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Correlation of FAPI PET Uptake with Immunohistochemistry in Explanted Lungs from Patients with Advanced Interstitial Lung Disease

Recent studies have demonstrated promising results of fibroblast activation protein (FAP) inhibitor (FAPI) PET in prognosticating and monitoring interstitial lung diseases (ILDs). As a first step toward successful translation, our primary aim was to validate the FAPI PET uptake through immunohistochemistry in patients with advanced ILD who underwent lung transplantation after a FAPI PET scan. Methods: This is a preliminary analysis of a single-center, open-label, single-arm, prospective exploratory biodistribution study of 68Ga-FAPI-46 PET imaging in patients with ILD (NCT05365802). Patients with ILD confirmed by high-resolution CT and scheduled for lung transplant were included. Tissue samples of explanted lungs were obtained from both the central and peripheral lung parenchyma of each lobe. Additional samples were obtained from areas of the lung corresponding to regions of FAPI PET activity. Immunohistochemical staining was performed with an anti-FAP antibody. Percentages of FAP immunohistochemistry-positive area were measured semiautomatically using QuPath software. SUVs in the areas of pathologic samples were measured on FAPI PET/CT by referencing the gross photomap of the explanted lung. A Spearman correlation coefficient test was used to assess the relationship between FAPI PET uptake and FAP immunohistochemical expression in each specimen. Results: Four patients with advanced ILD who underwent FAPI PET/CT before lung transplantation were included. The types of ILD were idiopathic pulmonary fibrosis (n = 2), rheumatoid arthritis–associated ILD (n = 1), and nonspecific interstitial pneumonia (n = 1). FAPI uptake was visualized mainly in the fibrotic area on CT. Twenty-nine surgical pathology samples from 3 patients were analyzed. FAP staining was predominantly positive in fibroblastic foci. FAPI PET SUVmax and SUVmean showed a positive correlation with the immunohistochemical FAP expression score (SUVmax: r = 0.57, P = 0.001; SUVmean: r = 0.54, P = 0.002). Conclusion: In this analysis conducted in patients who underwent lung transplantation after a FAPI PET scan, FAPI PET uptake was positively correlated with FAP immunohistochemistry. These findings provide a rationale for further investigation of FAPI PET as a potential imaging biomarker for ILD.




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New Tools Take Whole-Person Approach to Obesity Care [Family Medicine Updates]




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Nosferatu‘s Take on Count Orlok Sounds Fascinatingly Disgusting



Robert Eggers' re-imagining of the legendary vampire has his fangs out for prey in a very unusual manner.





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Turnbull and Shorten speak of mistakes

ROLLING UPDATES: Malcolm Turnbull and Bill Shorten have given candid interviews to Four Corners, where they reveal more about themselves and their hopes for winning the election.




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Treasury stake in NatWest falls to 11.4% on £1bn shares buyback

NATWEST has moved to reduce the UK Government’s stake in the bank after buying back a significant tranche of shares from the Treasury in what it described as a “another important milestone”, it was announced this morning.




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Boeing could ‘take over’ hunt

A veteran aviation expert said Boeing could take up the search for Malaysia Airlines Flight MH370.




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Rosneft poised for Arctic LNG stake

ENERGY giant Rosneft is poised to take control of a new Arctic Circle LNG project planned for an area of northern Russia fronting the Barents Sea.




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Take-Two CEO is Not Worried About Grand Theft Auto VI Performance on Xbox Series S

Take-Two CEO Strauss Zelnick in the company's latest earnings report said he isn't worried about Rockstar getting Grand Theft Auto VI to run on the Xbox Series S.

"Look, we support the platforms where the consumers are for as long as they’re there, and we find a way to support platforms despite different levels of tech," said Zelnick (via VideoGamesChronicle) when asked about the Xbox Series S.

Zelnick added, "Our labels are really good at that. I’m not really worried. I’ve never worried about where hardware was going. And I’ve said this many times over the years because, first of all, I don’t worry about things over which I have zero control.

