nl MonsterLabo updates The Beast fanless PC tower case By www.bit-tech.net Published On :: Mon, 25 Oct 2021 10:00:00 +0000 New design facilitates extended graphics card compatibility and customisable options. Full Article
nl PrimeStation Pulsar fanless workstation PC unveiled By www.bit-tech.net Published On :: Wed, 27 Oct 2021 10:00:00 +0000 Featuring the AMD Ryzen 7 PRO 5750G, this case=heatsink PC costs from $2,179. Full Article
nl Why do covid cases rise in summer, unlike other respiratory viruses? By www.newscientist.com Published On :: Thu, 22 Aug 2024 19:00:16 +0100 Flu and other respiratory viruses seem to barely exist outside of winter, but covid-19 cases have consistently risen every summer over the past few years Full Article
nl RFK Jr. launches online forum to crowdsource names for 4,000 Trump administration nominees By www.foxnews.com Published On :: Tue, 12 Nov 2024 14:32:54 -0500 Robert F. Kennedy Jr. launched a "Nominees for the People" forum to crowdsource 4,000 positions in the Trump administration to Make America Healthy Again. Full Article a2f26f21-fee7-5500-8e1a-89817bfc8e57 fnc Fox News fox-news/politics/elections/presidential/trump-transition fox-news/politics/elections fox-news/health fox-news/politics fox-news/person/donald-trump fox-news/politics article
nl William McGinley tapped as Trump's White House Counsel By www.foxnews.com Published On :: Tue, 12 Nov 2024 18:00:05 -0500 William McGinley is returning to the Trump White House to serve as his White House Counsel, President-elect Trump announced. Full Article 56b89cdf-1afe-5382-8a2c-5a66d2014e9d fnc Fox News fox-news/politics/elections/presidential/trump-transition fox-news/person/donald-trump fox-news/politics/executive/white-house fox-news/politics/judiciary/supreme-court fox-news/politics article
nl Donald Trump and Elon Musk: Could U.S. election's odd couple unleash a small-government revolution? By financialpost.com Published On :: Fri, 08 Nov 2024 20:04:45 +0000 The appointment of a political outsider like Musk could help Trump cut regulations and rein in government bureaucracy, even if the moves are unpopular Full Article Economy News
nl The Unlikely Inventor of the Automatic Rice Cooker By spectrum.ieee.org Published On :: Tue, 29 Oct 2024 14:00:04 +0000 “Cover, bring to a boil, then reduce heat. Simmer for 20 minutes.” These directions seem simple enough, and yet I have messed up many, many pots of rice over the years. My sympathies to anyone who’s ever had to boil rice on a stovetop, cook it in a clay pot over a kerosene or charcoal burner, or prepare it in a cast-iron cauldron. All hail the 1955 invention of the automatic rice cooker! How the automatic rice cooker was invented It isn’t often that housewives get credit in the annals of invention, but in the story of the automatic rice cooker, a woman takes center stage. That happened only after the first attempts at electrifying rice cooking, starting in the 1920s, turned out to be utter failures. Matsushita, Mitsubishi, and Sony all experimented with variations of placing electric heating coils inside wooden tubs or aluminum pots, but none of these cookers automatically switched off when the rice was done. The human cook—almost always a wife or daughter—still had to pay attention to avoid burning the rice. These electric rice cookers didn’t save any real time or effort, and they sold poorly. This article is part of our special report, “Reinventing Invention: Stories from Innovation’s Edge.” But Shogo Yamada, the energetic development manager of the electric appliance division for Toshiba, became convinced that his company could do better. In post–World War II Japan, he was demonstrating and selling electric washing machines all over the country. When he took a break from his sales pitch and actually talked to women about their daily household labors, he discovered that cooking rice—not laundry—was their most challenging chore. Rice was a mainstay of the Japanese diet, and women had to prepare it up to three times a day. It took hours of work, starting with getting up by 5:00 am to fan the flames of a kamado, a traditional earthenware stove fueled by charcoal or wood on which the rice pot was heated. The inability to properly mind the flame could earn a woman the label of “failed housewife.” In 1951, Yamada became the cheerleader of the rice cooker within Toshiba, which was understandably skittish given the past failures of other companies. To develop the product, he turned to Yoshitada Minami, the manager of a small family factory that produced electric water heaters for Toshiba. The water-heater business wasn’t great, and the factory was on the brink of bankruptcy. How Sources Influence the Telling of