A second Trump administration committed to cutting federal spending could mean very good things for non-traditional defense companies and startups because of a focus on affordability, Eric DeMarco, the president […]

Vatn Systems, a startup developing autonomous underwater vehicles (AUVs) for U.S. and allied military customers, on Tuesday said it has raised $13 million in seed funding to further expand its […]

Selecting a VFD that features remote startup can decrease the number of individuals needed onsite and provide valuable safety benefits.

Joel Spolsky on founding Stack Overflow, “land grabs” vs. “bootstrapping with profitability”, raising more money using “proof points”, what developers and companies get massively wrong, choosing your next job, and how to ask and answer on Stack Over

Chicago-based tech startup Albi has been named one of LinkedIn's Top 10 Most Successful Startups, recognizing the company’s transformative platform for restoration professionals. 

Washington, D.C. -- NAB Show is currently accepting applications from startup companies to feature their innovative products and solutions on the industry’s largest stage for media, entertainment and technology at the 2022 NAB Show, held April 23–27 in Las Vegas, Nev.

True Digital Park has opened its Work Space, a co-working and office zone with capacity for 4,500 workers, in a bid to provide an affordable area for startups to develop and attract venture capital funding.

Technology entrepreneur Elon Musk, the founder of Tesla, SpaceX and The Boring Company, gives a rapt audience a preview of gaming in Tesla cars, and described which failure most helped his career. - REUTERS

About one in every 10 European startups that have raised VC investment are also backed by an EU grant of equity financing, according to a research project conducted by Dealroom and Dealflow.eu. While the full report is expected to be published later this year, the authors presented a few preliminary numbers in Warsaw last week. In financial terms, the 10% share translates into EU-backed startups having raised €70bn in VC funding since 2010, or some 11% of total funding in Europe (which in this case includes the EU, Switzerland, Norway, UK, and Israel). With some €400bn in total enterprise value…

This story continues at The Next Web

In 1991, Sony brought the first rechargeable lithium-ion battery to market. The unique chemistry proved a game-changer in energy storage. Today everything from EVs to smartphones depends on it, with demand skyrocketing.  But lithium is rare, most of it comes from unstable markets outside Europe, and its extraction can cause extensive pollution. We need more lithium to enable the green transition and yet, currently, its use is unsustainable — both environmentally and economically. We’re stuck in a paradox. Munich-based startup Tozero believes that battery recycling offers a way out. Recycling batteries is far from a new concept, but the German venture…

This story continues at The Next Web

Few drugs are available to treat heavy metals that enter the body, either from lead poisoning or nuclear fallout. A UC Berkeley startup hopes to change that.

L.A.-area startups received $1.8 billion in the third quarter, the highest quarterly amount for the region, according to CB Insights. Most of it went to a single company.

The new funding will support Wheelocity’s plans to expand operations across 20,000 towns and villages in southern India over the next year, aiming to reach a user base of 10 million.

Wakefit cofounder Chaitanya Ramalingegowda attributed the increase in revenue to the company’s focus on strengthening its omnichannel presence, with some stores reaching maturity and a new wave of outlets opening, along with the benefits of an automated mattress factory.

Rentomojo reported a 60% rise in operating revenue to Rs 193 crore in FY24. Controlled rise in expenses during the year saw net profit surge more than threefold to Rs 22 crore last fiscal from Rs 6 crore in FY23.

He further claimed that the product is launched at a 15 per cent lower price compared to the existing products in the market. “We are retaining lower margins than other brands and it works for us, as we spend much less in marketing,” commented Shreyans Jain, co-founder, Nutrabay.

Jammbo, founded in 2023, presently has about 50 products in its portfolio, focusing on ride-on battery toys such as electric cars and bikes. It aims to expand its portfolio to over 200 products by the end of the current fiscal year. The startup has set up its global presence by entering the UAE market. Further, it plans to expand to the U.S. and the U.K. markets this fiscal.

Baby food startup Bebe Burp shared that it will utilise 60 per cent of the fund for growth, 20 per cent for operations, 10 per cent for product development, and the remaining for team building for a coherent production.

Startup H3X, with a facility in Louisville, has ambitions to become the world's leading supplier of advanced electric motors.

Unbabel on Wednesday announced an artificial intelligence-powered translation service, adding another rival to a highly competitive space.

