Ars speaks with users and partners unhappy with Broadcom's changes.

FrontierMath's difficult questions remain unpublished so that AI companies can't train against it.

Republicans need a "bold Senate GOP leader," Sen. Mike Lee (R-UT) said on Tuesday as three Republican senators -- Sen. Rick Scott (R-FL), Senate Republican Whip John Thune (R-SD), and Sen. John Cornyn (R-TX) -- vie for the position of Senate Majority Leader.

The post Sen. Mike Lee: ‘We Need a Bold Senate GOP Leader’ appeared first on Breitbart.

Mark Rylance is in talks to play Albus Dumbledore in Harry Potter TV series. Warner Bros. is yet to enter negotiations with the actor

Earlier this year, Feral Interactive’s superb iOS version of Alien: Isolation (Free) was updated to change the game’s business model …

Continue reading "‘Alien: Isolation’ for Android Is Now a Free To Start Release Just Like iOS Letting Everyone Try Two Missions for Free"

For our next dive into the retro games available on Switch, we’re going all the way back to 1989. Er, …

Continue reading "The 10 Best Game Boy and Game Boy Color Games on Nintendo Switch, Plus 5 We’d Like to See – SwitchArcade Special"

Netflix recently announced more games coming to its service in the coming months, but an unannounced (as far as I’m …

Continue reading "‘SpongeBob: Bubble Pop’ Is a New Bust-a-Move-Like Coming to iOS and Android Through Tic Toc Games, Nickelodeon, and Netflix"

In our tour through retro games available to buy on Switch, we’ve worked our way through the NES, Game Boy, …

Continue reading "The 10 Best Super NES Games on Nintendo Switch, Plus 5 We’d Like to See – SwitchArcade Special"

Hours after the ruling, the UK home secretary approved Lynch's extradition to the US.

Top Democrats on Tuesday evening filed a compromise economic development bill containing state support for the life sciences and climate technology industries, ticket sales regulations, a new live theater tax credit, educator diversity reforms and more.

What is Jupiter's great red spot? Researchers have observed the red spot changing over time.

There is not a ton of evidence of what education looked like in ancient society, but we do know it existed - although not for everyone.

In the midst of the Israel-Hamas war, President-elect Donald Trump announced he will nominate Huckabee, a loyalist and former Republican governor, to serve in the key post as ambassador to Israel.

Israeli airstrikes killed at least 46 people in the Gaza Strip in the past day, medics said. In Lebanon, warplanes struck Beirut's southern suburbs and killed 33 people in the country on Tuesday.

After seeing a social media call out for help rescuing a baby goat trapped on a cliff face near Honolulu, a group of hikers climbed to the rescue. The goat, nicknamed Bala, is now at a local animal sanctuary.

UPDATE: An emergency situation has been declared after wild storms left a trail of destruction on the Sunshine Coast. Brisbane residents have also described what was “like a tidal wave” hitting their homes.

REACTION to the first TV crew’s story to emerge from Nauru tonight ranged from stunned to cynical. And it was a surprise to Australia’s Immigration minister.

Dhaka (AFP) Nov 3, 2024
A Bangladeshi worker died in a air strike in Lebanon, Dhaka's foreign ministry said Sunday, as the Israeli bombardment hampered efforts to repatriate citizens. The foreign ministry estimates that between 70,000 and 100,000 of its nationals are working in Lebanon, many as labourers or domestic workers. The first flights, organised by Dhaka's government with the UN's International Organisa

Speaking with CBC News’s Eli Glasner, Cillian Murphy discusses ‘imploding emotionally’ in his role in Small Things Like These, his partnership with Matt Damon and Ben Affleck and how his experience on Oppenheimer influenced this film. CORRECTION: A previous version of this video interview includes reference to communities in Canada 'still finding bodies of Indigenous children in the ground' at 1:24. We have removed this portion of the interview. Searches at the sites of former residential schools using ground-penetrating radar have found evidence of possible unmarked graves.

The union representing Canada Post workers said it will be in a legal strike position on Friday, exactly one year after talks on a new contract began. But the union is holding back on deciding whether a job action will take place immediately.