"Secondly, I believe in the audience. The audience is going to show up if you have great properties, and so we just have to make sure to be on an array of platforms."

Zelnick added PC is an important platform to release games on, despite the fact Grand Theft Auto VI has not been announced for PC.

"If one platform diminishes in value, there’s always another one," he said. "So we’re seeing great growth in PC right now, for example. And I have been able to view that open formats would continue to grow. PC is an open format.

"I do think PC will continue to be a more and more important part of the console business going forward, and that isn’t complicated for us to support at all. So the bottom line is we are selective about which platforms we support. We make the tech work when we can make it work as long as the audience is big enough to make that worthwhile."

Grand Theft Auto VI will launch for the PlayStation 5 and Xbox Series X|S in Fall 2025.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463023/take-two-ceo-is-not-worried-about-grand-theft-auto-vi-performance-on-xbox-series-s/




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Helldivers 2 boss would "love to do a take" on Star Wars, Predator and Warhammer 40,000

The dominion of hated Super Earth threatens to expand afresh as Arrowhead CEO Johan Pilestedt toys openly with the prospect of Helldivers 2 cross-over games, beginning with tabletop wargame Trench Crusade and extending to, well, take your pick. Arrowhead's appetite for other licenses appears insatiable. It's the kind of sheer expansionism you'd expect from Earth's loathsome regime, whose "managed democracy" propaganda continues to enthrall thousands of hapless disposable imperialists. Pilestedt even wants to make a Fifth Element game! Milla Jovovich is spinning in her grave. Milla Jovovich isn't dead, you say? Well, that's good news at least.

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Take-Two are selling Private Division and closing Roll7 and Intercept, because they're in "the business of making great big hits"

Take-Two Interactive have sold their publishing label Private Division to an unnamed party, along with five of Private Division's "live and unreleased titles". The GTA 6 publisher have also finally confirmed that they have shut down OlliOlli World and Rollerdrome devs Roll7 together with Kerbal Space Program 2 creators Intercept Games, months after performing mass layoffs at both studios.

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GTA 6 release date won't slip to 2026, Take Two assure - they're "highly confident" about fall 2025

A few months ago, the rumour took root that GTA 6's release date would slip back from 2025 to 2026. An anonymous insider averred that studio heads were "worried" about the new open world game's progress - hence, perhaps, Rockstar's decision to mandate a full return to in-office work. Pshaw, say publishers Take-Two CEO. They announced a fall 2025 launch in March and have just doubled down on it in their latest financial briefing, with CEO Strauss Zelnick subsequently going on the tellybox to say that Take-Two are "highly confident in the timing", though he still has nothing to share about GTA 6 on PC.

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As survivors say #MeToo, what will it take to stop widespread sexual harassment?

Watch Video | Listen to the Audio

JUDY WOODRUFF: The hashtag #MeToo has millions of women sharing stories of abuse, shining a spotlight on a troubling reality in our society.

It was first used in 2007, but when actor Alyssa Milano tweeted it Sunday night to talk about sexual harassment and assault in the wake of the Harvey Weinstein story, it went viral. The hashtag was tweeted nearly a million times in just 48 hours. Facebook reported 45 percent of its users have friends who posted #MeToo, as women wrote about their experiences about the workplace and culture, and what should change.

We explore some of those issues with Fatima Goss Graves. She’s president of the National Women’s Law Center. Lisa Senecal wrote about her own experience for the online news site Daily Beast. She’s with the Vermont Commission on Women. And Melissa Silverstein is the founder of the blog and Web site Women and Hollywood.

Thank you all for joining us.

Lisa Senecal, I’m going to start with you.

You have had a personal experience with sexual harassment. That’s in part what has drawn you to this #MeToo campaign movement.

Just tell us briefly about what happened.

LISA SENECAL, Member, Vermont Commission on Women: Sure.

Like most women, I have had a number of experiences with sexual harassment, beginning with my first job, when I was 15 years old. And it’s really been a threat off and on throughout my entire professional career.