The European company had acquired Grubhub in 2020 in an all-stock deal for $7.8 billion, creating the world’s largest food delivery company outside China at the time. A deal for Grubhub could be finalized imminently, assuming the talks do not fall apart, the report said, adding that Grubhub is…

In This Article: (Bloomberg) -- Wonder Group Inc. is buying Grubhub from Just Eat Takeaway.com NV for about $650 million, acquiring the restaurant delivery service at a steep discount to the $7.3 billion price tag it commanded during the early days of the Covid pandemic. Most Read from…

Red Hat, the IBM-owned open source software firm, is acquiring Neural Magic, a startup that optimizes AI models to run faster on commodity processors and GPUs. From a report: The terms of the deal weren't disclosed. MIT research scientist Alex Matveev and professor Nir Shavit founded Somerville, Massachusetts-based Neural Magic in 2018, inspired by their work in high-performance execution engines for AI. Neural Magic's software aims to process AI workloads on processors and GPUs at speeds equivalent to specialized AI chips (e.g. TPUs). By running models on off-the-shelf processors, which usually have more available memory, the company's software can realize these performance gains. Big tech companies like AMD and a host of other startups, including NeuReality, Deci, CoCoPie, OctoML and DeepCube, offer some sort of AI optimization software. But Neural Magic is one of the few with a free platform and a collection of open source tools to complement it. Neural Magic had so far managed to raise $50 million in venture capital from backers like Andreessen Horowitz, New Enterprise Associations, Amdocs, Comcast Ventures, Pillar VC and Ridgeline Ventures.

Read more of this story at Slashdot.

Tech accelerator Startupbootcamp, British-East African business tycoon Ashish Thakkar’s Mara Group and Blend Financial Services are planning a $250 million (R4.4 billion) fund to invest in new African technology companies.

Design that Matters wins for contribution to humanity in education category

In August 2024, Pennsylvania resident Max Justice launched Setas Eternal Living. His flagship product, MyCoffin, is a biodegradable coffin made from mycelium, the root structure of mushrooms. Justice has utilized resources provided by Penn State Law's Entrepreneur Assistance and Intellectual Property clinics and Happy Valley LaunchBox to grow his business. 

Firefly Aerospace has raised $175 million in a late-stage funding round led by RPM Ventures, valuing the space startup at more than $2 billion, it said on Tuesday.

A new AI-powered, imaging-based technology that creates accurate three-dimensional models of tumors, veins and other soft tissue offers a promising new method to help surgeons operate on, and better treat, breast cancers. The technology, from Illinois-based startup SimBioSys, converts routine black-and-white MRI images into spatially accurate, volumetric images of a patient’s breasts. It then illuminates Read Article

Lifelike digital humans engage with audiences in real time. Autonomous systems streamline complex logistics. And AI-driven language tools break down communication barriers on the fly. This isn’t sci-fi. This is Tokyo’s startup scene. Supercharged by AI — and world-class academic and industrial might — the region has become a global innovation hub. And the NVIDIA Read Article

U.S.-based startup company Heliospect Genomics reportedly is offering wealthy couples embryo screening for IQ and other traits at $50,000 for 100 embryos.

The grant program provides hardware startups with reimbursement for working with local manufacturers.

Venture creation in biotech is witnessing a sustained contraction. After the pandemic bubble’s over-indulgence, the venture ecosystem appears to have reset its pace of launching new startups. According to the latest Pitchbook data, venture creation in biotech hit its slowest

The post The Biotech Startup Contraction Continues… And That’s A Good Thing appeared first on LifeSciVC.

Tech startups are stepping up to meet the needs of 60 million people worldwide who use opioids, representing about 1 percent of the world’s adult population. In the United States, deaths involving synthetic opioids have risen 1,040 percent from 2013 to 2019. The COVID-19 pandemic and continued prevalence of fentanyl have since worsened the toll, with an estimated 81,083 fatal overdoses in 2023 alone.

Innovations include biometric monitoring systems that help doctors determine proper medication dosages, nerve stimulators that relieve withdrawal symptoms, wearable and ingestible systems that watch for signs of an overdose, and autonomous drug delivery systems that could prevent overdose deaths.

Helping Patients Get the Dosage They Need

For decades, opioid blockers and other medications that suppress cravings have been the primary treatment tool for opioid addiction. However, despite its clinical dominance, this approach remains underutilized. In the United States, only about 22 percent of the 2.5 million adults with opioid use disorder receive medication-assisted therapy such as methadone, Suboxone, and similar drugs.

Determining patients’ ideal dosage during the early stages of treatment is crucial for keeping them in recovery programs. The shift from heroin to potent synthetic opioids, like fentanyl, has complicated this process, as the typical recommended medication doses can be too low for those with a high fentanyl tolerance.

