Over the last several years it has become clear that higher order assemblies on membranes, exemplified by signalosomes, are a paradigm for the regulation of many membrane signaling processes. We have recently combined two-color direct stochastic optical reconstruction microscopy (dSTORM) with the (Clus-DoC) algorithm that combines cluster detection and colocalization analysis to observe the organization of 5-lipoxygenase (5-LO) and 5-lipoxygenase–activating protein (FLAP) into higher order assemblies on the nuclear envelope of mast cells; these assemblies were linked to leukotriene (LT) C4 production. In this study we investigated whether higher order assemblies of 5-LO and FLAP included cytosolic phospholipase A2 (cPLA2) and were linked to LTB4 production in murine neutrophils. Using two- and three-color dSTORM supported by fluorescence lifetime imaging microscopy we identified higher order assemblies containing 40 molecules (median) (IQR: 23, 87) of 5-LO, and 53 molecules (62, 156) of FLAP monomer. 98 (18, 154) molecules of cPLA2 were clustered with 5-LO, and 77 (33, 114) molecules of cPLA2 were associated with FLAP. These assemblies were tightly linked to LTB4 formation. The activation-dependent close associations of cPLA2, FLAP, and 5-LO in higher order assemblies on the nuclear envelope support a model in which arachidonic acid is generated by cPLA2 in apposition to FLAP, facilitating its transfer to 5-LO to initiate LT synthesis.

The two Upstate New York districts are venturing beyond the largely white region to tap a more diverse pool of educators.

Two Republican legislators in Colorado have introduced a bill that would enact harsh consequences, including jail time, for teachers and teachers' unions who go on strike.

Colorado will no longer administer the full PARCC exam to students.

Dozens of Colorado school districts are asking voters next month for more funding for education through bond issues, mill levy overrides, or renewal of a city sales tax.

Teachers and other education advocates hope that tax-wary voters will be willing to approve an amendment that would pour more than $1.6 billion more into schools each year.

Teachers in Colorado forced at least one school district to close as they rallied at the capitol to call for more education funding.

The final version of the bill reduces the cost-of-living raises and increases employee contributions to their retirement, among other changes.

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

The STEM School shooting underscores the huge challenges educators face in keeping students safe, even as fatal and injurious gunfire inside K-12 schools remains statistically rare.

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

All 46 schools in the Mesa County Valley School District closed last Thursday and Friday after students and staff at more than a dozen schools experienced norovirus-like symptoms.

Students engaged in a protest against a culture they saw as punitive; their principal suspended them. What did a court say?

This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

Libraries -- Marketing.

We study the identity testing problem in the context of spin systems or undirected graphical models, where it takes the following form: given the parameter specification of the model $M$ and a sampling oracle for the distribution $mu_{M^*}$ of an unknown model $M^*$, can we efficiently determine if the two models $M$ and $M^*$ are the same? We consider identity testing for both soft-constraint and hard-constraint systems. In particular, we prove hardness results in two prototypical cases, the Ising model and proper colorings, and explore whether identity testing is any easier than structure learning. For the ferromagnetic (attractive) Ising model, Daskalakis et al. (2018) presented a polynomial-time algorithm for identity testing. We prove hardness results in the antiferromagnetic (repulsive) setting in the same regime of parameters where structure learning is known to require a super-polynomial number of samples. Specifically, for $n$-vertex graphs of maximum degree $d$, we prove that if $|eta| d = omega(log{n})$ (where $eta$ is the inverse temperature parameter), then there is no polynomial running time identity testing algorithm unless $RP=NP$. In the hard-constraint setting, we present hardness results for identity testing for proper colorings. Our results are based on the presumed hardness of #BIS, the problem of (approximately) counting independent sets in bipartite graphs.

Defendant’s Motion to Exclude Expert Testimony regarding evidence generated by STRmix denied.

(PRWeb May 08, 2020)

Read the full story at https://www.prweb.com/releases/colorado_court_rules_strmix_is_relevant_and_reliable_practice_for_interpreting_likelihood_ratios/prweb17101548.htm

Lin Liu, Yuqi Qiu, Loki Natarajan, Karen Messer.

Source: The Annals of Applied Statistics, Volume 13, Number 3, 1370--1396.

