President-elect Donald Trump's reelection was credited for emboldening a group of people waving Nazi flags in Michigan over the weekend.

WLNS reported that the flags were seen in two cities, including at a Jewish play.

According to the report, "many people" were seen displaying flags with swastikas on Saturday night as the Fowlerville Community Theater performed the "Diary of Anne Frank." The same group was also seen outside the American Legion Post in Howell.

"It was upsetting," cast member Becky Frank said. "You know, just knowing the character I was playing, knowing a lot of the research that I did on my character."

Witnesses said the protest began in Howell before moving to Fowlerville. Protesters were seen wearing masks with the number 1488, a white supremacist symbol.

"There was a group of people at the four-way intersection in downtown that had swastika flags and American flags," witness Alex Sutfill told WLNS. "They were sticking their arms up and yelling hail Hitler and Hail Trump and everything like that."

Peter Damerow said the group told him to go back to his country.

"They looked at me and one of them said," Damerow recalled. "No this is Pureville now, and we're here to make sure it stays pure."

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Massachusetts Sen. Liz Warren called out Donald Trump for 'corruption' even though he hasn't been sworn into office yet. Who would have thought Trump would violate a law that Warren wrote before getting the keys to the White House -- besides all of us?

Trump has not submitted a legally required ethics agreement stating he will avoid conflicts of interest, which must be signed before the presidential transaction occurs. According to the Presidential Transition Act, the signed agreement was due by Oct. 1.

Warren took to Xitter, and she was not pleased, but it doesn't do any good unless something is done about it.

Donald Trump and his transition team are already breaking the law.

I would know because I wrote the law.

Incoming presidents are required to prevent conflicts of interest and sign an ethics agreement.

This is what illegal corruption looks like. https://t.co/JJjJ59DgB5

— Elizabeth Warren (@SenWarren) November 11, 2024

Xitter had some thoughts:

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By Eli Yudin Published: November 12th, 2024

Hazel Mitchell has helped create more than twenty children's books, including her award-winning picture book Toby (Candlewick Press). Her illustrations appear in books by Cynthia Lord, JaNay Brown-Wood (Imani's Moon was mentioned on the Stephen Colbert show!), Lynn Parrish Sutton, Liza Gardner Walsh and others. You can find out more about Hazel and her work at HazelMitchell.com, Facebook, Instagram and Twitter.

Synopsis of SWEET PEA SUMMER (Candlewick):

During her mother’s absence, a young girl discovers the joys of gardening—and the rewards of persistence and a sharp eye—in a sweet intergenerational story. With warm, child-friendly illustrations and a simple narration, Hazel Mitchell tells a timeless story about holding on to hope in hard times and finding the strength and determination to see it through. A brief author’s note at the end offers a bit of history and a few details about sweet peas for aspiring gardeners.

Q. What inspired you to write Sweet Pea Summer?

My inspiration for the book were memories I have from staying with my grandparents when I was little (4-6 years old). They lived in a row of mill cottages in a Yorkshire town called Huddersfield. The town was born out of the wool trade and had many factories and tall towers, but was surrounded by beautiful countryside. I started to sketch my memories of staying with them - the cottage, the garden, the countryside with the moors and mill chimneys, the cats that were always scampering around, the long road that stretched away up a sloping hill to the town itself.

My granddad was an excellent gardener. I suspect this came from the war years in Britain when everyone grew their own food as much as possible. In my memory the garden was so, so long with a little greenhouse and was stuffed with veggies and flowers. Of course, my memory exaggerated everything. I was seeing through a small child's eyes. I even googled the road on Google Streetview and the cottage and the garden are still there, just much smaller than I recalled.

I decided there was a story in these sketches and my rememberings. I find that I'm often inspired by childhood memories, places and real life things, like my own dog who is the main character in the book 'Toby', also from Candlewick Press. I've even been known to use my house in books, or feature the landscape of Maine, where I live, and sometimes I draw objects from my home. it gives authenticity I think.

