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Machine Gun Kelly has 'no connection' with Austin Green amid Megan Fox pregnancy

Megan Fox's current beau Machine Gun Kelly is in “no relationship” with the actress’ ex-husband Brian Austin Green, as the couple expect their first baby together.According to TMZ, MGK and Green have had little to no contact over the past two years, with sources saying that the...




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Morrison police chief Bill Vinelli on leave amid investigation

“While the investigation takes place, the town will refrain from any additional comment on this matter," according to a press release.




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Why midlife is the perfect time to take control of your future health

The lifestyle choices you make in middle age play a particularly important role in how your brain ages




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A lost branch of the river Nile flowed past the pyramids of Egypt

Soil core samples show an ancient riverbed under the desert near many Egyptian pyramids, revealing an ancient waterway that dried up thousands of years ago




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Egyptian pyramid may have been built using a water-powered elevator

Ancient Egyptians may have relied on a vertical shaft that could be filled with water, along with a network of water channels and filtration structures, to build the Step Pyramid of Djoser 4500 years ago




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Midlife Fitness May Mean Healthier Old Age, Study Finds

Title: Midlife Fitness May Mean Healthier Old Age, Study Finds
Category: Health News
Created: 8/27/2012 6:05:00 PM
Last Editorial Review: 8/28/2012 12:00:00 AM




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High Cholesterol May Be Particularly Bad for Middle-Aged Men

Title: High Cholesterol May Be Particularly Bad for Middle-Aged Men
Category: Health News
Created: 8/27/2013 9:35:00 AM
Last Editorial Review: 8/27/2013 12:00:00 AM




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Middle-Aged Health Behavior a Matter of Degrees

Title: Middle-Aged Health Behavior a Matter of Degrees
Category: Health News
Created: 8/29/2013 9:35:00 AM
Last Editorial Review: 8/29/2013 12:00:00 AM




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furosemide

Title: furosemide
Category: Medications
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 8/10/2022 12:00:00 AM




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Antenatal Care Interventions to Increase Contraceptive Use Following Birth in Low- and Middle-Income Countries: Systematic Review and Narrative Synthesis

ABSTRACTIntroduction:Health risks associated with short interpregnancy intervals, coupled with women’s desires to avoid pregnancy following childbirth, underscore the need for effective postpartum family planning programs. The antenatal period provides an opportunity to intervene; however, evidence is limited on the effectiveness of interventions aimed at reaching women in the antenatal period to increase voluntary postpartum family planning in low- and middle-income countries (LMICs). This systematic review aimed to identify and describe interventions in LMICs that attempted to increase postpartum contraceptive use via contacts with pregnant women in the antenatal period.Methods:Studies published from January 2012 to July 2022 were considered if they were conducted in LMICs, evaluated an intervention delivered during the antenatal period, were designed to affect postpartum contraceptive use, were experimental or quasi-experimental, and were published in French or English. The main outcome of interest was postpartum contraceptive use within 1 year after birth, defined as the use of any method of contraception at the time of data collection. We searched EMBASE, Global Health, and Medline and manually searched the reference lists from studies included in the full-text screening.Results:We double-screened 771 records and included 34 reports on 31 unique interventions in the review. Twenty-three studies were published from 2018 on, with 21 studies conducted in sub-Saharan Africa. Approximately half of the study designs (n=16) were randomized controlled trials, and half (n=15) were quasi-experimental. Interventions were heterogeneous. Among the 24 studies that reported on the main outcome of interest, 18 reported a positive intervention effect, with intervention recipients having greater contraceptive use in the first year postpartum.Conclusion:While the studies in this systematic review were heterogeneous, the findings suggest that interventions that included a multifaceted package of initiatives appeared to be most likely to have a positive effect.




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Improving Maternity Care Where Home Births Are Still the Norm: Establishing Local Birthing Centers in Guatemala That Incorporate Traditional Midwives

ABSTRACTMore than half of births among Indigenous women in Guatemala are still being attended at home by providers with no formal training. We describe the incorporation of comadronas (traditional midwives) into casas maternas (birthing centers) in the rural highlands of western Guatemala. Although there was initial resistance to the casa, comadronas and clients have become increasingly enthusiastic about them. The casas provide the opportunity for comadronas to continue the cultural traditions of prayers, massages, and other practices that honor the vital spiritual dimension of childbirth close to home in a home-like environment with extended family support while at the same time providing a safer childbirth experience in which complications can be detected by trained personnel at the casa, managed locally, or promptly referred to a higher-level facility. Given the growing acceptance of this innovation in an environment in which geographical, financial, and cultural barriers to deliveries at higher-level facilities lead most women to deliver at home, casas maternas represent a feasible option for reducing the high level of maternal mortality in Guatemala.This article provides an update on the growing utilization of casas and provides new insights into the role of comadronas as birthing team members and enthusiastic promotors of casas maternas as a preferable alternative to home births. Through the end of 2023, these casas maternas had cared for 4,322 women giving birth. No maternal deaths occurred at a casa, but 4 died after referral.The Ministry of Health of Guatemala has recently adopted this approach and has begun to implement it in other rural areas where home births still predominate. This approach deserves consideration as a viable and feasible option for reducing maternal mortality throughout the world where home births are still common, while at the same time providing women with respectful and culturally appropriate care.