“Going viral” appears to be more than just a catchphrase when it comes to the rampant spread of misinformation

A fee created to push oil and gas companies to plug methane leaks could be axed by the incoming Trump administration, hampering efforts to curb the potent greenhouse gas

Looking back over the last 40 years at FDA (as I have), there are three characteristics that create a more progressive environment at the agency: continuity of leadership, presidential support, and increased funding. For FDA in 2013 (as the saying goes): 2 out of 3 ain’t bad. In particular, medical innovation seems poised to flourish in an FDA environment where there is continuity of policy and leadership, instead of a new team learning the ropes. I explore this and other themes in the latest issue of Pharmaphorum.com. You can read my thoughts at: http://www.pharmaphorum.com/2013/01/29/fda-post-election-continuity-and-progress-likely-to-mark-2013/.

Neurosurgeon Vitor Mendes Pereira has grown accustomed to treating brain aneurysms with only blurry images for guidance.

Equipped with a rough picture of the labyrinthine network of arteries in the brain, he does his best to insert mesh stents or coils of platinum wire—interventions intended to promote clotting and to seal off a bulging blood vessel.

The results are not always perfect. Without a precise window into the arterial architecture at the aneurysm site, Pereira says that he and other neurovascular specialists occasionally misplace these implants, leaving patients at a heightened risk of stroke, clotting, inflammation, and life-threatening ruptures. But a new fiber-optic imaging probe offers hope for improved outcomes.

Pereira et al./Science Translational Medicine

According to Pereira’s early clinical experience, the technology—a tiny snake-like device that winds its way through the intricate maze of brain arteries and, using spirals of light, captures high-resolution images from the inside-out—provides an unprecedented level of structural detail that enhances the ability of clinicians to troubleshoot implant placement and better manage disease complications.

“We can see a lot more information that was not accessible before,” says Pereira, director of endovascular research and innovation at St. Michael’s Hospital in Toronto. “This is, for us, an incredible step forward.”

And not just for brain aneurysms. In a report published today in Science Translational Medicine, Pereira and his colleagues describe their first-in-human experience using the platform to guide treatment for 32 people with strokes, artery hardening, and various other conditions arising from aberrant blood vessels in the brain.

Whereas before, with technologies such as CT scans, MRIs, ultrasounds, and x-rays, clinicians had a satellite-like view of the brain’s vascular network, now they have a Google Street View-like perspective, complete with in-depth views of artery walls, plaques, immune cell aggregates, implanted device positions, and more.

“The amount of detail you could get you would never ever see with any other imaging modality,” says Adnan Siddiqui, a neurosurgeon at the University at Buffalo, who was not involved in the research. “This technology holds promise to be able to really transform the way we evaluate success or failure of our procedures, as well as to diagnose complications before they occur.”

A Decade of Innovation

The new fiber-optic probe is flexible enough to snake through the body’s arteries and provide previously unavailable information to surgeons.Pereira et al./Science Translational Medicine

The new imaging platform is the brainchild of Giovanni Ughi, a biomedical engineer at the University of Massachusetts’ Chan Medical School in Worcester. About a decade ago, he set out to adapt a technique called optical coherence tomography (OCT) for imaging inside the brain’s arteries.

OCT relies on the backscattering of near-infrared light to create cross-sectional images with micrometer-scale spatial resolution. Although OCT had long been used in clinical settings to generate pictures from the back of the eye and from inside the arteries that supply blood to the heart, the technology had proven difficult to adapt for brain applications owing to several technical challenges.

One major challenge is that the fiber-optic probes used in the technology are typically quite stiff, making them too rigid to twist and bend through the convoluted passageways of the brain’s vasculature. Additionally, the torque cables—traditionally used to rotate the OCT lens to image surrounding vessels and devices in three dimensions as the probe retracts—were too large to fit inside the catheters that are telescopically advanced into the brain’s arteries to address blockages or other vascular issues.

“We had to invent a new technology,” Ughi explains. “Our probe had to be very, very flexible, but also very, very small to be compatible with the clinical workflow.”

To achieve these design criteria, Ughi and his colleagues altered the properties of the glass at the heart of their fiber-optic cables, devised a new system of rotational control that does away with torque cables, miniaturized the imaging lens, and made a number of other engineering innovations.

The end result: a slender probe, about the size of a fine wire, that spins 250 times per second, snapping images as it glides back through the blood vessel. Researchers flush out blood cells with a tablespoon of liquid, then manually or automatically retract the probe, revealing a section of the artery about the length of a lip balm tube.

