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Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction

RSC Med. Chem., 2024, 15,3652-3673
DOI: 10.1039/D4MD00425F, Review Article
Semim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra Borah
Metabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

RSC Med. Chem., 2024, 15,3746-3758
DOI: 10.1039/D4MD00122B, Research Article
Open Access
Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery

RSC Med. Chem., 2024, 15,3695-3703
DOI: 10.1039/D4MD00546E, Research Article
Miyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke Demizu
A novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Leaders of various parties condemn attack on govt. doctor




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Vikarabad attack: Former BRS MLA Narender Reddy taken into custody for questioning

He was picked up near his residence when he stepped out for a morning walk




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Yet another incident of doctor being attacked 




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Tackling diabetes epidemic

An India free of diabetes-related complications is eminently possible, if lifestyle changes are made




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Greater Chennai Corporation ready to tackle northeast monsoon: Minister

To drain rainwater, 1,324 pumps have been kept ready and eight are currently in use. A total of 134 pumps of 100 HP are available, and 466 tractor-mounted pumps — up from 243 last year — are ready for use this time, says Minister Nehru




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Policeman dies of heart attack while on duty




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Android to Tackle Data Harvesting Scam Apps

A key change to Android could reduce the risk of scammers stealing personal data or money. The update will mean sensitive apps won't open unless potentially risky apps are closed first. The idea is to tackle rogue apps which are designed to either capture personal data from another app, or to take control of the phone unbeknownst to the owner. Developer Choice Google's new tactic aims to find a balance between restricting the activities of such rogue apps and keeping the freedom of users to choose what apps they install, including those from sources other than the official Play Store. The ... (view more)




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Smart Tech Tackles Dementia

Five gadgets are in the running for a $1.3 million prize for using tech to tackle dementia. They range from high-tech glasses to a device that looks like a landline telephone. The projects have all made the final of the global Longitude prize for dementia. It's part of a wider series of prizes based on an 18th century contest that rewarded scientists for finding a way for sailors to determine the longitude of their location. The five finalists will each get the equivalent of $392,000 to develop their products before competing for the overall prize. The money comes from the UK government and ... (view more)




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6 Ways AI Empowers Contact Center Agents

Do you need to improve agent performance at your contact center? Here’s 6 ways AI tools can boost agent productivity, improving customer satisfaction in turn.

Continue reading...






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Tectonic-paleogeographic implications of a detailed Cretaceous-Cenozoic exhumation history in the Richardson Anticlinorium, northern Yukon, documented by multi-kinetic apatite fission track modelling

Lane, L S; Issler, D R; O'Sullivan, P B. Geoconvention 2020 abstracts; 2020 p. 1-2
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210002.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210002.jpg" title="Geoconvention 2020 abstracts; 2020 p. 1-2" height="150" border="1" /></a>




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Bioturbation, heavy mineral concentration, and high gamma-ray activity in the Lower Cretaceous McMurray Formation, Canada

Fustic, M; Nair, R; Wetzel, A; Siddiqui, R; Mathews, W; Wust, R; Bringue, M; Radovic, J. Palaeogeography, Palaeoclimatology, Palaeoecology vol. 564, 110187, 2020 p. 1-17, https://doi.org/10.1016/j.palaeo.2020.110187
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200671.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200671.jpg" title="Palaeogeography, Palaeoclimatology, Palaeoecology vol. 564, 110187, 2020 p. 1-17, https://doi.org/10.1016/j.palaeo.2020.110187" height="150" border="1" /></a>




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Geochemical database of Cretaceous High Arctic Large Igneous Province magmatic rocks, Arctic Canada

Bédard, J H; Saumur, B -M; Williamson, M -C; Tegner, C; Troll, V R; Deegan, F M; Evenchick, C A; Grasby, S E; Dewing, K. Geological Survey of Canada, Open File 8759, 2020, 7 pages, https://doi.org/10.4095/327829
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_327829.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_327829.jpg" title="Geological Survey of Canada, Open File 8759, 2020, 7 pages, https://doi.org/10.4095/327829" height="150" border="1" /></a>