HistoryAs someone who does a lot of research online, I often come across websites that tell very interesting histories, but without any citations. It takes only a little bit of digging before I find entire passages copied and pasted from one site to another, and so I spend a tremendous amount of time trying to track down the original source. Accounts of popular consumer products, such as the rice cooker, are particularly prone to this problem. That’s not to say that popular accounts are necessarily wrong; plus they are often much more engaging than boring academic pieces. This is just me offering a note of caution because every story offers a different perspective depending on its sources.For example, many popular blogs sing the praises of Fumiko Minami and her tireless contributions to the development of the rice maker. But in my research, I found no mention of Minami before Helen Macnaughtan’s 2012 book chapter, “Building up Steam as Consumers: Women, Rice Cookers and the Consumption of Everyday Household Goods in Japan,” which itself was based on episode 42 of the Project X: Challengers documentary series that was produced by NHK and aired in 2002.If instead I had relied solely on the description of the rice cooker’s early development provided by the Toshiba Science Museum (here’s an archived page from 2007), this month’s column would have offered a detailed technical description of how uncooked rice has a crystalline structure, but as it cooks, it becomes a gelatinized starch. The museum’s website notes that few engineers had ever considered the nature of cooking rice before the rice-cooker project, and it refers simply to the “project team” that discovered the process. There’s no mention of Fumiko.Both stories are factually correct, but they emphasize different details. Sometimes it’s worth asking who is part of the “project team” because the answer might surprise you. —A.M.Although Minami understood the basic technical principles for an electric rice cooker, he didn’t know or appreciate the finer details of preparing perfect rice. And so Minami turned to his wife, Fumiko.Fumiko, the mother of six children, spent five years researching and testing to document the ideal recipe. She continued to make rice three times a day, carefully measuring water-to-rice ratios, noting temperatures and timings, and prototyping rice-cooker designs. Conventional wisdom was that the heat source needed to be adjusted continuously to guarantee fluffy rice, but Fumiko found that heating the water and rice to a boil and then cooking for exactly 20 minutes produced consistently good results.But how would an automatic rice cooker know when the 20 minutes was up? A suggestion came from Toshiba engineers. A working model based on a double boiler (a pot within a pot for indirect heating) used evaporation to mark time. While the rice cooked in the inset pot, a bimetallic switch measured the temperature in the external pot. Boiling water would hold at a constant 100 °C, but once it had evaporated, the temperature would soar. When the internal temperature of the double boiler surpassed 100 °C, the switch would bend and cut the circuit. One cup of boiling water in the external pot took 20 minutes to evaporate. The same basic principle is still used in modern cookers.Yamada wanted to ensure that the rice cooker worked in all climates, so Fumiko tested various prototypes in extreme conditions: on her rooftop in cold winters and scorching summers and near steamy bathrooms to mimic high humidity. When Fumiko became ill from testing outside, her children pitched in to help. None of the aluminum and glass prototypes, it turned out, could maintain their internal temperature in cold weather. The final design drew inspiration from the Hokkaidō region, Japan’s northernmost prefecture. Yamada had seen insulated cooking pots there, so the Minami family tried covering the rice cooker with a triple-layered iron exterior. It worked.How Toshiba sold its automatic rice cookerToshiba’s automatic rice cooker went on sale on 10 December 1955, but initially, sales were slow. It didn’t help that the rice cooker was priced at 3,200 yen, about a third of the average Japanese monthly salary. It took some salesmanship to convince women they needed the new appliance. This was Yamada’s time to shine. He demonstrated using the rice cooker to prepare takikomi gohan, a rice dish seasoned with dashi, soy sauce, and a selection of meats and vegetables. When the dish was cooked in a traditional kamado, the soy sauce often burned, making the rather simple dish difficult to master. Women who saw Yamada’s demo were impressed with the ease offered by the rice cooker.Another clever sales technique was to get electricity