St. Michael’s Foundation

Clinical Confirmation

After initial testing in rabbits, dogs, pigs, and human cadavers, Ughi’s team sent the device to two clinical groups: Pereira’s in Toronto and Pedro Lylyk’s at the Sagrada Familia Clinic in Buenos Aires, Argentina. Across the two groups, neurosurgeons treated the 32 participants in the latest study, snaking the imaging probe through the patients’ groins or wrists and into their brains.

The procedure was safe and well-tolerated across different anatomies, underlying disease conditions, and the complexity of prior interventions. Moreover, the information provided frequently led to actionable insights—in one case, prompting clinicians to prescribe anti-platelet drugs when hidden clots were discovered; in another, aiding in the proper placement of stents that were not flush against the arterial wall.

“We were successful in every single case,” Ughi says. “So, this was a huge confirmation that the technology is ready to move forward.”

“We can see a lot more information that was not accessible before.” —Vitor Mendes Pereira, St. Michael’s Hospital

A startup called Spryte Medical aims to do just that. According to founder and CEO David Kolstad, the company is in discussions with regulatory authorities in Europe, Japan, and the United States to determine the steps necessary to bring the imaging probe to market.

At the same time, Spryte—with Ughi as senior director of advanced development and software engineering—is working on machine learning software to automate the image analysis process, thus simplifying diagnostics and treatment planning for clinicians.

Bolstered by the latest data, cerebrovascular specialists like Siddiqui now say they are chomping at the bit to get their hands on the imaging probe once it clears regulatory approval.

“I’m really impressed,” Siddiqui says. “This is a tool that many of us who do these procedures wish they had.”

Neuralink’s visual prosthesis Blindsight has been designated a breakthrough device by the U.S. Food and Drug Administration, which potentially sets the technology on a fast track to approval.

In confirming the news, an FDA spokesperson emphasized that the designation does not mean that Blindsight is yet considered safe or effective. Technologies in the program have potential to improve the current standard of care and are novel compared to what’s available on the market, but the devices still have to go through full clinical trials before seeking FDA approval.

Still, the announcement is a sign that Neuralink is moving closer to testing Blindsight in human patients. The company is recruiting people with vision loss for studies in the United States, Canada, and the United Kingdom.

Visual prostheses work by capturing visual information with a video camera, typically attached to glasses or a headset. Then a processor converts the data to an electrical signal that can be relayed to the nervous system. Retinal implants have been a common approach, with electrodes feeding the signal to nerves in the retina, at the back of the eye, from where it travels on to the brain. But Blindsight uses a brain implant to send the signal directly to neurons in the visual cortex.

In recent years, other companies developing artificial vision prosthetics have reached clinical research trials or beyond, only to struggle financially, leaving patients without support. Some of these technologies live on with new backing: Second Sight’s Orion cortical implant project is now in a clinical trial with Cortigent, and Pixium Vision’s Prima system is now owned by Science, with ex-Neuralink founder Max Hodak at the helm. No company has yet commercialized a visual prosthetic that uses a brain implant.

Elon Musk’s Claims About Blindsight

Very little information about Blindsight is publicly available. As of this writing, there is no official Blindsight page on the Neuralink website, and Neuralink did not respond to requests for comment. It’s also unclear how exactly Blindsight relates to a brain-computer interface that Neuralink has already implanted in two people with paralysis, who use their devices to control computer cursors.

Experts who spoke with IEEE Spectrum felt that, if judged against the strong claims made by Neuralink’s billionaire co-founder Elon Musk, Blindsight will almost certainly disappoint. However, some were still open to the possibility that Neuralink could successfully bring a device to market that can help people with vision loss, albeit with less dramatic effects on their sense of sight. While Musk’s personal fortune could help Blindsight weather difficulties that would end other projects, experts did not feel it was a guarantee of success.

After Neuralink announced on X (formerly Twitter) that Blindsight had received the breakthrough device designation, Musk wrote:

The Blindsight device from Neuralink will enable even those who have lost both eyes and their optic nerve to see.

Provided the visual cortex is intact, it will even enable those who have been blind from birth to see for the first time.

To set expectations correctly, the vision will be at first be [sic] low resolution, like Atari graphics, but eventually it has the potential be [sic] better than natural vision and enable you to see in infrared, ultraviolet or even radar wavelengths, like Geordi La Forge.

