The Government has defended missing its key 100,000 target for coronavirus tests for the sixth day in a row, highlighting “daily fluctuations” in availability.

Looking for new ways to combat kids who bully, some communities are threatening to fine parents with no evidence that the approach is effective.

UEFA's technical team of experienced trainers will look at the trends and talking points at UEFA EURO 2012 from a coaching point of view, helping to produce a report on the tournament.

Supplemented mother’s own milk is the preferred nutrition for very low birth weight infants.

Through targeted encouragement and guidance, most mothers are able to provide milk to their very low birth weight infants, both for early and prolonged feeding, in an open-bay NICU. (Read the full article)

Adolescents show mixed opinions over gender equality in recent survey.

Pharmacokinetic changes are often seen in patients with severe infections. Administration by continuous infusion has been suggested to optimize antibiotic exposure and pharmacokinetic/pharmacodynamic (PK/PD) target attainment for β-lactams. In an observational study, unbound piperacillin concentrations (n=196) were assessed in 78 critically ill patients following continuous infusion of piperacillin/tazobactam (ratio 8:1). The initial dose of 8, 12 or 16 g (piperacillin component) was determined by individual creatinine clearance (CRCL). Piperacillin concentrations were compared to the EUCAST clinical breakpoint MIC for Pseudomonas aeruginosa (16 mg/L), and the following PK/PD targets were evaluated: 100% fT>1xMIC and 100% fT>4xMIC. A population pharmacokinetic model was developed using NONMEM 7.4.3 consisting of a one-compartment disposition model with linear elimination separated into non-renal and renal (linearly increasing with patient CRCL) clearances. Target attainment was predicted and visualized for all individuals based on the utilized CRCL dosing algorithm. The target of 100% fT>1xMIC was achieved for all patients based on the administered dose, but few patients achieved the target of 100% fT>4xMIC. Probability of target attainment for a simulated cohort of patients showed, that increasing the daily dose by 4 g increments (piperacillin component) did not result in substantially improved target attainment for the 100% fT>4xMIC target. To conclude, in patients with high CRCL combined with high-MIC bacterial infections, even a CI regimen with a daily dose of 24 g may be insufficient to achieve therapeutic concentrations.

Despite the worldwide re-emergence of the chikungunya virus (CHIKV) and the high morbidity associated with CHIKV infections, there is no approved vaccine or antiviral treatment available. We here aim to identify the target of a novel class of CHIKV inhibitors i.e. CHVB series. CHVB compounds inhibit the in vitro replication of CHIKV isolates with 50% effective concentrations in the low micromolar range. A CHVB-resistant variant (CHVB^res) was selected that carried two mutations in the gene encoding nsP1 (responsible for viral RNA capping), one mutation in nsP2 and one mutation in nsP3. Reverse genetics studies demonstrated that both nsP1 mutations were necessary and sufficient to achieve ~18-fold resistance, suggesting that CHVB targets viral mRNA capping. Interestingly, CHVB^res was cross-resistant to the previously described CHIKV capping inhibitors from the MADTP series, suggesting they share a similar mechanism of action. In enzymatic assays, CHVB inhibited the methyltransferase and guanylyltransferase activities of alphavirus nsP1 proteins. To conclude, we identified a class of CHIKV inhibitors that targets the viral capping machinery. The potent anti-CHIKV activity makes this chemical scaffold a potential candidate for CHIKV drug development.

Bihar Water Minister Sanjay Kumar Jha hitout at the Delhi government after it claimed reimbursement over train fares paid for return of migrants stranded in the national capital amid the coronavirus...

The Delaware Public Service Commission (PSC) and Delaware Division of the Public Advocate have received numerous complaints of third-party electricity suppliers “spoofing” phone numbers in an effort to sign up households for new service contracts.

Governor announces rolling reopening; State of Emergency extended through May 31 WILMINGTON, Del. – In coordination with public health experts at the Delaware Division of Public Health (DPH), Governor John Carney on Friday announced June 1 as the target date for Phase I of Delaware’s economic reopening. Governor Carney has extended Delaware’s State of Emergency declaration, […]

  Golden Hammer Software took a trip earlier this year to New York to attend the Intel Android CodeFest.  We updated Big Mountain Snowboarding, Trick Shot Bowling, and Scribble Worm to run natively...

Commission must safeguard standards in the wake of Covid-19

The agricultural output in the economy grew by 3.5% in the third quarter (Q3) of FY20, against 3.1% in Q2 of FY20.

The government has taken measures to contain expenditure, like freeze on its employees’ dearness allowance; it has also announced a relief package to support the vulnerable and disadvantaged sections.

The central government will likely ramp up market borrowing in the second half of this fiscal, but may be forced to stick to its target for the first half at the moment.

For instance, German automaker Volkswagen, which has had a reasonable success with the Polo hatchback, arrived late to the party in the Indian compact sedan segment (with the Ameo) and still doesn’t have a sub-4 metre SUV.

The president emphasised the need to focus promoting medical tourism by highlighting the "successful efforts taken by Sri Lanka to contain the spread of the coronavirus."

By spinning off stake into a separate firm, Yahoo will be judged by its Web businesses

Executives and strategists try to keep their tactics under the radar, and Disney declined to provide an executive to comment on its tactics. But the studio’s answer to the online hate is there for all to see on the internet.

AU Small Finance Bank (SFB) reported an increase of 3.5% year-on-year in PAT to Rs 120 crore (our estimate: Rs 180 crore), affected by higher provisions of Rs 150 crore.

"Green Citizen Awards" will also be instituted to encourage citizens to contribute to environment protection and preservation work, Deputy Chief Minister Manish Sisodia said while presenting the budget in Delhi Assembly.

Announcing the revised calendar, the government said all the auctions covered by the calendar will have the facility of non-competitive bidding scheme, under which 5% of the notified amount will be reserved for the specified retail investors.

Drug formulations and biologicals, which contribute to almost 72% of exports, have shown 9.5% growth in FY20. However, export of bulk drugs and drug intermediates posted negative growth.

On December 5th  Nova Scotia conducted a new draw in its provincial Labor Market Priorities Stream with a link to Express Entry. It targets social and community service workers under the NOC 4212. This was the first NSNP draw that targeted NOC 4212.Candidates…

The Prime Minister of Canada has addressed the recently appointed Immigration Minister in a recent mandate letter. The mandate letter represents the top preferences for the Canadian immigration future, which comprises increasing immigration goals and…

The immigration authorities in Saskatchewan targeted 96 NOC codes and issued 595 invitations in their recent provincial draw for Expression of Interest draw on December 20. Saskatchewan Immigrant Nominee Program featured invitations in the provincial…