I am trying to understand the Linting process. I know that mainly JasperGold is the tool for this purpose. Though I think JasperGold is more suited for later stages of the design. As a RTL Design Engineer, I want to make sure that if another tool has the capability of doing Linting earlier in the flow. for example, does Xcelium, Genus or Confomal support linting. I have seen some contradicting information online regarding this topic, though I can't find anything related to Linting on any of these tools.

Thanks

BackgroundDuring the COVID-19 pandemic, global trends of reduced healthcare-seeking behaviour were observed. This raises concerns about the consequences of healthcare avoidance for population health.AimTo determine the association between healthcare avoidance during the early stages of the COVID-19 pandemic and all-cause mortality.Design and settingThis was a 32-month follow-up within the population-based Rotterdam Study, after sending a COVID-19 questionnaire at the onset of the pandemic in April 2020 to all communty dwelling participants (n = 6241/8732, response rate 71.5%).MethodCox proportional hazards models assessed the risk of all-cause mortality among respondents who avoided health care because of the COVID-19 pandemic. Mortality status was collected through municipality registries and medical records.ResultsOf 5656 respondents, one-fifth avoided health care because of the COVID-19 pandemic (n = 1143). Compared with non-avoiders, those who avoided health care more often reported symptoms of depression (n = 357, 31.2% versus n = 554, 12.3%) and anxiety (n = 340, 29.7% versus n = 549, 12.2%), and more often rated their health as poor to fair (n = 336, 29.4% versus n = 457, 10.1%) . Those who avoided health care had an increased adjusted risk of all-cause mortality (hazard ratio [HR] 1.30, 95% confidence interval [CI] = 1.01 to 1.67), which remained nearly identical after adjustment for history of any non-communicable disease (HR 1.20, 95% CI = 0.93 to 1.54). However, this association attenuated after additional adjustment for mental and physical self-perceived health factors (HR 0.93, 95% CI = 0.71 to 1.20).ConclusionThis study found an increased risk of all-cause mortality among individuals who avoided health care during COVID-19. These individuals were characterised by poor mental and physical self-perceived health. Therefore, interventions should be targeted to these vulnerable individuals to safeguard their access to primary and specialist care to limit health disparities, inside and beyond healthcare crises.

The dialing back or even genetically deleting a protein seems to spur oral cancer's growth might help limit its development and spread, according to researchers at Boston University's Henry M.

Software as a service (SaaS) — both a revelation and a revolution — completely disrupted the decades-old software selling paradigm. It turned buying software from an infrequent, high-cost and, for many companies, time-consuming process into a hosted, monthly and predictable cost-per-seat subscription service. SaaS has essentially become the de facto business model for early-stage startups […]

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In the early stages of building a startup, founders need every competitive advantage they can bring to bear. You’re not only competing against established players, but also with other pre-launch startups gunning for the same market opportunity. While it’s natural to focus on finding product-market fit, testing and iterating your MVP to launch-worthy status, adding […]

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All early-stage startup founders face countless challenges as they work to build, launch and scale a successful business. But confusing U.S. immigration and visa policies present an additional, dense layer of bureaucracy for foreign-born entrepreneurs interested in tapping the lucrative U.S. market. As a result, many of these founders, like tech startup co-founder Glen Wang, have […]

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Tapping personal savings or invoking the friends and family plan are signature hallmarks of fledgling startup finance. Eventually though, the majority of early-stage founders will leave their bootstrapping days behind and turn to institutional investors for the capital infusion they need to grow. It’s not easy for inexperienced, first-time founders to attract and secure their […]

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What determines the trajectory of your company? Is it the quality of your idea, perfect product market fit, your bold plan to TAM? One thing trumps these other important factors. The pitch — it’s the single most important step you’ll take to get your startup where you want it to go. The challenge is saying […]

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You’ve been head down and hard at work for what feels like a lifetime, you have an MVP to show for all that sweat equity and you’re ready to jump-start your company’s trajectory. Building a startup can be a slow, lonely endeavor, but getting into a business accelerator can change that in a big way. […]

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Perfect pitch, a singer’s ability to produce any given musical note without a reference tone, is a rare phenomenon — only 1-5 people out of every 10,000 have it. While your odds of creating a perfect pitch deck that captures coveted VC interest aren’t quite that dire, they’re not exactly in your favor, either. Venture […]

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Cambridge : Cambridge University Press, 2023.

