Imelda Flores Vazquez from Econometrica, Inc. explains how economists use mathematics to evaluate the efficacy of health care policies. When a hospital or government wants to adjust their health policies — for instance, by encouraging more frequent screenings for certain diseases — how do they know whether their program will work or not? If the service has already been implemented elsewhere, researchers can use that data to estimate its effects. But if the idea is brand-new, or has only been used in very different settings, then it's harder to predict how well the new program will work. Luckily, a tool called a microsimulation can help researchers make an educated guess.

Conroy Overdose's 'Life of a Star' birthday bash sizzled recently at Cool Breeze Entertainment Complex in Church Pen, St Catherine. Glamorous ladies and dapper gents gathered for a night of high fashion and revelry. The Sharper Lane venue pulsed...

Preclinical data have shown that ¹⁶¹Tb-labeled peptides targeting the somatostatin receptor are therapeutically more effective for peptide receptor radionuclide therapy than are their ¹⁷⁷Lu-labeled counterparts. To further substantiate this enhanced therapeutic effect, we performed cellular dosimetry to quantify the absorbed dose to the cell nucleus and compared dose–response curves to evaluate differences in relative biological effectiveness in vitro. Methods: CA20948 cell survival was assessed after treatment with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE (agonist) and with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTA-LM3 (antagonist) via a clonogenic assay. Cell binding, internalization, and dissociation assays were performed up to 7 d to acquire time-integrated activity coefficients. Separate S values for each type of particle emission (Auger/internal conversion [IC] electrons and β^– particles) were computed via Monte Carlo simulations, while considering spheric cells. Once the absorbed dose to the cell nucleus was calculated, survival curves were fitted to the appropriate linear or linear-quadratic model and corresponding relative biological effectiveness was evaluated. Results: Although the radiopeptide uptake was independent of the radionuclide, [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 delivered a 3.6 and 3.8 times higher dose to the nucleus, respectively, than their ¹⁷⁷Lu-labeled counterparts on saturated receptor binding. This increased nucleus-absorbed dose was mainly due to the additional emission of IC and not Auger electrons by ¹⁶¹Tb. When activity concentrations were considered, both [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 showed a lower survival fraction than did labeling with ¹⁷⁷Lu. When the absorbed dose to the nucleus was considered, no significant difference could be observed between the dose–response curves for [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE. [¹⁶¹Tb]Tb-DOTA-LM3 showed a linear-quadratic dose response, whereas [¹⁶¹Tb]Tb-DOTATATE showed only a linear dose response within the observed dose range, suggesting additional cell membrane damage by Auger electrons. Conclusion: The IC, rather than Auger, electrons emitted by ¹⁶¹Tb resulted in a higher absorbed dose to the cell nucleus and lower clonogenic survival for [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 than for the ¹⁷⁷Lu-labeled analogs. In contrast, [¹⁶¹Tb]Tb-DOTATATE showed no higher dose response than [¹⁷⁷Lu]Lu-DOTATATE, whereas for [¹⁶¹Tb]Tb-DOTA-LM3 an additional quadratic response was observed. Because of this quadratic response, potentially caused by cell membrane damage, [¹⁶¹Tb]Tb-DOTA-LM3 is a more effective radiopeptide than [¹⁶¹Tb]Tb-DOTATATE for labeling with ¹⁶¹Tb.

As Week 3 of the provincial election campaign begins, there are questions about how Nova Scotia's major political parties plan to combat the rising number of opioid overdose deaths. 

A date has been set for an inquest into the circumstances surrounding the death of a 37-year-old man in police custody in Atikokan, Ont. who overdosed while in police custody in October 2020. The incident led to an investigation by the province's Special Investigations Unit.

Stress, fluid flow, and motion analysis lend credence to company's designs for Boeing, Airbus, and other major aerospace companies

Will provide Naloxone kits and training at Seaford event Insurance Commissioner Trinidad Navarro, the Town of Seaford, and Aquila Behavioral Health of Delaware have joined forces to deliver life-saving overdose reversal medication to residents on July 27 from 4:00 to 6:00PM at Williams Pond Park. Free opioid rescue kits provided by the Division of Public […]

Commissioner Navarro to provide Naloxone kits and training at event Insurance Commissioner Trinidad Navarro, in collaboration with Public Health’s Kent County Community Response Team, the First Presbyterian Church of Smyrna, and the Smyrna-Clayton Ministerium will provide free training and opioid rescue kits to residents on Wednesday, October 14 from 2:00 to 5:00PM. The event, taking […]

Recommendations include housing, trauma training, expanding recovery resources in the criminal justice system The Delaware Drug Overdose Fatality Review Commission (DOFRC) has released its second annual report to Governor John Carney and the General Assembly. The 18-page report, released Tuesday, details five policy recommendations based on its review of a sample of 130 overdose fatalities […]

