After weeks of voting and tens of thousands of ballots cast, you, our readers, have determined who is the greatest athlete in Colorado history.

After weeks of voting and tens of thousands of ballots cast, you, our readers, have determined who is the greatest athlete in Colorado history.

When FanDuel asked, Will the Broncos Make the Playoffs?, 97% of the weekend action among Colorado bettors was on “Yes.” These days, if you can’t trust your heart, trust your gut.

Editor’s Note: Fifth of a five-part series on Colorado baseball icons. The first four profiled were Scott Bullock, Jenny and Steve Cavnar, Chris Hanks and Jim Danley.

Colorways & Toeboxes Live from L.A.

These celebs brought a pop of color to the 2019 BET Awards!

Colorways & Toeboxes Live from L.A.

The Hall of Famer addresses the hidden impact of COVID-19.

Watching the movie Joker, I felt repeatedly that I was watching a film that Greg Heisler could have lit. The use of color was unique, sophisticated and fearless — almost a character unto itself.

In this outstanding 15-minute short produced by Vanity Fair, Joker cinematographer Lawrence Sher dissects his own use of light and color in the movie. Read more »

I mentioned a couple weeks ago that it’s always a good idea to pick colors you enjoy embroidering with. If …

On Monday, I shared a weekend embroidery finish with you – this scrolly design embroidered on the corner of a …

More than 130 people in the state have been diagnosed with COVID-19, and one has died.

More than 130 people in the state have been diagnosed with COVID-19, and one has died.

The post Color Photography Exercises to Help You Improve Your Skills appeared first on Digital Photography School. It was authored by Kevin Landwer-Johan.

Use these fun color photography exercises to not only expand your knowledge of color but so you can use color more effectively in your photos.

The post Color Photography Exercises to Help You Improve Your Skills appeared first on Digital Photography School. It was authored by Kevin Landwer-Johan.

The Trojans' offensive struggles continued as they fell 78-57 to the No. 20 Buffaloes at Galen Center and missed a shot at first place in the Pac-12.

Onyeka Okongwu had 21 points, Jonah Mathews added 17, and Nick Rakocevic had 14 points and 11 rebounds but USC could not hold onto a 14-point lead and finish a comeback in a 70-66 loss to Colorado.

USC freshman Alissa Pili scored 22 points to lead USC to a 69-54 win over Colorado in the opening round of the Pac-12 women's basketball tournament.

A player on the Colorado Avalanche has tested positive for the COVID-19 virus, making him the third NHL player known to have tested positive for the novel coronavirus.

The four NHL players known to have tested positive all faced the Kings at Staples Center in the last few days before the NHL suspended play March 12.

Dodgers utility man Kiké Hernández is eager to play because he'll be a free agent this winter, but he's having fun staying busy with his wife, Mariana.

The No. 9 UCLA Bruins earned a wire-to-wire 62-52 win over Colorado at Pauley Pavilion and moved into second place in the Pac-12 standings.

Former UCLA tight end Matt Lynch tweeted that he was headed back home to Colorado, where he'll play for the Buffaloes immediately once sports restart.

Paris Fashion Week: For fall and winter 2020, Anthony Vaccarello also explored the fabrics — and the "bourgeois elegance" of 1990s-era YSL.

Diane Rodriguez, ex-associate artistic director of Center Theatre Group, is remembered for her work with Luis Valdez and Culture Clash, among others.

Cinematographers Rodrigo Prieto and Lawrence Sher compare notes on their films, 'The Irishman' and 'Joker.'

Hispanic, Latino or both? White or a person of color? The identity debate sparked after some declared Banderas a "person of color" when the Oscars' overwhelmingly white acting nominations were announced.

¿Hispano, latino o ambos? ¿Blanco o de color? El debate sobre la identidad se desató después de que algunos declararan a Banderas como "persona de color" cuando se anunciaron las nominaciones de los Oscars de actuación abrumadoramente blanca.

Cynthia Erivo, Oscar-nominated for 'Harriet,' has been a sartorial surprise at the Golden Globes, Screen Actors Guild Awards and Critics' Choice Awards.

Netflix's animated adaptation of Lois Lowry's book "The Willoughbys," featuring the voices of Will Forte, Maya Rudolph and Martin Short, is hard to love.

You can see this art in person while you social distance. The Harrison Center will send colorful "smoke" from its historic chimney for the first time.

A colorful morning at the Hendricks County 4-H Fair

You can see this art in person while you social distance. The Harrison Center will send colorful "smoke" from its historic chimney for the first time.

The Amateur Traveler talks to Brad Hugg soon to be the host of the Colorado Podcast about his state. He talks about the citieson teh frontal range and gives us a great circle route that takes in 14ers (peaks over 14 thousand feet), huge sand dunes, buttes, Mesa Verde, and the ski resorts near the continental divide.

