The World Bank Group

Bend into a pretzel, if you can, but do so with a better understanding of yoga

Due to wide disparity in vaccine supply, of the 52 countries in Africa, 38 have given at least one dose to <5% of population

Study suggests activating PPAR receptor leads to increased cellular connections in hippocampus

Durban, South Africa :: Logos Hope is helping promote The Bible App for Kids in South Africa with OneHope

Ahead of her arrival, Delhi Chief Minister Arvind Kejriwal had tweeted to welcome her. "@FLOTUS will attend happiness class in our school today. Great day for our teachers, students and Delhiites. For centuries, India has taught spirituality to the world. Am happy that she will take back the msg of happiness from our school," Kejriwal said.

A proteomic study reveals wide-ranging protein differences among brain cells treated with various concentrations of PBDE-99.

To investigate the effect of high-energy X-rays on site-specific radiation-damage, low-dose diffraction data were collected from radiation-sensitive crystals of the metal enzyme cytochrome c oxidase. Data were collected at the Structural Biology I beamline (BL41XU) at SPring-8, using 30 keV X-rays and a highly sensitive pixel array detector equipped with a cadmium telluride sensor. The experimental setup of continuous sample translation using multiple crystals allowed the average diffraction weighted dose per data set to be reduced to 58 kGy, and the resulting data revealed a ligand structure featuring an identical bond length to that in the damage-free structure determined using an X-ray free-electron laser. However, precise analysis of the residual density around the ligand structure refined with the synchrotron data showed the possibility of a small level of specific damage, which might have resulted from the accumulated dose of 58 kGy per data set. Further investigation of the photon-energy dependence of specific damage, as assessed by variations in UV-vis absorption spectra, was conducted using an on-line spectrometer at various energies ranging from 10 to 30 keV. No evidence was found for specific radiation damage being energy dependent.

The local Fourier-space relation between diffracted intensity I, diffraction wavevector q and dose D, ilde I(q,D), is key to probing and understanding radiation damage by X-rays and energetic particles in both diffraction and imaging experiments. The models used in protein crystallography for the last 50 years provide good fits to experimental I(q) versus nominal dose data, but have unclear physical significance. More recently, a fit to diffraction and imaging experiments suggested that the maximum tolerable dose varies as q−1 or linearly with resolution. Here, it is shown that crystallographic data have been strongly perturbed by the effects of spatially nonuniform crystal irradiation and diffraction during data collection. Reanalysis shows that these data are consistent with a purely exponential local dose dependence, ilde I(q,D) = I0(q)exp[−D/De(q)], where De(q) ∝ qα with α ≃ 1.7. A physics-based model for radiation damage, in which damage events occurring at random locations within a sample each cause energy deposition and blurring of the electron density within a small volume, predicts this exponential variation with dose for all q values and a decay exponent α ≃ 2 in two and three dimensions, roughly consistent with both diffraction and imaging experiments over more than two orders of magnitude in resolution. The B-factor model used to account for radiation damage in crystallographic scaling programs is consistent with α = 2, but may not accurately capture the dose dependencies of structure factors under typical nonuniform illumination conditions. The strong q dependence of radiation-induced diffraction decays implies that the previously proposed 20–30 MGy dose limit for protein crystallography should be replaced by a resolution-dependent dose limit that, for atomic resolution data sets, will be much smaller. The results suggest that the physics underlying basic experimental trends in radiation damage at T ≃ 100 K is straightforward and universal. Deviations of the local I(q, D) from strictly exponential behavior may provide mechanistic insights, especially into the radiation-damage processes responsible for the greatly increased radiation sensitivity observed at T ≃ 300 K.

File: (L-R) "The Sarah Silverman Program" writer Harris Wittels, comedian Sarah Silverman, executive producer/head writer Dan Sterling and actress Laura Silverman, arrive at Comedy Central's Emmy Awards party at the STK restaurant Sept. 21, 2008 in Los Angeles.; Credit: Ethan Miller/Getty Images

Harris Wittels, a comedy writer who worked on "Parks & Recreation," has died at 30, the Los Angeles Police Department's Jane Kim tells KPCC.

Wittels was discovered by his assistant around 12 p.m., Kim said, and was already dead. Kim said that Wittels' death was a possible overdose, but that the Coroner's Office would determine the cause of death. Wittels had attended drug rehab twice.

Comedy Central, where Wittels worked on "The Sarah Silverman Program" and "Secret Girlfriend," confirmed Wittels' death, as did the comedy show he appeared at Wednesday night.