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Siliceous microfossils and agglutinated foraminifera from the Upper Cretaceous Smoking Hills and Mason River formations in the Smoking Hills area, Northwest Territories

Diaz, J F; Galloway, J M; Bringué, M; Pedersen, P K; Grasby, S E. Geological Survey of Canada, Open File 8716, 2020, 21 pages, https://doi.org/10.4095/325466
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_325466.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_325466.jpg" title="Geological Survey of Canada, Open File 8716, 2020, 21 pages, https://doi.org/10.4095/325466" height="150" border="1" /></a>




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Dinoflagellate cyst taxonomy of the Late Cretaceous Smoking Hills Formation (Horton-Anderson Plains, NWT)

Bringué, M; Fensome, R A; Galloway, J M. Geoconvention 2020 abstracts; 2020 p. 1-2
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20190494.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20190494.jpg" title="Geoconvention 2020 abstracts; 2020 p. 1-2" height="150" border="1" /></a>




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The age, foraminifera, and palynology of the Upper Cretaceous Eagle Plain Group, northern Yukon

McNeil, D H; Dixon, J; Bell, K M. Geological Survey of Canada, Current Research (Online) 2021-2, 2021, 13 pages, https://doi.org/10.4095/328237
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_328237.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_328237.jpg" title="Geological Survey of Canada, Current Research (Online) 2021-2, 2021, 13 pages, https://doi.org/10.4095/328237" height="150" border="1" /></a>




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An integrated paleoenvironmental study of Lower Cretaceous to lower Cenozoic strata of the Labrador margin, offshore eastern Canada

Dafoe, L T; Williams, G L. The Atlantic Geoscience Society (AGS), 47th Colloquium and Annual Meeting, program with abstracts/La Société Géoscientifique de l'Atlantique, 47th Colloquium and Annual Meeting, program with abstracts; 2021 p. 17-18
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200739.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200739.jpg" title="The Atlantic Geoscience Society (AGS), 47th Colloquium and Annual Meeting, program with abstracts/La Société Géoscientifique de l'Atlantique, 47th Colloquium and Annual Meeting, program with abstracts; 2021 p. 17-18" height="150" border="1" /></a>




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Whitehorse Trough record of Late Triassic-Cretaceous accretionary orogenic cycle from detrital mineral thermochronometry, British Columbia, Northwest Territories, and Yukon

Kellett, D A; Coutand, I; Zagorevski, A; Grujic, D; Dewing, K. Geological Survey of Canada, Open File 8879, 2022, 1 sheet, https://doi.org/10.4095/329781
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_329781.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_329781.jpg" title="Geological Survey of Canada, Open File 8879, 2022, 1 sheet, https://doi.org/10.4095/329781" height="150" border="1" /></a>




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Geochemical variation in the Jurassic-Cretaceous strata of the Baccalieu I-78 well, Flemish Pass Basin, Canada: chemostratigraphic and paleoenvironmental implications

Bingham-Koslowski, N; Azmy, K. Geoscience Canada; Geoscience Canada vol. 49, no. 2, 2022 p. 75, https://doi.org/10.12789/geocanj.2022.49.188
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210643.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210643.jpg" title="Geoscience Canada; Geoscience Canada vol. 49, no. 2, 2022 p. 75, https://doi.org/10.12789/geocanj.2022.49.188" height="150" border="1" /></a>




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Volcanism-triggered climatic control on Late Cretaceous oceans

Sun, R; Yao, H; Deng, C; Grasby, S E; Wang, C; Chen, X; Yin, R. Geochemistry, Geophysics, Geosystems (G3) vol. 23, issue 4, e2021GC010292, 2022 p. 1-9, https://doi.org/10.1029/2021GC010292
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210591.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210591.jpg" title="Geochemistry, Geophysics, Geosystems (G3) vol. 23, issue 4, e2021GC010292, 2022 p. 1-9, https://doi.org/10.1029/2021GC010292" height="150" border="1" /></a>