The Amateur Traveler talks to Kara Williams of TheVacationGals.com about Aspen, Colorado. Like so many locals who live in that area of Colorado, Kara came for the winters but stayed for the summers. She tells us about this historic silver-mining town that is better known as a winter playground for the wealthy now than for its mining past. Whether you are skiing, hiking or fly fishing it has a wealth of outdoor activities. It offers great, if not always inexpensive, food and a wealth of artistic events set in a gorgeous mountain valley. Kara describes side trips to the Ghost towns of Ashcroft and Independence, to the continental divide at Independence Pass and to the caves at The Grottos. She also tells you whether the Aspen Crud is something you want to get. Aspen also hosts festivals as diverse as the Aspen Institute, Jazz Aspen Snowmass, the Aspen Music Festival and School and Aspen Summer Words.

Hear about travel to Denver, Colorado as the Amateur Traveler talks to Lance Longwell from TravelAdicts.net about his home town, the "Mile High City". Denver is the capital of the state of Colorado and sits where the Great Plains meet the Rocky Mountains.

Hear about travel to Southwest Colorado as the Amateur Traveler talks to Kelly Beasley and Marshall Wendler about road trips they have made to Durango and Silverton.

• Upstream Color review
• The Kings of Summer review
• Blackfish review
• What We Watched: Fruitvale Station, At World's End, The Spectacular Now, Elysium, Only God Forgives, and The ABCs of Death
• Grand Theft Auto 5 talk

(ICFO-The Institute of Photonic Sciences) ICFO researchers report on a new method to obtain high color purity 3D objects with the use of a new class of nanoparticles.

Rationale: Fluorescence molecular endoscopy (FME) is an emerging technique that has the potential to improve the 22% colorectal polyp detection miss-rate. We determined the optimal dose-to-imaging interval and safety of FME using EMI-137, a c-Met targeted fluorescent peptide, in a population at high-risk for colorectal cancer. Methods: We performed in vivo FME and quantification of fluorescence by multi-diameter single-fiber reflectance, single-fiber fluorescence spectroscopy in 15 patients with a dysplastic colorectal adenoma. EMI-137 was intravenously administered (0.13mg/kg) at a one-, two- or three-hour dose-to-imaging interval (N = 3 patients per cohort). Two cohorts were expanded to six patients based on target-to-background ratios (TBR). Fluorescence was correlated to histopathology and c-Met expression. EMI-137 binding specificity was assessed by fluorescence microscopy and in vitro experiments. Results: FME using EMI-137 appeared to be safe and well tolerated. All dose-to-imaging intervals showed significantly increased fluorescence in the colorectal lesions compared to surrounding tissue, with a TBR of 1.53, 1.66 and 1.74 respectively (mean intrinsic fluorescence (Q·μ^f_a,x) = 0.035 vs. 0.023mm^-1, P<0.0003; 0.034 vs. 0.021mm^-1, P<0.0001; 0.033 vs. 0.019mm^-1, P<0.0001). Fluorescence correlated to histopathology on a macroscopic and microscopic level, with significant c-Met overexpression in dysplastic mucosa. In vitro, a dose-dependent specific binding was confirmed. Conclusion: FME using EMI-137 appeared to be safe and feasible within a one-to-three hour dose-to-imaging interval. No clinically significant differences were observed between the cohorts, although a one-hour dose-to-imaging interval was preferred from a clinical perspective. Future studies will investigate EMI-137 for improved colorectal polyp detection during screening colonoscopies.

At diagnosis 22% of colorectal cancer (CRC) patients have metastases and 50% later develop metastasis. Peptide receptor radionuclide therapy (PRRT) with lutetium-177 (¹⁷⁷Lu)-PSMA-617 is employed to treat metastatic prostate cancer (PC). ¹⁷⁷Lu-PSMA-617 targets Prostate Specific Membrane Antigen (PSMA) a cell surface protein enriched in PC and the neovasculature of other solid tumors including CRC. We performed gallium-68 (⁶⁸Ga)-PSMA-11 PET-CT imaging of ten metastatic CRC patients to assess metastasis avidity. Eight patients had lesions lacking avidity and two had solitary metastases exhibiting very low avidity. Despite expression of PSMA in CRC neovasculature, none of the patients exhibited tumor avidity sufficient to be considered for ¹⁷⁷Lu-PSMA-617 PRRT.