Comedy Central tweet

Meltdown Show tweet

Wittels was also well known for his @Humblebrag Twitter account and later book, helping to popularize the idea online of the false modesty of bragging while trying not to look like you're bragging.

Wittels had spoken about his struggles with addiction in places including Pete Holmes's podcast "You Made It Weird" in a November episode.

"I just really stopped caring about my life," Wittels said on "You Made It Weird," explaining how he got into doing drugs. "I just really started to think, well, if I'm only here for 80 years, then who cares if I spend it high or not?"

Wittels received his first big break when Sarah Silverman saw him performing comedy and gave him a job writing for her Comedy Central show.

Wittels also wrote for HBO's "Eastbound & Down," several MTV awards shows and the American Music Awards. He had a recurring role on "Parks & Recreation" and was a regular guest on the "Comedy Bang Bang" podcast.

Comedians, actors and fans mourned Wittels' death online.

Harris Wittels Storify

See Wittels in a scene from "Parks & Recreation":

Wittels on Parks & Recreation

Listen to Wittels on "Comedy Bang Bang":

Wittels on Comedy Bang Bang

This story has been updated.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Insufficient evidence exists to support claims that taking megadoses of dietary antioxidants, such as selenium and vitamins C and E, or carotenoids, including beta-carotene, can prevent chronic diseases, says the latest report on Dietary Reference Intakes (DRIs) from the Institute of Medicine of the National Academies.

A new report by the National Academies of Sciences, Engineering, and Medicine proposes a strategy that the U.S. Environmental Protection Agency (EPA) should use to evaluate the evidence of adverse human health effects from low doses of exposure to chemicals that can disrupt the endocrine system.

Non-target aquatic wildlife species may be more vulnerable to pesticides’ effects, with repeated exposure to low doses over the long-term, if they compete with other species for food, according to a recent study. Understanding how this process occurs can help those undertaking risk assessments and managing pesticides in the natural environment.

Setting cycle and footpaths further back from the road can significantly lower the amount of air pollution that cyclists and pedestrians inhale, suggests new research. While wide gaps are not always practical, the study shows that even small increases in distance could substantially reduce the dose of pollution.

New Hampshire distillery Tamworth turns the healthy spice into a tribute to Alexander Von Humboldt, the "forgotten father of environmentalism."

Study participants on higher doses of statins were 15 percent more likely to develop diabetes than those on lower doses.

Researchers find that more than 10 percent of patients may be taking aspirin unnecessarily, and the risks may outweigh the benefits.

Once considered a dead zone for green building, Miami Beach will soon be getting its first LEED Platinum home in the form of 2020 Alton Road, a super-sleek, sup

CEDAR RAPIDS — A Dubuque woman who helped her boyfriend and another person buy heroin that later led to a fatal overdose was convicted Thursday in federal court. Jacqueline M. Birch, 23,...

CEDAR RAPIDS — A Dubuque woman who helped her boyfriend and another person buy heroin that later led to a fatal overdose was convicted Thursday in federal court.

Jacqueline M. Birch, 23, pleaded guilty in U.S. District Court to one count of aiding and abetting the distribution of a controlled substance.

During the plea hearing, Birch admitted she knew that another person was going to illegally distribute a drug last May, and she aided in that distribution.

Evidence at a previous hearing showed that Birch drove her boyfriend, Mateusz Syryjczyk, 29, of Rockford, Ill., and another person, not identified in court documents, to a residence in Dubuque on May 27. Birch and the other person went into the residence and bought heroin from a dealer. The three drove to a hotel in Dubuque and all used the heroin.

The other person began to overdose in the room, but Birch and Syryjczyk didn’t immediately call 911, according to evidence. Over many hours, Birch occasionally would perform CPR on the person to restore some breathing function, though the person never regained consciousness.

Eventually, Birch and Syryjczyk decided to call 911, and Syryjczyk took the remaining drug paraphernalia from the room to prevent law enforcement from finding it, according to court documents. Birch and Syryjczyk also made false statements to police about the cause of the person’s condition.

Court documents showed the overdose victim died at the scene. An autopsy later determined the cause of death was use of heroin, fentanyl and valeryl fentanyl.

Syryjczyk previously pleaded to misprision of a felony and remains free on bond pending sentencing.

Birch faces up to 20 years in federal prison, a $1 million fine and supervised release for life following her prison term.

Sentencing will be set after a presentencing report is prepared.

The case was investigated by the Dubuque Drug Task Force and is being prosecuted by Assistant U.S. Attorney Dan Chatham.