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Exploring the role of High Arctic Large Igneous Province volcanism on Early Cretaceous Arctic forests

Galloway, J M; Fensome, R A; Swindles, G T; Hadlari, T; Schröder-Adams, C; Herrle, J O; Fath, J; Pugh, A. Cretaceous Research vol. 129, 105022, 2022 p. 1-26, https://doi.org/10.1016/j.cretres.2021.105022
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210274.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210274.jpg" title="Cretaceous Research vol. 129, 105022, 2022 p. 1-26, https://doi.org/10.1016/j.cretres.2021.105022" height="150" border="1" /></a>




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Historical development of a litho- and biostratigraphic framework for onshore Cretaceous-Paleocene deposits along western Baffin Bay

Haggart, J W; Dafoe, L T; Bell, K M; Williams, G L; Burden, E T; Currie, L D; Fensome, R A; Sweet, A R. Geological synthesis of Baffin Island (Nunavut) and the Labrador-Baffin Seaway; by Dafoe, L T (ed.); Bingham-Koslowski, N (ed.); Geological Survey of Canada, Bulletin 608, 2022 p. 107-135, https://doi.org/10.4095/321828
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_321828.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_321828.jpg" title="Geological synthesis of Baffin Island (Nunavut) and the Labrador-Baffin Seaway; by Dafoe, L T (ed.); Bingham-Koslowski, N (ed.); Geological Survey of Canada, Bulletin 608, 2022 p. 107-135, https://doi.org/10.4095/321828" height="150" border="1" /></a>




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Basaltic sills emplaced into organic-rich sedimentary rocks: consequences for organic matter maturation and Cretaceous paleo-climate

Bédard, J H; Dewing, K; Grasby, S E; Nabelek, P; Heimdal, T H; Yakymchuk, C; Sheih, S; Rumney, J; Deegan, F M; Troll, V. Geological Society of America Bulletin 2023, 2023 p. 1-25, https://doi.org/10.1130/B36982.1
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20230095.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20230095.jpg" title="Geological Society of America Bulletin 2023, 2023 p. 1-25, https://doi.org/10.1130/B36982.1" height="150" border="1" /></a>




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Whitehorse Trough records Late Triassic-Cretaceous accretionary orogenic cycle in the Northern Canadian Cordillera via detrital mineral thermochronology

Kellett, D A; Coutand, I; Zagorevski, A; Grujic, D; Dewing, K; Beranek, L. Canadian Journal of Earth Sciences 2023 p. 1-25, https://doi.org/10.1139/cjes-2023-0082
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20220220.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20220220.jpg" title="Canadian Journal of Earth Sciences 2023 p. 1-25, https://doi.org/10.1139/cjes-2023-0082" height="150" border="1" /></a>





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Former US ambassador accuses Sky News of creating a ‘self-licking ice cream’ to attack Kevin Rudd - The Conversation

  1. Former US ambassador accuses Sky News of creating a ‘self-licking ice cream’ to attack Kevin Rudd  The Conversation
  2. Ditching Rudd over Trump insults would be ‘worst possible signal’: Turnbull  Sydney Morning Herald
  3. Senior Liberal calls for Rudd to be sacked after Trump advisor suggests US ambassador is on thin ice  9News




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MUSTACHE RIDES

MUSTACHE RIDES wanna go for a ride.




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Full Contact Skydiving is the "This is Real and I am Terrified" Event of the Week





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Why Rake And Stack When You Could Bake And Snack?!




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One of Italy’s most beautiful cities issues 10-point plan to tackle overtourism

The city has repeatedly pressed for a special regulation from the national government




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Encoding of Vibrotactile Stimuli by Mechanoreceptors in Rodent Glabrous Skin