companies to serve as Toshiba distributors. At the time, Japan was facing a national power surplus stemming from the widespread replacement of carbon-filament lightbulbs with more efficient tungsten ones. The energy savings were so remarkable that operations at half of the country’s power plants had to be curtailed. But with utilities distributing Toshiba rice cookers, increased demand for electricity was baked in.Within a year, Toshiba was selling more than 200,000 rice cookers a month. Many of them came from the Minamis’ factory, which was rescued from near-bankruptcy in the process.How the automatic rice cooker conquered the worldFrom there, the story becomes an international one with complex localization issues. Japanese sushi rice is not the same as Thai sticky rice which is not the same as Persian tahdig, Indian basmati, Italian risotto, or Spanish paella. You see where I’m going with this. Every culture that has a unique rice dish almost always uses its own regional rice with its own preparation preferences. And so countries wanted their own type of automatic electric rice cooker (although some rejected automation in favor of traditional cooking methods).Yoshiko Nakano, a professor at the University of Hong Kong, wrote a book in 2009 about the localized/globalized nature of rice cookers. Where There Are Asians, There Are Rice Cookers traces the popularization of the rice cooker from Japan to China and then the world by way of Hong Kong. One of the key differences between the Japanese and Chinese rice cooker is that the latter has a glass lid, which Chinese cooks demanded so they could see when to add sausage. More innovation and diversification followed. Modern rice cookers have settings to give Iranians crispy rice at the bottom of the pot, one to let Thai customers cook noodles, one for perfect rice porridge, and one for steel-cut oats.My friend Hyungsub Choi, in his 2022 article “Before Localization: The Story of the Electric Rice Cooker in South Korea,” pushes back a bit on Nakano’s argument that countries were insistent on tailoring cookers to their tastes. From 1965, when the first domestic rice cooker appeared in South Korea, to the early 1990s, Korean manufacturers engaged in “conscious copying,” Choi argues. That is, they didn’t bother with either innovation or adaptation. As a result, most Koreans had to put up with inferior domestic models. Even after the Korean government made it a national goal to build a better rice cooker, manufacturers failed to deliver one, perhaps because none of the engineers involved knew how to cook rice. It’s a good reminder that the history of technology is not always the story of innovation and progress.Eventually, the Asian diaspora brought the rice cooker to all parts of the globe, including South Carolina, where I now live and which coincidentally has a long history of rice cultivation. I bought my first rice cooker on a whim, but not for its rice-cooking ability. I was intrigued by the yogurt-making function. Similar to rice, yogurt requires a constant temperature over a specific length of time. Although successful, my yogurt experiment was fleeting—store-bought was just too convenient. But the rice cooking blew my mind. Perfect rice. Every. Single. Time. I am never going back to overflowing pots of starchy water.Part of a continuing series looking at historical artifacts that embrace the boundless potential of technology.An abridged version of this article appears in the November 2024 print issue as “The Automatic Rice Cooker’s Unlikely Inventor.”ReferencesHelen Macnaughtan’s 2012 book chapter, “Building up Steam as Consumers: Women, Rice Cookers and the Consumption of Everyday Household Goods in Japan,” was a great resource in understanding the development of the Toshiba ER-4. The chapter appeared in The Historical Consumer: Consumption and Everyday Life in Japan, 1850-2000, edited by Penelope Francks and Janet Hunter (Palgrave Macmillan).Yoshiko Nakano’s book Where There are Asians, There are Rice Cookers (Hong Kong University Press, 2009) takes the story much further with her focus on the National (Panasonic) rice cooker and its adaptation and adoption around the world.The Toshiba Science Museum, in Kawasaki, Japan, where we sourced our main image of the original ER-4, closed to the public in June. I do not know what the future holds for its collections, but luckily some of its Web pages have been archived to continue to help researchers like me. Full Article Cooking Invention Kitchen appliance Past forward Rice cooker Toshiba Type:departments
