Starts: Wed, 11 Dec 2024 19:00:00 -0500
12/11/2024 05:00:00PM
Location: Vancouver, Canada

Analysis and Visualization of Quantitative Proteomics Data Using FragPipe-Analyst  ACS Publications

quantms: a cloud-based pipeline for quantitative proteomics enables the reanalysis of public proteomics data  Nature.com

Olympus now distributes Creaform’s Pipecheck Analyze software.

Taper Pipe Threads are one of the more challenging threads to produce and measure. The ASME B1.20.1-2013 Pipe Threads, General Purpose (Inch) is the current standard that covers both the part thread specifications and the gages for NPT, NPSC, NPTR, NPSM and NPSL threads.

The System 1738 PVC Product Line is a flue gas venting plumbing and mechanical solution certified to the stringent UL 1738 standard, a development for gas-fired water heaters, furnaces, and boilers. 

“We put together some sections of 2 ½-inch pipe, and Joe tried to drive a nail through them with a hammer. I remember him reporting back and saying, ‘This is not your typical plastic.’”

Scott Piper and Kim Carter discuss Cloud Security. The Shared Responsibility Model, assets, risks, and countermeasures, evaluation techniques for comparing the security stature of CSPs. Scott discusses his FLAWS CTF engine. Covering tools Security Monkey and StreamAlert.

Sean Knapp of Ascend.io talks to Robert Blume about data pipeline automation with an orchestration layer.

Nir Valtman, co-Founder and CEO at Arnica, discusses pipelineless security with SE Radio host Priyanka Raghavan. They start by defining pipelines and then consider how to add security. Nir lays out the key challenges in getting good code coverage with the pipeline-based approach, and then describes how to implement a pipelineless approach and the advantages it offers. Priyanka quizzes him on the concept of "zero new hardcoded secrets," as well as some ways to protect GitHub repositories, and Nir shares examples of how a pipelineless approach could help in these scenarios. They then discuss false positives and handling developer fatigue in dealing with alerts. The show ends with some discussion around the product that Arnica offers and how it implements the pipelineless methodology.

Understanding how water behaves during freezing and thawing is essential for effective water damage restoration during the winter months.

dklaughman has added a photo to the pool:

At Bombay Hook NWR, Delaware.

Deadline reports that Marv Films (Matthew Vaughn's UK-based production company) "is plotting 'something like seven more Kingsman films' as part of the company’s expansion plans." That's... ambitious! But other spy franchises have certainly sustained that many or more. At least one of those seven films is expected to be a spinoff centered on the American spies (including Channing Tatum and Jeff Bridges) introduced in the second movie, Statesman. If previous plans mooted by Vaughn are still in effect, another is likely to be a third and supposedly final movie about the characters from the first two films, Eggsy (Taron Edgerton) and Harry Hart (Colin Firth), said to close out that trilogy. 

The next Kingsman movie we see will definitely be the WWI-set prequel The King's Man, long in the can and delayed by the global pandemic. That's currently slated for February, but likely to change again. It stars Harris Dickinson, Ralph Fiennes, Gemma Arterton, Rhys Ifans, Tom Hollander, and Daniel Brühl. With a cast like that an an exciting new time period less well mined by other spy franchises (and even a more serious tone judging from the trailers), I'm hopeful some more of these upcoming Kingsman films are sequels to The King's Man. Perhaps Dickinson and Fiennes will get as many movies as Edgerton and Firth.

According to Marv Group CEO Zygi Kamasa (per the trade), the company also has a Kingsman TV series in the works. 

ERICO® and TRUFAST® have teamed together to market the CADDY® PYRAMID family of rooftop pipe and equipment supports to the roofing market in North America.

Patented Tubos pipe extensions are now available in 2-, 3-, 4- and 5-inch diameters to accommodate most common vent stack sizes, saving time on the roof.

Tubos Vent Pipe Extensions offers a roofing industry product designed to securely extend vent stacks, prevent leaks, and ensure code compliance, even in harsh weather.

Jim Barr, president of Barr Roofing in Abilene, Texas, received the 2024 recipient of the NRCA's J.A. Piper Award during its 137th Annual Convention.

TSA's proposed cybersecurity regulation aims to ensure "higher-risk" pipelines and railways are defended from cyber attacks.

The post TSA proposes cybersecurity requirements for pipelines, railroad operators first appeared on Federal News Network.

US recovers most of Colonial Pipeline Bitcoin ransom following cyberattack

Thanks to wide adoption of the Infrastructure as Code (IaC) approach, programmatic provisioning of cloud resources is slowly transforming almost every aspect of computing, with administration of web apps having emerged as a key use case. With IaC, it's possible to streamline resource management tasks, shorten time-to-market, control costs, and scale at will. The adoption of continuous integration and continuous delivery (CICD) pipelines is already making a huge difference in web app deployment and cloud resource management.

