The show stars Ella Purnell, Aaron Moten, Kyle MacLachlan, and Walton Goggins, among others, and quickly gained popularity with a massive 65 million views within 16 days of its Season 1 release in April

The documentary features accounts from friends and colleagues, including Rana Daggubatti, Taapsee Pannu, and Nagarjuna Akkineni

Nolan has set up his much-awaited ‘Oppenheimer’ follow-up at Universal Pictures, eyeing a mid-2026 IMAX release 

His significant contributions to horror cinema led to his recognition with a Lifetime Achievement Award at the New York City Horror Film Festival

Set in a near future where an unknown disease has ravaged American society, the story follows a civilian pilot living a solitary life on an abandoned Colorado airbase with his dog and a tough ex-Marine

The 90-second trailer, which was delayed several times before being released, offers minimal details but hints at themes of prophecy, betrayal, and resurrection

Released in 1993 and directed by the Abbas-Mustan duo, ‘Baazigar’ was a game-changer for Shah Rukh Khan’s career, marking his debut in an anti-hero role that diverged sharply from typical Bollywood protagonists of that era

Earlier this year, Feral Interactive’s superb iOS version of Alien: Isolation (Free) was updated to change the game’s business model …

Continue reading "‘Alien: Isolation’ for Android Is Now a Free To Start Release Just Like iOS Letting Everyone Try Two Missions for Free"

During Gamescom Opening Night Live 2024, HoYoverse had reveals and new information for each of its main games. Genshin Impact …

Continue reading "Gamescom 2024: Zenless Zone Zero, Honkai Star Rail, and Genshin Impact See New Announcements and Trailers"

Hello gentle readers, and welcome to the SwitchArcade Round-Up for August 27th, 2024. In today’s article, we kick things off …

Continue reading "SwitchArcade Round-Up: Today’s Nintendo Direct, Full Review of ‘EGGCONSOLE Star Trader’, Plus New Releases and Sales"

HoYoverse’s Honkai Star Rail (Free) version 2.5 update titled “Flying Aureus Shot to Lupine Rue" was just showcased during a …

Continue reading "‘Honkai Star Rail’ Version 2.5 “Flying Aureus Shot to Lupine Rue” Update Releases on September 10th, New Trailer Showcased During Livestream"

Hello everyone, and welcome to the week! It’s time once again for our look back at the noteworthy updates of …

Continue reading "Best iPhone Game Updates: ‘Peglin’, ‘Brawl Stars’, ‘Genshin Impact’, ‘Royal Match’, and More"

Harvest Moon: Home Sweet Home has been a very interesting game to follow pre-release. I say this not only because …

Continue reading "‘Harvest Moon: Home Sweet Home’ iOS Review – A Great Start, but Needs More Work"

Welcome to this week’s edition of the Steam Deck Weekly. If you missed my Warhammer 40000: Space Marine 2 Steam …

Continue reading "Steam Deck Weekly: NBA 2K25, ARCO, ODDADA, DATE a LIVE Ren Dystopia, Star Trucker, Skull and Bones, & More Reviews With New Verified Games"

Single-player campaign, ranked multiplayer available free of charge.

The grant program provides hardware startups with reimbursement for working with local manufacturers.

Jason, 84, said senior actors had a ‘tremendous amount to offer’

Viewers were left stunned by ‘savage’ exit of character in first episode of new season

The Tesla CEO hosted ‘SNL’ in 2021

The ‘Scream Queens’ actor revealed her white co-star made a ‘weighted’ reference to Martin Luther King

December 31, 2020 at 11.59 pm – across the world there was a collective sigh of relief that the ‘lost year’ is truly behind us. The end of a year, ...

The post Start 2021 Fresh With These 12 New Year Resolutions appeared first on Star Observer.

A voyage in this kind of spacecraft — while still conceptual — would take multiple lifetimes, crossing unimaginable gulfs of interstellar space. The theoretical exercise puts aside technical problems, including the propulsion system, and focusses on the design of the habitat and society.

Signal users may be familiar with the problem of creating group chats just for a group call, but that’s about to become a thing of the past. You can now share a call link and let up to 50 people hop in, all in the span of a few seconds. The days of selecting contacts one by one are over.