Musk included a picture of La Forge, a character from the science-fiction franchise Star Trek who wears a vision-enhancing visor.

Experts Puncture the Blindsight Hype

“[Musk] will build the best cortical implant we can build with current technology. It will not produce anything like normal vision. [Yet] it might produce vision that can transform the lives of blind people,” said Ione Fine, a computational neuroscientist at the University of Washington, who has written about the potential limitations of cortical implants, given the complexity of the human visual system. Fine previously worked for the company Second Sight.

A successful visual prosthetic might more realistically be thought of as assistive technology than a cure for blindness. “At best, we’re talking about something that’s augmentative to a cane and a guide dog; not something that replaces a cane and a guide dog,” said Philip Troyk, a biomedical engineer at the Illinois Institute of Technology.

Restoring natural vision is beyond the reach of today’s technology. But among Musks recent claims, Troyk says that a form of infrared sensing is plausible and has already been tested with one of his patients, who used it for help locating people within a room. That patient has a 400-electrode device implanted in the visual cortex as part of a collaborative research effort called the Intracortical Visual Prosthesis Project (ICVP). By comparison, Blindsight may have more than 1,000 electrodes, if it’s a similar device to Neuralink’s brain-computer interface.

Experts say they’d like more information about Neuralink’s visual prosthetic. “I’m leery about the fact that they are very superficial in their description of the devices,” said Gislin Dagnelie, a vision scientist at Johns Hopkins University who has been involved in multiple clinical trials for vision prosthetics, including a Second Sight retinal implant, and who is currently collaborating on the ICVP. “There’s no clear evaluation or pre-clinical work that has been published,” says Dagnelie. “It’s all based on: ‘Trust us, we’re Neuralink.’”

In the short term, too much hype could mislead clinical trial participants. It could also degrade interest in small but meaningful advancements in visual prosthetics. “Some of the [Neuralink] technology is exciting, and has potential,” said Troyk. “The way the messaging is being done detracts from that, potentially.”

Experts agree that the incoming Trump administration will likely shake things up in the prescription drug world — most notably when it comes to research and development, drug pricing and PBM reform.

The post What Might the Future of Prescription Drugs Look Like Under Trump? appeared first on MedCity News.

The US Centers for Disease Control and Prevention said on Wednesday that slivered onions served on McDonald's, opens new tab Quarter Pounder hamburgers and other menu items were the likely source of an E. coli outbreak that sickened 90 people. The outbreak linked to Quarter Pounder was first reported on Oct 22, and slivered onions were suspected to be the source of the infections. The US Food and Drug Administration and the company have confirmed that Taylor Farms was the supplier for the affected locations, and it has since recalled several batches of yellow onions produced in a Colorado facility. The FDA on Wednesday said it had initiated inspections at a Taylor Farms processing center in Colorado, a state where 29 people have fallen ill due to the outbreak. An onion grower of interest in Washington state is also being investigated, the FDA added. The CDC said the number of infected people has risen by 15 people from 75 and 27 persons have been hospitalised due to the illness, which has already killed one person.

BEIRUT/JERUSALEM — The Israeli military pounded Beirut's southern suburbs with airstrikes on Tuesday (Nov 12), mounting one of its heaviest daytime attacks yet on the Hezbollah-controlled area, and struck the middle of the country where more than 20 people were killed. Smoke billowed over Beirut as around a dozen strikes hit the southern suburbs starting in midmorning. After posting warnings to civilians on social media, the Israeli military said it struck Hezbollah targets in Beirut's Dahiyeh area and later said it dismantled most of the group's weapons and missile facilities. Israel said it had taken steps to reduce harm to civilians and repeated its standing accusation that Hezbollah deliberately embeds itself into civilian areas to use residents as human shields, a charge Hezbollah rejects. In northern Israel, two people were killed in the city of Nahariya when a residential building was struck, Israeli police said. Hezbollah later claimed responsibility for a drone attack that it said was aimed at a military base east of Nahariya.