The most egregious offense was an actual assault that occurred with a male executive. Unfortunately, because of an NDA — and we can go into the evils of nondisclosures another time — but because of that, there isn’t a lot that I’m able to say about the specific event.

But the issue of sexual harassment and finally having this come to the fore, so many women are already familiar with it from being on the receiving end. And I think, especially with the #MeToo campaign, it’s been really wonderful and an eye-opening experience for men to realize just how pervasive an issue this is.

JUDY WOODRUFF: So, in your experience, it was a business setting.

Melissa Silverstein, you have been writing about women in Hollywood for 10 years. Of course, that’s where the Harvey Weinstein story came from.

If it’s been going on in Hollywood forever, why hasn’t it been talked about more before now?

MELISSA SILVERSTEIN, Founder, Women and Hollywood: Well, I think there was a culture of silence created around this man and also within this industry.

People were afraid. People are afraid for their jobs. It’s a very relational industry, where if someone is going to blacklist you, you are not going to get your next job.

So I think the way that a person was able to conduct himself for 30 years like this was to build a culture of fear, to make people sign nondisclosure agreements, and to get them to shut up.

JUDY WOODRUFF: Fatima Goss Graves, here with me in Washington with the National Women’s Law Center, we have been talking about Hollywood.

We have talking about the business workplace. Is there any field of work where this isn’t going on?

FATIMA GOSS GRAVES, President, National Women’s Law Center: Right.

The issue of harassment and assault, it’s a Hollywood problem, but really it’s an everywhere problem. It infects industries across the board, whether you’re high-wage jobs, low-wage jobs, male-dominated fields, but also female-dominated fields.

Restaurants are some of the areas where you have some of the highest rates of EEOC charges. And that’s not a male-dominated field.

JUDY WOODRUFF: EEOC, the Equal Employment Opportunity Commission.

Lisa Senecal, some people are saying that they’re uncomfortable with this #MeToo campaign movement because they’re saying, once again, women are being asked to go public with what happened to them, but there is no promise that there is going to be anything done about it. How do you see this?

LISA SENECAL: I don’t necessarily believe that women are being asked to come forward.

I think this is an opportunity to come forward, if that’s something that women want to do, but there’s no obligation to do it. And there’s been a lot of support for letting women know that if this isn’t something you’re comfortable with at this time, no one is obligated to tell their story, and no one is allowed to force you to tell your story before you’re ready.

But the stories are important. Without them, the degree to which this happens across all industries, across genders as well — we know that this happens to men. This happens to the transgender.

It’s not specific to women, although it affects us most frequently. Until we have a critical mass of women who are able to get the men in their lives, the men that they work with to understand how pervasive a problem it is, and then can get men to begin to act on this, because this isn’t a women’s issue.

This is a violence issue, and an issue of power and who has the power. So until the people who still primarily do hold the power, which is primarily men and primarily white men, until they’re going to begin to act, then the problems are going to persist.

JUDY WOODRUFF: Melissa Silverstein, how do you see that? What is it going to take for this to be a change?

MELISSA SILVERSTEIN: The fact that we’re having a global conversation about sexual harassment — I have been doing media for the last week all over the world.

People are really enthralled by this and want to see change. This is a global issue. And, also, Hollywood is a global industry. Seventy cents of every dollar of Hollywood studio movies are made outside the United States.

So what people are looking for is Hollywood to step up. And, today, we had a leader in Hollywood, Kathleen Kennedy, to say we need to have a commission, cross-industry commission, of people who are going to look into this and put a stop to it once and for all.

JUDY WOODRUFF: And pick up on that, Fatima Goss Graves. Just across the board, what is it going to take?

FATIMA GOSS GRAVES: Right.

We know that there are things that would make a difference here. If employers had processes that their employees actually use, you wouldn’t have harassment in the shadows. Right now, most people don’t report harassment to anyone. And it’s because they think their employers won’t do anything, or, worse, that they would experience retaliation.

JUDY WOODRUFF: And that’s — because that’s been what happened.

