London is crowned best major city in Europe in fDi's FDI Strategy category, with Glasgow, Vilnius, Reykjavik and Galway also winning out.

North Rhine-Westphalia is fDi's top large region for FDI Strategy, with the Basque Country topping the table for mid-sized regions and Ireland South East first among small regions. 

Despite its thriving automotive sector, Gothenburg is vulnerable to global economic pressures. However, local authorities are confident that their strategies will see the city ride out the uncertainties related to Brexit and the US-China trade wars.

As the Digital Kazakhstan programme creates an environment conducive to innovation, start-up hubs are springing up across the country. Their task? To move the economy beyond commodities and make the country a regional centre of innovation. 

The Apple AirTag (4-Pack) is available for $69.99 at Best Buy; buy now for 30% off its original price of $99.99.

Shop these early Best Buy Black Friday deals on Motorola razr and razr+ phones and take up to 50% off new smartphones.

Is it a controversial design choice or a completely acceptable location for the new Mac mini power button?

As of Nov. 12, get the Shark Clean and Empty Cordless Vacuum for $199 at Walmart, down from its usual price of $319. That's 37% off.

Russia has conducted a third launch of its new heavy-class Angara rocket, the first developed after the fall of the Soviet Union 30 years ago this month.

Manchester United legend, Rio Ferdinand has suggested that new manager, Ruben Amorim may have made a mistake in not keeping former interim manager, Ruud van Nistelrooy at the club. Amorim arrived at Man United on Monday to officially take charge at Old Trafford having been named Erik ten Hag’s permanent replacement a few weeks ago. […]

Man Utd: Rio Ferdinand identifies first mistake Amorim has made

Zhuhai, China — Stealth fighter jets and attack drones took center stage as China's largest air show officially opened on Tuesday, an opportunity for Beijing to showcase its growing military might to potential customers and rivals alike. China has poured resources into modernizing and expanding its aviation capabilities as it faces off against the United States and others around regional flashpoints like Taiwan. Record numbers of Chinese warplanes have been sent around the self-ruled democratic island, which Beijing claims as its territory, over the past few years. The star of Airshow China, which showcases Beijing's civil and military aerospace sector every two years in the southern city of Zhuhai, is the new J-35A stealth fighter jet. Its inclusion in the airshow suggests it is nearly ready to enter operation, which would make China the only country other than the United States to have two stealth fighters in action, experts said. The J-35A is lighter than China's existing model, the J20, and looks more similar in design to a US F-35. A group of J20s performed a display flight on Tuesday morning, flying in a diamond formation across a grey sky. State news agency Xinhua quoted military expert Wang Mingzhi as saying the combination of the two models greatly enhances the People's Liberation Army Air Force (PLAAF)'s "ability to conduct offensive operations in high-threat and contested environments." Attack drones The airshow will feature a dedicated drone zone for the first time, reflecting their increased prominence in warzones, including Ukraine. The SS-UAV -- a massive mothership that can rapidly release swarms of smaller drones for intelligence gathering, as well as strikes -- will be on display in Zhuhai, according to the South China Morning Post. In October the United States unveiled sanctions targeting China-based companies linked to the production of drones that Russia has deployed in Ukraine. Moscow and Beijing have deepened military and defense ties since Russia's invasion of its neighbor three years ago, and the secretary of its Security Council, Sergei Shoigu, is due to visit Zhuhai. This year the show's focus is squarely on the military sector, as it coincides with the 75th anniversary of the PLAAF, but China's burgeoning space industry will also be showcasing developments. A model of a homegrown reusable space cargo shuttle will debut at the show, Xinhua reported on Monday. Named Haoloong, the shuttle is designed to be launched on a commercial rocket, and then dock with China's space station Tiangong. "It can re-enter the atmosphere, fly and land horizontally at a designated airport, allowing for recovery and reuse," Xinhua said. Beijing has poured huge resources into its space program over the past decade in an effort to catch up to traditional space powers the United States and Russia.