SINGAPORE - When an online retailer began selling his products on e-commerce platform Qoo10 in August 2023, he did not bat an eyelid when it took 30 to 45 days for the platform to disburse his first payout, compared with about three to seven days for other e-commerce sites he was using. But nearly a year later in July, payments owed to his business by Qoo10 had ballooned to about $1.6 million, as the platform’s payment delays exceeded two months and disbursements began trickling in, in smaller amounts. The Singaporean, who wanted to be known only as Mr T and did not wish to divulge what he sold, pulled the plug on his Qoo10 shop this year in the middle of July, and filed a civil claim with the courts. He obtained a default judgment in October for Qoo10 to pay him what he is owed, after the e-commerce site failed to serve a notice of intention to contest or not contest the claim. Mr T, who added that he had borrowed nearly $1 million from banks, friends and relatives to pay his suppliers, said: “I am not holding out hope that I will get much, or any, of my money back from Qoo10... By this point, I just want closure because it’s been so stressful.”

National parties’ unknown income rose from 66% to 71% in the three years before and after the scheme’s introduction

Oct 3, 2022

House Foreign Affairs Committee Ranking Member Mike McCaul (R-TX) and Ambassador Paula J. Dobriansky spoke about how the U.S. can better compete against China and Russia on technology and supply chains. Other topics included making changes to improve the defense industrial base, protecting critical supply chain infrastructure, and preparedness for major events like a pandemic.

May 23, 2024

Our data-centric way of seeing the world isn't serving us well. Barath Raghavan and Bruce Schneier argue that we need new socio-technical systems that leave room for the inherent messiness of reality.

Jun 3, 2024

In the wake of a Microsoft spying controversy, it’s time for an ecosystem perspective.

Apr 18, 2024

Assaf Zoran argues that an attack on Iran's nuclear facilities may have the opposite result of prompting an escalation in Iran’s nuclear developments, a pattern previously observed in response to kinetic actions attributed to Israel.

Carely�s founder Mike Eidsaune takes part in Brookdale�s Entrepreneur in Residence program during a short stay in Brookdale Kettering.

Video 1 Preview Image Caption

STOUFFER�S�, FIT KITCHEN� headed to Tempe, Arizona to host Fit City Event featuring a competitive softball game with a twist coached by two of baseball�s biggest stars encouraging fans to find their fit

You’re the one who called in this pizza? Slow down there, chief, we’ll get to the pizza. You won’t mind if I step in. Nice place you got here; looks expensive.

Üks tänahommikusel loodusretkel kohatud tiivulistest – väike nunnukas.

The highly anticipated Jake Paul vs. Mike Tyson fight is set to arrive soon, and this has sparked major excitement among fans about its release time. Netflix is bringing this exclusive event to its platform, making it accessible for fans wanting to witness the showdown. In it, boxing legend Mike Tyson will go up against […]

The post What Time Does Jake Paul vs. Mike Tyson Fight Release on Netflix? appeared first on ComingSoon.net - Movie Trailers, TV & Streaming News, and More.

With just days to go before the November 5 presidential election, fears are growing that Republicans intend to interfere with the official results in order to install Donald Trump as president. At Sunday’s Madison Square Garden rally, Trump said he had a “little secret” with House Speaker Mike Johnson that would have a “big impact” on the outcome, though neither he nor Johnson elaborated on what that entailed. Elie Mystal, the justice correspondent for The Nation, says the secret is almost certainly a plan to force a contingent election, whereby no candidate wins a majority of the Electoral College and the president is instead chosen by the House of Representatives, where Republicans hold a slim majority. Mystal notes that even if Democrats challenge such an outcome, the case would still end up before a Supreme Court with a conservative supermajority that is likely to side with Trump.

Shortly after Donald Trump was announced as the winner of the U.S. presidential election, Israeli Prime Minister Benjamin Netanyahu took to social media to enthusiastically congratulate him. Meanwhile, the Israeli military continued its violent assault on Gaza, killing multiple Palestinians in strikes on apartment buildings and homes. We speak to Palestinian American journalist Rami Khouri about what we know of Trump’s pro-Israel policies and how Trump beat Kamala Harris for the presidency. “Trump out-dramatized Harris, and that’s how he won,” he says.

As per sources within the Finance Ministry, the Centre is likely to maintain its original budgeted estimate of ₹22.07 lakh crore for direct tax collection when it revises estimates in February. ...

India's gaming market surged by 23% year-on-year, reaching $3.8 billion in revenue in FY 2023-24, even as the sector faces a 28% GST on online gaming, recent reports reveal....

Rod-shaped fragments of RNA called “obelisks” were discovered in gut and mouth bacteria for the first time