FATIMA GOSS GRAVES: And that is. They’re right to believe that they will experience retaliation, because they do. They’re shamed. They’re blamed.

But employees could make a difference. Right? They can be — take it seriously and communicate that to their workplace. They can also have the right policies that are in place. And, finally, they could, when someone comes forward, be really clear that they take it seriously and that they will not tolerate retaliation.

Those are things that aren’t happening among employers frequently enough.

JUDY WOODRUFF: Lisa Senecal, as somebody who had it happen to you in a business environment, what changes need to be made in the workplace? What has to happen?

LISA SENECAL: Well, I agree completely with what was just said.

Too often, the workplace education that goes on is incredibly insufficient. It’s more of companies wanting to be able to check the box and say that they did their sexual harassment training. And it isn’t truly something within the culture of companies that they believe that this is a problem and that it is a right of all people working at that company not to be harassed.

So, until it starts to be taken more seriously, and when a woman or anyone comes forward with an accusation, it does have to be taken so much more seriously. And the knee-jerk response, as was in my case, cannot be to shame the woman, can’t be to blame her for somehow bringing this on herself, and putting women back in a position of being victimized a second time because they’re not taken seriously when they come forward.

JUDY WOODRUFF: Melissa Silverstein, yes, go ahead.

MELISSA SILVERSTEIN: I just wanted to add, one of the things that’s so fundamental about this is how this — how it’s so normalized for all of us to go through this kind of harassment, especially in Hollywood, and how people kind of laugh off, oh, you know, that’s locker room talk, or, you know, this is the movie business, get used to it.

And what we need to do is really pierce that veil of the normalization of this kind of conduct, because it starts with, you know, the comments, and then it can escalate very quickly.

So we really need to just change people’s attitudes and get rid of the toxic masculinity. Hollywood has no much institutionalized sexism that sometimes I feel like we need to just start over, if possible.

JUDY WOODRUFF: Joining us also is Leigh Gilmore, a professor at Wellesley College who’s written a book about why — titled “Why We Doubt What Women Say About Their Lives.”

Leigh Gilmore, why don’t women — why haven’t women been believed and taken seriously on this, and could we now be at a moment when they are?

LEIGH GILMORE, Wellesley College: It’s good to be with you, Judy.

I think we have a persistent and a pervasive culture of doubting what women say, especially when they’re bringing forward accounts of harm into the public sphere. So we have these pre-made default cultural narratives of women’s unreliability. We have he said/she said, which is a false equivalence narrative.

We have that notion that nobody knows what really happened. We have that notion that you can’t really trust what women say. None of these are based in fact, but they are part of a kind of cloud that enables us to doubt any woman before she speaks up.

And it’s quite intimidating. And so, if we’re at a point of change, we really are at a moment where I think we have a new level of visibility, and we have the opportunity to amplify the voices of women who are speaking out.

So, insofar as we have that opportunity, there is a form of solidarity, and more women speaking can lead to change.

JUDY WOODRUFF: Fatima Goss Graves, as somebody who works on these issues from a legal standpoint, are we, could we be at a watershed point, or is it just a whole lot more complicated?

FATIMA GOSS GRAVES: Well, the culture change typically has to go together with both the enforcement of the laws and the policy change.

And so we’re at a tipping point, surely, on culture change. But I will tell you, you know, the National Women’s Law Center runs a hot line. And over the last two weeks, we have had double the intake on harassment.

And we have a new network called the Legal Network for Gender Equity, so we’re — attorneys are joining with us and will be ready to take these cases. But those people who are making these calls and contacting us, I think that that shows that you have people who are ready to come forward on social media, and there is power there, but it seems like there are people who are ready to come forward in other ways, too.

JUDY WOODRUFF: I want to quickly go around and ask each one of you about the role of men in all of this.

Lisa Senecal?

LISA SENECAL: Oh, I think it’s critical for men as allies to be coming forward and supporting women who do come forward.