nl The voice of America Online’s “You’ve got mail” has died at age 74 By arstechnica.com Published On :: Fri, 08 Nov 2024 16:13:47 +0000 His cassette recording, made for $200 in 1989, was a sound that defined an online generation. Full Article Tech 1989 1990s AOL Elwood Edwards email Harry McCracken Internet internet history Jimmy Fallon modem Obituaries obituary online history online services Quantum Link retrotech Steve Case Technologizer The Simpsons Tom Hanks You've Got Mail
nl The Tears of Unfathomable Sadness: SNL Cast Member Admits That Elon Musk Made Her Cry By twitchy.com Published On :: Tue, 12 Nov 2024 15:30:00 -0500 Full Article <![CDATA[crying]]> <![CDATA[Elon Musk]]> <![CDATA[saturday night live]]> <![CDATA[SNL]]>
nl Maximising Online Visibility and SEO for Restaurants: Tips and Techniques By www.chartsattack.com Published On :: Mon, 30 Sep 2024 10:48:10 +0000 In the bustling world of the restaurant industry, standing out is more challenging than ever. With diners increasingly turning to the internet to discover their next meal, having a strong online presence is crucial. This guide will show you practical tips and techniques to maximise your restaurant’s online visibility and enhance your SEO efforts. By […] The post Maximising Online Visibility and SEO for Restaurants: Tips and Techniques appeared first on Chart Attack. Full Article Business Online Visibility SEO SEO for Restaurants
nl How to Transform Your Online Presence with a Custom Website By www.chartsattack.com Published On :: Tue, 01 Oct 2024 07:14:33 +0000 In today’s digital age, your website is more than just a virtual storefront—it’s the heart of your online presence. Whether you’re a small business, a growing startup, or an established brand, a custom-designed website can be the key to standing out in a crowded market. But what does it take to truly transform your digital […] The post How to Transform Your Online Presence with a Custom Website appeared first on Chart Attack. Full Article Business Custom Website Online presence User Experience web design agency
nl President-Elect Donald Trump Picks William McGinley to Serve as White House Counsel By www.breitbart.com Published On :: Wed, 13 Nov 2024 01:35:16 +0000 President-elect Donald Trump revealed on Tuesday evening that he had chosen William McGinley to serve as his White House Counsel. The post President-Elect Donald Trump Picks William McGinley to Serve as White House Counsel appeared first on Breitbart. Full Article 2024 Election Politics Donald Trump Elise Stefanik Mike Huckabee Stephen Miller Trump cabinet
nl Unleashing Transformation By gigaom.com Published On :: Wed, 30 Oct 2024 15:49:34 +0000 AI isn’t just another tool in the technology toolkit; it’s a revolution waiting to be led. As tech leaders, this is your The post Unleashing Transformation appeared first on Gigaom. Full Article
nl Video game libraries lose legal appeal to emulate physical game collections online By arstechnica.com Published On :: Fri, 25 Oct 2024 19:25:44 +0000 Register of Copyrights sides with industry's "market harm" argument for rereleased games. Full Article Gaming Policy
nl Mohanlal - Shobana’s film helmed by Tharun Moorthy titled ‘Thudarum’ By www.thehindu.com Published On :: Sat, 09 Nov 2024 16:08:20 +0530 The supporting cast ‘Thudarum’ includes Binu Pappu, Maniyanpilla Raju, Farhaan Faasil, and Thomas Mathew Full Article Movies
nl Ohtani, Lindor, Marte finalists for NL MVP; Judge, Witt, Soto contend for AL honour By www.cbc.ca Published On :: Mon, 11 Nov 2024 20:37:57 EST Los Angeles Dodgers star Shohei Ohtani is a finalist for his first National League MVP award after winning the AL honor twice, joined among the top three in NL voting by New York Mets shortstop Francisco Lindor and Arizona second baseman Ketel Marte. Full Article Sports/Baseball/MLB
nl Gamescom 2024: Zenless Zone Zero, Honkai Star Rail, and Genshin Impact See New Announcements and Trailers By toucharcade.com Published On :: Wed, 21 Aug 2024 06:46:32 +0000 During Gamescom Opening Night Live 2024, HoYoverse had reveals and new information for each of its main games. Genshin Impact … Continue reading "Gamescom 2024: Zenless Zone Zero, Honkai Star Rail, and Genshin Impact See New Announcements and Trailers" Full Article Android Featured Free Games iPad Games iPhone games News Universal
nl ‘Squid Game: Unleashed’ Gets Full Trailer at Gamescom 2024, More Games Announced for Netflix By toucharcade.com Published On :: Wed, 21 Aug 2024 08:54:13 +0000 Following its announcement recently, Netflix’s upcoming multiplayer game based on Squid Game, Squid Game: Unleashed, has gotten its first reveal … Continue reading "‘Squid Game: Unleashed’ Gets Full Trailer at Gamescom 2024, More Games Announced for Netflix" Full Article Android Featured Games iPad Games iPhone games News Universal Upcoming Games Squid Game: Unleashed