Q. What was the writing and illustration process like?

After some note making, more doodles and musing I decided on the main character of a girl. She's not exactly me. My sister also went to stay with my grandparents when my mother was ill and that was really the nugget that set me rolling. The girl is sad and missing her mother, so Grandpa invites her to help in the garden and, in particular, to look after the sweet peas. (My own grandfather grew chrysanthemums, but I decided children would relate more to sweet peas. Plus it is easier to say!).

The grandparents do not look like my grandparents and even though the child is not really me, I guess she shares some of my personality characteristics and DO I love gardening! (Although I always fail with sweet peas, which is ironic). I found I had all the inspiration I needed to get started on roughing out a story.

Writing and illustrating Sweet Pea Summer was a long process, as most books tend to me. There are a lot of images in the book, which is kind of graphic novelish in a way, with multiple images on some pages that follow a grid layout. Although I did preliminary character and setting sketches, I then spent time writing scene progressions and story boarding before I was ready to do the first full dummy.

I've found this saves me time in the long run, when I finally start to sketch I can be pretty certain I have the rudimentary story arc and length of book down. We had 2-3 edits and rehashes before my editors, art director and myself were all happy to go to finals. Finals are always the very long and arduous stage of the book for me. The first spark of story and hashing it out is the inspirational bit.

I did all the art for Sweet Pea in pencil and watercolor (usually I colour an under painting digitally), but I felt this book needed a traditional watercolour feel. It was a longer process for sure! Along the way I did a good amount of picture research especially on the landscapes and the flowers - plus the process of growing them, which features in the story. The parallel between the illness of the m/c's mom and the flowers failing to open was important to me. didn't want it to be too obvious to the reader.

My editor, Liz Bicknell at Candlewick Press, was very helpful, as always, keeping the story on track. Pam Consolazio was my art director, and her nickname was Sweet Pea as a child! it is lovely when you find unexpected connections. I scan my own artwork, which gives me the luxury of making any tweaks to the final art. I think the whole book took about 2 years, including edits etc.

It's wonderful when your book finally arrives in your mailbox! (Just like any birth, the pain recedes!) It was especially concerning in this time of the pandemic, but everything went well and the books arrived in time for publication.

Q. What advice do you have for young writers and illustrators?

My advice to young writers and illustrators is always work on stories that you love and feel an emotional response to whether, happy, sad, funny or just that you just love and know the subject. It will always show in your work!

----

For more insights from book creators, see my Inkygirl interview archives.

Beggin' your pardon sir, but if we're all dressed differently, exactly why is it called a uniform?

In this episode I'm joined by Tim Stillman to discuss the goings-on at Euro 2024, with a fair amount of focus on England, and the Bukayo Saka debate that has been going on this week, before we chat about some lesser-fancied teams who have caught the eye throughout the tournament. Then we touch on the future of Emile Smith Rowe who has been linked with Fulham and Palace this week, wonder if Arsenal might get involved in the shady-pricing that other clubs have been party to of late, the Declan Rice 'problem', and lots more.

Follow Tim @stillmanator

Get extra bonus content and help support Arseblog by becoming an Arseblog Member on Patreon: https://www.patreon.com/arseblog

Hosted on Acast. See acast.com/privacy for more information.

The new producing artistic director of the theater and music theater season at the arts center sat for an interview for our ‘What I think’ series.

A capital espanhola inaugura um espaço para enterrar bebês que não chegaram a nascer.

As Chris Billam-Smith's unification bout against Gilberto Ramirez nears, BBC Sport speaks to those closest to him.

The UK Health Security Agency argued naming the junior officials could put them at risk of abuse.

The easily spreadable virus can affect people of all ages and have huge consequences during winter.

A court challenge means the government will look again at the cap on the Disabled Facilities Grant.

It is also set to be the world's first breach of 1.5C of warming across an entire calendar year.