Men also need to be willing to call out other men, whether that’s one-on-one, whether it’s in a group setting within a company, or socially. If a man hears, sees someone doing something inappropriate, they need to have the courage to stand up, even in front of other men, and say, it’s not OK, it’s inappropriate behavior, and it’s not going to be tolerated.

And until it’s also men joining in, women can’t do this by themselves. There is an organization, A Call to Men, that I’m a big fan of. And one of their mantras is, if women could have stopped abuse and assault, they would have done it already.

And that’s completely true. It’s not something that women are going to be able to do alone. It shouldn’t be looked at as only a women’s issue. And until people look at this on a larger scale and understand that this affects the bottom line of companies, it affects productivity, it affects, you know, absenteeism, just across the board, this is not a women’s issue.

It is a human issue.

JUDY WOODRUFF: Right.

Melissa Silverstein, what about that?

And we should point out that men are themselves the victims of sexual harassment and abuse at times.

MELISSA SILVERSTEIN: I feel that this is on men.

The men are most of the perpetrators. They’re also the collaborators. And, at The Weinstein Company, their board was all men, and they were all complicit in creating an environment that allowed this to thrive.

In Hollywood, there’s not a single woman, even the people at the tippy-top of the industry, who don’t report to men. This is also about getting more women into leadership positions and getting the men — and holding the men accountable.

The men in this industry need to step up. They need to say, we want to be — we want to create this industry in a way that women can thrive and don’t have to experience this anymore.

JUDY WOODRUFF: Leigh Gilmore?

LEIGH GILMORE: We’re talking about awareness and accountability.

So, as wonderful as it is to have increased visibility, and it enables us to connect the dots and to see the long histories of sexual abuse, harassment and discrimination, we need new levels of accountability.

I will echo the notion that Harvey Weinstein’s board certainly knew about these accusations. There’s a DA who failed to charge him. We have ample examples of failures.

And what we really need to do is to correct those. The role of men is certainly important here. Minimally, they can show up and be witnesses.

JUDY WOODRUFF: And, finally, Fatima Goss Graves, the role of men and how we prevent this.

FATIMA GOSS GRAVES: We have had a little bit of conversation about men as survivors, but the conversation we haven’t really had is about what happens when men are abusers or enablers or allow this to happen in the workplaces, in schools, or in women’s everyday lives?

And so now we have an opportunity culturally for that conversation. That culture is going to have to hit where policy-makers are. It’s going to have to hit where employers are in order to make a real difference.

JUDY WOODRUFF: Well, it’s clear that everyone is hoping this is a watershed moment, that things will change as a result of what’s happened here. But we will see.

And we appreciate all of you joining us in this conversation, Fatima Goss Graves here with me in Washington, Lisa Senecal, Melissa Silverstein, and Leigh Gilmore.

We thank you all.

FATIMA GOSS GRAVES: Thank you.

MELISSA SILVERSTEIN: Thank you.

The post As survivors say #MeToo, what will it take to stop widespread sexual harassment? appeared first on PBS NewsHour.




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Could we take the entire solar system on a voyage through space?

To transport our planet across the universe, we would need to bring the whole solar system to sustain life on Earth – on this episode of Dead Planets Society, our hosts contemplate how to shepherd all that baggage on this scenic journey




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Smart TVs take snapshots of what you watch multiple times per second

Smart TVs from Samsung and LG monitor what you are watching even when you are using the screens to display a feed from a connected laptop or video game console




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Video Friday: HAND to Take on Robotic Hands



Video Friday is your weekly selection of awesome robotics videos, collected by your friends at IEEE Spectrum robotics. We also post a weekly calendar of upcoming robotics events for the next few months. Please send us your events for inclusion.

ICRA@40: 23–26 September 2024, ROTTERDAM, NETHERLANDS
IROS 2024: 14–18 October 2024, ABU DHABI, UAE
ICSR 2024: 23–26 October 2024, ODENSE, DENMARK
Cybathlon 2024: 25–27 October 2024, ZURICH

Enjoy today’s videos!