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The diagnostic odyssey of a patient with dihydropyrimidinase deficiency: a case report and review of the literature [RESEARCH REPORT]

Dihydropyrimidinase (DHP) deficiency is an autosomal recessive metabolic disorder caused by biallelic pathogenic variants of DPYS. Patients with DHP deficiency exhibit a broad spectrum of phenotypes, ranging from severe neurological and gastrointestinal involvement to cases with no apparent symptoms. The biochemical diagnosis of DHP deficiency is based on the detection of a significant amount of dihydropyrimidines in urine, plasma, and cerebrospinal fluid samples. Molecular genetic testing, specifically the identification of biallelic pathogenic variants in DPYS, has proven instrumental in confirming the diagnosis and facilitating family studies. This case study documents the diagnostic journey of an 18-yr-old patient with DHP deficiency, highlighting features at the severe end of the clinical spectrum. Notably, our patient exhibited previously unreported skeletal features that positively responded to bisphosphonate treatment, contributing valuable insights to the clinical characterization of DHP deficiency. Additionally, a novel DPYS variant was identified and confirmed pathogenicity through metabolic testing, further expanding the variant spectrum of the gene. Our case emphasizes the importance of a comprehensive diagnostic approach using genetic sequencing and metabolic testing for accurate diagnosis.




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First-of-Its-Kind Glowing Sea Creature Discovered in Ocean’s ‘Midnight Zone’



A nudibranch from the midnight zone has fingers on its tail, collects food with a hood, and glows.




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Far-right groups gain ground in Sweden and Germany amid migrant influx

Watch Video | Listen to the Audio

JUDY WOODRUFF: But first: Sunday’s elections Austria were the latest ample of a shift to the right Europe’s politics, as 31-year-old Christian Kurz was elected chancellor on an anti-immigration platform.

He may now form a government with a far-right party founded in the 1950s by former Nazis.

That follows recent elections in Germany, where a far-right party roiled the race and dealt a blow to returning leader Angela Merkel.

In Sweden, too, there is a strong challenge from the right and a neo-Nazi group that looks stand in elections next year.

Special correspondent Malcolm Brabant ha been surveying the political landscape in Germany and Sweden, and he begins his report in Scandinavia.

MALCOLM BRABANT, Special Correspondent: In a Gothenburg parking lot, supporters of the Nordic Resistance Movement form up for what they hope will be their biggest-ever march, to propagate an ideology espoused by mother of eight Paulina Forslund.

PAULINA FORSLUND, Nordic Resistance Movement: When white becomes the minority, they will be destroyed. I want my children to have a secure future. I want them not only for them to have a secure Sweden. I want them to have a secure world. And I want other people to fight for the same thing.

MALCOLM BRABANT: When addressing her fellow neo-Nazis, Forslund’s rhetoric sharpens.

PAULINA FORSLUND (through interpreter): I’m the welder’s daughter, the forester’s grandchild. My line consists of hardworking men and women. It’s people like them we can thank for the welfare system that our lying politicians are now giving away to imported scum.

MALCOLM BRABANT: Clearly expecting trouble, the movement’s leaders have a muscular protection detail, marching past a silent protest. The sign reads “No Nazis on our streets.”

This protester would only give her name as Johanna.

JOHANNA, Anti-Nazi Protester: They are racist people. They are people who think that certain people are better than others, and I will not stand for that. It’s not something I think has a place in a modern society.

MALCOLM BRABANT: Experts say the resistance movement is recruiting aggressively, and believe this demonstration is emblematic of the rise of the far right.

It took place on Yom Kippur, the Jewish day of atonement.

Allan Stutzinky is leader of Gothenburg’s Jewish community.

ALLAN STUTZINKY, Jewish Community Leader (through interpreter): Nazism has returned. The descendants of the murderers are organizing the same marches today, waving the same flags, shouting the same slogans, and have the same racist agenda.

MALCOLM BRABANT: Anna Johansson is a member of the governing Social Democrat Party. It’s considering outlawing the Nordic Resistance Movement.