In Atlanta today, President Trump will announce big changes to the regulations that govern one of the nation's most significant environmental laws. The aim is to speed up approval for major projects like pipelines and highways, but critics say it could sideline the concerns of poor and minority communities impacted by those projects, and discount their impact on climate change. The 50-year-old National Environmental Policy Act, or NEPA, was signed into law by President Richard Nixon. It requires federal agencies to consider the environmental effects of proposed projects before they are approved. It also gives the public and interest groups the ability to comment on those evaluations. The administration's new regulations are expected to reduce the types and number of projects that will be subject to review under the NEPA. An earlier version of the proposed rules truncated those reviews in an effort to streamline processes that can take years to complete. It also dropped a requirement

The Butterfield Front Street Mile in Hamilton got underway on Friday night with stirring performances by the Bermuda Regiment Band and the Bermuda Islands Pipe Band. Hundreds of spectators lined the city’s main street to enjoy the Regiment band, decked out in full regalia, and the soothing sounds of the pipe band. In the event’s […]

When Trump descended the escalator at Trump Tower in 2015 to announce his presidential campaign, he tapped into something that had been brewing in online spaces for years. What made Trump unique wasn’t just his message, but his ability to speak the language of internet culture – his unfiltered tweets, his willingness to be politically […]

The post The Alt-Right Pipeline and the Rise of Trump: How Digital Radicalization Found Its Political Voice appeared first on Feminist Majority Foundation.

They will be performing one final time at this year's Remembrance Sunday commemorations in Dagenham.

[jump to video]

Long story (not very) short? One night in 2003--after killing it in front of audience of about 30 lucky people in Oakland--The Long Winters needed a place to crash, and my wife and I were happy to oblige. 

So, they drove their Big Stinky Blue Van over the bridge, slept on our floor, and by breakfast the next morning, it'd become clear to me that I'd provided lodging to a man who was not only very likely a member of my karass--he was also one of the smartest bullshit artists I'd ever met. 

Almost eight years later, although I don't see him nearly as much as I'd like, I still count the guy as one of my best pals ever.

That's John Roderick. And, I think you need to know about him.

John doesn't read this site--he's more of a Twitter person--so I don't risk feeding his astounding excess of dignity by saying he's one of the most gifted writers and bon vivants of our generation. He's just the best. In large part because he's congenitally incapable of suffering bullshit.

This was never more apparent than the Saturday morning in 2007 when we sat in my back yard and talked about a lot of stuff. Playing guitar, advertising on the web, the evil work of promoters, and why everyone is always trying to shortchange everyone on copper pipe. 

That talking became a four-part interview I ran on the late and occasionally lamented The Merlin Show, and, to this day, it's one of my favorite things I've been lucky enough to post to the web.

So, y'know how I'm definitely "not for everyone?" Well, John is really "not for everyone."

He's opinionated and arrogant and undiplomatic and unironically loves Judas Priest--meaning everyone will find at least one thing not to like about him. Despite being hairy and enjoying laying on your bed, John is not exactly a teddy bear. 

But, John's also right a lot. And, he never sands off the edges of his personality or opinions to make you theoretically "like" him. Which, it will come as no surprise to you, is a big reason I love the guy more than a free prime rib dinner. 

So, why the jizzfest about that awful jerk, John Roderick?

Because, as I noted the other day on the Twitter, in our first episode of Back to Work I misattributed a line that should have been credited to John. Which in itself is unimportant, except inasmuch as finding that link to correct the error got me watching our 50-some minutes of chatting again. I also received some at-responses and emails that reminded me how much people enjoyed our chat. 

But, really it made me realize how much that rambling morning in my back yard still resonates so much with stuff I care a lot about. Independence. Agency. Directness. And, never apologizing for wanting to get paid. Also, guitars and talkative hippies.

So, anyway. John. 

I edited all four parts of the video into one big (streamable/downloadable) movie that should make it way easier to watch at a sitting. Should that interest you. Which it may not. Which, as ever, is totally fine, and kind of the point.

But. If you like Dan and my new show (and, seriously—God bless you magnificent bastards who helped briefly make B2W the most popular podcast in the world [gulp]), I think you'll really like this interview a lot too. I hope so, anyway.

Thus, submitted for your disapproval, permit me to present my four-year-old visit with the acerbic, opinionated, and reportedly unlikeable bullshit artist whom I respect and adore more than just about anybody. 

