When healthy volunteers are scanned as part of a research project, unexpected findings, with uncertain implications, can be thrown up. Joanna Wardlaw, professor of applied neuroimaging and honorary consultant neuroradiologist at the University of Edinburgh, joins us to discuss how her group deals with these incidental findings, and what...

If this were Britain, Russia or India, Rudy Giuliani '08 caps would not be on the clearance racks. In those countries, where bigwigs and insiders get to nominate party leaders, the former Republican front-runner and establishment favorite would have long ago been anointed the winner.

Ron DeSantis had a thin record on K-12 issues as a Florida congressman, but as a first-term Republican governor he’s pushed an aggressive agenda on issues such as vouchers, teacher salaries and bonus pay, and even the common core.

Rosario, Argentina :: Church members from a vulnerable community learn about human trafficking and experience care and respect.

God uses theatrical evangelism camps to impact children from vulnerable populations as well as the short-term volunteers who serve.

OM EAST rejoices at God’s provision sent by post.

Rosario, Argentina :: Church members from a vulnerable community learn about human trafficking and experience care and respect.

The CPT1A p.P479L variant is common to northern aboriginal populations, leads to reduced enzyme activity, and may be associated with increased infant mortality rates.

The p.P479L variant is common in British Columbia First Nations with a coastal distribution correlated with regions of high infant mortality. Homozygotes display an altered acylcarnitine profile and are overrepresented in cases of sudden unexpected infant death in these areas. (Read the full article)

Tympanometry provides a measure of middle ear function. There has been no description of the relationship between measurements of middle ear function in the absence of gross anatomic defects and clinical outcome among children with acute nontraumatic coma.

This study reveals an unexpected association between abnormal middle ear function and death in childhood acute coma. These findings call for more investigations on the relationship between middle and inner ear anatomy and function and intracranial dynamics and clinical outcomes. (Read the full article)

Certain characteristics of the sleep environment increase the risk for sleep-related, sudden, and unexplained infant death. These characteristics have the potential to generate asphyxia. The relationship between the deaths occurring in these environments and neurochemical abnormalities in the brainstem that may impair protective responses to asphyxia is unknown.

We report neurochemical brainstem abnormalities underlying cases of sudden infant death that are associated with and without potential asphyxial situations in the sleep environment at death. The means to detect and treat these abnormalities in infants at risk are needed. (Read the full article)

The unexpected transition to online classes due to the COVID-19 pandemic has prompted many changes for undergraduate students and their instructors. To understand the magnitude of these impacts and potentially improve digital learning, researchers in the Penn State School of Engineering Design and Professional Programs have received a $196,136 grant from the National Science Foundation.

Manogepix (APX001A) is the active moiety of the novel drug candidate fosmanogepix (APX001). We previously reported the broad-spectrum activity of manogepix but also observed a correlation between increased manogepix and fluconazole MICs. Here we extended this study and included isolates with acquired fluconazole resistance.

Isolates (n=835) were identified using CHROMagar, MALDI-TOF and, when needed, ITS-sequencing. EUCAST E.Def 7.3.1 susceptibility testing included manogepix, amphotericin B, anidulafungin, micafungin, fluconazole and voriconazole. Manogepix wildtype-upper-limit (WT-UL) values were established following EUCAST-principles for ECOFF setting allowing wildtype/non-wildtype classification. Drug-specific MIC correlations were investigated using Pearson's correlation.

Manogepix modal MICs were low (range 0.004-0.06 mg/L against 16/20 included species). Exceptions were C. krusei and C. inconspicua, and to a lesser extent C. kefyr and Pichia kluyveri. The activity was independent of Fks echinocandin hot-spot alterations (n=17). Adopting the WT-UL established for C. albicans, C. dubliniensis, C. glabrata, C. parapsilosis and C. tropicalis, 14/724 (1.9%) isolates were non-wildtype for manogepix. Twelve of these (85.7%) were also non-wildtype for fluconazole. A statistically significant correlation was observed between manogepix and fluconazole MICs for C. albicans, C. dubliniensis, C. glabrata, C. parapsilosis and C. tropicalis (Pearson r=0.401-0.575), but not between manogepix and micafungin or amphotericin B MICs for any species except C. tropicalis (r=0.519 for manogepix versus micafungin).

Broad-spectrum activity was confirmed for manogepix against contemporary yeast. However, a 1-4 two-fold-dilution increase in manogepix MICs is observed in a subset of isolates with acquired fluconazole resistance. Further studies on the potential underlying mechanism and implication for optimal dosing are warranted.

Rosario, Argentina :: Church members from a vulnerable community learn about human trafficking and experience care and respect.

Rosario, Argentina :: Church members from a vulnerable community learn about human trafficking and experience care and respect.

Yong Y. Han
Dec 1, 2005; 116:1506-1512
ARTICLES

Rosario, Argentina :: Church members from a vulnerable community learn about human trafficking and experience care and respect.