ANNA JOHANSSON, Swedish Social Democratic Party: In Sweden and in Denmark, and in other countries, extreme parties are growing, and the hatred is spreading around.

MALCOLM BRABANT: “Go home to mama,” he shouts. “Nazi pigs,” chant the anti- fascist protesters, as a bottle flies through the air.

DAMON, Nordic Resistance Movement: If someone calls themselves a Nazi, most of us would dissociate with that person. That’s nothing we stand for ourselves. I never call myself a Nazi. I’m a national socialist.

MALCOLM BRABANT: Hitler’s party was also called National Socialist, but Damon, a 40-year-old welder, insists he’s a nonviolent family man.

DAMON: The demographic landscape of our — of the whole of Europe is changing, so, basically, it’s a concern on preserving my heritage for my family and our kin.

MALCOLM BRABANT: This demonstration has been stopped short of its destination. The Nordic Resistance Movement is currently trapped between a line of police and anti-fascist protesters. And it looks as though this demonstration isn’t going any further.

Violence briefly erupts as the resistance movement tries to break through police lines, and several marchers are arrested.

PAULINA FORSLUND: We are not your enemy. We are the government’s enemy.

They say we live in a democracy, but we have never had an election about if we want to take all these people in.

MALCOLM BRABANT: When Europe’s refugee crisis began in 2015, Sweden copied Germany’s open-door policy, and 160,000 migrants entered the country. Two years on, Sweden has tighter borders and has begun deporting some of the newcomers.

The new atmosphere alarms Floid Gumbo, entertaining an anti-Nazi rally.

FLOID GUMBO, Singer Originally from Zimbabwe: I came to Sweden over 20 years ago. The climate in Sweden, the people were so friendly, and things were completely different, more welcoming. And I feel like things have sort of gradually changed.

I’m very concerned, because I have children, because I’m thinking what I experienced here is not the same kind of climate, atmosphere that they are going to experience here.

ANNA JOHANSSON: It’s not so long ago that the Nazis ruined Europe. And that makes me very worried. The German elections were terrifying, I think.

MALCOLM BRABANT: Johansson is referring to last month’s success of the right-wing Alternative For Germany Party, or AFD, when it entered Parliament for the first time with 13 percent of the vote.

HUGH BRONSON, Alternative For Germany Party: The AFD only came into existence because Merkel deserted the traditional conservative Christian voters. They were looking for a home, and the AFD has offered them a safe place.

MALCOLM BRABANT: Hugh Bronson is deputy leader of the AFD in Berlin.

Now his party, the third largest in Parliament, is demanding that Angela Merkel imposes tougher immigration rules.

Your opponents claim that you are a party of hate. What’s your response to that?

HUGH BRONSON: We embrace foreigners who respect our laws, pay their taxes, send their children to school, and go about their normal life. The problem is with people who abuse the system to have a better life, or let others pay for their better lives, or who are criminals.

MALCOLM BRABANT: Outside the opera house in Dresden, former East Germany, singer Luca Bergelt is dismayed by the political landscape shifting to the right.

LUCA BERGELT, Singer: My fear is that they will tear Europe apart. They are going to raise up the walls again. They’re going to build new walls between the countries, and that Europe will get more close into itself.

MALCOLM BRABANT: Anti-immigrant sentiment is strong in Dresden. The city was the birthplace of a pan-European anti-Islamic movement, and it delivered the largest number of votes for the right-wing party.

On a holiday to celebrate German unification after the fall of communism, retired engineer Wilfried Schmidt explained why he sent a message to Angela Merkel.

WILFRIED SCHMIDT, Retired Engineer (through interpretor): Let’s put it this way. We all need to recognize that Germany is undergoing social changes that are becoming harder to control. For one, there is mass immigration from difficult regions that is increasingly uncontrollable, of people with entirely different concepts of life, from fundamental differently structured societies that are problematic.

MALCOLM BRABANT: About one million migrants poured into Germany in 2015. Chancellor Merkel consistently defended her pro-refugee policies, but now she has been punished by voters who believe she ignored their concerns.

Chancellor Merkel has promised to listen to the people who voted for the AFD, and she says she’s going to try to win them over with what she calls good politics. But she will not countenance having the party in her coalition.

But the chancellor needs to find new partners who are prepared to be tough on immigration.

As she tries to forge a coalition, the chancellor has agreed to put an annual cap of 200,000 on the number of immigrants, something she previously refused to do. But will it be enough to woo back people who deserted her at the election?

A question for Werner Patzelt, a political scientist at Dresden University.

WERNER PATZELT, Dresden University: Since Chancellor Merkel has made so many U-turns in German domestic politics, it wouldn’t be a surprise if she would try to do a U-turn, also winning back AFD voters.