The purpose of this study was to establish the dose-response relationship of selective internal radiation therapy (SIRT) in patients with metastatic colorectal cancer (mCRC), when informed by radiobiological sensitivity parameters derived from mCRC cell lines exposed to yttrium-90 (⁹⁰Y). Methods: 23 mCRC patients with liver metastases refractory to chemotherapy were included. ⁹⁰Y bremsstrahlung SPECT images were transformed into dose maps assuming the local dose deposition method. Baseline and follow-up CT scans were segmented to derive liver and tumor volumes. Mean, median, and D₇₀ (minimum dose to 70% of tumor volume) values determined from dose maps were correlated with change in tumor volume and vRECIST response using linear and logistic regression, respectively. Radiosensitivity parameters determined by clonogenic assays of mCRC cell lines HT-29 and DLD-1 after exposure to ⁹⁰Y or external beam radiotherapy (EBRT; 6MV photons) were used in biological effective dose (BED) calculations. Results: Mean administered radioactivity was 1469±428 MBq (847-2185 MBq), achieving a mean radiation absorbed tumor dose of 35.5±9.4 Gy and mean normal liver dose of 26.4±6.8 Gy. A 1.0 Gy increase in mean, median, and D₇₀ absorbed dose was associated with reduction in tumor volume of 1.8%, 1.8%, and 1.5%, respectively, and increased probability of vRECIST response (odds ratio: 1.09, 1.09, and 1.10 respectively). Threshold mean, median and D₇₀ doses for response were 48.3, 48.8, and 41.8 Gy respectively. EBRT-equivalent BEDs for ⁹⁰Y are up to 50% smaller than those calculated by applying protraction-corrected radiobiological parameters derived from EBRT alone. Conclusion: Dosimetric studies have assumed equivalence between ⁹⁰Y SIRT and EBRT, leading to inflation of BED for SIRT and possible under-treatment. Radiobiological parameters for ⁹⁰Y were applied to a BED model, providing a calculation method that has the potential to improve assessment of tumor control.

Colorectal cancer (CRC) arises as the consequence of progressive changes from normal epithelial cells through polyp to tumor, and thus is an useful model for studying metabolic shift. In the present study, we studied the metabolomic profiles using high analyte specific gas chromatography/mass spectrometry (GC/MS) and liquid chromatography tandem mass spectrometry (LC/MS/MS) to attain a systems-level view of the shift in metabolism in cells progressing along the path to CRC. Colonic tissues including tumor, polyps and adjacent matched normal mucosa from 26 patients with sporadic CRC from freshly isolated resections were used for this study. The metabolic profiles were obtained using GC/MS and LC/MS/MS. Our data suggest there was a distinct profile change of a wide range of metabolites from mucosa to tumor tissues. Various amino acids and lipids in the polyps and tumors were elevated, suggesting higher energy needs for increased cellular proliferation. In contrast, significant depletion of glucose and inositol in polyps revealed that glycolysis may be critical in early tumorigenesis. In addition, the accumulation of hypoxanthine and xanthine, and the decrease of uric acid concentration, suggest that the purine biosynthesis pathway could have been substituted by the salvage pathway in CRC. Further, there was a step-wise reduction of deoxycholic acid concentration from mucosa to tumors. It appears that to gain a growth advantage, cancer cells may adopt alternate metabolic pathways in tumorigenesis and this flexibility allows them to adapt and thrive in harsh environment.

Over the last several years it has become clear that higher order assemblies on membranes, exemplified by signalosomes, are a paradigm for the regulation of many membrane signaling processes. We have recently combined two-color direct stochastic optical reconstruction microscopy (dSTORM) with the (Clus-DoC) algorithm that combines cluster detection and colocalization analysis to observe the organization of 5-lipoxygenase (5-LO) and 5-lipoxygenase–activating protein (FLAP) into higher order assemblies on the nuclear envelope of mast cells; these assemblies were linked to leukotriene (LT) C4 production. In this study we investigated whether higher order assemblies of 5-LO and FLAP included cytosolic phospholipase A2 (cPLA2) and were linked to LTB4 production in murine neutrophils. Using two- and three-color dSTORM supported by fluorescence lifetime imaging microscopy we identified higher order assemblies containing 40 molecules (median) (IQR: 23, 87) of 5-LO, and 53 molecules (62, 156) of FLAP monomer. 98 (18, 154) molecules of cPLA2 were clustered with 5-LO, and 77 (33, 114) molecules of cPLA2 were associated with FLAP. These assemblies were tightly linked to LTB4 formation. The activation-dependent close associations of cPLA2, FLAP, and 5-LO in higher order assemblies on the nuclear envelope support a model in which arachidonic acid is generated by cPLA2 in apposition to FLAP, facilitating its transfer to 5-LO to initiate LT synthesis.

OBJECTIVE

To assess the costs and project the potential lifetime cost-effectiveness of the ongoing Autoimmunity Screening for Kids (ASK) program, a large-scale, presymptomatic type 1 diabetes screening program for children and adolescents in the metropolitan Denver region.

Long before word recently broke that white referees in the National Basketball Association were calling fouls at a higher rate on black athletes than on white athletes, and long before studies found racial disparities in how black and white applicants get called for job interviews, researchers no...