The U.S. Senate's Democratic majority began a crusade on Tuesday to confirm as many new federal judges nominated by President Joe Biden as possible to avoid leaving vacancies that Republican Donald Trump could fill after taking office on Jan. 20. With Republicans set to take control of the chamber on Jan. 3, the Senate on Tuesday held a confirmation vote on one of Biden's judicial nominees - former prosecutor April Perry - for the first time since Trump won the Nov. 5 presidential election. The Senate voted 51-44 in favor of her becoming a U.S. district court judge in Illinois. All told, Biden has announced another 30 judicial nominees who are awaiting Senate confirmation votes. Sixteen have already have been reviewed by the Senate Judiciary Committee and are awaiting a final confirmation vote by the full Senate. Another 14 nominees are awaiting committee review. The U.S. Constitution assigns to the Senate the power to confirm a president's nominees for life-tenured seats on the federal judiciary. "We are going to get as many done as we can," Democratic Senate Majority Leader Chuck Schumer said in a statement. Trump made 234 judicial appointments during his first four years in office, the second most of any president in a single term, and succeeded in moving the judiciary rightward - including building a 6-3 conservative majority on the U.S. Supreme Court with three appointees. Biden has appointed a host of liberal judges. Since the beginning of his presidency in 2021, the Senate has confirmed 214 Biden judicial nominees, including liberal Supreme Court Justice Ketanji Brown Jackson. About two-thirds were women, and the same share were racial minorities. Senate Democrats are under pressure to swiftly confirm the remaining nominees, along with any new picks Biden may name in the waning weeks of his presidency. How many nominees Senate Democrats will be able to confirm remains to be seen. Trump in a social media post on Sunday called on the Senate to halt approving Biden's nominees, saying, "Democrats are looking to ram through their Judges." Billionaire Trump backer Elon Musk on Tuesday wrote on social media that "activist" judicial nominees are "bad for the country." Mike Davis, a Trump ally at the conservative judicial advocacy group Article III Project, in another post urged Senate Republicans to vote down all judicial appointments until January. "The American people voted for monumental change," Davis wrote on social media last week. "Grind the Senate to a halt." Current Senate Republican leader Mitch McConnell's office declined comment. McConnell has consistently opposed Biden's nominees and, as majority leader, was instrumental in getting Trump's previous nominees confirmed. Trump's judicial appointees have been involved in major decisions welcomed by conservatives including Supreme Court rulings rolling back abortion rights, widening gun rights, rejecting race-conscious collegiate admissions and limiting the power of federal regulatory agencies. Judicial nominees require a simple majority for confirmation. Democrats currently hold a slim 51-49 majority, meaning that they can ill afford any defections or absences if Republicans show up in force to oppose Biden's nominees during the chamber's post-election "lame duck" session. West Virginia Senator Joe Manchin, an independent who caucuses with the Democrats, has said he would not vote for any nominee who does not garner at least one Republican vote. Must-pass legislation like a spending bill to avert a government shutdown also may consume precious time during the session. 'Every possible nominee' Biden's allies have said a concerted push to confirm his remaining nominees would allow him to build on his legacy of helping to diversify a federal bench long dominated by white men. He is not done nominating judges. On Friday, Biden announced his first post-election nominee, Tali Farhadian Weinstein, who after unsuccessfully running in the 2021 Democratic primary to be Manhattan district attorney was picked for a job as a federal district judge in New York. A spokesperson for Senator Dick Durbin, the No. 2 Senate Democrat and chair of the Judiciary Committee, said in a statement that he "aims to confirm every possible nominee before the end of this Congress." White House spokesperson Andrew Bates on Monday noted that during Trump's first term, the Republican-controlled Senate confirmed 18 judges after Biden had won the 2020 election but before he took office. Pending nominees include five to the influential federal appeals courts. Republicans said before the election that they had the votes to block two of them: Adeel Mangi, who would become the first Muslim federal appellate judge, and North Carolina Solicitor General Ryan Park, who unsuccessfully defended the race-conscious admissions policies before the Supreme Court. There are several others nominated to serve as trial court judges like Perry, a former prosecutor now working at Chicago-headquartered GE HealthCare who would join the bench in Illinois. Biden nominated her to a judgeship in April after her prior nomination to become Chicago's top federal prosecutor was blocked by Republican Senator JD Vance. Vance began placing a hold on Biden's nominees to the U.S. Justice Department in 2023 after Special Counsel Jack Smith secured the first of two federal indictments against Trump, who subsequently picked the senator as his vice presidential running mate.

Dutch coach, Eric Ten Hag was eventually booted out of Manchester United 30 months after his appointment in May 2022. The former Ajax gaffer didn’t quite succeed with the Red Devils in terms of quality, squad depth and results but he was able to deliver two trophies( Carabao, FA Cup) in his two years in […]

The post For Manchester United, hiring Ruben Amorim could be a big mistake first appeared on Business Hallmark.