Meet Hotrod.

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Engineers Use 3D CAD and Simulation To Customize Products With Quick Modifications, Testing, and Demonstrations

PHY Interface for the PCI Express (PCIe), SATA, USB, DisplayPort, and USB4 Architectures (PIPE) enables the development of the Physical Layer (PHY) and Media Access Layer (MAC) design separately, providing a standard communication interface between these two components in the system.

In recent years, the PIPE interface specification has incorporated many enhancements to support new features and advancements happening in the supported protocols. As the supported features increase, so does the count of signals on PIPE interface. To address the issue of increasing signal count, the message bus interface was introduced in PIPE 4.4 and utilized for PCIe lane margining at the receiver and elastic buffer depth control.

In PIPE 5.0, all the legacy PIPE signals without critical timing requirements were mapped into message bus registers so that their associated functionality could be accessed via the message bus interface instead of implementing dedicated signals. It was decided that any new feature added in the new version of PIPE specification will be available only via message bus accesses unless they have critical timing requirements that need dedicated signals.

Message Bus Interface

The message bus interface provides a way to initiate and participate in non-latency-sensitive PIPE operations using a small number of wires. It also enables future PIPE operations to be added without adding additional wires. The use of this interface requires the device to be in a power state with PCLK running.

Control and status bits used for PIPE operations are mapped into 8-bit registers that are hosted in 12-bit address spaces in the PHY and the MAC. The registers are accessed using read-and-write commands driven over the signals M2P_MessageBus[7:0] and P2M_MessageBus[7:0]. These signals are synchronous with the PCLK and are reset with Reset#.

Message Bus Interface Commands

The 4-bit commands are used for accessing the PIPE registers across the message bus. A transaction consists of a command and any associated address and data.

All the following are time multiplexed over the bus from MAC and PHY:

1. Commands (write_uncommitted, write_committed, read, read completion, write_ack)
2. 12-bit address used for all types and read and writes
3. 8-bit data, either read or written

There can be cases where multiple PIPE interface signals can change on the same PCLK. To address such cases, the concept of write_uncommitted and write_committed is introduced.

The uncommitted write should be saved into a write buffer, and its associated data values are updated into the relevant PIPE register at a future time when a write_committed is received, taking effect during the same PCLK cycle. Once a write_committed is sent, no new writes, whether committed or uncommitted, and any read command may be sent until a write_ack is received. Also, it is allowed to send NOP commands between write uncommitted and write committed. 

A simple timing demonstration of message bus:

Message Address Space

MAC and PHY each implement unique 12-bit address spaces. These address spaces will host registers associated with the PIPE operations. MAC accesses PHY registers using M2P_MessageBus[7:0], and PHY accesses the MAC registers using the M2P_MessageBus[7:0].

The MAC and PHY access specific bits in the registers to: initiate operations, Initiate handshakes, and Indicate status.

Each 12-bit address space is divided into four main regions: the receiver address region, the transmitter address region, the common address region, and the vendor-specific address region.

Each register field has an attribute description of either level or 1-cycle assertion. When a level field is written, the value written is maintained by the hardware until the next write to that field or until a reset occurs. When a 1-cycle field is written to assert the value high, the hardware maintains the assertion for only a single cycle and then automatically resets the value to zero on the next cycle.

Cadence has a mature Verification IP solution for the verification of various aspects and topologies of PIPE PHY design. For more details, you may refer to the Simulation VIP for PIPE PHY | Cadence page, or you may send an email to support@cadence.com.

Hello,

I have been running this `uvm_reg_hw_reset_seq` sequence for the AHB protocol. My UVM Adapter looks like:

Issue: When I use basic reg.write, my write access are working well, as that is managed by the driver i.e. once adapter gives the packet to the driver, the driver supplies the address and the control signals to the DUT on the first clock cycle and then the write data on the next clock cycle. But when I am performing the read operation, somehow the UVM adapter is reading the data at the same clock cycle where read address + Controls are supplied and this is triggering read failure messages from the `uvm_reg_hw_reset_seq` sequence. What should I modify in the driver/sequencer/adapter so that the UVM adapter can read the data on the next cycle instead of the same clock cycle.

