“The fear of the Lord is the beginning of wisdom; a good understanding have all those who do His commandments” (Psalm 111:10).

Saving faith is obedient faith.

The wisdom of God resulting from the fear of the Lord leads to obedience. When we fear the Lord, we submit to His wisdom and commit ourselves to keeping His commandments. In the New Testament Jesus said the same thing: “If you love Me, you will keep My commandments” (John 14:15). We aren’t always as obedient as we ought to be, but the pattern of our lives turns from disobedience to a submissive heart of obedience. First John 2:3 says, “By this we know that we have come to know Him, if we keep His commandments.” A person’s claim to be a Christian is meaningless if he’s not obedient.

From a positive perspective, fearing the Lord involves obeying His commandments; from a negative perspective, it involves turning away from evil. Job 28:28 says, “The fear of the Lord, that is wisdom; and to depart from evil is understanding.” Equal to wisdom is understanding, and equal to fearing the Lord is departing from evil. Proverbs 8:13 says, “The fear of the Lord is to hate evil.” Obeying the Lord’s commandments and shunning evil are dynamics that work in the soul of one who truly fears God. The fear of the Lord is not some feeling you try to generate within yourself; it’s the result of believing in the true God and living a life of love and obedience to Him. What about you? Does obedience to God’s Word characterize your life?

Suggestions for Prayer

Jesus Christ paid the price for your sin and ushered you into a relationship with God. Honor His work by obeying His Word, and ask Him to help you see evil from His perspective.

For Further Study

Read the following verses: Deuteronomy 6:1-2, 13-15, 24; 8:6; 10:12-13; 13:4; 17:19; 28:58-59; 31:12. What characterizes the life of a person who fears the Lord?

From Strength for Today by John MacArthur Copyright © 1997. Used by permission of Crossway Books, a division of Good News Publishers, Wheaton, IL 60187, www.crossway.com.

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The recent summit underscored Hong Kong's position as a "super-connector" and "super value adder," solidifying its status as a premier regional business hub and a vital link to the global market, that could support the eight major steps announced by President Xi Jinping last year to enhance the high-quality development of the Belt and Road Initiative (BRI).

US-ROK-Japan Trilateral Global Leadership Youth Summit

The Quad Committee of the House of Representatives, composed of the Committees on Dangerous Drugs, Public Order and Safety, Human Rights, and Public Accounts continued its joint inquiry into the extrajudicial killings during the Duterte administration's drug war on Wednesday, November 13. 

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Ukraine's crippling 55 percent tax on private gas producers threatens to damage the economy, scare off investors and decimate gas production.

At the biggest summit since Copenhagen, negotiators from developed and developing countries converge in Paris to hammer out a meaningful international agreement to combat climate change.

The upcoming summit between U.S. and African leaders is likely to make progress on a number of investment, development and security issues.

Proceeding to the discovery phase means both parties must collect and exchange evidence.

Israeli health experts reveal that 1 in 10 youth struggle with eating disorders, highlighting a need for urgent action.

Former French MP Meyer Habib describes his worries about France's future as antisemitism soars across Europe and violence becomes normalized.

[Capital FM] NAIROBI -- Talks between the National Assembly Education Committee,university lecturers, and public universities failed to kick off on Tuesday amid a stalement over a strike declared unprotected by courts.

[Liberian Investigator] Monrovia -- Sources have hinted to The Liberian Investigator that the Executive Branch, through the Ministry of Finance & Development Planning, is contemplating submitting the 2025 draft national budget to the breakaway "majority bloc" in the House of Representatives later this week.

For 65 years China has been taking over Tibet, abusing Tibetans and destroying their culture, and no one's doing anything about it.

How will Israel respond to Iran’s recent ballistic missiles barrage? “Strategic patience” is the best course. Israel has its hands full with Hamas and Hezbollah. Now is not the time to escalate a new major war with Iran, which could have nuclear implications. Israeli intelligence is still chafing from its failure to preempt Hamas’ attack […]

MANILA, Philippines — The Office of the Civil Defense (OCD) on Wednesday said the government is ready to respond to the effects of typhoons in the coming days and weeks of the year. OCD head Ariel Nepomuceno, however, admitted that the consecutive storms/typhoons in the past few weeks are unprecedented, even in the current system the government has for disaster response. “Nakalatag naman ‘yung sistema natin, although admittedly itong sistema natin hindi na-assume ‘yung ganitong scenario, bago rin sa’tin ito,” said Nepomuceno during a Kapihan sa Manila Hotel briefing. (Our system is in place, although admittedly our system did not […]...