Now, all you have to do is create a call link after going to the Calls tab and send it to whomever you want. The link is also reusable, which is convenient if you have fixed call times. Participants can raise their hands and send emojis. Hosts can set the room up so people must be approved before joining the conversation.

Based on Signal’s blog post, the new group call experience highly resembles Zoom. Those interested in privacy yet desire a conference call-like experience may find the new update helpful. Like Zoom, the desktop app offers more options.

Besides Zoom, these features will be familiar to frequent users of Microsoft Teams, Google Meet and some WhatsApp users. Raising hands is found on all three platforms as a non-verbal way to signal the speaker. WhatsApp does have a lower participant count of 32 people after an update in June. While there’s no raise hands function, doing certain gestures can send emojis for all to see. It’s worth noting that many apps with group call functionality are adopting similar features.

These new features are available on Android, iOS, Windows and macOS. If you don’t see them yet, we recommend updating your Signal app.

Actor Elliot Page and musician Rufus Wainwright were among the stars who honoured 2SLGBTQ+ charities at the inaugural PTP Pink Awards in Toronto Thursday, in the shadow of a U.S. election that has many worried about queer and trans rights.

Actor Tony Todd, known for his haunting portrayal of a killer in the horror film Candyman and roles in many other films and television shows, has died, says his longtime manager.

If it seems like the Christmas shopping season starts earlier every year, you're not wrong. In response to growing customer demand, stores of all stripes brought out their festive collections weeks before the unofficial start of the holiday shopping season.

SEMI Radradra’s sister has directly contradicted reports in the Fiji Times that her brother was leaving the NRL for French rugby.

Seth Messingham from Hornsby North Public School and Zac “Nugget” Bovis from Berowra Public School represented North Sydney in the NSW PSSA Boy’s football State Carnival at Valentine Sports Park in Glenwood to secure a win North Sydney hasn’t seen since 1969.

SYDNEY FC headed to Barker College last week to promote their upcoming school holiday bootcamps which they hope will uncover the next Ronaldo.

Venture creation in biotech is witnessing a sustained contraction. After the pandemic bubble’s over-indulgence, the venture ecosystem appears to have reset its pace of launching new startups. According to the latest Pitchbook data, venture creation in biotech hit its slowest

The post The Biotech Startup Contraction Continues… And That’s A Good Thing appeared first on LifeSciVC.

By Arthur O. Tzianabos, PhD, CEO of Lifordi Immunotherapeutics, as part of the From the Trenches feature of LifeSciVC As the biotech industry continues to pick up steam, I have been getting a number of phone calls from folks in

The post Stars and Scars… Some Lessons Learned About Leadership appeared first on LifeSciVC.

Tech startups are stepping up to meet the needs of 60 million people worldwide who use opioids, representing about 1 percent of the world’s adult population. In the United States, deaths involving synthetic opioids have risen 1,040 percent from 2013 to 2019. The COVID-19 pandemic and continued prevalence of fentanyl have since worsened the toll, with an estimated 81,083 fatal overdoses in 2023 alone.

Innovations include biometric monitoring systems that help doctors determine proper medication dosages, nerve stimulators that relieve withdrawal symptoms, wearable and ingestible systems that watch for signs of an overdose, and autonomous drug delivery systems that could prevent overdose deaths.

Helping Patients Get the Dosage They Need

For decades, opioid blockers and other medications that suppress cravings have been the primary treatment tool for opioid addiction. However, despite its clinical dominance, this approach remains underutilized. In the United States, only about 22 percent of the 2.5 million adults with opioid use disorder receive medication-assisted therapy such as methadone, Suboxone, and similar drugs.

Determining patients’ ideal dosage during the early stages of treatment is crucial for keeping them in recovery programs. The shift from heroin to potent synthetic opioids, like fentanyl, has complicated this process, as the typical recommended medication doses can be too low for those with a high fentanyl tolerance.

A North Carolina-based startup is developing a predictive algorithm to help clinicians tailor these protocols and track real-time progress with biometric data. OpiAID, which is currently working with 1,000 patients across three clinical sites, recently launched a research pilot with virtual treatment provider Bicycle Health. Patients taking Suboxone will wear a Samsung Galaxy Watch6 to measure their heart rate, body movements, and skin temperature. OpiAID CEO David Reeser says clinicians can derive unique stress indications from this data, particularly during withdrawal. (He declined to share specifics on how the algorithm works.)