The National Science Foundation Human AugmentatioN via Dexterity Engineering Research Center (HAND ERC) was announced in August 2024. Funded for up to 10 years and $52 million, the HAND ERC is led by Northwestern University, with core members Texas A&M, Florida A&M, Carnegie Mellon, and MIT, and support from Wisconsin-Madison, Syracuse, and an innovation ecosystem consisting of companies, national labs, and civic and advocacy organizations. HAND will develop versatile, easy-to-use dexterous robot end effectors (hands).

[ HAND ]

The Environmental Robotics Lab at ETH Zurich, in partnership with Wilderness International (and some help from DJI and Audi), is using drones to sample DNA from the tops of trees in the Peruvian rainforest. Somehow, the treetops are where 60 to 90 percent of biodiversity is found, and these drones can help researchers determine what the heck is going on up there.

[ ERL ]

Thanks, Steffen!

1X introduces NEO Beta, “the pre-production build of our home humanoid.”

“Our priority is safety,” said Bernt Børnich, CEO at 1X. “Safety is the cornerstone that allows us to confidently introduce NEO Beta into homes, where it will gather essential feedback and demonstrate its capabilities in real-world settings. This year, we are deploying a limited number of NEO units in selected homes for research and development purposes. Doing so means we are taking another step toward achieving our mission.”

[ 1X ]

We love MangDang’s fun and affordable approach to robotics with Mini Pupper. The next generation of the little legged robot has just launched on Kickstarter, featuring new and updated robots that make it easy to explore embodied AI.

The Kickstarter is already fully funded after just a day or two, but there are still plenty of robots up for grabs.

[ Kickstarter ]

Quadrupeds in space can use their legs to reorient themselves. Or, if you throw one off a roof, it can learn to land on its feet.

To be presented at CoRL 2024.

[ ARL ]

HEBI Robotics, which apparently was once headquartered inside a Pittsburgh public bus, has imbued a table with actuators and a mind of its own.

[ HEBI Robotics ]

Carcinization is a concept in evolutionary biology where a crustacean that isn’t a crab eventually becomes a crab. So why not do the same thing with robots? Crab robots solve all problems!

[ KAIST ]

Waymo is smart, but also humans are really, really dumb sometimes.

[ Waymo ]

The Robotics Department of the University of Michigan created an interactive community art project. The group that led the creation believed that while roboticists typically take on critical and impactful problems in transportation, medicine, mobility, logistics, and manufacturing, there are many opportunities to find play and amusement. The final piece is a grid of art boxes, produced by different members of our robotics community, which offer an eight-inch-square view into their own work with robotics.

[ Michigan Robotics ]

I appreciate that UBTECH’s humanoid is doing an actual job, but why would you use a humanoid for this?

[ UBTECH ]

I’m sure most actuators go through some form of life-cycle testing. But if you really want to test an electric motor, put it into a BattleBot and see what happens.

[ Hardcore Robotics ]

Yes, but have you tried fighting a BattleBot?

[ AgileX ]

In this video, we present collaboration aerial grasping and transportation using multiple quadrotors with cable-suspended payloads. Grasping using a suspended gripper requires accurate tracking of the electromagnet to ensure a successful grasp while switching between different slack and taut modes. In this work, we grasp the payload using a hybrid control approach that switches between a quadrotor position control and a payload position control based on cable slackness. Finally, we use two quadrotors with suspended electromagnet systems to collaboratively grasp and pick up a larger payload for transportation.

[ Hybrid Robotics ]

I had not realized that the floretizing of broccoli was so violent.

[ Oxipital ]

While the RoboCup was held over a month ago, we still wanted to make a small summary of our results, the most memorable moments, and of course an homage to everyone who is involved with the B-Human team: the team members, the sponsors, and the fans at home. Thank you so much for making B-Human the team it is!

[ B-Human ]




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Trump Takes On Censorship in First Major Policy Statement




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New comet makes historically close approach to Earth today, but spotting it will take some luck

Comet Nishimura (C/2023 P1) was discovered in August and is now whizzing by Earth, but finding it in the sky will be a challenge.