Keep on reading: Gov't ready for calamity response; staff fatigue a big concern - OCD

MANILA, Philippines — The excess campaign funds of then-president Rodrigo Duterte were used for the reward system of police officers during his administration’s brutal war on drugs.  Duterte himself admitted this to Santa Rosa City Rep. Dan Fernandez during the House of Representatives quad committee during its 11th probe on his controversial anti-drug campaign.  “I still remember that you mentioned na yung pera galing sa donation ng inyong campaign funds will be utilized for the reward system, that’s private money,” Fernandez said.  (I still remember you mentioned that the money from the donation for your campaign funds would be utilized […]...

Keep on reading: Excess campaign funds used for drug war reward system, Duterte admits

[Shabelle] Riyadh, Saudi Arabia -- Somali President Hassan Sheikh Mohamud has touched down in Riyadh on Sunday evening for the Extraordinary Arab and Islamic States Summit.

The meeting comes while the region prepares for incoming US President Donald Trump to take office.

Netanyahu admits Israel behind pager attack in Lebanon

US says it will not limit arms transfers to Israel after some aid improvements to Gaza

Sarah Strack is Forus Director

When the weather is bad, the residents of the Litoral neighborhood in Manzanillo, Cuba, are forced to evacuate their houses. When it’s calm, the sea penetrates the foundations of houses, leaving them vulnerable. Now the community is getting together to restore the mangroves and improve the environment to return their homes to safety.

Dwayne Johnson has since easily surpassed both Hollywood A-ListersDwayne Johnson had big Hollywood dreams from the get-go. In an interview with GQ Magazine published Monday, November 12, the wrestler-turned-Hollywood-star recalled declaring early in his career that he would one day surpass the...

Tom Brady on fatherhoood Tom Brady finds being a father the “hardest job,” one he admits he is not good at.The former NFL star accepted the fact that he didn't always give his best being a father to son Jack, 17, whom he shares with ex Bridget Moynahan, as well as son Benjamin,...

The Paris Agreement on climate change is a decade old this month. While there has been progress – with new net zero pledges and new technological solutions, we are still grappling with the reality that global temperatures continue to soar. 2023 was the hottest year ever on record. This alarming trend poses grave consequences for […]

Remarks by Masatsugu Asakawa, President, Asian Development Bank, at the 8th Greater Mekong Subregion Summit, Plenary Session, 7 November 2024

Remarks by Masatsugu Asakawa, President, Asian Development Bank, at the 8th Greater Mekong Subregion Summit, Leaders’ Retreat, 7 November 2024

Nations have begun setting carbon-cutting targets for the decade ahead, and how ambitious these pledges are could make or break global efforts to avoid dangerous levels of climate change.

Nearly 200 countries are supposed to publish updated climate plans by early February, but so far only three have done so.

On Wednesday, the UK became the latest, announcing during the COP29 climate summit in Azerbaijan that it would raise its target to cut greenhouse gas emissions.

All eyes will be on other big polluters like China, India, and the United States, though future US climate action is unclear following Donald Trump’s election.

Why do they matter?

The world has agreed to try and limit global warming to 1.5 degrees Celsius above pre-industrial levels, but is nowhere near on track.

Above this threshold, scientists say humanity risks disastrous consequences from volatile weather to major ecological “tipping points” at land and sea.

Last month, the United Nations warned that even if all existing plans are implemented in full, temperatures would rise 2.6°C by the century’s end, a catastrophic outcome.

The UN says the next round of climate plans must show a “quantum leap” in ambition to avert the worst.

The G20 — which accounts for 77 per cent of total greenhouse gas emissions — is under particular pressure to step up.

Early movers

Just before COP29 opened in Azerbaijan, the United Arab Emirates announced a 47pc reduction in emissions by 2035 compared with 2019 in its updated climate plan.

Observers said the roadmap failed to account for exported emissions —including those from its sales of crude oil abroad.

Next year’s UN climate host, Brazil, has partly unveiled its plan, increasing its emissions reduction target from a 59pc cut by 2035, from 2005 levels, to a 67pc reduction.