Somatosensory coding in rodents has been mostly studied in the whisker system and hairy skin, whereas the function of low-threshold mechanoreceptors (LTMRs) in the rodent glabrous skin has received scant attention, unlike in primates where the glabrous skin has been the focus. The relative activation of different LTMR subtypes carries information about vibrotactile stimuli, as does the rate and temporal patterning of LTMR spikes. Rate coding depends on the probability of a spike occurring on each stimulus cycle (reliability), whereas temporal coding depends on the timing of spikes relative to the stimulus cycle (precision). Using in vivo extracellular recordings in male rats and mice of either sex, we measured the reliability and precision of LTMR responses to tactile stimuli including sustained pressure and vibration. Similar to other species, rodent LTMRs were separated into rapid-adapting (RA) or slow-adapting based on their response to sustained pressure. However, unlike the dichotomous frequency preference characteristic of RA1 and RA2/Pacinian afferents in other species, rodent RAs fell along a continuum. Fitting generalized linear models to experimental data reproduced the reliability and precision of rodent RAs. The resulting model parameters highlight key mechanistic differences across the RA spectrum; specifically, the integration window of different RAs transitions from wide to narrow as tuning preferences across the population move from low to high frequencies. Our results show that rodent RAs can support both rate and temporal coding, but their heterogeneity suggests that coactivation patterns play a greater role in population coding than for dichotomously tuned primate RAs.




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Christmas cheer for poor children in Tacloban

Students from OM Philippines-Cebu's Alternative Learning System bring children joy through a Christmas party, following the trauma caused by Bohol earthquake and Typhoon Haiyan.




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A needle in a haystack

In an Istanbul neighbourhood of 200,000 people, an OM worker, prompted by God, asks a question to the only person who knows the answer.




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TACO team touches hearts

The TACO team in Turkey uses creative arts like dance, music, and drama to share the good news with Muslim people groups across the region.




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R Ashwin Confident He Has "Figured Out" Smith, Shares Tactical Insight

Ravichandran Ashwin and Steve Smith will face off during the Border-Gavaskar Trophy starting November 22 in Perth.




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Bizarre: Flying Ants 'Attack' Stops Ind vs SA T20I. Internet Reacts - Watch

After India had set hosts South Africa a target of 220,Ryan Rickelton and Reeza Hendricks scored seven in one over when play had to be stopped as insects caused the play to stop





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Fingers pointing in all directions: Dutch politicians debate Amsterdam attacks, antisemitism


The members of the House debated the role of lack of integration, antisemitism within the Muslim population, and failure of authority in a discussion about the attacks.




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Eight PTI men ‘exonerated’ in Lahore corps commander house attack case

• Govt objects to repeal of prison rules for PTI founder
• Imran booked in 54 cases across Punjab, LHC told

LAHORE/ISLAMABAD: An anti-terrorism court (ATC) on Tuesday disposed of pre-arrest bail petitions of eight PTI activists in the case regarding an attack on the Lahore corps commander’s residence after police declared them innocent in the investigation.

ATC-I Judge Manzer Ali Gill was hearing the bail petitions of 32 activists when a prosecutor stated that a joint investigation team (JIT), formed to probe the May 9 incidents, had exonerated eight of the petitioners for lack of evidence.

At this, the lawyer for the activists sought the court permission to withdraw their bail petitions.

The judge adjourned the bail petitions of other activists till Dec 11 and 13, asking them to join the JIT investigation.

The judge allowed the request and disposed of the petitions of Tanzila Imran, Ri­­zwana Ghazanfar, Makiya Saeed, Shah­baz Amir Ali, Farooq Ahmad, Usman Naveed, Zirk Khan and Mian Ahmad Rehman.

Sarwar Road police of Lahore had registered a case against PTI leaders and workers for attacking the Lahore corps commander house, also known as Jinnah House, on May 9 last year.

Separately, ATC-III Judge Arshad Javed adjourned the hearing of post-arrest bail petitions by the PTI leaders, including Shah Mahmood Qureshi, Dr Yasmin Rashid and Mian Mehmoodur Rasheed, in May 9 cases.

The judge directed the petitioners’ lawyers to conclude their arguments on the next hearing; otherwise, the petitions would be decided on the basis of police record.

The judge postponed the pleas of Rasheed till Nov 12, Dr Yasmin till Nov 13 & 16, and Qureshi till Nov 19.