Just FYI: The waveforms of the read operation are correct, it is just the Adapter and the `uvm_reg_hw_reset_seq`. The AHB Driver + AHB Monitor is fully proven and verified to be working correctly.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Title: EpiPen Price Hikes: What to Know
Category: Health News
Created: 8/23/2016 12:00:00 AM
Last Editorial Review: 8/23/2016 12:00:00 AM

Title: 'Bagpipe' Lung Infection Kills Piper
Category: Health News
Created: 8/23/2016 12:00:00 AM
Last Editorial Review: 8/23/2016 12:00:00 AM

Title: Play a Wind Instrument? Beware 'Bagpipe Lung'
Category: Health News
Created: 8/24/2016 12:00:00 AM
Last Editorial Review: 8/24/2016 12:00:00 AM

Title: The True Cost of EpiPen Coupons
Category: Health News
Created: 8/26/2016 12:00:00 AM
Last Editorial Review: 8/26/2016 12:00:00 AM

Mitochondrial dysfunction is a hallmark of many genetic neurodegenerative diseases, but therapeutic options to reverse mitochondrial dysfunction are limited. While recent studies support the possibility of improving mitochondrial fusion/fission dynamics and motility to correct mitochondrial dysfunction and resulting neurodegeneration in Charcot-Marie-Tooth disease (CMT) and other neuropathies, the clinical utility of reported compounds and relevance of preclinical models are uncertain. Here, we describe motor and sensory neuron dysfunction characteristic of clinical CMT type 2 A in a CRISPR/Casp-engineered Mfn2 Thr105Met (T105M) mutant knock-in mouse. We further demonstrate that daily oral treatment with a novel mitofusin activator derived from the natural product piperine can reverse these neurologic phenotypes. Piperine derivative 8015 promoted mitochondrial fusion and motility in Mfn2-deficient cells in a mitofusin-dependent manner and reversed mitochondrial dysfunction in cultured fibroblasts and reprogrammed motor neurons from a human CMT2A patient carrying the MFN2 T105M mutation. Like previous mitofusin activators, 8015 exhibited stereospecific functionality, but the more active stereoisomer, 8015-P2, is unique in that it has subnanomolar potency and undergoes entero-hepatic recirculation which extends its in vivo half-life. Daily administration of 8015-P2 to Mfn2 T105M knock-in mice for 6 weeks normalized neuromuscular and sensory dysfunction and corrected histological/ultrastructural neurodegeneration and neurogenic myoatrophy. These studies describe a more clinically relevant mouse model of CMT2A and an improved mitofusin activator derived from piperine. We posit that 8015-P2 and other piperine derivatives may benefit CMT2A or other neurodegenerative conditions wherein mitochondrial dysdynamism plays a contributory role.

In all honesty, Toads Of The Bayou could have been several notches less ribbet-ing than its Steam demo ended up being, because its stylised pixel fly-snatchers are just that good. There’s only one of the three characters available in the freebie (one of the others is a toad nun with a shotgun), but he’s got a little cutlass, a flintlock pistol, and a can-do attitude - at least when it comes to either stabbing or shooting things. The game itself is a little bit deckbuilder, a little bit Into The Breach: turn based strategy with perfect information and various tricks you can pull to make enemies hit each other instead of the thing you’re trying to protect. Indulge yourself on the gourmet tray-tray below.

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By adopting a contingent workforce model and investing in the right data tools to power better informed decision-making and talent strategy, healthcare organizations can begin to address staffing challenges and turn their talent goals into reality. 

The post Closing Staffing Gaps in Healthcare by Utilizing Diverse Pipelines of Contingent Talent appeared first on MedCity News.

Jul 23, 2024

In the lead up to the October 2021 federal elections, the streets of Baghdad were lined with posters of female candidates. Some were familiar faces with clear political baggage and history, like Sara Iyad Allawi, the daughter of Iraq’s former prime minister. Others were former members of parliament from entrenched political parties. What drew the most excitement from observers, however, were the campaigns of civil activists who had participated in the October protest movement. Locally known as the “Tishreen Movement”, the October protest movement was the largest sustained protest movement in post-2003 Iraq’s history, which took place between October 2019 and February 2020 and involved the participation of hundreds of thousands across multiple cities. The protest movement succeeded in pushing for a new electoral law and in holding early elections, though the elections were only six months ahead of the traditional schedule by the time they were organized. These women represented a new type of female candidate, one without ties to the entrenched elite and who represented. Iraq’s youthful society. Their participation, like the protest movement itself, heralded to many a new era of Iraqi politics, one where younger women were confident enough to run for office and who relied on grassroots campaigning and social media.

GOVERNMENT OF INDIA MINISTRY OF FINANCE (DEPARTMENT OF REVENUE)

Amicus Therapeutics Announces First Quarter 2010 Financial Results and Product Pipeline Advancements

[s.l.] : Universitaire Pers Leuven, 2023.

Villages in Andhra Pradesh are putting discarded tyres and PVC pipes to good use... and the kids are loving it

Old pipelines to be connected to newly laid pipelines to facilitate national highway widening

Marketline