It is expected to unveil a more complete plan during COP29.

Plans from other major emitters, like the European Union and China, are not expected until next year.

And the current US government could soon outline Washington’s new pledge, despite questions over Trump following through once in office.

David Waskow, of the World Resources Institute, said it would help guide American cities, states and businesses wishing to continue climate action under Trump.

“It also sends an important signal internationally, a set of benchmarks for what the US ought to do,” he added.

What do countries need to do?

By signing the Paris accord, nearly 200 nations agreed to halt rising temperatures “well below 2°C” and strive for the safer goal of 1.5°C.

But it did not prescribe how to get there.

The deal left it up to countries to voluntarily chart their own plans and targets, known as Nationally Determined Contributions (NDCs).

These include emission reduction targets and measures to achieve them, such as rolling out renewable energy, electrifying transport, and ending deforestation.

There is no set template for countries to follow but richer countries —historically the largest emitters — have a responsibility to pledge the deepest emission cuts.

The plans must be reviewed every five years, with each update supposed to be more ambitious than the last. This time around countries are expected to improve their 2030 targets and outline economy-wide action they will take to 2035.

What’s the aim?

An agreement at last year’s COP28 climate summit “encouraged” countries to come forward with plans aligned with halting warming to 1.5°C.

To have a hope of meeting that goal, emissions must be slashed 42pc by 2030 and 57pc by 2035, the UN’s Environment Programme said last month.

Currently, however, emissions are continuing to rise.

Keeping 1.5°C on track would require a collective effort “only ever seen following a global conflict”, it added.

Without pulling together “on a scale and pace never seen before… the 1.5°C goal will soon be dead,” said UNEP executive director Inger Andersen.

The big moment for assessing progress towards the 1.5°C goal comes at a crunch COP30 climate summit in Brazil next year.

What about fossil fuels?

Scientists and the International Energy Agency have said that developing new fossil fuel projects is incompatible with halting warming to 1.5°C.

But many fossil fuel-producing countries argue that new oil and gas projects will be needed as the world transitions to net zero emissions.

Countries are under pressure to outline in their updated plans how they intend to reduce their reliance on fossil fuels, something all nations agreed on at last year’s COP.

Header image: This picture taken on November 12 shows a wind turbine at the lignite-fired power station operated by German energy giant RWE near Neurath, western Germany. — AFP

AFTER silently watching Israel’s genocidal war in Gaza for the past one year, the leaders of the Arab and Muslim countries have once more met in Riyadh to discuss the escalating conflict.

The so-called international alliance conceived by Saudi Arabia, with its aim of pressing for the establishment of a Palestinian state, failed to formulate a concrete plan of action to stop the Israeli invasion that has been extended to Lebanon.

Interestingly, the resolution issued at the conclusion of the joint summit of the Organisation of Islamic Cooperation and Arab League is restricted to the usual condemnation of Israeli aggression. It doesn’t even plainly describe the ongoing Israeli military action in Gaza, which has killed more than 43,000 people, mostly women and children, as a genocide.

There is no suggestion to sever the diplomatic and trade ties with Israel that some of these countries continue to have, despite the war crimes being committed by the Zionist forces. With the complete blockade of the Gaza Strip, more than a million people face death by starvation and disease. Mere condemnation cannot stop Israel’s genocidal war. It is nothing short of a betrayal of the hapless people of Palestine.

In fact, the inaction of the Muslim world has given impunity to the Zionist state, which is now threatening to annihilate the entire occupied territory. The latest summit was held a year after a similar gathering in Riyadh. Then, too, the leaders had merely condemned the Israeli military action in Gaza. They could not agree on even a minimum plan of action to stop Israeli atrocities.

The OIC-Arab League resolution does not go beyond the usual condemnation of Israel.

They did not even leverage their oil and economic capabilities to apply pressure on countries supplying arms to Israel to stop the war. One year of war crimes doesn’t seem to have brought any change in their position, which can be described as capitulation. The resolution is as toothless as the previous one.

The most shocking part of the resolution is the decision “to affirm support and express appreciation for the tireless efforts made by the Arab Republic of Egypt and the State of Qatar in cooperation with the United States of America to achieve an immediate and permanent ceasefire in the Gaza Strip… “. It couldn’t get more outrageous given that the ongoing genocide in Gaza is essentially supported by the US. It is massive American military aid that has helped Israel sustain its war.