Rosario, Argentina :: Church members from a vulnerable community learn about human trafficking and experience care and respect.

Rosario, Argentina :: Church members from a vulnerable community learn about human trafficking and experience care and respect.

Rosario, Argentina :: Church members from a vulnerable community learn about human trafficking and experience care and respect.

Rosario, Argentina :: Church members from a vulnerable community learn about human trafficking and experience care and respect.

An OMer in Kazakhstan tells of a Kazakh friend and believer who, finding herself pregnant again before she is ready, wrestles with cultural norms.

As international coal prices are on the rise, Hanwha Chemical's prospect is getting brighter. That's because the Korean company uses naphtha to produce polyvinyl chloride (PVC) while its rivals in China are largely based on coal, which will make it more price competitive vis-a-vis the Chinese chemical producers. According to Korea Resources Corp. and chemical industry sources on September 10, the freight-on-board (FOB) price of bituminous coal out of the Chinese port of Qinhuangdao was US$95....

Microbial mat communities are associated with extensive (~700 km²) and morphologically variable carbonate structures, termed microbialites, in the hypersaline Great Salt Lake (GSL), Utah. However, whether the composition of GSL mat communities covaries with microbialite morphology and lake environment is unknown. Moreover, the potential adaptations that allow the establishment of these extensive mat communities at high salinity (14% to 17% total salts) are poorly understood. To address these questions, microbial mats were sampled from seven locations in the south arm of GSL representing different lake environments and microbialite morphologies. Despite the morphological differences, microbialite-associated mats were taxonomically similar and were dominated by the cyanobacterium Euhalothece and several heterotrophic bacteria. Metagenomic sequencing of a representative mat revealed Euhalothece and subdominant Thiohalocapsa populations that harbor the Calvin cycle and nitrogenase, suggesting they supply fixed carbon and nitrogen to heterotrophic bacteria. Fifteen of the next sixteen most abundant taxa are inferred to be aerobic heterotrophs and, surprisingly, harbor reaction center, rhodopsin, and/or bacteriochlorophyll biosynthesis proteins, suggesting aerobic photoheterotrophic (APH) capabilities. Importantly, proteins involved in APH are enriched in the GSL community relative to that in microbialite mat communities from lower salinity environments. These findings indicate that the ability to integrate light into energy metabolism is a key adaptation allowing for robust mat development in the hypersaline GSL.

IMPORTANCE The earliest evidence of life on Earth is from organosedimentary structures, termed microbialites, preserved in 3.481-billion-year-old (Ga) rocks. Phototrophic microbial mats form in association with an ~700-km² expanse of morphologically diverse microbialites in the hypersaline Great Salt Lake (GSL), Utah. Here, we show taxonomically similar microbial mat communities are associated with morphologically diverse microbialites across the lake. Metagenomic sequencing reveals an abundance and diversity of autotrophic and heterotrophic taxa capable of harvesting light energy to drive metabolism. The unexpected abundance of and diversity in the mechanisms of harvesting light energy observed in GSL mat populations likely function to minimize niche overlap among coinhabiting taxa, provide a mechanism(s) to increase energy yield and osmotic balance during salt stress, and enhance fitness. Together, these physiological benefits promote the formation of robust mats that, in turn, influence the formation of morphologically diverse microbialite structures that can be imprinted in the rock record.

Antituberculosis (anti-TB) drug development is dependent on informative trials to secure the development of new antibiotics and combination regimens. Clofazimine (CLO) and pyrazinamide (PZA) are important components of recommended standard multidrug treatments of TB. Paradoxically, in a phase IIa trial aiming to define the early bactericidal activity (EBA) of CLO and PZA monotherapy over the first 14 days of treatment, no significant drug effect was demonstrated for the two drugs using traditional statistical analysis. Using a model-based analysis, we characterized the statistically significant exposure-response relationships for both drugs that could explain the original findings of an increase in the numbers of CFU with CLO treatment and no effect with PZA. Sensitive analyses are crucial for exploring drug effects in early clinical trials to make the right decisions for advancement to further development. We propose that this quantitative semimechanistic approach provides a rational framework for analyzing phase IIa EBA studies and can accelerate anti-TB drug development.

The OpenAI project demonstrated "emergent behavior" by the AI players, including surfing

The brain has a powerful ability to remember and connect events separated in time. And now, in a new study in mice, scientists have shed light on how the brain can form such enduring links.

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Lockdown Britain has embraced the sausage, with sales up 33%. But there’s much more you can do with them than fry-ups, sandwiches and casseroles

When you Google famous quotes about sausages (say you need an opener for an article), one of the first comes from Phoebe Waller-Bridge, who apparently once said: “Sausages are just funny. I don’t know why. I can’t explain it.”