But this is a really hard political task, because so many of them are so much disappointed by the Christian Democratic Union in general, and by Chancellor Merkel in particular, that they will do anything to avoid going back.

MALCOLM BRABANT: Back in Sweden, the governing party is horrified at the concept of conceding ground to right-wingers, and is trying to isolate them.

ANNA JOHANSSON: Experience shows that, when you adopt the ideas from these right-wing parties, they spread. These parties have their agenda implemented by other parties. And I wouldn’t want to see that happen in Sweden.

FLOID GUMBO: We’re all human beings. We share this world. We’re all here. There’s enough space for us all.

MALCOLM BRABANT: But that’s an appeal that an increasing number of Swedes are rejecting, as the country and much of Europe go through a crisis of identity.

For the PBS NewsHour, I’m Malcolm Brabant in Gothenburg.

The post Far-right groups gain ground in Sweden and Germany amid migrant influx appeared first on PBS NewsHour.




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South of Midnight Gets 30-Minute 'Weaving Hazel's Journey' Documentary

Publisher Xbox Game Studios and developer Compulsion Games have released a 30-minute long documentary on for South of Midnight titled "Weaving Hazel's Journey."

The video share a behind-the-scenes look at the upcoming third-person action-adventure game. It explores the development and world building, as well as providing a look at new gameplay.

View the documentary below:

South of Midnight will launch for the Xbox Series X|S, PC via Steam and Microsoft Store, and Xbox Game Pass in 2025.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463044/south-of-midnight-gets-30-minute-weaving-hazels-journey-documentary/




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Driving Middle East’s Innovation in Robotics and Future of Automation



This is a sponsored article brought to you by Khalifa University of Science and Technology.

Abu Dhabi-based Khalifa University of Science and Technology in the United Arab Emirates (UAE) will be hosting the 36th edition of the IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2024) to highlight the Middle East and North Africa (MENA) region’s rapidly advancing capabilities in the robotics and intelligent transport systems.

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Themed “Robotics for Sustainable Development,” the IROS 2024 will be held from 14-18 October 2024 at the Abu Dhabi National Exhibition Center (ADNEC) in the UAE’s capital city. It will offer a platform for universities and research institutions to display their research and innovation activities and initiatives in robotics, gathering researchers, academics, leading corporate majors, and industry professionals from around the globe.

A total of 13 forums, nine global-level competitions and challenges covering various aspects of robotics and AI, an IROS Expo, as well as an exclusive Career Fair will also be part of IROS 2024. The challenges and competitions will focus on physical or athletic intelligence of robots, remote robot navigation, robot manipulation, underwater robotics, as well as perception and sensing.

Delegates for the event will represent sectors including manufacturing, healthcare, logistics, agriculture, defense, security, and mining sectors with 60 percent of the talent pool having over six years of experience in robotics. A major component of the conference will be the poster sessions, keynotes, panel discussions by researchers and scientists, and networking events.

Khalifa University will be hosting IROS 2024 to highlight the Middle East and North Africa (MENA) region’s rapidly advancing capabilities in the robotics and intelligent transport systems.Khalifa University

Abu Dhabi ranks first on the world’s safest cities list in 2024, according to online database Numbeo, out of 329 global cities in the 2024 standings, holding the title for eight consecutive years since 2017, reflecting the emirate’s ongoing efforts to ensure a good quality of life for citizens and residents.

With a multicultural community, Abu Dhabi is home to people from more than 200 nationalities and draws a large number of tourists to some of the top art galleries in the city such as Louvre Abu Dhabi and the Guggenheim Abu Dhabi, as well as other destinations such as Ferrari World Abu Dhabi and Warner Bros. World Abu Dhabi.

The UAE and Abu Dhabi have increasingly become a center for creative skillsets, human capital and advanced technologies, attracting several international and regional events such as the global COP28 UAE climate summit, in which more than 160 countries participated.

Abu Dhabi city itself has hosted a number of association conventions such as the 34th International Nursing Research Congress and is set to host the UNCTAD World Investment Forum, the 13th World Trade Organization (WTO) Ministerial Conference (MC13), the 12th World Environment Education Congress in 2024, and the IUCN World Conservation Congress in 2025.