Abstract:
It is common to encounter missing data among the potential predictor variables in the setting of model selection. For example, in a recent study we attempted to improve the US guidelines for risk stratification after screening colonoscopy ( Cancer Causes Control 27 (2016) 1175–1185), with the aim to help reduce both overuse and underuse of follow-on surveillance colonoscopy. The goal was to incorporate selected additional informative variables into a neoplasia risk-prediction model, going beyond the three currently established risk factors, using a large dataset pooled from seven different prospective studies in North America. Unfortunately, not all candidate variables were collected in all studies, so that one or more important potential predictors were missing on over half of the subjects. Thus, while variable selection was a main focus of the study, it was necessary to address the substantial amount of missing data. Multiple imputation can effectively address missing data, and there are also good approaches to incorporate the variable selection process into model-based confidence intervals. However, there is not consensus on appropriate methods of inference which address both issues simultaneously. Our goal here is to study the properties of model-based confidence intervals in the setting of imputation for missing data followed by variable selection. We use both simulation and theory to compare three approaches to such post-imputation-selection inference: a multiple-imputation approach based on Rubin’s Rules for variance estimation ( Comput. Statist. Data Anal. 71 (2014) 758–770); a single imputation-selection followed by bootstrap percentile confidence intervals; and a new bootstrap model-averaging approach presented here, following Efron ( J. Amer. Statist. Assoc. 109 (2014) 991–1007). We investigate relative strengths and weaknesses of each method. The “Rubin’s Rules” multiple imputation estimator can have severe undercoverage, and is not recommended. The imputation-selection estimator with bootstrap percentile confidence intervals works well. The bootstrap-model-averaged estimator, with the “Efron’s Rules” estimated variance, may be preferred if the true effect sizes are moderate. We apply these results to the colorectal neoplasia risk-prediction problem which motivated the present work.

And they’re available in 19 fun prints.

The Library Street Collective's "We All Rise" coloring book features drawings by around 30 contemporary artists

Biologist Tagide deCarvalho created this award-winning image of the tardigrade using fluorescent stains

The new book 'The Rainbow Atlas' invites readers on a vivid journey across the globe

Locals at the inle lake drying the clothes in the sun after dye them with colors.

With the release of Trolls World Tour, and a new generation entranced by the ugly-but-cute toy, it appears the troll's lucky streak lives on

The post SOLIDWORKS Apps for Kids How-To: Edit Text and Its Color in Capture It appeared first on SOLIDWORKS Education Blog.

The Long Beach, Calif., school district is deploying a multifaceted strategy to put more students of color in high-level math courses and help them succeed.

By automatically enrolling all students in high-level courses, schools in Washington state are working to erase a long entrenched form of inequity.

Caregiver behavioral symptom ratings are frequently used to assist in diagnosing childhood behavioral disorders. Although behavioral disorders are highly comorbid with learning disabilities (LDs), little work has examined the utility of caregiver ratings of learning concerns for screening of comorbid LD.

The validity of a time- and cost-efficient caregiver rating of academic concerns (Colorado Learning Difficulties Questionnaire) was examined. The screening measure accurately predicted children without LD, suggesting that the absence of parent-reported difficulties may be adequate to rule out overt LD. (Read the full article)

The Colorado Supreme Court decided Douglas County's Choice Scholarship Program is unconstitutional.

The Brother ADS-1250W is a fast and accurate, no-nonsense portable document scanner for the small-business traveler.

Don't expect Amazon to use this Print-Color display in a new Kindle any time soon, but we could see Print-Color eReaders in some form by mid-2020.

The Brooklyn District Attorney released data to show the disparities in arrests. The NYPD released data to show the demographics of summonses.

The STEM School shooting underscores the huge challenges educators face in keeping students safe, even as fatal and injurious gunfire inside K-12 schools remains statistically rare.