A ruling upholding the constitutionality of the Bangsamoro Organic Law but excluding Sulu from the Bangsamoro Autonomous Region in Muslim Mindanao is immediately executory, according to the Supreme Court.

LONDON — Discontented, economically squeezed voters have turned against sitting governments on both right and left during many of the dozens of elections held this year, as global power blocs shift and political certainties crumble. From India to South Africa to Britain, voters dealt blows to long-governing parties. Elections to the European Parliament showed growing support for the continent's far right, while France's centrist president scrambled to fend off a similar surge at home. If there’s a global trend, Eurasia Group president Ian Bremmer said at a summit in Canada in June, it’s that “people are tired of the incumbents.” More than 40 countries have held elections already this year. More uncertainty awaits — nations home to over half the world’s population are going to the polls in 2024. The world is already anxiously turning to November’s presidential election in the U.S., where an acrimonious campaign was dealt a shocking blow by an assassination attempt against Republican nominee and former president, Donald Trump. Unpopular incumbents Aftershocks from the COVID-19 pandemic, conflicts in Africa, Europe and the Middle East, and spiking prices for food and fuel have left dissatisfied voters eager for change. “Voters really, really don’t like inflation,” said Rob Ford, professor of political science at the University of Manchester. “And they punish governments that deliver it, whether they are at fault or not.” Inflation and unemployment are rising in India, the world’s largest democracy, where Prime Minister Narendra Modi’s Hindu nationalist Bharatiya Janata Party unexpectedly lost its parliamentary majority after a decade of dominance. Modi was forced to rely on coalition partners to govern as the opposition doubled its strength in parliament. In South Africa, sky-high rates of unemployment and inequality helped drive a dramatic loss of support for the African National Congress, which had governed ever since the end of the apartheid system of white minority rule in 1994. The party once led by Nelson Mandela lost its parliamentary majority for the first time and was forced to enter a coalition with opposition parties. In Britain, the center-left Labour Party won election in a landslide, ousting the Conservatives after 14 years. As in so many countries, Prime Minister Keir Starmer faces a jaded electorate that wants lower prices and better public services — but is deeply skeptical of politicians’ ability to deliver change. US-China tensions Caught between world powers China and the United States, Taiwan held one of the year's most significant elections. Lai Ching-te, of the Democratic Progressive Party, won a presidential election that was seen as a referendum on the island’s relationship with China, which claims Taiwan as its own. Beijing regards Lai as a separatist and ramped up military pressure with drills in the Taiwan Strait. Lai has promised to strengthen the defenses of the self-governing island, and the U.S. has pledged to help it defend itself, heightening tensions in one of the world’s flashpoints. In Bangladesh, an important partner of the U.S. that has drawn closer to China, Prime Minister Sheikh Hasina won a fourth successive term in an election that opposition parties boycotted. The U.S. and U.K. said the vote was not credible, free or fair. Political dynasties In several countries, family ties helped secure or cement power. Pakistan held messy parliamentary elections – under the eye of the country’s powerful military — that saw well-established political figures vie to become prime minister. The winner, atop a coalition government, was Prime Minister Shehbaz Sharif, younger brother of three-time premier Nawaz Sharif. Opponents say the election was rigged in his favor, with opponent and former prime minister, Imran Khan, imprisoned and blocked from running. The situation remains unstable, with Pakistan’s Supreme Court ruling that Khan’s party was improperly denied some seats. In Indonesia, Southeast Asia’s largest democracy, former Defense Minister Prabowo Subianto was officially declared president more than two months after an election in which he won over 58% of the vote. His two losing rivals alleged fraud and nepotism — Subianto’s vice president-elect is outgoing leader Joko Widodo’s son, and Subianto was the son-in-law of Indonesia’s late dictator, Suharto. The country’s highest court rejected their arguments. Some outcomes were predictable. Russian President Vladimir Putin was reelected to a fifth term in a preordained election that followed his relentless crackdown on dissent. Rwanda's election extended the 30-year rule of President Paul Kagame, an authoritarian leader who ran almost unopposed. Far right's uneven march The far right has gained ground in Europe as the continent experiences economic instability and an influx of migrants from troubled lands. Elections for the parliament of the 27-nation European Union shifted the bloc’s center of gravity, with the far right rocking ruling parties in France and Germany, the EU’s traditional driving forces. The EU election triggered a political earthquake in France. After his centrist, pro-business party took a pasting, President Emmanuel Macron called a risky snap parliamentary election in hope of stemming a far-right surge. The anti-immigration National Rally party won the first round, but alliances and tactical voting by the center and left knocked it down to third place in the second round and left a divided legislature. New faces, daunting challenges A presidential election tested Senegal's reputation as a stable democracy in West Africa, a region rocked by a recent spate of coups. The surprise winner was little-known opposition figure Basirou Diomaye Faye, released from prison before polling day as part of a political amnesty. Faye is Africa’s youngest elected leader, and his rise reflects widespread frustration among Senegal’s youth with the country’s direction. Senegal has made new oil and gas discoveries in recent years, but the population has yet to see any real benefit. Mexico elected Claudia Sheinbaum as the first female president in the country’s 200-year history. A protege of outgoing President Andrés Manuel López Obrador, the 61-year-old former Mexico City mayor vowed to continue in the direction set by the popular leftist leader. She faces a polarized electorate, daunting drug-related violence, an increasingly influential military and tensions over migration with the U.S. Uncertainty is the new normal On July 28, Venezuelan President Nicolás Maduro will seek to extend a decade-plus presidency marked by a complex political, social and economic crisis that has driven millions into poverty or out of the country. Opposition parties have banded together, but the ruling party has tight control over the voting process, and many doubt votes will be counted fairly. South Sudan, the world’s youngest country, is scheduled to hold its long-delayed first elections in December. That would represent a key milestone, but the vote is rife with danger and vulnerable to failure. Looming above all is the choice U.S. voters will make Nov. 5 in a tense and divided country. The July 13 shooting at a Trump rally in Pennsylvania, in which the former president was wounded and a rallygoer was killed, came as Democrats agonize over the fitness of President Joe Biden, who has resisted calls to step aside. The prospect of a second term for Trump, a protectionist wary of international entanglements, is evidence of the world’s shifting power blocs and crumbling political certainties. "The world is in the transition," said Neil Melvin, director of international security at defense think tank the Royal United Services Institute. “There are very broad processes on the way which are reshaping international order," he added. "It’s a kind of anti-globalization. It’s a growing return to the nation state and against multilateralism.”