Khalifa University’s Center for Robotics and Autonomous Systems (KU-CARS) includes a vibrant multidisciplinary environment for conducting robotics and autonomous vehicle-related research and innovation.Khalifa University

Dr. Jorge Dias, IROS 2024 General Chair, said: “Khalifa University is delighted to bring the Intelligent Robots and Systems 2024 to Abu Dhabi in the UAE and highlight the innovations in line with the theme Robotics for Sustainable Development. As the region’s rapidly advancing capabilities in robotics and intelligent transport systems gain momentum, this event serves as a platform to incubate ideas, exchange knowledge, foster collaboration, and showcase our research and innovation activities. By hosting IROS 2024, Khalifa University aims to reaffirm the UAE’s status as a global innovation hub and destination for all industry stakeholders to collaborate on cutting-edge research and explore opportunities for growth within the UAE’s innovation ecosystem.”

“This event serves as a platform to incubate ideas, exchange knowledge, foster collaboration, and showcase our research and innovation activities” —Dr. Jorge Dias, IROS 2024 General Chair

Dr. Dias added: “The organizing committee of IROS 2024 has received over 4000 submissions representing 60 countries, with China leading with 1,029 papers, followed by the U.S. (777), Germany (302), and Japan (253), as well as the U.K. and South Korea (173 each). The UAE with a total of 68 papers comes atop the Arab region.”

Driving innovation at Khalifa University is the Center for Robotics and Autonomous Systems (KU-CARS) with around 50 researchers and state-of-the-art laboratory facilities, including a vibrant multidisciplinary environment for conducting robotics and autonomous vehicle-related research and innovation.

IROS 2024 is sponsored by IEEE Robotics and Automation Society, Abu Dhabi Convention and Exhibition Bureau, the Robotics Society of Japan (RSJ), the Society of Instrument and Control Engineers (SICE), the New Technology Foundation, and the IEEE Industrial Electronics Society (IES).

More information at https://iros2024-abudhabi.org/




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Steven Witkoff chosen by Trump as special envoy to the Middle East

President-elect Donald Trump has tapped Steven Witkoff to be special envoy to the Middle East, marking another key position for his incoming administration.




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Speaker Johnson could face challenger amid simmering GOP discontent

House Speaker Mike Johnson is seeking a smooth re-election to another term wielding the gavel, but a small group of discontent conservatives are again vying to shake things up at the top.




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Laser Mapping Reveals Previously Unknown Maya City with Stone Pyramids in Mexico

Using a laser-based detection system, archaeologists have discovered over 6,500 pre-Hispanic structures -- including a previously unknown Maya city named Valeriana -- in Campeche, Mexico.

The post Laser Mapping Reveals Previously Unknown Maya City with Stone Pyramids in Mexico appeared first on Sci.News: Breaking Science News.




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Next-generation technology is a critical mid-step in dementia care

New technologies will radically change the experience of living with and caring for someone with Alzheimer's, says Professor Fiona Carragher, chief policy and research officer at Alzheimer's Society, UK




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Trump announces pick of real estate tycoon Steven Witkoff for Middle East envoy

President-elect Trump announced that he had picked real estate investor and campaign donor Steve Witkoff to be his special envoy to the Middle East.



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Dolphins' Tyreek Hill floats latest theory about arrest near NFL stadium amid battle with wrist injury

In the first quarter of Monday's Dolphins-Rams game, ESPN reported that Tyreek Hill said a torn ligament in his wrist became worst after he was detained by police.



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Microsoft reports big profits amid massive AI investments

Xbox hardware sales dropped 29 percent, but that barely made a dent.




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Saudi Royals Ask Trump to ‘Finish What You Started’ in Middle East


Prince Turki bin Faisal al-Saud, former Saudi ambassador to the United States, has written an open letter to President-elect Donald Trump asking him to “finish what you started the last time you occupied the White House” with respect to Middle Eastern affairs.

The post Saudi Royals Ask Trump to ‘Finish What You Started’ in Middle East appeared first on Breitbart.




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President-Elect Donald Trump Picks Businessman Steven Witkoff to Be Special Envoy to Middle East


President-elect Donald Trump announced that he has picked businessman and real estate investor Steven Witkoff to serve as Special Envoy to the Middle East.

The post President-Elect Donald Trump Picks Businessman Steven Witkoff to Be Special Envoy to Middle East appeared first on Breitbart.




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Andrew Hulshult 2024 Interview: DOOM IDKFA, Blood Swamps, DUSK, Iron Lung, AMID EVIL, Music, Guitars, Cold Brew Coffee, and More

When I first wrote about boomer shooters last year on Steam Deck and also on Switch, aside from New Blood …




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A Biotech Midsummer’s Madness

By Arthur Tzianabos, CEO of Lifordi Immunotherapeutics, as part of the From The Trenches feature of LifeSciVC Greetings from Lake Winnipesaukee in NH where I am at this time every year. It’s midsummer and vacation time for me and the

The post A Biotech Midsummer’s Madness appeared first on LifeSciVC.