Such a probe can easily be fabricated into a strip-based kit that may enable on-site diagnosis

The Army is requesting bids for a $25 million contract for wearable sensors to detect early symptoms of COVID-19.

The startups in this cohort have raised over $39 million.

The post Sequoia India & SEA announces its third cohort of early stage startups appeared first on DealStreetAsia.

Online angel investment platform, Angels Partners, announced this year had been exceptional in connecting entrepreneurs and investors across different locations (India, USA & EU) and industries.

Edinburgh : Oliver and Boyd, 1884.

Synaptic dysfunction provoking dysregulated cortical neural circuits is currently hypothesized as a key pathophysiological process underlying clinical manifestations in Alzheimer's disease and related neurodegenerative tauopathies. Here, we conducted PET along with postmortem assays to investigate time course changes of excitatory and inhibitory synaptic constituents in an rTg4510 mouse model of tauopathy, which develops tau pathologies leading to noticeable brain atrophy at 5-6 months of age. Both male and female mice were analyzed in this study. We observed that radiosignals derived from [¹¹C]flumazenil, a tracer for benzodiazepine receptor, in rTg4510 mice were significantly lower than the levels in nontransgenic littermates at 2-3 months of age. In contrast, retentions of (E)-[¹¹C]ABP688, a tracer for mGluR5, were unaltered relative to controls at 2 months of age but then gradually declined with aging in parallel with progressive brain atrophy. Biochemical and immunohistochemical assessment of postmortem brain tissues demonstrated that inhibitory, but not excitatory, synaptic constituents selectively diminished without overt loss of somas of GABAergic interneurons in the neocortex and hippocampus of rTg4510 mice at 2 months of age, which was concurrent with enhanced immunoreactivity of cFos, a well-characterized immediate early gene, suggesting that impaired inhibitory neurotransmission may cause hyperexcitability of cortical circuits. Our findings indicate that tau-induced disruption of the inhibitory synapse may be a critical trigger of progressive neurodegeneration, resulting in massive neuronal loss, and PET assessments of inhibitory versus excitatory synapses potentially offer in vivo indices for hyperexcitability and excitotoxicity early in the etiologic pathway of neurodegenerative tauopathies.

SIGNIFICANCE STATEMENT In this study, we examined the in vivo status of excitatory and inhibitory synapses in the brain of the rTg4510 tauopathy mouse model by PET imaging with (E)-[¹¹C]ABP688 and [¹¹C]flumazenil, respectively. We identified inhibitory synapse as being significantly dysregulated before brain atrophy at 2 months of age, while excitatory synapse stayed relatively intact at this stage. In line with this observation, postmortem assessment of brain tissues demonstrated selective attenuation of inhibitory synaptic constituents accompanied by the upregulation of cFos before the formation of tau pathology in the forebrain at young ages. Our findings indicate that selective degeneration of inhibitory synapse with hyperexcitability in the cortical circuit constitutes the critical early pathophysiology of tauopathy.

The World Health Organisation's chief has warned that most countries are still in the early stages of their coronavirus epidemics and others are starting to see a resurgence in cases.

Good morning and welcome back to TechCrunch’s Equity Monday, a jumpstart for your week. Equity had a busy last few days, so to help you catch up: Friday’s episode was a lot of fun (Duolingo, Figma, OMERS, and aquafaba), and we also dropped an Equity Shot on Saturday, digging into the first major technology earnings week. […]

Early Stage SF is around the corner, on April 28 in San Francisco, and we are more than excited for this brand new event. The intimate gathering of founders, VCs, operators and tech industry experts is all about giving founders the tools they need to find success, no matter the challenge ahead of them. Struggling […]

Early Stage SF is around the corner, on April 28 in San Francisco, and we are more than excited for this brand new event. The intimate gathering of founders, VCs, operators and tech industry experts is all about giving founders the tools they need to find success, no matter the challenge ahead of them. Struggling […]

TC Early Stage SF goes down on April 28, and we are getting pretty damn excited about it! The show will bring together 50+ experts across startup core competencies, such as fundraising, operations and marketing. We’ll hear from VCs on how to create the perfect pitch deck and how to identify the right investors for […]

REALITY CHECK: Doctors explain the myth behind the disease usually found during second opinion through Navya