Responsibility for the funding of cancer medication is set to be taken over by the Health Ministry from the Malta Community Chest Fund • Minister announces Paola Health Hub set to launch operations this week

Nazir SiyalKARACHI: Sindh Government have posted Mr. Mehboob Ali Siyal, as Secretary (Revenue), Board of Revenue Sindh, against an existing vacancy here yesterday. Mr. Mehboob Ali Siyal will take charge as Secretary Revenue on Wednesday. A vibrant Officer of Sindh … read more

If God is still speaking to us today—even if only through mental impressions and still, small voices—shouldn’t we consider those messages to as relevant as anything written in Scripture, if not more so? That very issue was hotly debated during the Great Awakening. It was one area where Jonathan Edwards and George Whitefield did not (in the beginning) see eye to eye.

Hansen was comfortably reelected to the state Senate last week, winning 84% of the vote.

Nations have begun setting carbon-cutting targets for the decade ahead, and how ambitious these pledges are could make or break global efforts to avoid dangerous levels of climate change.

Nearly 200 countries are supposed to publish updated climate plans by early February, but so far only three have done so.

On Wednesday, the UK became the latest, announcing during the COP29 climate summit in Azerbaijan that it would raise its target to cut greenhouse gas emissions.

All eyes will be on other big polluters like China, India, and the United States, though future US climate action is unclear following Donald Trump’s election.

Why do they matter?

The world has agreed to try and limit global warming to 1.5 degrees Celsius above pre-industrial levels, but is nowhere near on track.

Above this threshold, scientists say humanity risks disastrous consequences from volatile weather to major ecological “tipping points” at land and sea.

Last month, the United Nations warned that even if all existing plans are implemented in full, temperatures would rise 2.6°C by the century’s end, a catastrophic outcome.

The UN says the next round of climate plans must show a “quantum leap” in ambition to avert the worst.

The G20 — which accounts for 77 per cent of total greenhouse gas emissions — is under particular pressure to step up.

Early movers

Just before COP29 opened in Azerbaijan, the United Arab Emirates announced a 47pc reduction in emissions by 2035 compared with 2019 in its updated climate plan.

Observers said the roadmap failed to account for exported emissions —including those from its sales of crude oil abroad.

Next year’s UN climate host, Brazil, has partly unveiled its plan, increasing its emissions reduction target from a 59pc cut by 2035, from 2005 levels, to a 67pc reduction.