Willem-Alexander says Jewish people must feel safe in the Netherlands after Israeli football supporters come under attack.

As heads of Arab and Islamic states meet in Riyadh, Trump's victory raises questions for the region.

Mohamed Bin Salman was speaking at the opening of a summit of Muslim and Arab leaders in Riyadh.

Kylian Mbappe wasn't always the best footballing prospect. But he, and his family, had the clearest plan. Project Mbappe continues.

Arab and Muslim leaders demanded that Israel withdraw from occupied Palestinian territories as a precondition for regional peace, while denouncing "shocking" Israeli crimes in war-ravaged Gaza.

The United Nations's humanitarian aid chief told a meeting of the Security Council (UNSC) that "acts reminiscent of the gravest international crimes" are being committed in Gaza.

Scientific tests confirm rivers and dams have been poisoned by the raw sewage dumped by the municipality in the Bloubankspruit and Crocodile Rivers, killing aquatic life and destroying businesses and livelihoods.

The first AI image generation model I got to play around with was Midjourney v2 in summer 2022. A month earlier, OpenAI had launched DALL-E 2 in beta, and the results looked unbelievably magical. You could generate images in any art style simply by prompting an AI with the name of an artist. I didn’t […]

The following article, Lunatic Democrat Murders Wife and Kids, Commits Suicide Over His Hate for Donald Trump, was first published on Conservative Firing Line.

This is how mentally deranged liberals are… a Democrat in Minnesota was so filled with rage that Donald Trump won the election last week that he murdered his own wife and kids and then committed suicide to prevent them all from having to live during the next Trump presidency. Notice how you never heard any …

Continue reading Lunatic Democrat Murders Wife and Kids, Commits Suicide Over His Hate for Donald Trump ...

Chairman Klein and members of the Senate Industry, Business and Labor Committee- My name is David Heinemeier Hansson, and I’m the CTO and co-founder of Basecamp, a small internet company from Chicago that sells project-management software and email services. I first testified on the topic of big tech monopolies at the House Antitrust Subcommittee’s field… keep reading

Mitochondria are specialized compartments that produce requisite ATP to fuel cellular functions and serve as centers of metabolite processing, cellular signaling, and apoptosis. To accomplish these roles, mitochondria rely on the genetic information in their small genome (mitochondrial DNA) and the nucleus. A growing appreciation for mitochondria's role in a myriad of human diseases, including inherited genetic disorders, degenerative diseases, inflammation, and cancer, has fueled the study of biochemical mechanisms that control mitochondrial function. The mitochondrial transcriptional machinery is different from nuclear machinery. The in vitro re-constituted transcriptional complexes of Saccharomyces cerevisiae (yeast) and humans, aided with high-resolution structures and biochemical characterizations, have provided a deeper understanding of the mechanism and regulation of mitochondrial DNA transcription. In this review, we will discuss recent advances in the structure and mechanism of mitochondrial transcription initiation. We will follow up with recent discoveries and formative findings regarding the regulatory events that control mitochondrial DNA transcription, focusing on those involved in cross-talk between the mitochondria and nucleus.

Making the circular economy work for global development: how the UN Summit of the Future can deliver 23 September 2024 — 6:15PM TO 9:00PM Anonymous (not verified) 5 September 2024 Online

This policy roundtable focusses on how to advance implementation of a global approach and collaboration to an inclusive circular economy for an updated post-2030 SDG framework.

As the world looks beyond the Sustainable Development Goals (SDGs) towards the post-2030 era, integrating the principles of the circular economy into the future global development agenda becomes imperative.  

A new Chatham House research paper about the role of the circular economy for the SDGs and their possible extension into the post-2030 development agenda will be launched in September 2024 during the UN Summit of the Future and the New York Climate Week. The paper outlines the rationale for the integration of circular economy goals into for the next crucial phase of international development and how to meet net-zero 2050 targets. It provides actionable recommendations on international cooperation mechanisms for policymakers and stakeholders at the UN Summit for the Future in 2024 and beyond.