The bench, comprising Chief Justice Aamer Farooq and Justice Saman Rafat Imtiaz, issued a notice to Advocate Sher Afzal Marwat on whose petition the section was set aside, seeking his response.

Prison rules

Meanwhile, a two-member division bench of the Islamabad High Court (IHC) took up the petition of the chief commissioner Islamabad against setting aside of Section 265 of the Punjab Prison Rules that prohibits political discussion during prisoner meetings with visitors.

The plea contested Justice Sardar Ejaz Ishaq Khan’s verdict, which had struck down Section 265.

Advocate General Islamabad Ayaz Shaukat argued that the IHC lacked jurisdiction to intervene in Punjab’s laws and maintained that the single bench did not have the authority to nullify provisions in the Punjab Prison Rules.

Chief Justice Farooq asked, “So, you are saying that the Islamabad High Court cannot interfere in any provincial law?”

Justice Imtiaz noted that the Punjab Prison Rules are also applicable to prisoners in Isla­mabad, suggesting an overlap in jurisdiction.

The CJ inquired whether a formal notice under Section 27A was issued to the attorney general or the advocate general by the single bench, a requirement before declaring any law invalid.

While the advocate general said he had been summoned, he acknowledged that a formal notice was not issued.

Advocate General Shaukat requested the immediate suspension of the single bench’s decision, but Chief Justice Farooq scheduled a formal hearing for the next week.

Justice Farooq Haider was hearing a petition filed by Imran’s sister, Noreen Niazi, challenging the non-disclosure of the cases’ details against her brother.

Cases against Imran

Also on Tuesday, Punjab Police told the La­­­hore High Court that 54 criminal cases, in­­cluding those related to May 9, had been registered against PTI founding chairman Imran Khan in different cities of the province.

An additional advocate general presented a report on behalf of the inspector general of police, revealing that 21 cases were registered in Lahore, 19 in Rawalpindi, seven in Sheikhupura, five in Faisalabad and one each in Gujranwala and Mianwali.

The cases include attacks on the Jinnah House, Askari Tower at Liberty Roundabout, General Headquarters in Rawalpindi and office of an intelligence agency in Faisalabad. A law officer for the Federal Investigation Agency (FIA) sought additional time to provide details of the cases, if any, against Imran Khan.

The judge allowed the request and adjourned further hearing till Nov 20.

Published in Dawn, November 13th, 2024




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Evening brief: BJP asks Delhi govt to close schools amid rising AQI; IMA condemns attack on doctor in Chennai; and more - Hindustan Times

  1. Evening brief: BJP asks Delhi govt to close schools amid rising AQI; IMA condemns attack on doctor in Chennai; and more  Hindustan Times
  2. Smog Blanket Over North India, Air Quality Drops To "Severe" Level  NDTV
  3. BJP targets govt on pollution, AAP says don’t play politics  The Times of India
  4. Delhi overtakes Lahore to become world's most polluted city  The Economic Times
  5. City In Greyscale: Season’s First Fog, ‘Severe’ Air Day  The Times of India




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5 Tactics to Ride out the Conundrums of IT Industry

In recent times, Indian IT industry has been one of the most plausible and impactful success stories, in various ways.




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Hitachi Data Systems adds Native NAS and Cloud Tiering to Virtual Storage Platform

Hitachi Data Systems (HDS), a wholly owned subsidiary of Hitachi, Ltd. (TSE:6501)




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Institution of Tehelka under attack

The honorable Supreme Court of India in a judgment on the appointment of Central Vigilance Commissioner held...




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Japan's Hitachi Develops Lensless Camera Technology

Japanese multinational conglomerate company Hitachi Ltd. on Tuesday said it has developed a camera technology that can capture video images without using a lens, the first of this kind in Japan.




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Zhuhai Car Attack: President Xi And Li Qiang Call For Swift Action And Investigation

Authorities in Zhuhai, a southern Chinese city, are facing backlash as they quickly clear memorials left by the public after a deadly car attack on Monday. The tragedy, which occurred at a sports center in the city of 2.5 million people,