Notwithstanding the occasional rebuke by US officials, there has never been any real American pressure on Israel to implement a ceasefire. In fact, the Biden administration has repeatedly vetoed resolutions in the UN calling for one. Some of the Arab rulers are believed to have tacitly supported what Israel has described as its war against Hamas. Moreover, America has its bases in Arab countries, and concerns have been raised that they could have supplied Israel with weapons to kill Palestinians. These countries have not prohibited the use of these bases.

Significantly, the latest summit took place soon after Donald Trump’s victory, which has been hailed by some member countries, prompting observers to conclude that it was meant to send a message to the incoming US administration. It seems that the ‘international alliance’ is now pinning its hopes on the incoming Trump administration to get Israel to agree to a ceasefire and accept the creation of a Palestinian state.

For instance, while addressing a Council of Foreign Ministers preparatory meeting a day before the summit, Pakistan’s Foreign Minister Ishaq Dar expressed the hope that the incoming US administration would “lend its weight to reinvigorate efforts for peace in the Middle East”. His remarks show his utter ignorance about Trump’s hard-line approach to the Middle East conflict.

Such expectations from the president-elect, who is considered even more pro-Israel than the outgoing Biden administration, are unrealistic. During his election campaign, Trump had called on Israel to finish the offensive and “get the job done”. He has stated that he would “defend our friend and ally in the State of Israel like nobody has ever”.

How can one forget that in his previous term he shifted the American embassy to occupied Jerusalem? The move defied Washington’s earlier position of not recognising one of the most sacred of Islam’s holy places as Israel’s capital. In his previous term, Trump had also endorsed Israeli settlements in occupied West Bank, which are illegal under international law. Under the so-called Abraham Accords, he oversaw the establishment of diplomatic relations between Israel, the UAE, Bahrain, and Morocco.

Although Saudi Arabia did not enter into such an agreement, it did indicate its willingness to recognise Israel in return for security and economic benefits, though insisting there would be no diplomatic ties without a Palestinian state. Some analysts believe that the Riyadh summit has sent a clear signal to the incoming Trump administration that it can rely on the kingdom as a strong partner in extending American interests in the region. The summit has pushed for greater American leverage in bringing the war to an end.

But it is very clear that the incoming Trump administration will not push for the establishment of a Palestinian state as envisaged by the ‘international alliance’. There has been no mention of the two-state solution in his recent statements on the Middle East conflict.

Since winning the election, Trump has spoken to the Israeli prime minister more than once. Therefore, it’s not surprising to see the right-wing Israeli government harden its position after Trump’s election.

In a recent statement, Israeli Foreign Minister Gideon Sa’ar opposed the establishment of a Palestinian state, saying it was “unrealistic”. Surely the inaction of the Arab and Muslim countries has made things worse for the Palestinians. The joint resolution indicates that these countries do not have any intention of using their leverage to put pressure on Israel and its allies to end the war.

The writer is an author and journalist.

zhussain100@yahoo.com

X: @hidhussain

Published in Dawn, November 13th, 2024

to workir conditioning system on 2004 mit

The technical assistance (TA), which will be approved with the proposed Integrated Water Resources Management Project, will help the Ministry of Water Resources and Meteorology: (i) implement one of the activities of output 2 (para 6), (ii) inform rice farmers about and train them to implement innovative climate mitigative water management technology, and (iii) disseminate this innovative AWD technology to the entire country. The TA project's demonstration activities are expected to reduce emissions by 11,750 tons of carbon dioxide equivalent.

Ultra-fast pulses of laser light can be shaped into vortices similar to smoke rings – when chained together, they can carry enough information to transmit a simple image

Alan Turing's theories about computation seem to have a startling consequence, placing hard limits on how fast or slow any physical process in the universe can grow

In Iceland, scientists are planning to drill two boreholes to a reservoir of liquid rock. One will give us our first direct measurements of magma – the other could supercharge geothermal power

Alan Turing's theories about computation seem to have a startling consequence, placing hard limits on how fast or slow any physical process in the universe can grow

Although the COP16 summit in Colombia ended with some important agreements, countries still aren’t moving fast enough to stem biodiversity loss

This year’s average global temperature is almost certain to exceed 1.5°C above pre-industrial times – a milestone that should spur urgent action, say climate scientists