The aim of the roundtable is to bring together stakeholders and leaders from intergovernmental organisations, business, governments and civil society. The focus of the roundtable meeting is: 

• Reflections on the Summit of the Future and the role of circularity for an updated post-2030 SDG framework.
• Discussion on key aspects of the institutional arrangements and international coordination that are needed for a globally coordinated approach to achieve an inclusive circular economy that supports SDG implementation. 
• Development of joint strategies on how to advance implementation of a global approach and collaboration to an inclusive circular economy as a follow-up from the Summit of the Future.

The objective is to emerge from the roundtable with a clearer roadmap for translating the recommendations for international coordination into concrete actions, with a shared commitment to driving meaningful change on the international level.

The event is co-hosted by Chatham House and partners from the Global Circular Economy Roadmap initiative including the African Circular Economy Network, the African Development Bank, Circular Change, Circular Innovation Lab, Circle Economy, EU CE Stakeholder Platform, Hanns Seidel Foundation, Institute of Global Environmental Strategies, Sitra, UNIDO, World Business Council on Sustainable Development, World Economic Forum and the Wyss Academy for Nature.

Further background information is available on the initiative website.

More speakers to be announced.

Numerous iron-sulfur (Fe-S) proteins with diverse functions are present in the matrix and respiratory chain complexes of mitochondria. Although [4Fe-4S] clusters are the most common type of Fe-S cluster in mitochondria, the molecular mechanism of [4Fe-4S] cluster assembly and insertion into target proteins by the mitochondrial iron-sulfur cluster (ISC) maturation system is not well-understood. Here we report a detailed characterization of two late-acting Fe-S cluster-carrier proteins from Arabidopsis thaliana, NFU4 and NFU5. Yeast two-hybrid and bimolecular fluorescence complementation studies demonstrated interaction of both the NFU4 and NFU5 proteins with the ISCA class of Fe-S carrier proteins. Recombinant NFU4 and NFU5 were purified as apo-proteins after expression in Escherichia coli. In vitro Fe-S cluster reconstitution led to the insertion of one [4Fe-4S]2+ cluster per homodimer as determined by UV-visible absorption/CD, resonance Raman and EPR spectroscopy, and analytical studies. Cluster transfer reactions, monitored by UV-visible absorption and CD spectroscopy, showed that a [4Fe-4S]2+ cluster-bound ISCA1a/2 heterodimer is effective in transferring [4Fe-4S]2+ clusters to both NFU4 and NFU5 with negligible back reaction. In addition, [4Fe-4S]2+ cluster-bound ISCA1a/2, NFU4, and NFU5 were all found to be effective [4Fe-4S]2+ cluster donors for maturation of the mitochondrial apo-aconitase 2 as assessed by enzyme activity measurements. The results demonstrate rapid, unidirectional, and quantitative [4Fe-4S]2+ cluster transfer from ISCA1a/2 to NFU4 or NFU5 that further delineates their respective positions in the plant ISC machinery and their contributions to the maturation of client [4Fe-4S] cluster-containing proteins.

The cystic fibrosis transmembrane conductance regulator (CFTR) is a plasma membrane anion channel that plays a key role in controlling transepithelial fluid movement. Excessive activation results in intestinal fluid loss during secretory diarrheas, whereas CFTR mutations underlie cystic fibrosis (CF). Anion permeability depends both on how well CFTR channels work (permeation/gating) and on how many are present at the membrane. Recently, treatments with two drug classes targeting CFTR—one boosting ion-channel function (potentiators) and the other increasing plasma membrane density (correctors)—have provided significant health benefits to CF patients. Here, we present an image-based fluorescence assay that can rapidly and simultaneously estimate both CFTR ion-channel function and the protein's proximity to the membrane. We monitor F508del-CFTR, the most common CF-causing variant, and confirm rescue by low temperature, CFTR-targeting drugs and second-site revertant mutation R1070W. In addition, we characterize a panel of 62 CF-causing mutations. Our measurements correlate well with published data (electrophysiology and biochemistry), further confirming validity of the assay. Finally, we profile effects of acute treatment with approved potentiator drug VX-770 on the rare-mutation panel. Mapping the potentiation profile on CFTR structures raises mechanistic hypotheses on drug action, suggesting that VX-770 might allow an open-channel conformation with an alternative arrangement of domain interfaces. The assay is a valuable tool for investigation of CFTR molecular mechanisms, allowing accurate inferences on gating/permeation. In addition, by providing a two-dimensional characterization of the CFTR protein, it could better inform development of single-drug and precision therapies addressing the root cause of CF disease.

