On the final Sunday of Pascha, Fr. John Whiteford reminds us to come humbly and meekly towards Christ.

On this Sunday, Fr. Andrew tells us that we may be spiritually blind to the Light of the World.

Fr. Apostolos shares on the Sunday of the Blind Man. "Jesus Christ ardently desires to remove from us our own deeply seated spiritual blindness, replacing the shattered eyes of our unrepentant hearts with the eyes of faith capable of receiving the vision of His glory."

Fr. Apostolos Hill delivers a homily on the blindness of ingratitude, while wearing a blindfold for effect. This is the perfect reminder for those listening to be grateful for that which is given to them.

Using some recent surgeries in his eye, Fr. Apostolos Hill explains the importance of staying vigilant to the blindness of our soul.

Fr. Apostolos Hill shares a homily on the Sunday of the Blind Man about the Causes and Cures of Spiritual Blindness.

Sunday of the Blind Man - Sixth Sunday of Pascha

In the story of the healing of the Blind Man, the willfully blind refuse to believe the truth about Jesus even when confronted with irrefutable proof. Fr Thomas reminds us that we must carefully consider all the teachings and deeds of Jesus so that we can be witnesses to the Son of God.

On the Sunday of the Blind Man, Fr. Gregory points out that Jesus is referring not to the blind man who now sees but rather addresses the hostile questioning of the Pharisees who see physically but not spiritually.

It is imperative always to follow the light—never the darkness. The light is given to us in Christ our Lord and conveyed through the teaching of the Church.

You may not know the name for it, but if you drive at night, you’ve probably experienced situational night blindness. It can occur “when you are temporarily blinded by a bright light such as an oncoming car’s headlights,” the Texas Department of Insurance says.

“From alarms and task chunking to time-estimation exercises, the strategies below can help you develop a more ‘ACCURATE’ sense of time.”

Vision damage from a complication of premature birth can be halted if it’s caught soon enough — and a California Perinatal Quality Care (CPQCC) and Stanford Medicine-led study shows the state’s screening process is helping close racial gaps.

The post California excels at screening babies for main cause of childhood blindness appeared first on Scope.

Location: Main Media Collection - Video record 42302 DVD

Mutations in the GUCY2D gene coding for the dimeric human retinal membrane guanylyl cyclase (RetGC) isozyme RetGC1 cause various forms of blindness, ranging from rod dysfunction to rod and cone degeneration. We tested how the mutations causing recessive congenital stationary night blindness (CSNB), recessive Leber's congenital amaurosis (LCA1), and dominant cone–rod dystrophy-6 (CORD6) affected RetGC1 activity and regulation by RetGC-activating proteins (GCAPs) and retinal degeneration-3 protein (RD3). CSNB mutations R666W, R761W, and L911F, as well as LCA1 mutations R768W and G982VfsX39, disabled RetGC1 activation by human GCAP1, -2, and -3. The R666W and R761W substitutions compromised binding of GCAP1 with RetGC1 in HEK293 cells. In contrast, G982VfsX39 and L911F RetGC1 retained the ability to bind GCAP1 in cyto but failed to effectively bind RD3. R768W RetGC1 did not bind either GCAP1 or RD3. The co-expression of GUCY2D allelic combinations linked to CSNB did not restore RetGC1 activity in vitro. The CORD6 mutation R838S in the RetGC1 dimerization domain strongly dominated the Ca2+ sensitivity of cyclase regulation by GCAP1 in RetGC1 heterodimer produced by co-expression of WT and the R838S subunits. It required higher Ca2+ concentrations to decelerate GCAP-activated RetGC1 heterodimer—6-fold higher than WT and 2-fold higher than the Ser838-harboring homodimer. The heterodimer was also more resistant than homodimers to inhibition by RD3. The observed biochemical changes can explain the dominant CORD6 blindness and recessive LCA1 blindness, both of which affect rods and cones, but they cannot explain the selective loss of rod function in recessive CSNB.

Voltage-gated Cav1 and Cav2 Ca2+ channels are comprised of a pore-forming α1 subunit (Cav1.1-1.4, Cav2.1-2.3) and auxiliary β (β1-4) and α2δ (α2δ−1−4) subunits. The properties of these channels vary with distinct combinations of Cav subunits and alternative splicing of the encoding transcripts. Therefore, the impact of disease-causing mutations affecting these channels may depend on the identities of Cav subunits and splice variants. Here, we analyzed the effects of a congenital stationary night blindness type 2 (CSNB2)-causing mutation, I745T (IT), in Cav1.4 channels typical of those in human retina: Cav1.4 splice variants with or without exon 47 (Cav1.4+ex47 and Cav1.4Δex47, respectively), and the auxiliary subunits, β2X13 and α2δ-4. We find that IT caused both Cav1.4 splice variants to activate at significantly more negative voltages and with slower deactivation kinetics than the corresponding WT channels. These effects of the IT mutation, along with unexpected alterations in ion selectivity, were generally larger in channels lacking exon 47. The weaker ion selectivity caused by IT led to hyperpolarizing shifts in the reversal potential and large outward currents that were evident in channels containing the auxiliary subunits β2X13 and α2δ-4 but not in those with β2A and α2δ-1. We conclude that the IT mutation stabilizes channel opening and alters ion selectivity of Cav1.4 in a manner that is strengthened by exclusion of exon 47 and inclusion of β2X13 and α2δ-4. Our results reveal complex actions of IT in modifying the properties of Cav1.4 channels, which may influence the pathological consequences of this mutation in retinal photoreceptors.