nl Capcom Updates ‘Resident Evil 4', ‘Resident Evil Village’, and ‘Resident Evil 7’ on iOS With Online DRM By toucharcade.com Published On :: Tue, 27 Aug 2024 10:53:36 +0000 Usually, updates for premium priced ports on mobile are good to have for optimization or compatibility reasons, but Capcom’s newest … Continue reading "Capcom Updates ‘Resident Evil 4', ‘Resident Evil Village’, and ‘Resident Evil 7’ on iOS With Online DRM" Full Article Featured Free Games iPad Games iPhone games News Universal
nl Trump names longtime election attorney Bill McGinley as his White House counsel By www.npr.org Published On :: Tue, 12 Nov 2024 18:28:23 -0500 As White House Counsel, McGinley will be the point legal adviser for the president in regards to ethics, oversight and judicial nominations. He served as cabinet secretary during Trump's first term. Full Article
nl For console games, downloads are approaching a tipping point By arstechnica.com Published On :: Fri, 03 Nov 2017 16:18:05 +0000 Destiny 2's digital success could spell long-term trouble for discs Full Article Gaming business console digital downloads sales
nl Now on-demand: Ars’ online IT roundtable on navigating 2020 schadenfreude By arstechnica.com Published On :: Thu, 15 Oct 2020 18:03:49 +0000 Replay our October 15 chat on, “Finding certainty in IT when the world is uncertain.” Full Article Ars Technica Videos Biz & IT business dell-tech it uncertainty live live event livestream
nl Ars online IT roundtable: What’s the future of the data center? By arstechnica.com Published On :: Thu, 21 Jan 2021 19:30:45 +0000 Join Sean Gallagher, Dell's Ivan Nekrasov, and me today, January 21, at 3:15pm Eastern! Full Article Ars Technica Videos Biz & IT business datacenter dell-tech future of the datacenter live event livestream
nl SNL cast member reveals Elon Musk made her cry when he hosted the show By www.independent.co.uk Published On :: 2024-11-12T13:42:46+00:00 ‘I’m gonna come out and say it at long last,’ sketch show star said Full Article News TV & Radio Culture
nl Elon Musk doubles down on SNL star Chloe Fineman’s claims he made her cry By www.independent.co.uk Published On :: 2024-11-13T03:24:47+00:00 The Tesla CEO hosted ‘SNL’ in 2021 Full Article News TV & Radio Culture
nl Stay safe online By www.starobserver.com.au Published On :: Wed, 01 Apr 2020 00:52:54 +0000 STAY SAFE ONLINE With much of the real world now having been uploaded into cyberspace, the amount of time and number of things you do online has probably increased dramatically. ... The post Stay safe online appeared first on Star Observer. Full Article Coronavirus (COVID-19) Features Healthy Living Life + Style News
nl Secret tape not the only talking point By www.couriermail.com.au Published On :: Wed, 29 Jun 2016 14:00:00 GMT THE reasons behind a decision to release a secret expletive-laden recording of former Chief Justice Tim Carmody are almost as juicy as the tape is expected to be. Full Article
nl Mattel apologizes for mistakenly printing porn website on Wicked toy doll packaging By www.cbc.ca Published On :: Mon, 11 Nov 2024 13:08:11 EST Toy giant Mattel says it "deeply" regrets an error on the packaging of its Wicked movie-themed dolls, which mistakenly links toy buyers to a pornographic website. Full Article News/Entertainment
nl Influenceur en cryptomonnaie enlevé dans le Vieux-Montréal: le corps décomposé de Kevin Mirshahi retrouvé By www.journaldemontreal.com Published On :: Tue, 12 Nov 2024 11:34:23 EST Le corps ligoté en état de décomposition retrouvé le 30 octobre dans l’un des parcs les plus achalandés de Montréal est celui de Kevin Mirshahi. Full Article
nl Enlevée par ses frères dans un resto: «Elle criait d’appeler le 911» By www.journaldemontreal.com Published On :: Tue, 12 Nov 2024 16:16:35 EST Une ado qui aurait été enlevée de force par ses propres frères était en panique et criait d’appeler le 911, selon un témoin appelé au procès. Full Article
nl Cineplex says it will make online purchase fee more obvious following penalty By www.cbc.ca Published On :: Wed, 06 Nov 2024 16:52:38 EST Cineplex Inc. says it will continue adding a fee to some online ticket purchases after being penalized earlier this fall for alleged deceptive marketing, but it will adjust how the charge is communicated to moviegoers. Full Article News/Business
nl Annual rental prices fell for the 1st time in over three years, but only in big cities By www.cbc.ca Published On :: Thu, 07 Nov 2024 13:23:14 EST Canadian rental prices fell 1.2 per cent in October compared to the same time last year. It's the first time that annual rents have declined since July 2021, according to a new report. Full Article News/Business