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Scary Stories: Establishing a Field Amid Skepticism



In the spirit of the Halloween season, IEEE Spectrum presents a pair of stories that—although grounded in scientific truth rather than the macabre—were no less harrowing for those who lived them. In today’s installment, Robert Langer had to push back against his field’s conventional wisdom to pioneer a drug-delivery mechanism vital to modern medicine.

Nicknamed the Edison of Medicine, Robert Langer is one of the world’s most-cited researchers, with over 1,600 published papers, 1,400 patents, and a top-dog role as one of MIT’s nine prestigious Institute Professors. Langer pioneered the now-ubiquitous drug delivery systems used in modern cancer treatments and vaccines, indirectly saving countless lives throughout his 50-year career.

But, much like Edison and other inventors, Langer’s big ideas were initially met with skepticism from the scientific establishment.

He came up in the 1970s as a chemical engineering postdoc working in the lab of Dr. Judah Folkman, a pediatric surgeon at the Boston Children’s Hospital. Langer was tasked with solving what many believed was an impossible problem—isolating angiogenesis inhibitors to halt cancer growth. Folkman’s vision of stopping tumors from forming their own self-sustaining blood vessels was compelling enough, but few believed it possible.

Langer encountered both practical and social challenges before his first breakthrough. One day, a lab technician accidentally spilled six months’ worth of samples onto the floor, forcing him to repeat the painstaking process of dialyzing extracts. Those months of additional work steered Langer’s development of novel microspheres that could deliver large molecules of medicine directly to tumors.

In the 1970s, Langer developed these tiny microspheres to release large molecules through solid materials, a groundbreaking proof-of-concept for drug delivery.Robert Langer

Langer then submitted the discovery to prestigious journals and was invited to speak at a conference in Michigan in 1976. He practiced the 20-minute presentation for weeks, hoping for positive feedback from respected materials scientists. But when he stepped off the podium, a group approached him and said bluntly, “We don’t believe anything you just said.” They insisted that macromolecules were simply too large to pass through solid materials, and his choice of organic solvents would destroy many inputs. Conventional wisdom said so.

Nature published Langer’s paper three months later, demonstrating for the first time that non-inflammatory polymers could enable the sustained release of proteins and other macromolecules. The same year, Science published his isolation mechanism to restrict tumor growth.

Langer and Folkman’s research paved the way for modern drug delivery.MIT and Boston Children’s Hospital

Even with impressive publications, Langer still struggled to secure funding for his work in controlling macromolecule delivery, isolating the first angiogenesis inhibitors, and testing their behavior. His first two grant proposals were rejected on the same day, a devastating blow for a young academic. The reviewers doubted his experience as “just an engineer” who knew nothing about cancer or biology. One colleague tried to cheer him up, saying, “It’s probably good those grants were rejected early in your career. Since you’re not supporting any graduate students, you don’t have to let anyone go.” Langer thought the colleague was probably right, but the rejections still stung.

His patent applications, filed alongside Folkman at the Boston Children’s Hospital, were rejected five years in a row. After all, it’s difficult to prove you’ve got something good if you’re the only one doing it. Langer remembers feeling disappointed but not crushed entirely. Eventually, other scientists cited his findings and expanded upon them, giving Langer and Folkman the validation needed for intellectual property development. As of this writing, the pair’s two studies from 1976 have been cited nearly 2,000 times.

As the head of MIT’s Langer Lab, he often shares these same stories of rejection with early-career students and researchers. He leads a team of over 100 undergrads, grad students, postdoctoral fellows, and visiting scientists, all finding new ways to deliver genetically engineered proteins, DNA, and RNA, among other research areas. Langer’s reputation is further bolstered by the many successful companies he co-founded or advised, like mRNA leader Moderna, which rose to prominence after developing its widely used COVID-19 vaccine.

Langer sometimes thinks back to those early days—the shattered samples, the cold rejections, and the criticism from senior scientists. He maintains that “Conventional wisdom isn’t always correct, and it’s important to never give up—(almost) regardless of what others say.”




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Relaxed Federal Regulations Amid Pandemic Can Help Jails Better Treat Opioid Use Disorder

Few correctional facilities in the United States have treatment programs for individuals with opioid use disorder (OUD), despite clear evidence that certain medications reduce the risk of overdose and death. Even in facilities where treatment is available, the COVID-19 pandemic has complicated efforts to provide such care.