Recommendations include a whole-person approach to substance use disorder treatment and broadened non-opioid options for chronic pain treatment  The Delaware Drug Overdose Fatality Review Commission (DOFRC) has released its second annual report to Governor John Carney and the General Assembly, announced Attorney General Kathy Jennings. The report examines a sample of 108 cases from fatal overdoses that occurred […]

Governor John Carney has ordered the Delaware state flag at State facilities be lowered to half staff on Monday, August 31 in observance of Overdose Awareness Day. The Governor’s order only applies to State facilities, however local governments, businesses and Delawareans flying the Delaware state flag are encouraged to participate as well. The Delaware state […]

Governor Carney has ordered the Delaware flag to be lowered to half-staff on Tuesday, August 31, 2021, in recognition of International Overdose Awareness Day, as declared through his signing of SJR4. We encourage local governments, businesses and Delawareans to do the same to promote awareness of overdose prevention and acknowledge all who have suffered the […]

Flag Lowering for International Overdose Awareness Day Governor Carney has ordered the Delaware flag to be lowered to half-staff on Wednesday, August 31, 2022, from sunrise to sunset, in recognition of International Overdose Awareness Day, as declared by Senate Joint Resolution 6. We encourage local governments, businesses and Delawareans to do the same to promote […]

Governor John Carney has ordered the Delaware flag to be lowered to half-staff at all state facilities on Thursday, August 31, 2023, from sunrise to sunset, in recognition of International Overdose Awareness Day, as declared by Senate Joint Resolution 2.

DOVER, DE (March 15, 2022) – The Division of Public Health’s (DPH) Office of Health Crisis Response (OHCR), has initiated a Restaurant Accolade Program to train and educate restaurant industry staff on how to reverse an opioid overdose and support coworkers with substance use disorder (SUD). The program was developed to assist restaurants, hospitality groups, and […]

Delawareans struggling with substance use disorder can call DHSS’ Division of Substance Abuse and Mental Health’s 24/7 Delaware Hope Line – a single point of contact where callers can connect to a variety of resources and information, including support from clinicians and peer specialists plus crisis assistance.

DOVER, DE (August 30, 2022) – The Division of Public Health (DPH) is releasing a 2020 State Unintentional Drug Overdose Reporting System (SUDORS) fact sheet on all drug overdose deaths that occurred in Delaware. This snapshot contains fatality data abstracted from the state’s Overdose Data to Action (OD2A) collaborative. DPH collects and analyzes unintentional drug overdose […]

NEW CASTLE (Nov. 4, 2022) – The Division of Substance Abuse and Mental Health, in collaboration with the Lt. Governor’s Office and the Delaware Art Museum, is seeking personal stories and photos from Delaware families who have lost loved ones to drug overdoses. The submissions will be used to create an emotional and educational exhibition […]

Health Officials Fear Opioid Epidemic Has Not Plateaued   NEW CASTLE (Dec. 8, 2022) – In a heartbreaking sign that the opioid epidemic has not plateaued in Delaware, deaths from suspected overdoses in November set a new monthly high total, according to death investigation reports from the Division of Forensic Science. In November 2022, 43 […]

DOVER, DE (Jan. 3, 2023) – Through the Centers for Disease Control and Prevention’s State Unintentional Drug Overdose Reporting System (SUDORS), Delaware was recently among 47 states to contribute data to the CDC’s Dec. 16, 2022, Morbidity and Mortality Weekly Report, titled “Drug Overdose Deaths Among Persons Aged 10-19 Years – United States, July 2019-December 2021.” The Division of Public Health (DPH) utilizes SUDORS to track available trends and characteristics of […]

Over the past three months (November and December 2022 and January 2023), preliminary data indicates that suspected overdose deaths in Delaware have increased. Suspected accidental overdose data is reported by the Division of Forensic Science (DFS) and is considered preliminary until all data is finalized. Since November, the average monthly increase of suspected overdose deaths is 18.4%. In January 2023, 53 people died from suspected overdoses in Delaware, which represents a 47% increase over […]

NEW CASTLE – The Delaware Division of Substance Abuse and Mental Health (DSAMH) announces the launch of the Health Equity Advancement Project, consisting of two funding opportunities that seek to develop strategies for addressing rising opioid overdose deaths among Black and African American communities in Delaware. DSAMH will award eight mini grants as well as […]

In collaboration with the Delaware Division of Forensic Science (DFS), the Delaware Division of Public Health (DPH) announces the addition of suspected drug overdose death counts to the agency’s publicly available My Healthy Community (MHC) data dashboard. These data can be viewed on the Drug Overdose Deaths tab within the Mental Health and Substance Use Disorder section of MHC. […]

Division of Forensic Science Annual Report Finds Fentanyl Still Involved in More Than 80% of Deaths; Cocaine Link on the Rise NEW CASTLE (May 24, 2022) – In what health officials fear is another consequence of the uncertainty associated with the COVID-19 pandemic, Delaware’s overdose deaths increased more than 15% in 2021 to a record […]