THE MEZZANINE GALLERY TO EXHIBIT HUGH PHIBB’S “WHAT THE WATER SAID…” WATERCOLORS Wilmington, Del. (January 24, 2018) – What the Water Said…Flowers, Places & Faces will be on view in the Mezzanine Gallery from February 2-23, 2018. A free opening reception to meet the artist will be held on Friday, February 2 from 5-7 p.m. […]

  On view from September 7-28, 2018 Free opening reception on Friday, September 7 at 5 p.m. Wilmington, Del. (August 28, 2018) – Established Color, an exhibition of paintings by Thomas Del Porte, will be on view in the Mezzanine Gallery from September 7-28, 2018. Del Porte received a 2018 Fellowship Visual Arts: Painting. The artist […]

On view from August 2-30, 2019 Free opening reception on Friday, August 2 at 5 p.m. Wilmington, Del. (July 23, 2019) – The Realistic Colors of Art, an exhibition of drawings of public transportation by Wilmington artist Geraldo Gonzalez, will be on view in the Mezzanine Gallery from August 2-30, 2019. The artist will host […]

A wildfire crew from the Delaware Forest Service is now working on the 300-acre Wilson Fire, located 9 miles north of Meeker, Colorado in Rio Blanco County. Started by lightning on July 7, the blaze is currently 15 percent contained and is threatening oil and gas production equipment. Delaware’s crew is comprised of 17 firefighters from Delaware and three from West Virginia. The crew flew from Harrisburg, PA on Sunday to the Rocky Mountain region along with teams from Maryland, New Hampshire, and two crews from Pennsylvania.

In late-June, Delaware’s forests get an annual “physical” or “check-up” – just after spring’s “leaf-out" blankets the state in a wave of green color. Just as people should visit the doctor to be screened for potential diseases, trees are examined with a variety of tools to hopefully spot minor issues before they turn into major ones. Armed with a digital camera, GPS technology, and a tablet equipped with specialized software and satellite data, forest health specialist Bill Seybold boards a small plane for a sky-high view of the First State. The annual aerial survey is specifically designed to detect potential threats that can only be seen from the air. Fortunately, early results from the 2018 aerial forest survey indicate no major outbreaks of tree diseases or insect pests.

The Delaware Forest Service is sending a 20-person wildfire crew to Colorado's Rocky Mountain region as more uncontained large fires in the West has increased the demand for trained firefighters. The National Fire Preparedness Level was increased to 3 on a 5-point scale on June 29, indicating that wildfire activity is occurring in multiple geographic areas and mobilization of resources through national agencies is moderate to heavy.  The crew mobilized on Tuesday, July 3 at Blackbird State Forest in Smyrna, Delaware and will travel to Denver from Philadelphia on July 4 for positioning in the Rocky Mountain Geographic Area, which has reported 5 new fires and currently has 6 uncontained large fires. Nationally, 66 fires are currently burning a total of 578,424 acres. As of July 3, a total of 277 wildfire crews  are currently deployed across all regions of the U.S. and wildfire activity is expected to increase.

#VictoryPages presents rare historical footage of the Battle of Berlin for the first time in color as part of RT’s tribute to the 75th anniversary of the defeat of fascism.
Read Full Article at RT.com

This Metasploit module exploits a buffer overflow vulnerability in Advantec WebAccess. The vulnerability exists in the dvs.ocx ActiveX control, where a dangerous call to sprintf can be reached with user controlled data through the GetColor function. This Metasploit module has been tested successfully on Windows XP SP3 with IE6 and Windows 7 SP1 with IE8 and IE 9.

Oce Colorwave 500 printer suffers from authentication bypass, cross site request forgery, and cross site scripting vulnerabilities.

In the wake of the flooding in Colorado, the National Credit Union Administration has activated its disaster relief policy to help protect consumers and ensure the continuity of credit union services in affected areas.

Chestnut forests in the Kazdağları, surrounded by yellow and red tones and autumn outfits, attract photographers and outdoor sports enthusiasts.

Domestic and international tourists will not be able to witness the beauty of the tulip gardens, which hosts the splash of all colors and is visited by thousands of people every year in the Central Anatolian province of Karaman's Kazımkarabekir district, due to the strict measures to tackle the coronavirus pandemic.

The residents of the southeastern province of Mardin practicing self-isolation rules due to the coronavirus outbreak are organizing on social media and flying kites from rooftops at certain times every day.

Surrounded by the White River National Forest, the 11,600-acre Seven Lakes Ranch located in the Meeker Valley is up for sale three years removed from extensive renovations.

A recent study outlined Colorado's most lightning-struck corridors, and it highlights much of the Denver metropolitan area as the most vulnerable part of Colorado to lightning.

Imagine zipping down a 750-foot zipline over your private lake, then taking in the beautiful Colorado views from the comfort of the expansive front porch of your log home.