue dye

WOLD a clear, upland area (mostly in place names now)

WOOLLEN   post on double Ls

YOBBO / YOBBY  hooligan / hooliganish

YODELLED   post on double Ls

Systematic review produced by the EPPI-Centre in 2015.This systematic review aimed to evaluate the effect of HAART and ARV monotherapy on liver disease progression and liver-related mortality in individuals co-infected with HIV and hepatitis C, including in patients with haemophilia.

The last time we changed the site’s server, the archives stopped working. For anyone looking to relive the whole LFG adventure up to the indefinite hiatus, we offer this alternative. This is a work in progress, published early so that […]

The post Alternate Archive appeared first on Looking For Group.

Scientists have cured a handful of people of HIV by piggybacking on treatments they received for blood cancer. But does that bring a widespread cure any closer?

The Internet Archive, an online repository of web pages, was offline Thursday after its founder confirmed a major cyberattack that exposed the data of millions of users and left the site defaced.

Five years ago I was posting a lot to a publication called NewCo Shift, which is now offline. I got ahold of the archives, and found this review, which hasn’t lost any of its relevance – in fact, it kind of reads like it was written last week.  Everyone in tech loves Yuval Noah Harari. … Continue reading "From the Archive: Tech Must Get Over Its Superman Complex, Or We’re All Screwed"

RNA-protein interfaces control key replication events during the HIV-1 life cycle. The viral trans-activator of transcription (Tat) protein uses an archetypal arginine-rich motif (ARM) to recruit the host positive transcription elongation factor b (pTEFb) complex onto the viral trans-activation response (TAR) RNA, leading to activation of HIV transcription. Efforts to block this interaction have stimulated production of biologics designed to disrupt this essential RNA-protein interface. Here, we present four co-crystal structures of lab-evolved TAR-binding proteins (TBPs) in complex with HIV-1 TAR. Our results reveal that high-affinity binding requires a distinct sequence and spacing of arginines within a specific β2-β3 hairpin loop that arose during selection. Although loops with as many as five arginines were analyzed, only three arginines could bind simultaneously with major-groove guanines. Amino acids that promote backbone interactions within the β2-β3 loop were also observed to be important for high-affinity interactions. Based on structural and affinity analyses, we designed two cyclic peptide mimics of the TAR-binding β2-β3 loop sequences present in two high-affinity TBPs (KD values of 4.2 ± 0.3 and 3.0 ± 0.3 nm). Our efforts yielded low-molecular weight compounds that bind TAR with low micromolar affinity (KD values ranging from 3.6 to 22 μm). Significantly, one cyclic compound within this series blocked binding of the Tat-ARM peptide to TAR in solution assays, whereas its linear counterpart did not. Overall, this work provides insight into protein-mediated TAR recognition and lays the ground for the development of cyclic peptide inhibitors of a vital HIV-1 RNA-protein interaction.

The HIV-1 protein Gag assembles at the plasma membrane and drives virion budding, assisted by the cellular endosomal complex required for transport (ESCRT) proteins. Two ESCRT proteins, TSG101 and ALIX, bind to the Gag C-terminal p6 peptide. TSG101 binding is important for efficient HIV-1 release, but how ESCRTs contribute to the budding process and how their activity is coordinated with Gag assembly is poorly understood. Yeast, allowing genetic manipulation that is not easily available in human cells, has been used to characterize the cellular ESCRT function. Previous work reported Gag budding from yeast spheroplasts, but Gag release was ESCRT-independent. We developed a yeast model for ESCRT-dependent Gag release. We combined yeast genetics and Gag mutational analysis with Gag-ESCRT binding studies and the characterization of Gag-plasma membrane binding and Gag release. With our system, we identified a previously unknown interaction between ESCRT proteins and the Gag N-terminal protein region. Mutations in the Gag-plasma membrane–binding matrix domain that reduced Gag-ESCRT binding increased Gag-plasma membrane binding and Gag release. ESCRT knockout mutants showed that the release enhancement was an ESCRT-dependent effect. Similarly, matrix mutation enhanced Gag release from human HEK293 cells. Release enhancement partly depended on ALIX binding to p6, although binding site mutation did not impair WT Gag release. Accordingly, the relative affinity for matrix compared with p6 in GST-pulldown experiments was higher for ALIX than for TSG101. We suggest that a transient matrix-ESCRT interaction is replaced when Gag binds to the plasma membrane. This step may activate ESCRT proteins and thereby coordinate ESCRT function with virion assembly.