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AI-powered attack drones take flight

A company announced the launch of two new advanced drones designed to improve military operations with the use of cutting-edge technology.



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SteelSeries CEO welcomes takeover by GN Group

GN owns audio brands like Jabra and sought a way into the eSports market.




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Major labour shortage looms in Atlantic Canada as immigration cuts take hold

Atlantic Canadians say the region has room to grow, but is facing a shrinking labour pool




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Will Canada Post deliver? A look inside the labour dispute, the stakes and what comes next

Canada Post workers might soon be putting down their mailbags and grabbing picket signs




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Coroner takes aim over privacy

Media outlets fear being dragged in to coronial inquests and forced to defend themselves whenever they report deaths.




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Frontgate Sale: Take 25% Off Any One Item

Shop outdoor furniture, decor, bedding and more for your home at Frontgate.

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]




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Top 9 Mistakes to Avoid When Filing Your Swiss Tax Return

Filing your Swiss tax return can be a complicated process, especially if you aren’t aware of the common pitfalls. Mistakes are easy to make and can result in delays, additional fees, or even penalties. Getting the details right will help you save time and avoid unnecessary issues. This article outlines the top mistakes to avoid […]

The post Top 9 Mistakes to Avoid When Filing Your Swiss Tax Return appeared first on Chart Attack.




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Thousands of hacked TP-Link routers used in yearslong account takeover attacks

The botnet is being skillfully used to launch "highly evasive" password-spraying attacks.




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Law enforcement operation takes down 22,000 malicious IP addresses worldwide

Operation Synergia II took aim at phishing, ransomware, and information stealing.




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Donald Trump's Administration Takes Shape After 15 Official or Expected Picks


President-elect Donald Trump has made many selections to lead his administration as his transition gets underway, ranging from chief of staff to head of the Environmental Protection Agency (EPA). At the same time, a number of crucial positions have yet to be filled just one week removed from the landslide election.

The post Donald Trump’s Administration Takes Shape After 15 Official or Expected Picks appeared first on Breitbart.





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Will the new Nintendo Music app lead to more DMCA takedowns from Nintendo?

Subscription music app gives Nintendo new reason to crack down on third-party music uploads.




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‘Vijay 69’ movie review: Anupam Kher takes a dip in the channel of mediocrity

Promising to be inspiring, ‘Vijay 69’ turns out like a mildly entertaining episode in Anupam Kher’s popular play, ‘Kucch Bhi Ho Sakta Hai’




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Larocque's early goal propels Canada to 4-1 win over U.S. to take lead in Rivalry Series

​​​​​​​Jocelyne Larocque scored less than 4 minutes into the game, Sarah Nurse added a goal midway through the first period and Canada cruised to a 4-1 win over the United States in Boston on Sunday to take a 2-1 lead in the five-game Rivalry Series.




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I’m a Celeb has made a huge casting mistake. The show won’t be the same

ITV previously seemed very happy to oblige politicians in urgent need of money, rehabilitation or just missing the attention, writes Sean O’Grady. But this year’s roster is different




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An Overwatch: Classic event will take fans all the way back to the beginning

For the first time in over two years, Overwatch 2 players will be able to group up in teams of six. A three-week event featuring that format starts tomorrow, November 12. But there’s a twist: you won’t be able to select Kiriko or Sombra, or battle it out with an additional player on each side on Push maps just yet. That’s because in Overwatch 2’s first real taste of 6v6, Blizzard is taking us all the way back to the beginning with a limited-time mode called Overwatch: Classic.

You will be able to experience Overwatch almost exactly as it was upon its May 2016 debut. That means you can choose from the first 21 heroes, who all have their original kits and abilities. That means Hanzo loses his Lunge jump but regains his dreaded Scatter Arrow, Bastion and Torbjorn are vastly different than they are now and Cassidy's Flashbang once again stun locks enemies for a moment. 

Symmetra reverts to being a support who can teleport allies almost anywhere on the map from the spawn room, while Mercy can will once again bring five dead teammates back to life. Ultimate abilities will charge up faster too.