Roland Bruderer
May 1, 2015; 14:1400-1410
Research

David A. Mitchell
Jun 1, 2006; 47:1118-1127
Thematic Reviews

The Committee to Protect Journalists named winner of the Chatham House Prize 2018 News Release sysadmin 5 October 2018

The Committee to Protect Journalists (CPJ) has been voted the winner of this year’s Chatham House Prize.

Strengthening Our Commitment to the Next Generation News Release NCapeling 9 November 2020

Panel of Young Advisers and Queen Elizabeth II Academy Ambassadors underscore our drive to reach, engage and inspire young people to change their world.

Persuasion or manipulation? Limiting campaigning online Expert comment NCapeling 15 February 2021

To tackle online disinformation and manipulation effectively, regulators must clarify the dividing line between legitimate and illegitimate campaign practices.

Democracy is at risk, not only from disinformation but from systemic manipulation of public debate online. Evidence shows social media drives control of narratives, polarization, and division on issues of politics and identity. We are now seeing regulators turn their attention to protecting democracy from disinformation and manipulation. But how should they distinguish between legitimate and illegitimate online information practices, between persuasive and manipulative campaigning?

Unregulated, the tactics of disinformation and manipulation have spread far and wide. They are no longer the preserve merely of disaffected individuals, hostile international actors, and authoritarian regimes. Facebook’s periodic reporting on coordinated inauthentic behaviour and Twitter’s on foreign information operations reveal that militaries, governments, and political campaigners in a wide range of countries, including parts of Europe and America, have engaged in manipulative or deceptive information campaigns.

For example, in September 2019, Twitter removed 259 accounts it says were ‘falsely boosting’ public sentiment online that it found to be operated by Spain’s conservative and Christian-democratic political party Partido Popular. In October 2020, Facebook removed accounts with around 400,000 followers linked to Rally Forge, a US marketing firm which Facebook claims was working on behalf of right-wing organisations Turning Point USA and Inclusive Conservation Group. And in December 2020, Facebook took down a network of accounts with more than 6,000 followers, targeting audiences in Francophone Africa and focusing on France’s policies there, finding it linked with individuals associated with the French military.

Public influence on a global scale

Even more revealingly, in its 2020 Global Inventory of Organized Social Media Manipulation, the Oxford Internet Institute (OII) found that in 81 countries, government agencies and/or political parties are using ‘computational propaganda’ in social media to shape public attitudes.

These 81 countries span the world and include not only authoritarian and less democratic regimes but also developed democracies such as many EU member states. OII found that countries with the largest capacity for computational propaganda – which include the UK, US, and Australia – have permanent teams devoted to shaping the online space overseas and at home.

OII categorizes computational propaganda as four types of communication strategy – the creation of disinformation or manipulated content such as doctored images and videos; the use of personal data to target specific segments of the population with disinformation or other false narratives; trolling, doxing or online harassment of political opponents, activists or journalists; and mass-reporting of content or accounts posted or run by opponents as part of gaming the platforms’ automated flagging, demotion, and take-down systems.