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During B-cell development, cells progress through multiple developmental stages, with the pro-B-cell stage defining commitment to the B-cell lineage. YY1 is a ubiquitous transcription factor that is capable of both activation and repression functions. We found here that knockout of YY1 at the pro-B-cell stage eliminates B lineage commitment. YY1 knockout pro-B cells can generate T lineage cells in vitro using the OP9-DL4 feeder system and in vivo after injection into sublethally irradiated Rag1^–/– mice. These T lineage-like cells lose their B lineage transcript profile and gain a T-cell lineage profile. Single-cell RNA-seq experiments showed that as YY1 knockout pro-B cells transition into T lineage cells in vitro, various cell clusters adopt transcript profiles representing a multiplicity of hematopoietic lineages, indicating unusual lineage plasticity. In addition, YY1 KO pro-B cells in vivo can give rise to other hematopoietic lineages in vivo. Evaluation of RNA-seq, scRNA-seq, ChIP-seq, and scATAC-seq data indicates that YY1 controls numerous chromatin-modifying proteins leading to increased accessibility of alternative lineage genes in YY1 knockout pro-B cells. Given the ubiquitous nature of YY1 and its dual activation and repression functions, YY1 may regulate commitment in multiple cell lineages.

ABSTRACTIntroduction:Family Planning 2020 (FP2020) was established in 2012 with the goal of expanding contraceptive access. By 2020, 46 countries had made commitments to FP2020. A sustained focus on adolescents and youth (AY) began in 2016. During the commitment formulation process, substantial support was offered to countries to develop AY commitments based on sound data, research evidence, and programmatic experience. This study assesses how country commitments under FP2020 and FP2030 have evolved over time with respect to improving attention to and focus on the needs of adolescents and youth sexual and reproductive health (AYSRH).Methods:We analyzed the content of FP2020 and FP2030 country commitments focusing on AY (aged 10–24 years) using a scoring guideline we developed to measure the AY commitments in terms of completeness, clarity, and quality.Results:This analysis shows that FP2030 commitments better articulate strategies and activities to reach AY with contraceptive information and services when compared to FP2020 commitments.Conclusion:FP2030 commitments are stronger in some areas on AYSRH, such as commitment to establish national or local policies, strategies, and guidance for AY programming, specifying the target audience of the AY commitment, and partnering with AY or youth-led organizations in commitments. However, more work remains to be done by countries to dedicate a budget for achieving AY objectives, including measurable targets for monitoring progress, identifying and addressing the root causes that impact AY access to and use of contraception, including child marriage and gender-based violence, and reducing financial barriers to access contraception.

Mitochondrial dysfunction is a hallmark of many genetic neurodegenerative diseases, but therapeutic options to reverse mitochondrial dysfunction are limited. While recent studies support the possibility of improving mitochondrial fusion/fission dynamics and motility to correct mitochondrial dysfunction and resulting neurodegeneration in Charcot-Marie-Tooth disease (CMT) and other neuropathies, the clinical utility of reported compounds and relevance of preclinical models are uncertain. Here, we describe motor and sensory neuron dysfunction characteristic of clinical CMT type 2 A in a CRISPR/Casp-engineered Mfn2 Thr105Met (T105M) mutant knock-in mouse. We further demonstrate that daily oral treatment with a novel mitofusin activator derived from the natural product piperine can reverse these neurologic phenotypes. Piperine derivative 8015 promoted mitochondrial fusion and motility in Mfn2-deficient cells in a mitofusin-dependent manner and reversed mitochondrial dysfunction in cultured fibroblasts and reprogrammed motor neurons from a human CMT2A patient carrying the MFN2 T105M mutation. Like previous mitofusin activators, 8015 exhibited stereospecific functionality, but the more active stereoisomer, 8015-P2, is unique in that it has subnanomolar potency and undergoes entero-hepatic recirculation which extends its in vivo half-life. Daily administration of 8015-P2 to Mfn2 T105M knock-in mice for 6 weeks normalized neuromuscular and sensory dysfunction and corrected histological/ultrastructural neurodegeneration and neurogenic myoatrophy. These studies describe a more clinically relevant mouse model of CMT2A and an improved mitofusin activator derived from piperine. We posit that 8015-P2 and other piperine derivatives may benefit CMT2A or other neurodegenerative conditions wherein mitochondrial dysdynamism plays a contributory role.