nl Port of Montreal employer threatens lockout Sunday unless union agrees to 'final' offer By www.cbc.ca Published On :: Fri, 08 Nov 2024 15:50:41 EST The employers' association is threatening to lock out workers at 9 p.m. Sunday if a deal isn't reached. Full Article News/Canada/Montreal
nl How an alleged Russian plot suddenly upended Canada's air cargo rules By www.cbc.ca Published On :: Sat, 09 Nov 2024 04:00:49 EST Transport Canada quietly changed air cargo importation rules for 55 mostly European countries in September, throwing the system into chaos — all in response to an alleged Russian plot to place firebombs on planes destined for North America. Full Article News/Canada
nl Holiday in Greenland? New airports aim to entice tourists By www.bbc.com Published On :: Sun, 20 Oct 2024 23:27:58 GMT The Arctic territory hopes that three new airports will pave the way for direct flights from the US and Europe. Full Article
nl National online certificate course for pathologists on cervical cancer screening to begin from November 25 By www.pharmabiz.com Published On :: Saturday, November 9, 2024 08:00 IST The Indian Council of Medical Research─National Institute of Cancer Prevention and Research (ICMR─NICPR) is set to launch its first─ever DHR─funded National NICPR─ECHO online certificate course on cervical Full Article
nl FTC Announces Final Rule to Prohibit Deceptive Online Reviews and Testimonials By cohealthcom.org Published On :: Thu, 22 Aug 2024 18:56:13 +0000 Effective on October 21st of this year, the Federal Trade Commission (FTC) issued a new final rule that is intended to better combat “fake” reviews and testimonials by prohibiting the sale or purchase of “fake reviews” as well as granting the agency the opportunity to seek civil penalties against willful violators. The FTC made only […] Full Article Regulatory/FDA Endorsement Guide FAQs FTC guidance Jim Potter
nl Massachusetts High Court Rules Online Tracking Doesn’t Violate State Wiretap Law By cohealthcom.org Published On :: Wed, 30 Oct 2024 12:23:03 +0000 Sorry, but you do not have permission to view this content. Full Article Courts/First Amendment
nl MHRA to consult on making two progestogen-only contraceptives available without a prescription By www.pharmaceutical-journal.com Published On :: Mon, 15 Feb 2021 12:22 GMT Consultations on the reclassification of two progestogen-only contraceptive pills from prescription-only to pharmacy medicines have been launched. Full Article
nl Online yoga classes prove helpful for back pain in new study By www.npr.org Published On :: Tue, 12 Nov 2024 08:00:00 -0500 Participant reported relief from chronic low back pain and reduced need for pain-relief medications. Full Article
nl Menjelajahi Dunia Keajaiban Slot Online Pragmatic Play By biosimilarnews.com Published On :: Fri, 16 Feb 2024 09:20:08 +0000 Dunia perjudian daring telah menyaksikan kemunculan penyedia perangkat lunak yang menghebohkan, dan di antara mereka, Pragmatic Play telah berhasil menarik perhatian para pemain dengan berbagai slot online unggulan. Dalam artikel… The post Menjelajahi Dunia Keajaiban Slot Online Pragmatic Play appeared first on Biosimilarnews. Full Article News Review Tips & Trik
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nl Tiny Biosensor Unlocks the Secrets of Sweat By spectrum.ieee.org Published On :: Wed, 24 Apr 2024 15:00:04 +0000 Sweat: We all do it. It plays an essential role in controlling body temperature by cooling the skin through evaporation. But it can also carry salts and other molecules out of the body in the process. In medieval Europe, people would lick babies; if the skin was salty, they knew that serious illness was likely. (We now know that salty skin can be an indicator for cystic fibrosis.)Scientists continue to study how the materials in sweat can reveal details about an individual’s health, but often they must rely on gathering samples from subjects during strenuous exercise in order to get samples that are sufficiently large for analysis.Now researchers in China have developed a wearable sensor system that can collect and process small amounts of sweat while providing continuous detection. They have named the design a “skin-interfaced intelligent graphene nanoelectronic” patch, or SIGN for short. The researchers, who described their work in a paper published in Advanced Functional Materials, did not respond to IEEE Spectrum’s interview requests. The SIGN sensor patch relies on three separate components to accomplish its task. First, the sweat must be transported from the skin into microfluidic chambers. Next, a special membrane removes impurities from the fluid. Finally, this liquid is delivered to a bioreceptor that can be tuned to detect different metabolites.The