Doubtless some of the governments included within OII’s statistics argue their behaviour is legitimate and appropriate, either to disseminate information important to the public interest or to wrestle control of the narrative away from hostile actors. Similarly, no doubt some political campaigners removed by the platforms for alleged engagement in ‘inauthentic behaviour’ or ‘manipulation’ would defend the legitimacy of their conduct.

The fact is that clear limits of acceptable propaganda and information influence operations online do not exist. Platforms still share little information overall about what information operations they see being conducted online. Applicable legal principles such as international human rights law have not yet crystallised into clear rules. As information operations are rarely exposed to public view – with notable exceptions such as the Cambridge Analytica scandal – there is relatively little constraint in media and public scrutiny or censure.

OII’s annual reports and the platforms’ periodic reports demonstrate a continual expansion of deceptive and manipulative practices since 2016, and increasing involvement of private commercial companies in their deployment. Given the power of political influence as a driver, this absence of clear limits may result in ever more sophisticated techniques being deployed in the search for maximal influence.

Ambiguity over reasonable limits on manipulation plays into the hands of governments which regulate ostensibly in the name of combating disinformation, but actually in the interests of maintaining their own control of the narrative and in disregard of the human right to freedom of expression. Following Singapore’s 2019 prohibition of online untruths, 17 governments ranging from Bolivia to Vietnam to Hungary passed regulations during 2020 criminalising ‘fake news’ on COVID-19 while many other governments are alleged to censor opposition arguments or criticisms of official state narratives.

Clear limits are needed. Facebook itself has been calling for societal discussion about the limits of acceptable online behaviour for some time and has issued recommendations of its own.

The European Democracy Action Plan: Aiming to protect pluralism and vigour in democracy

The European Democracy Action Plan (EDAP), which complements the European Commission’s Digital Services Act and Digital Markets Act proposals, is a welcome step. It is ground-breaking in its efforts to protect the pluralism and vigour of European democracies by tackling all forms of online manipulation, while respecting human rights.

While the EDAP tackles disinformation, it also condemns two categories of online manipulation – information influence operations which EDAP describes as ‘coordinated efforts by either domestic or foreign actors to influence a target audience using a range of deceptive means’ and foreign interference, described as ‘coercive and deceptive efforts to disrupt the free formation and expression of individuals’ political will by a foreign state actor or its agents’. These categories include influence operations such as harnessing fake accounts or gaming algorithms, and the suppression of independent information sources through censorship or mass reporting.

But the categories are so broad they risk capturing disinformation practices not only of rogue actors, but also of governments and political campaigners both outside and within the EU. The European Commission plans to work towards refined definitions. Its discussions with member states and other stakeholders should start to determine which practices ought to be tackled as manipulative, and which ought to be tolerated as legitimate campaigning or public information practices.

The extent of the EDAP proposals on disinformation demonstrates the EU’s determination to tackle online manipulation. The EDAP calls for improved practical measures building on the Commission’s 2020 acceleration of effort in the face of COVID-19 disinformation. The Commission is considering how best to impose costs on perpetrators of disinformation, such as by disrupting financial incentives or even imposing sanctions for repeated offences.

Beyond the regulatory and risk management framework proposed by the Digital Services Act (DSA), the Commission says it will issue guidance for platforms and other stakeholders to strengthen their measures against disinformation, building on the existing EU Code of Practice on Disinformation and eventually leading to a strengthened Code with more robust monitoring requirements. These are elements of a broader package of measures in the EDAP to preserve democracy in Europe.

Until there are clear limits, manipulative practices will continue to develop and to spread. More actors will resort to them in order not to be outgunned by opponents. It is hoped forthcoming European discussions – involving EU member state governments, the European Parliament, civil society, academia and the online platforms – will begin to shape at least a European and maybe a global consensus on the limits of information influence, publicly condemning unacceptable practices while safeguarding freedom of expression.

Most importantly, following the example of the EDAP, the preservation of democracy and human rights – rather than the promotion of political or commercial interest – should be the lodestar for those discussions.