In addition, just like in Overwatch for a brief period at the very beginning, there are initially no limits on hero selection. So if you and your teammates want to run with a composition of four Winstons and two Lucios, have at it. However, this will only apply for the first few days, after which Blizzard will apply the single hero limit rule for the rest of the event. Games will take place under the Quick Play ruleset, rather than the Competitive format.

The original 12 maps will be available too — including the assault maps that Blizzard retired from the main modes during the transition to Overwatch 2. While assault maps are still available in the Arcade and custom games, you'll once again be dealing with the notorious choke points of the otherwise gorgeous Hanamura, Temple of Anubis and Volskaya Industries.

Blizzard Entertainment

Things won't be exactly as they were in May 2016, however. Original maps that have seen major reworks over the years — Dorado, Numbani, Route 66 and Watchpoint: Gibraltar — will appear as they are in the current game. You'll only be able to use the original default Overwatch skins and no, there are no loot boxes. The user interface remains the same too, which hopefully means the ping system will still be in place.

Blizzard doesn't plan for this to be a one-and-done deal. There will be other Overwatch: Classic events in the future, focusing on various moments in the game's history, like the infamous triple-tank, triple-support GOATS meta. This limited-time mode is also separate from the other 6v6 tests Blizzard plans to run in the coming months as it looks to measure players' interest in that format and garner feedback.

There's a good chance that this limited-time mode will bring some lapsed players back into the mix, even just for a sip of nostalgia. I first played Overwatch several months after its debut, so it'll be fun to see roughly how the game felt at the very beginning. I will be instalocking Mei every match so I can remember what it's like to freeze an opponent before giving them a cheeky wave and firing an icicle into their skull. Ah, memories...

This article originally appeared on Engadget at https://www.engadget.com/gaming/an-overwatch-classic-event-will-take-fans-all-the-way-back-to-the-beginning-171538261.html?src=rss




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Amazon reportedly wants drivers to wear AR glasses for improved efficiency until robots can take over

Amazon is reportedly developing smart glasses for its delivery drivers, according to sources who spoke to Reuters. These glasses are intended to cut “seconds” from each delivery because, well, productivity or whatever. Sources say that they are an extension of the pre-existing Echo Frames smart glasses and are known by the internal code Amelia.

These seconds will be shaved off in a couple of ways. First of all, the glasses reportedly include an embedded display to guide delivery drivers around and within buildings. They will allegedly also provide drivers with “turn-by-turn navigation” instructions while driving. Finally, wearing AR glasses means that drivers won’t have to carry a handheld GPS device. You know what that means. They’ll be able to carry more packages at once. It’s a real mitzvah.

I’m being snarky, and for good reason, but there could be some actual benefit here. I’ve been a delivery driver before and often the biggest time-sink is wandering around labyrinthine building complexes like a lost puppy. I wouldn’t have minded a device that told me where the elevator was. However, I would not have liked being forced to wear cumbersome AR glasses to make that happen.

To that end, the sources tell Reuters that this project is not an absolute certainty. The glasses could be shelved if they don’t live up to the initial promise or if they’re too expensive to manufacture. Even if things go smoothly, it’ll likely be years before Amazon drivers are mandated to wear the glasses. The company is reportedly having trouble integrating a battery that can last a full eight-hour shift and settling on a design that doesn’t cause fatigue during use. There’s also the matter of collecting all of that building and neighborhood data, which is no small feat.

Amazon told Reuters that it is “continuously innovating to create an even safer and better delivery experience for drivers” but refused to comment on the existence of these AR glasses. "We otherwise don’t comment on our product roadmap,” a spokesperson said.

The Echo Frames have turned out to be a pretty big misfire for Amazon. The same report indicates that the company has sold only 10,000 units since the third-gen glasses came out last year.

This article originally appeared on Engadget at https://www.engadget.com/big-tech/amazon-reportedly-wants-drivers-to-wear-ar-glasses-for-improved-efficiency-until-robots-can-take-over-174910167.html?src=rss




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