Waller-Bridge is not wrong. Sausages are inherently funny. But their comedic value is also what holds them back. In the kitchen, no one takes sausages seriously. You very rarely see anyone serving sausages on Come Dine With Me; it would be an act of self-sabotage. You cannot win with sausages. They’re a culinary joke, unrefined, a bit naff.

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Fifty years ago, on May 9, 1970, The Guess Who became the first-ever Canadian rock band to top Billboard's Hot 100 chart.

The brain has a powerful ability to remember and connect events separated in time. And now, in a new study in mice published today in Neuron, scientists at Columbia's Zuckerman Institute have shed light on how the brain can form such enduring links.

The U.S. economy is in a medically-induced coma. Unemployment is soaring. Companies are teetering on the brink of bankruptcy. It is unclear when our lives will return to their pre-pandemic state.

One thing seems apparent: As people lose jobs and health insurance, Medicaid enrollment will jump, perhaps by as much as 20% to 30%. This will have profound implications for the drug channel.

Today, I focus on how this increase will affect retail pharmacies and pharmacy benefit managers (PBMs). Below, I review Medicaid enrollment trends, how states manage prescriptions, and the factors driving the coming boom in Medicaid enrollment.

As I explain, many (but not all) retail pharmacies will benefit from Medicaid growth. PBMs, however, will not fare as well. Read on and see if you agree.

In early May, Drug Channels Institute will host two live video webinars: Industry Update and COVID-19 Impact: Retail & Specialty Pharmacies (May 1) and Industry Update and COVID-19 Impact: PBMs & Payers (May 8). CLICK HERE TO LEARN MORE AND SIGN UP. DCI will donate 20% of all profits from these events to The Center for Disaster Philanthropy’s COVID-19 Response Fund.

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From chia to hemp, seeds were a prominent force among the 500-plus new products at the annual tradeshow in Los Angeles.

From the craft room to the bathroom to the kitchen, the humble apple has many more application than just sauce and pie.

It is as counterintuitive as it is true: Around the world, communities who have resided on the land the longest often have the most tenuous rights to that land.

A look at this year's Casa FOA, an exhibition which combines charity and patrimony conservation showcasing the best architecture and design from the Argentine capital.

Data showed China's exports rose 3.5% from a year ago, versus a 15.7% decline in a Reuters poll.

George Milling-Stanley, who helped create the SPDR Gold Trust, says the precious metal is not just a hedge against inflation but against the unexpected.

If you loved The Unexpected Party sequence from The Hobbit: An Unexpected Journey then our friends from Weta Workshop have something for you. You can now buy a board game version of this sequence in the film. The purpose of this game is to be the first person to complete all 15 lines of the […]

Cheese shops and gun stores are among the services still open in locked down places around the world.

In his recent interview, director of the hit show Money Heist, Alex Rodrigo chose his ideal Indian cast for the show. His choices are sure to make you want an Indian series of the show soon.

The Director of Cultural Partnerships at King's College London reflects on the growing appetite among artists and arts organisations for evidence about the impact and value of what they do  

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Deepak, 50, was interviewed in Hastings during a segment about how the beach was deserted and eagle-eyed viewers were quick to recognise the 90's icon on Sunday's BBC news.

David George's father found him unconscious in his bedroom in Glasgow after David left play-time with his brother and sister to watch Transformers. The toddler died of SUDC after falling asleep.

ReutersThe Labor Department reported on Thursday that 5.2 million Americans filed for unemployment insurance in the week that ended April 11.More than 22 million jobless claims were filed over the last four weeks, setting a record for that period of time. Still, more than 47 million Americans could lose their jobs in the second quarter as a result of the novel coronavirus pandemic, according to the Federal Reserve Bank of St. Louis.If you were recently laid off or furloughed, or suspect you may be soon, here's what human resources and retirement experts want you to know. For example, you should know where to access your state's unemployment application and make sure to ask your employer about health insurance benefits. Visit Business Insider's homepage for more stories.Mass layoffs and furloughs

When Florian Reuter joined German drone taxi startup Volocopter in 2015 as CEO, co-founders Stephan Wolf and Alexander Zosel had impressive tech, but no clear path to market."When we started out there was not even an idea of how these types of vehicles would ever be certified," Reuter told Business Insider. "Now we have a whole new category created for us."Volocopter now has equity funding of €122 million and the company continues to add corporate strategic partners to a list that includes Daimler, Intel, and Micron.Now, the team is focused on completing its certification with the European aviation authority to become the first commercial air taxi company.This article is part of a series on growing a small business, called "From 1 to 100."If disruption is the path to a billion-dollar startup,

President Donald Trump enjoyed a close working relationship with Jennifer Hawkins when she was crowned Miss Universe 16 years ago. 

PAUL NEWMAN IN KATUNAYAKE: Crawley, 22, was again composed and classy on Sunday as he scored 91 in the first warm-up of England's Sri Lanka tour before getting out carelessly.