Two of the preeminent researchers of gene therapy hope to improve their patients' sight in an experimental operation (Stephen Voss/WPN)

The viewfinders are outfitted with special lenses that help people with red-green colorblindness distinguish between hues

Vision is initiated by capturing photons in highly specialized sensory cilia known as the photoreceptor outer segment. Because of its lipid and protein composition, the outer segments are prone to photo-oxidation, requiring photoreceptors to have robust antioxidant defenses and high metabolic synthesis rates to regenerate the outer segments every 10 days. Both processes required high levels of glucose uptake and utilization. Retinitis pigmentosa is a prevalent form of inherited retinal degeneration characterized by initial loss of low-light vision caused by the death of rod photoreceptors. In this disease, rods die as a direct effect of an inherited mutation. Following the loss of rods, cones eventually degenerate, resulting in complete blindness. The progression of vision loss in retinitis pigmentosa suggested that rod photoreceptors were necessary to maintain healthy cones. We identified a protein secreted by rods that functions to promote cone survival, and we named it rod-derived cone viability factor (RdCVF). RdCVF is encoded by an alternative splice product of the nucleoredoxin-like 1 (NXNL1) gene, and RdCVF was found to accelerate the uptake of glucose by cones. Without RdCVF, cones eventually die because of compromised glucose uptake and utilization. The NXNL1 gene also encodes for the thioredoxin RdCVFL, which reduces cysteines in photoreceptor proteins that are oxidized, providing a defense against radical oxygen species. We will review here the main steps of discovering this novel intercellular signaling currently under translation as a broad-spectrum treatment for retinitis pigmentosa.

India, a nation known for its resilience and progress, is burdened by a preventable blindness crisis. Over 85% of its blind citizens could have seen the light if early measures had been taken.

New research demonstrates an extreme form of inattentional blindness in which we fail to see the unexpected

There’s much more to visual perception than meets the eye. What we see is not merely a matter of patterns of light falling on the retina, but rather is heavily influenced by so-called ‘top-down’ brain mechanisms, which can alter the visual information, and other types of sensory information, that enters the brain before it even reaches our conscious awareness.

Related: Memory contaminates perception | Mo Costandi

Related: Language boosts invisible objects into visual awareness | Mo Costandi

Plant blindess is the "inability to see or notice the plants in one's own environment," which leads to "the inability to recognize the importance of plants."

Touching a giant hogweed can cause burns and even blindness.

Described herein are devices, compositions, and methods for improving color discernment.

Michael Cleveland has been called “one of the premier fiddle players of his generation, if not in all of bluegrass history.” He's also been completely blind since birth.

This kangaroo species normally lives high in the treetops but is now being found in odd places, unable to see and confused, and one ecologist is trying to find out the cause.

Because everything is currently terrible, I binge-watched Love is Blind. In case you are planning to do the same, this is a spoiler-free post. You probably know the premise: contestants in this romantic reality romp go on speed dates in little pods. They can’t see their conversation partners, and at the end of the dates […]

London : D. Bogue, 1881.

Wiesbaden : J.F. Bergmann, 1885.

Title: New Drug Could Help Stop Blindness From Thyroid Eye Disease
Category: Health News
Created: 1/22/2020 12:00:00 AM
Last Editorial Review: 1/23/2020 12:00:00 AM

Quick test to identify which people with glaucoma are at risk of rapid progression to blindness using artificial intelligence. A new test can detect

In premature infants, very low dose of Avastin (bevacizumab) was found to prevent blindness from retinopathy of prematurity (ROP), revealed results from

Blindness Might be as well be termed as an epidemic in Sri Lanka as Nearly 1 million people suffer from it and cataract could be the reason behind it.

MARTIN SAMUEL - CHIEF SPORTS WRITER: Sack FINA. After the disgrace of the Sun Yang doping case, swimming's governing body has no authority and no credibility.

There are 70 million diabetics in India, 80 percent of them have vision problems about which they are either not aware or lack access to good eye care. Swapna Majumdar reports how NGOs are partnering to reach out to the marginalised and providing them better eye care and prevention.

Various independent studies and research reveal close to 20 per cent of students across India suffering from some degree of visual impairment. A new initiative from the Nayonika Eye Care Charitable Trust seeks to correct this through the combined efforts of a wider network.

Leggett, Jeremy K

Online Resource

Browsery LC212.42.S44 2019

Megastar Amitabh Bachchan has launched a 'See Now' campaign, centred in UP, to help end avoidable blindness.

Rhitu Chatterjee discusses Project Prakash and the neuroscience behind reversing blindness in children, teenagers, and adults in rural India; David Grimm talks about where dogs came from, when life first evolved, and holes in the brain. Hosted by Susanne Bard. [Img: Francois de Halleux CC BY-NC-ND 2.0]

Castro, Brian, 1950- author

Title: Blindness [electronic resource] : the history of a mental image in western thought / Moshe Barasch.
Author: Barasch, Moshe.
Imprint: New York : Routledge, 2001.
Shelfmark: Taylor & Francis ebooks
Subjects: Blind -- History.
Blind -- Public opinion.
Blind in art.
Blind in literature.
Blind. fast (OCoLC)fst00834291
Blind in art. fast (OCoLC)fst00834377
Blind in literature. fast (OCoLC)fst00834378
Blind -- Public opinion. fast (OCoLC)fst00834341