It is expected to unveil a more complete plan during COP29.

Plans from other major emitters, like the European Union and China, are not expected until next year.

And the current US government could soon outline Washington’s new pledge, despite questions over Trump following through once in office.

David Waskow, of the World Resources Institute, said it would help guide American cities, states and businesses wishing to continue climate action under Trump.

“It also sends an important signal internationally, a set of benchmarks for what the US ought to do,” he added.

What do countries need to do?

By signing the Paris accord, nearly 200 nations agreed to halt rising temperatures “well below 2°C” and strive for the safer goal of 1.5°C.

But it did not prescribe how to get there.

The deal left it up to countries to voluntarily chart their own plans and targets, known as Nationally Determined Contributions (NDCs).

These include emission reduction targets and measures to achieve them, such as rolling out renewable energy, electrifying transport, and ending deforestation.

There is no set template for countries to follow but richer countries —historically the largest emitters — have a responsibility to pledge the deepest emission cuts.

The plans must be reviewed every five years, with each update supposed to be more ambitious than the last. This time around countries are expected to improve their 2030 targets and outline economy-wide action they will take to 2035.

What’s the aim?

An agreement at last year’s COP28 climate summit “encouraged” countries to come forward with plans aligned with halting warming to 1.5°C.

To have a hope of meeting that goal, emissions must be slashed 42pc by 2030 and 57pc by 2035, the UN’s Environment Programme said last month.

Currently, however, emissions are continuing to rise.

Keeping 1.5°C on track would require a collective effort “only ever seen following a global conflict”, it added.

Without pulling together “on a scale and pace never seen before… the 1.5°C goal will soon be dead,” said UNEP executive director Inger Andersen.

The big moment for assessing progress towards the 1.5°C goal comes at a crunch COP30 climate summit in Brazil next year.

What about fossil fuels?

Scientists and the International Energy Agency have said that developing new fossil fuel projects is incompatible with halting warming to 1.5°C.

But many fossil fuel-producing countries argue that new oil and gas projects will be needed as the world transitions to net zero emissions.

Countries are under pressure to outline in their updated plans how they intend to reduce their reliance on fossil fuels, something all nations agreed on at last year’s COP.

Header image: This picture taken on November 12 shows a wind turbine at the lignite-fired power station operated by German energy giant RWE near Neurath, western Germany. — AFP

The lifestyle choices you make in middle age play a particularly important role in how your brain ages

The discovery that a small blue blob of neurons, the locus coeruleus, controls your mode of thinking suggests ways to increase learning, creativity, focus and alertness

Photographer Enrico Sacchetti captures the power and potential of ITER, an international nuclear fusion experiment currently under construction in southern France

Title: Should You Take Ashwagandha For Thyroid Issues?
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Purpose:

Colorectal cancer (CRC) screening is recommended starting at age 45, but there has been little research on strategies to promote screening among patients younger than 50. This study assessed the effect of a multicomponent intervention on screening completion in this age group.

Organic anion transporting polypeptides (OATP, gene symbol SLCO) are well-recognized key determinants for the absorption, distribution, and excretion of a wide spectrum of endogenous and exogenous compounds including many antineoplastic agents. It was therefore proposed as a potential drug target for cancer therapy. In our previous study, it was found that low-dose X-ray and carbon ion irradiation both upregulated the expression of OATP family member OATP1A2 and in turn, led to a more dramatic killing effect when cancer cells were cotreated with antitumor drugs such as methotrexate. In the present study, the underlying mechanism of the phenomenon was explored in breast cancer cell line MCF-7. It was found that the nonreceptor tyrosine kinase v-YES-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES-1) was temporally coordinated with the change of OATP1A2 after irradiation. The overexpression of YES-1 significantly increased OATP1A2 both at the mRNA and protein level. The signal transducer and activator of transcription 3 (STAT3) pathway is likely the downstream target of YES-1 because phosphorylation and nuclear accumulation of STAT3 were both enhanced after overexpressing YES-1 in MCF-7 cells. Further investigation revealed that there are two possible binding sites of STAT3 localized at the upstream sequence of SLCO1A2, the encoding gene of OATP1A2. Electrophoretic mobility shift assay and chromatin immunoprecipitation analysis suggested that these two sites bound to STAT3 specifically and the overexpression of YES-1 significantly increased the association of the transcription factor with the putative binding sites. Finally, inhibition or knockdown of YES-1 attenuated the induction effect of radiation on the expression of OATP1A2.