NEWARK (Jan. 18, 2023) – Today, Lieutenant Governor Bethany Hall-Long, along with top leaders from the Delaware Department of Health and Social Services (DHSS) and Delaware Department of Safety and Homeland Security (DSHS), led a community response briefing to provide the latest information about suspected drug overdose deaths in the state, current and emerging dangers […]

The Delaware Drug Overdose Fatality Review Commission (DOFRC) has released its third annual report to Governor John Carney and the General Assembly, announced Attorney General Kathy Jennings. The report examines a sample of 148 cases from fatal overdoses that occurred in 2021, and includes data collected from death certificates, medical records, legal records, and treatment history.  The […]

Title: Low-Dose Aspirin, Other Painkillers May Lower Colon Cancer Risk
Category: Health News
Created: 8/24/2015 12:00:00 AM
Last Editorial Review: 8/25/2015 12:00:00 AM

Title: Synthetic Fentanyl Fueling Surge in Overdose Deaths: CDC
Category: Health News
Created: 8/25/2016 12:00:00 AM
Last Editorial Review: 8/26/2016 12:00:00 AM

The consumption of ⁹-tetrahydrocannabinol (THC)- or cannabis-containing edibles has increased in recent years; however, the behavioral and neural circuit effects of such consumption remain unknown, especially in the context of ingestion of higher doses resulting in cannabis intoxication. We examined the neural and behavioral effects of acute high-dose edible cannabis consumption (AHDECC). Sprague-Dawley rats (six males, seven females) were implanted with electrodes in the prefrontal cortex (PFC), dorsal hippocampus (dHipp), cingulate cortex (Cg), and nucleus accumbens (NAc). Rats were provided access to a mixture of Nutella (6 g/kg) and THC-containing cannabis oil (20 mg/kg) for 10 minutes, during which they voluntarily consumed all of the provided Nutella and THC mixture. Cannabis tetrad and neural oscillations were examined 2, 4, 8, and 24 hours after exposure. In another cohort (16 males, 15 females), we examined the effects of AHDECC on learning and prepulse inhibition and serum and brain THC and 11-hydroxy-THC concentrations. AHDECC resulted in higher brain and serum THC and 11-hydroxy-THC levels in female rats over 24 hours. AHDECC also produced: 1) Cg, dHipp, and NAc gamma power suppression, with the suppression being greater in female rats, in a time-dependent manner; 2) hypolocomotion, hypothermia, and antinociception in a time-dependent manner; and 3) learning and prepulse inhibition impairments. Additionally, most neural activity and behavior changes appear 2 hours after ingestion, suggesting that interventions around this time might be effective in reversing/reducing the effects of AHDECC.

BACKGROUND AND PURPOSE:

Gadolinium-based contrast agents are widely used for meningioma imaging; however, concerns exist regarding their side effects, cost, and environmental impact. At the standard gadolinium dose, most meningiomas show avid contrast enhancement, suggesting that administering a smaller dose may be feasible. The purpose of this study was to evaluate the impact of a lower gadolinium dose on the differentiation between meningiomas and adjacent intracranial tissues.

A single dose of a smallpox vaccine seems to lower the risk of catching mpox by around 60 per cent, and two doses would probably be even better

Fox News host Sean Hannity says the "decentralization of power as our founders intended is very much on its way to DC."

SOLARIS, a phase 3 clinical trial led by Dana-Farber Cancer Institute, tested the addition of high-dose medlinkvitamin D3/medlink to standard treatment

Canadian vaccination programs could eliminate medlinkcervical cancer/medlink by switching to a 1-dose gender-neutral medlinkhuman papillomavirus/medlink

The Union Health Ministry addressed recent media reports claiming that India has a high number of "zero dose children"-children who have not received any vaccines-based on a UNICEF report.

A recent study looked at information about people who died from medlinkdrug overdoses/medlink in the United States between 2020 and 2021. The study

New research based on patient health records on lowering high cholesterol suggests that rosuvastatin can harm the kidneys, especially at high doses of the medicine.

Long-term, low-dose antiviral treatment lowers the risk of vision-damaging inflammation, infection, and pain from shingles affecting the eye, according

Nile Therapeutics Completes Dose Escalation in Ongoing Phase II Study

Transcendental Meditation (Regd) (TM (Regd) ) and its advanced aspect, the TM-Sidhi (Regd) program, may decrease the rising deaths due to opioids and other drugs. The

medlinkAcupuncture/medlink can treat methadone dose and opioid cravings in patients receiving methadone maintenance therapy (MMT), suggests a new study.

A US pharmaceutical company has recalled its two products due to concerns regarding incorrect markings on the dosage cups.Perrigo Company is voluntarily

As vaccination numbers increase, airlines and the government look for the middle path to revive the beleagured travel sector

Many unapproved FDC formulations contain banned, restricted, or never approved drugs

Although the campaign ended on September 30, sources said government hospitals will continue to administer free doses till further orders