“Identifying stress biometrically plays a role in how resilient someone will be,” Reeser adds. “For instance, poor heart rate variability during sleep could indicate that a patient may be more susceptible that day. In the presence of measurable amounts of withdrawal, the potential for relapse on illicit medications may be more likely.”

Nerve Stimulators Provide Opioid Withdrawal Relief

While OpiAID’s software solution relies on monitoring patients, electrical nerve stimulation devices take direct action. These behind-the-ear wearables distribute electrodes at nerve endings around the ear and send electrical pulses to block pain signals and relieve withdrawal symptoms like anxiety and nausea.

The U.S. Food and Drug Administration (FDA) has cleared several nerve stimulator devices, such as DyAnsys’ Drug Relief, which periodically administers low-level electrical pulses to the ear’s cranial nerves. Others include Spark Biomedical’s Sparrow system and NET Recovery’s NETNeuro device.

Masimo’s behind-the-ear Bridge device costs US $595 for treatment providers.Masimo

Similarly, Masimo’s Bridge relieves withdrawal symptoms by stimulating the brain and spinal cord via electrodes. The device is intended to help patients initiating, transitioning into, or tapering off medication-assisted treatment. In a clinical trial, Bridge reduced symptom severity by 85 percent in the first hour and 97 percent by the fifth day. A Masimo spokesperson said the company’s typical customers are treatment providers and correctional facilities, though it’s also seeing interest from emergency room physicians.

Devices Monitor Blood Oxygen to Prevent Overdose Deaths

In 2023, the FDA cleared Masimo’s Opioid Halo device to monitor blood oxygen levels and alert emergency contacts if it detects opioid-induced respiratory depression, the leading cause of overdose deaths. The product includes a pulse oximeter cable and disposable sensors connected to a mobile app.

Opioid Halo utilizes Masimo’s signal extraction technology, first developed in the 1990s, which improves upon conventional oxygen monitoring techniques by filtering out artifacts caused by blood movement. Masimo employs four signal-processing engines to distinguish the true signal from noise that can lead to false alarms; for example, they distinguish between arterial blood and low-oxygen venous blood.

Masimo’s Opioid Halo system is available over-the-counter without a prescription. Masimo

Opioid Halo is available over-the-counter for US $250. A spokesperson says sales have continued to show promise as more healthcare providers recommend it to high-risk patients.

An Ingestible Sensor to Watch Over Patients

Last year, in a first-in-human clinical study, doctors used an ingestible sensor to monitor vital signs from patients’ stomachs. Researchers analyzed the breathing patterns and heart rates of 10 sleep study patients at West Virginia University. Some participants had episodes of central sleep apnea, which can be a proxy for opioid-induced respiratory depression. The capsule transmitted this data wirelessly to external equipment linked to the cloud.

Celero’s Rescue-Rx capsule would reside in a user’s stomach for one week.Benjamin Pless/Celero Systems

“To our knowledge, this is the first time anyone has demonstrated the ability to accurately monitor human cardiac and respiratory signals from an ingestible device,” says Benjamin Pless, one of the study’s co-authors. “This was done using very low-power circuitry including a radio, microprocessor, and accelerometer along with software for distinguishing various physiological signals.”

Pless and colleagues from MIT and Harvard Medical School started Celero Systems to commercialize a modified version of that capsule, one that will also release an opioid antagonist after detecting respiratory depression. Pless, Celero’s CEO, says the team has successfully demonstrated the delivery of nalmefene, an opioid antagonist similar to Narcan, to rapidly reverse overdoses.

Celero’s next step is integrating the vitals-monitoring feature for human trials. The company’s final device, Rescue-Rx, is intended to stay in the stomach for one week before passing naturally. Pless says Rescue-Rx’s ingestible format will make the therapy cheaper and more accessible than wearable autoinjectors or implants.

Celero’s capsule can detect vital signs from within the stomach. www.youtube.com

Autonomous Delivery of Overdose Medication

Rescue-Rx isn’t the only autonomous drug-delivery project under development. A recent IEEE Transactions on Biomedical Circuits and Systems paper introduced a wrist-worn near-infrared spectroscopy sensor to detect low blood oxygen levels related to an overdose.