transport system relies on a combination of hydrophilic (water-attracting) and hydrophobic (water-repelling) materials. This system can move aqueous solutions along microchannels, even against gravity. This makes it possible to transport small samples with precision, regardless of the device’s orientation.The fluid is transported to a Janus membrane, where impurities are blocked. This means that the sample that reaches the sensor is more likely to produce accurate results.Finally, the purified sweat arrives at a flexible biosensor. This graphene sensor is activated by enzymes designed to detect the desired biomarker. The result is a transistor that can accurately measure the amount of the biomarker in the sample. At its center, the system has a membrane that removes impurities from sweat and a biosensor that detects biomarkers.Harbin Institute of Technology/Shenyang Aerospace UniversityOne interesting feature of the SIGN patch is that it can provide continuous measurements. The researchers tested the device through multiple cycles of samples with known concentrations of a target biomarker, and it was about as accurate after five cycles as it was after just one. This result suggests that it could be worn over an extended period without having to be replaced.Continuous measurements can provide useful longitudinal data. However, Tess Skyrme, a senior technology analyst at the research firm IDTechEx, points out that continuous devices can have very different sampling rates. “Overall, the right balance of efficient, comfortable, and granular data collection is necessary to disrupt the market,” she says, noting that devices also need to optimize “battery life, calibration, and data accuracy.”The researchers have focused on lactate—a metabolite that can be used to assess a person’s levels of exercise and fatigue—as the initial biomarker to be detected. This function is of particular interest to athletes, but it can also be used to monitor the health status of workers in jobs that require strenuous physical activity, especially in hazardous or extreme working conditions.Not all experts are convinced that biomarkers in sweat can provide accurate health data. Jason Heikenfeld, director of the Novel Device Lab at the University of Cincinnati, has pivoted his research on wearable biosensing from sweat to the interstitial fluid between blood vessels and cells. “Sweat glucose and lactate are way inferior to measures that can be made in interstitial fluid with devices like glucose monitors,” he tells Spectrum.The researchers also developed a package to house the sensor. It’s designed to minimize power consumption, using a low-power microcontroller, and it includes a Bluetooth communications chip to transmit data wirelessly from the SIGN patch. The initial design provides for 2 hours of continuous use without charging, or up to 20 hours in standby mode. Full Article Health monitoring Microchannels Sweat Wearable sensor
nl Unlocking the Future of Radioligand Therapy: From Discovery to Delivering at Scale By medcitynews.com Published On :: Tue, 12 Nov 2024 14:50:00 +0000 As radiopharmaceuticals enter a new phase, industry leaders must rethink external services and internal capabilities to master the complexities of delivering advanced therapies. The post Unlocking the Future of Radioligand Therapy: From Discovery to Delivering at Scale appeared first on MedCity News. Full Article BioPharma Daily MedCity Influencers Pharma Pharmacy biopharma nl Cancer Treatment pharmaceuticals radioligand therapy RLT
nl Spatial Dependence, Nonlinear Panel Models, and More New Features in SAS/ETS 14.1 By support.sas.com Published On :: 2016-08-12T12:00:00Z This paper highlights the many enhancements to SAS/ETS software and demonstrates how these features can help your organization increase revenue and enhance productivity. Full Article
nl Fitting Multilevel Hierarchical Mixed Models Using PROC NLMIXED By support.sas.com Published On :: 2016-10-06T12:00:00Z This paper provides an example that shows you how to use multiple RANDOM statements in PROC NLMIXED to fit nested nonlinear mixed models, and it provides details about the computation that is involved in fitting these models. Full Article
nl How Online Privacy Is Like Fishing By www.belfercenter.org Published On :: Jun 3, 2024 Jun 3, 2024 In the wake of a Microsoft spying controversy, it’s time for an ecosystem perspective. Full Article
nl The Government Isn't Ready for the Violence Trump Might Unleash By www.belfercenter.org Published On :: Apr 7, 2024 Apr 7, 2024 Juliette Kayyem argues that the Biden administration should lay out transparent plans to safeguard the electoral process no matter who is ultimately sworn in. Full Article