A North Carolina-based startup is developing a predictive algorithm to help clinicians tailor these protocols and track real-time progress with biometric data. OpiAID, which is currently working with 1,000 patients across three clinical sites, recently launched a research pilot with virtual treatment provider Bicycle Health. Patients taking Suboxone will wear a Samsung Galaxy Watch6 to measure their heart rate, body movements, and skin temperature. OpiAID CEO David Reeser says clinicians can derive unique stress indications from this data, particularly during withdrawal. (He declined to share specifics on how the algorithm works.)

“Identifying stress biometrically plays a role in how resilient someone will be,” Reeser adds. “For instance, poor heart rate variability during sleep could indicate that a patient may be more susceptible that day. In the presence of measurable amounts of withdrawal, the potential for relapse on illicit medications may be more likely.”

Nerve Stimulators Provide Opioid Withdrawal Relief

While OpiAID’s software solution relies on monitoring patients, electrical nerve stimulation devices take direct action. These behind-the-ear wearables distribute electrodes at nerve endings around the ear and send electrical pulses to block pain signals and relieve withdrawal symptoms like anxiety and nausea.

The U.S. Food and Drug Administration (FDA) has cleared several nerve stimulator devices, such as DyAnsys’ Drug Relief, which periodically administers low-level electrical pulses to the ear’s cranial nerves. Others include Spark Biomedical’s Sparrow system and NET Recovery’s NETNeuro device.

Masimo’s behind-the-ear Bridge device costs US $595 for treatment providers.Masimo

Similarly, Masimo’s Bridge relieves withdrawal symptoms by stimulating the brain and spinal cord via electrodes. The device is intended to help patients initiating, transitioning into, or tapering off medication-assisted treatment. In a clinical trial, Bridge reduced symptom severity by 85 percent in the first hour and 97 percent by the fifth day. A Masimo spokesperson said the company’s typical customers are treatment providers and correctional facilities, though it’s also seeing interest from emergency room physicians.

Devices Monitor Blood Oxygen to Prevent Overdose Deaths

In 2023, the FDA cleared Masimo’s Opioid Halo device to monitor blood oxygen levels and alert emergency contacts if it detects opioid-induced respiratory depression, the leading cause of overdose deaths. The product includes a pulse oximeter cable and disposable sensors connected to a mobile app.

Opioid Halo utilizes Masimo’s signal extraction technology, first developed in the 1990s, which improves upon conventional oxygen monitoring techniques by filtering out artifacts caused by blood movement. Masimo employs four signal-processing engines to distinguish the true signal from noise that can lead to false alarms; for example, they distinguish between arterial blood and low-oxygen venous blood.

Masimo’s Opioid Halo system is available over-the-counter without a prescription. Masimo

Opioid Halo is available over-the-counter for US $250. A spokesperson says sales have continued to show promise as more healthcare providers recommend it to high-risk patients.

An Ingestible Sensor to Watch Over Patients

Last year, in a first-in-human clinical study, doctors used an ingestible sensor to monitor vital signs from patients’ stomachs. Researchers analyzed the breathing patterns and heart rates of 10 sleep study patients at West Virginia University. Some participants had episodes of central sleep apnea, which can be a proxy for opioid-induced respiratory depression. The capsule transmitted this data wirelessly to external equipment linked to the cloud.

Celero’s Rescue-Rx capsule would reside in a user’s stomach for one week.Benjamin Pless/Celero Systems

“To our knowledge, this is the first time anyone has demonstrated the ability to accurately monitor human cardiac and respiratory signals from an ingestible device,” says Benjamin Pless, one of the study’s co-authors. “This was done using very low-power circuitry including a radio, microprocessor, and accelerometer along with software for distinguishing various physiological signals.”

Pless and colleagues from MIT and Harvard Medical School started Celero Systems to commercialize a modified version of that capsule, one that will also release an opioid antagonist after detecting respiratory depression. Pless, Celero’s CEO, says the team has successfully demonstrated the delivery of nalmefene, an opioid antagonist similar to Narcan, to rapidly reverse overdoses.

Celero’s next step is integrating the vitals-monitoring feature for human trials. The company’s final device, Rescue-Rx, is intended to stay in the stomach for one week before passing naturally. Pless says Rescue-Rx’s ingestible format will make the therapy cheaper and more accessible than wearable autoinjectors or implants.