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U.S. feared LeT attack in India in mid-2009; warned Pakistan

U.S. feared another LeT attack in India in mid-2009, and sought Pakistan's help to ‘disrupt and prevent' it



  • The India Cables

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Data | Andheri East: Not a NOTA notable, just a blip amid falling vote shares

NOTA continues to be salient in Naxalite areas, but its share has fallen in recent elections




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EVENT DEBRIEF: The Geopolitics of Latin America Amid the War in Ukraine and China-U.S. Tensions

The following is an event write-up about the recent Future of Diplomacy Project (FDP) seminar on “The Geopolitics of Latin America amid the War in Ukraine and China-U.S. Tensions” moderated by Negah Angha, Fellow at the Institute of Politics, on March 29, 2023.




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Who Supports Gender Quotas in Transitioning and Authoritarian States in the Middle East and North Africa?

What are the drivers of citizens’ support for electoral gender quotas in transitioning and authoritarian states? Despite extensive research examining public support for women in politics in democracies, we know little about how the public perceives them in less democratic settings. To address this shortcoming, we use original survey data from authoritarian Morocco and transitioning Tunisia – two Arab countries hailed for their progressive gender policies. We argue that in these countries where citizens lack political information, they instead rely on their assessment of the government’s performance to form attitudes toward gender quotas. Furthermore, electoral legitimacy plays an important role in shaping citizens’ support for quotas, which are closely linked to how elections and legislatures operate. The findings offer strong support for our theoretical expectations and uncover important gender differences.




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The Middle East Conflict That the U.S. Can't Stay Out Of

Juliette Kayyem argues that the sooner President Joe Biden acknowledges that the United States will likely be drawn into a fight to protect shipping traffic through the Suez Canal, the more time the U.S. military has to plan, and the less severe the harm will be to the global economy.




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America Fueled the Fire in the Middle East

Stephen Walt argues that the tragic irony is that the individuals and organizations in the United States that have been the most ardent in shielding Israel from criticism and pushing one administration after another to back Israel, no matter what it does, have in fact done enormous damage to the country that they were trying to help.




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Event Debrief: Planning the Mid-Transition for Just and Sustainable Decarbonization

Emily Grubert, Associate Professor of Sustainable Energy Policy and of Civil and Environmental Engineering and Earth Sciences at the University of Notre Dame, discussed the dangers of an unplanned transition from a fossil-based energy system to a zero-carbon energy system during a talk at Harvard Kennedy School.




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The New Influencers: A Primer on the Expanding Role of Middle Powers in Africa

This original primer, conducted as research for The Africa Futures Project, is an initial exploration into the evolving roles and increasing influence of “middle powers” in Africa. It covers a diverse array of existing and aspiring middle powers, presenting key points for each nation under four distinct analytical lenses.





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New Survey Shows UK Public Willing to Pay �10 for Missed GP Appointments to Support the NHS Amid Widespread Concerns About Government Spending on Healthcare - Healthcare leaders and the public say how they would balance the NHSï¿

Healthcare leaders and the public say how they would balance the NHS� books




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Our AI Opportunity Initiative comes to the Middle East and North Africa

Google is committed to make benefits of AI more accessible and inclusive for everyone in the Middle East and North Africa.



  • Google in the Middle East
  • AI

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Rami Khouri: U.S. Voters Are Sick of Foreign Wars. Can Trump Strike a Grand Bargain in Middle East?

Shortly after Donald Trump was announced as the winner of the U.S. presidential election, Israeli Prime Minister Benjamin Netanyahu took to social media to enthusiastically congratulate him. Meanwhile, the Israeli military continued its violent assault on Gaza, killing multiple Palestinians in strikes on apartment buildings and homes. We speak to Palestinian American journalist Rami Khouri about what we know of Trump’s pro-Israel policies and how Trump beat Kamala Harris for the presidency. “Trump out-dramatized Harris, and that’s how he won,” he says.




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"Complete Charade": Qatar Withdraws from Ceasefire Talks, Middle East Prepares for Trump Presidency

We speak with Dutch Palestinian analyst Mouin Rabbani about the latest developments in the Middle East as Israel continues its deadly assaults on Gaza and Lebanon. Qatar recently announced it will no longer act as mediator for ceasefire talks, saying the two sides were not serious about reaching a deal to stop the fighting. “This entire process from the outset has been a complete charade,” Rabbani says of the U.S.-backed ceasefire negotiations, urging Egypt to follow suit and also stop acting as a mediator. Rabbani also discusses how a second Trump administration could deal with the region, saying Trump’s “erratic” behavior makes predictions difficult, but that signs point to a more aggressive posture toward Iran.




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India's Online Gaming Market Surges by 23% in FY24 Amidst GST Hike

India's gaming market surged by 23% year-on-year, reaching $3.8 billion in revenue in FY 2023-24, even as the sector faces a 28% GST on online gaming, recent reports reveal....