Purdue University biomedical engineering professor Hugh Lee and graduate student Juan Mesa, who both co-authored the study, say that while additional human experiments are necessary, the findings represent a valuable tool in counteracting the epidemic. “Our wearable device consistently detected low-oxygenation events, triggered alarms, and activated the circuitry designed to release the antidote through the implantable capsule,” they wrote in an email.

Lee and Purdue colleagues founded Rescue Biomedical to commercialize the A2D2 system, which includes a wristband and an implanted naloxone capsule that releases the drug if oxygen levels drop below 90 percent. Next, the team will evaluate the closed-loop system in mice.

This story was updated on 27 August 2024 to correct the name of Masimo’s Opioid Halo device.

While startups in highly regulated industries like healthcare and finance are almost certain to face heightened scrutiny, there are controllable factors that can offset these challenges.

The post The Startup Economy is Turbulent. Here’s How Founders Can Recognize and Avoid Common Pitfalls appeared first on MedCity News.

Denzel Washington has confirmed he will star in Black Panther 3 before his retirement. The 69-year-old actor is the first to talk about the existence of a third film in the blockbuster Marvel franchise — which will follow the 2018 original and 2022 sequel Black Panther: Wakanda Forever — and has also revealed the film will be among a handful of roles he will take on before he bows out of acting after a career spanning four decades. Confirming director Ryan Coogler has written a role just for the Oscar-winner for the third instalment, Denzel told Australia's Today show: "At this point in my career, I'm only interested in working with the best, I don't know how many more films I will make, probably not that many. I want to do things that I haven't done." Sharing the roles he has lined up before he bids farewell to his Hollywood career, he said: "I played Othello at 22, I'm now going to play it at 70. After that, I'm playing Hannibal. After that, I've been talking with Steve McQueen about a film. After that, Ryan Coogler is writing a part for me in the next Black Panther.

UNITED NATIONS — The United States stressed at the United Nations (UN) on Tuesday (Nov 12) that "there must be no forcible displacement, nor policy of starvation in Gaza" by Israel, warning such policies would have grave implications under US and international law. The remarks by US Ambassador to the UN Linda Thomas-Greenfield came just hours after Washington said its ally Israel was doing enough to address the humanitarian crisis in Israel to avoid facing potential restrictions on US military aid. "Still, Israel must ensure its actions are fully implemented - and its improvements sustained over time," Thomas-Greenfield told the UN Security Council. It was also urgently important that Israel pause implementation of a law banning the operation of the UN Palestinian relief agency UNRWA, she added.

KOLKATA — A court in the eastern state of West Bengal began the trial on Monday (Nov 11) of a police volunteer accused of raping and murdering a doctor at a government hospital in August, a case that sparked outrage over the lack of safety for women in India. The woman's body was found in a classroom at the R.G. Kar Medical College and Hospital in the state capital Kolkata on Aug 9, the federal police said. They also said they had arrested a police volunteer, Sanjay Roy, for the crime.

The estranged DMK M.P. spoke about party's corrupt image & predicted its downfall; criticised ‘freebies'; praised Rahul Gandhi; was ‘very downbeat' about United Progressive Alliance's electoral prospects

Sep 2, 2015

"The seed industry in sub-Saharan Africa is informal in nature, with approximately 80% of farmers saving and replanting seeds from year to year. This gives them security of access. But improved varieties — including high-yielding and hybrid crops — will increase productivity and income. To get these seeds into the hands of farmers, a better marketing and distribution system is needed. Local small and medium-sized seed enterprises have a comparative advantage in reaching this underserved market due to their size and market reach."

Oct 26, 2015

"African leaders would like to escape the colonial trap of being viewed simply as raw material exporters. But their efforts to add value to the materials continue to be frustrated by existing EU policies."

JJ Abrams sought the authenticity of Skellig Michael for Star Wars � The Force Awakens

Discover the complete story behind the making of Star Wars: The Force Awakens when it comes to Digital HD April 1, and Blu-ray Combo Pack & DVD April 5.

International Stars at the Closing of the XVIII Habanos Festival

�El Vato� :30 sec video promo

Two Jedi performers ascend the world�s tallest building