Celero’s capsule can detect vital signs from within the stomach. www.youtube.com

Autonomous Delivery of Overdose Medication

Rescue-Rx isn’t the only autonomous drug-delivery project under development. A recent IEEE Transactions on Biomedical Circuits and Systems paper introduced a wrist-worn near-infrared spectroscopy sensor to detect low blood oxygen levels related to an overdose.

Purdue University biomedical engineering professor Hugh Lee and graduate student Juan Mesa, who both co-authored the study, say that while additional human experiments are necessary, the findings represent a valuable tool in counteracting the epidemic. “Our wearable device consistently detected low-oxygenation events, triggered alarms, and activated the circuitry designed to release the antidote through the implantable capsule,” they wrote in an email.

Lee and Purdue colleagues founded Rescue Biomedical to commercialize the A2D2 system, which includes a wristband and an implanted naloxone capsule that releases the drug if oxygen levels drop below 90 percent. Next, the team will evaluate the closed-loop system in mice.

This story was updated on 27 August 2024 to correct the name of Masimo’s Opioid Halo device.

While startups in highly regulated industries like healthcare and finance are almost certain to face heightened scrutiny, there are controllable factors that can offset these challenges.

The post The Startup Economy is Turbulent. Here’s How Founders Can Recognize and Avoid Common Pitfalls appeared first on MedCity News.

SMASHD Labs Season 2 is a 10-week accelerator program based out of Los Angeles talent firm Atom Factory. We are inviting companies at the intersection of entertainment, technology, and culture to work alongside our team to accelerate their growth. Join us and our roster of world-class mentors for a masterclass in hustle.

As enterprise platforms gradually eat into the workflows of accountants, many are choosing to leave the industry, especially as AI automates away a lot of the core, manual work required. More than 300,000 U.S. accountants and auditors left their jobs between 2019 and 2021, and the number of accountants in the U.S. has declined 15.9% […]

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Ameba takes the unstructured data in a retailer’s supply chain systems, sprinkles in some generative AI, and makes the whole thing more efficient. 

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These days, private investors have a range of options for investing in startups without having to deal with them in real life. This ecosystem more or less started with AngelList, but there are now a plethora of options — such as Carta, Allocations, Vauban, and Odin — that startups can use to raise funding and […]

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U.S. venture capital giant General Catalyst has announced a fresh $8 billion in funds as it looks to ramp up its investments in multi-sector early-stage startups globally, with a specific focus on the U.S., Europe, and India. The capital constitutes around $4.5 billion for its “core VC funds,” which spans seed and growth equity funding, […]

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Computer vision applications are getting a huge boost from advances in smartphones combined with AI that helps fill in the gaps of what everyday devices cannot see. Using these tools, a startup out of Munich called Beyond Presence believes it holds the keys to what is coming next: Hyper-realistic avatars that look and sound exactly […]

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There’s a big opportunity for generative AI in the world of translation, and a startup called Panjaya is taking the concept to the next level: a hyperrealistic, GenAI-based dubbing tool for videos that recreates a person’s original voice speaking the new language, with the video and the speaker’s physical movements automatically modifying to match up […]

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Cybersecurity continues to command a lot of attention from enterprises looking for better protection from malicious hackers, and VCs want in on the action. In the latest example, TechCrunch has learned and confirmed that Upwind — a specialist in assessing and securing cloud infrastructure — is closing in on a $100 million round at a […]

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Abel creates AI that uses body cam footage and other data to fill out consuming police reports. For research, founder Daniel Francis shadowed the police.

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Storing great pools of data is an increasingly figured-out challenge. Between public clouds, and data lakes more specifically, you can stick oceans of corporate data in any number of places. But leveraging that data into something useful is another challenge altogether. The analogy that data is this era’s oil is at best half-baked. Oil takes […]

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Tofino Capital, a venture capital firm targeting early-stage startups in emerging markets, has launched its $10 million fund. It is announcing the first close of this fund at $5 million and hopes to achieve a final close nine months from now.   The firm, founded by Eliot Pence and Aubrey Hruby, wants to back startups in Africa, […]

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At TechCrunch Early Stage, we sat down with Felicis Ventures partners Viviana Faga and Niki Pezeshki to talk about scaling, and why it's crucial to be "10x better" than the incumbents.

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Disrupt is just a few short weeks away. Alongside our return to a live, in-person show, we’ve beefed up the Battlefield program. Two hundred companies have been hand selected by the TechCrunch editorial staff to grace the expo hall, 20 of which will launch their company for the first time live on our stage. The […]

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