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♫♪ ♬ He's leaving On that midnight train to Georgia ♫♪ ♬




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Today in Middle-earth, October 25

The following event took place in Middle-earth on October 25:
  • The Dwarves venture into the Mountain (1341)
  • The Elvenking's host leave Mirkwood for Erebor (1341)
  • The Council of Elrond (1418)
  • The Council of Hobbits... and a Wizard.
  • [Join us on the Discussion Boards here]

October 25, 2941 (S.R. 1341)

1. The Dwarves venture into the Mountain.

(determined from text)

"Now do be careful!" whispered the hobbit, "and as quiet as you can be!  There may be no Smaug at the bottom, but then again there may be..."

(Tolkien, 1966 Ballantine, p. 224-228 TH)

October 25, 2941 (S.R. 1341) 2. The Elvenking's host leave Mirkwood for Erebor. (determined from text) "...the Elvenking rode forth...  ...marching with many spearmen and bowmen..." (Tolkien, 1966 Ballantine, p. 224-228 TH)

October 25, 3018 (S.R. 1418)

1. Council of Elrond.

(from the appendices)

"Suddenly as they were talking a single clear bell rang out.  'That is the warning bell for the Council of Elrond,' cried Gandalf.  'Come along now! Both you and Bilbo are wanted.'"

(Tolkien, 1965 Ballantine, p. 314-354 FotR)

2. Council of Hobbits... and a Wizard. (from the appendices) "Later that day the hobbits held a meeting of their own in Bilbo's room." (Tolkien, 1965 Ballantine, p. 356 FotR)




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Today in Middle-earth, November 3

The following event(s) took place in Middle-earth on November 3,

  • Battle of Bywater, and Passing of Saruman. End of the War of the Ring (1419)
  • [Join us on the Discussion Boards here]
  • .

 November 3, 3019 (S.R. 1419)

1. Battle of Bywater, and Passing of Saruman. End of the War of the Ring.

(from the appendices)

"...a messenger from the Tookland rode in. He was in high spirits. 'The Thain has raised all our country,' he said, 'and the news is going like fire all ways.…"

(Tolkien, 1965 Ballantine, p. 363-371 RotK)




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Black Cat Starts Mysteriously Losing Its Color, Other Vexed Void Owners Question When Their Cute Cats Go From Midnight to Moonlight

We may or may not be a helicopter cat pawrent - meaning that we may or may not go to Google for every pawssible thing that might be wrong with our cats. Their meow sounds a little different than normal? Google. They all of a sudden start sleeping in a random spot we've never seen them sleep in before? Google. They didn't eat the food that they normally love? Google. Most of the things we google end up being purrfectly fine (we are not prone to overreaction, not one bit). But if our black cat started losing its beautiful black color, now that would be a thing to google!

There are a few pawssible explanations for this: the first is a meowgnificent genetic trait called "vitiligo" - which causes cats to lose pigment in their fur, giving them unique and rare fur patterns. Another option is called a "fever coat", which is a temporary change in a cat's fur pigment due to illness or stress. The last, and final option that we know of, is that this black beauty is just getting old. Either way, you'd be surprised how many vexed void owners chimed in with their black cats that went from midnight to moonlight. Scroll down to see all these fading felines below!




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The Anatomy of Mr. Middle

“Being determines consciousness.” — Marx The upper petit-bourgeois is a strange character indeed, his consciousness made up of a thousand pieces that are all at war with one another, producing a marvelous opportunity for study. All of modern society, one might say, is collected in this species, in various proportions, and various strengths, with different … Continue reading The Anatomy of Mr. Middle




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'His hand pauses in midair': Front desk attendant gets scolded for using his phone at work, instead he maliciously complies with company policy by wasting other precious office resources

No personal cell phones? Okay. This employee took his malicious compliance to the next level after getting scolded one too many times for using his cell phone on the job. 

I get it… It doesn't look good for a hotel receptionist to scroll memes while the line at the concierge starts to grow. Smacking your gum, rolling your eyes, and scrolling endlessly really isn't something you're supposed to be doing at work, but as many of us forget, our phones are actually super useful little tools. We've grown accustomed to traveling around all day with a tiny computer in our pocket that it's easy to let slip their more convenient functions. The front desk reception guy in our next tale knew all the ways his phone could help out clients, but after his manager got on his back about using his personal device on the clock, he decided to use the second language translating tool at his disposal. 

Keep scrolling to read how an employee turned a spiteful MC into a memorable guest experience when a traveler needed help with a quick translation.




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Bali Urges Dengue Fever Vaccinations for Foreign Tourists Amid Rising Cases

The Bali regional government in Indonesia is advising foreign tourists visiting the resort island to receive dengue vaccinations due to the current rise