Comments: (319) 398-8318; trish.mehaffey@thegazette.com

In the case of a package (1) for single-dose films (2) containing active substances, comprising an upper packaging material element (3) and a lower packaging material element (4) which are connected together by a peripheral seal area or respectively sealing seam (5) such that a cavity (6) for holding the film (2) is formed, said cavity being enclosed on all sides, wherein the upper packaging material element (3) and the lower packaging material element (4) each have at least one cut (7, 8) in the region of the seal area or respectively, the sealing seam (5), said cuts being congruent, andat least one cut (7, 8) is crossed by a folding or bending line (10), the folding or bending line (10) is formed in a weakened manner.

The present invention pertains to a system and method for X-ray imaging wherein a targeted fluence at the detector for projection images can be achieved at a plurality of projection angles around the imaging subject by control of exposure times implemented during image acquisition. Exposure time for a second projection image may be determined by the fluence in a first projection image, and in a third projection image by the fluence in a second projection image, where projection images are acquired within two degrees of one another. An acquisition parameter calculation can be configured to calculate acquisition parameters, such as said exposure times, to achieve the targeted fluence in projection images and can be coupled to a rotation controller that implements the acquisition parameters by controlling a relative angle between the imaging subject and X-ray image acquisition device.

Among other things, one or more systems and/or techniques are described for dynamically adjusting, in a fan-angle direction, attenuation of radiation during an examination of an object such that portions of the object that are not represented in resulting (tilted/targeted) images of the object are exposed to less radiation than portions of the object that are represented in resulting (tilted/targeted) images of the object. As a rotating gantry is rotated, blades of a pre-object collimator are dynamically repositioned to selectively attenuate emitted radiation. A collimator adjustment component may be configured to determine how to reposition the blades based at least in part upon at least one of a desired tilt of the resulting (tilted) image(s), a translational position of the object, and a gantry rotation angle, for example.

A method of treating an object with radiation that includes generating volumetric image data of an area of interest of an object and emitting a therapeutic radiation beam towards the area of interest of the object in accordance with a reference plan. The method further includes evaluating the volumetric image data and at least one parameter of the therapeutic radiation beam to provide a real-time, on-line or off-line evaluation and on-line or off-line modification of the reference plan.

A compressible fluid powered device includes a dose chamber. An inlet supplies pressurized fluid to the dose chamber. An outlet for releases pressurized fluid from the dose chamber. A moveable divider divides the dose chamber into a primary space and a secondary space, movement of the divider expanding one space at the expense of the other. At least one flow pathway from one space to the other, which collectively allow gas to flow in both directions past the divider and pressure to equalize across the divider, the flow pathway being much more limited than the outlet.

A disposable sterile breakable vial includes a handle section and a vial section which are completely separable in response to a manually applied separation force. The vial section includes a sterile void dimensioned to contain a unit dose of a sterile therapeutic topical agent. An elongated member comprises a proximal portion supported by the handle section and a distal portion provided with a sterile applicator element, such as a brush. At least the applicator element is completely enclosed within the vial section with the applicator element immersed within the therapeutic topical agent. A hermetic seal between the handle and vial sections maintains sterility of at least the vial section prior to handle and vial section separation. Complete separation of the handle section and the vial section exposes the elongated member and the applicator element for topical application of the therapeutic agent saturating the applicator element.

The present disclosure relates to a dose indicator comprising, a chassis comprising a 42 chassis frame and a displacement portion, an indexable first display unit, mountable on the chassis, the first display unit being indexable about a first display axis, the indexable first display unit comprising a plurality of indexing teeth, a first display non-return arm, and a drive pawl connected at its proximal part to the displacement portion, the drive pawl comprising a socket at its distal part, the socket being adapted to engage an indexing tooth of the first display unit during indexing. The disclosure further relates to an actuator for an inhaler, wherein the actuator comprises a dose indicator as described above. The present disclosure is also directed to an inhaler comprising such actuator.

The invention is directed to a dose indicating mechanism for drug delivery device (1) configured for the delivery of a medicament contained in single medicament cartridge (2), the medicament comprising at least one first drug and one second drug, wherein the dose indicating mechanism comprises a body (3), a dose dial component (7) configured to move relative to the body (3) during dose setting and first dose indicator means (10) configured to display a set dose of the medicament and/or of first drug in dependence of the displacement of dose dial component (7) during dose setting. In order to provide the user with further information, a second dose indicator means (15) is provided that is configured to display a set dose of the second drug during dose setting. The invention is also directed to a respective drug delivery device.

A method and apparatus for controlling a dose of extreme ultraviolet (EUV) radiation generated by a laser produced plasma (LPP) EUV light source. In one embodiment, a running total of the EUV energy generated over a predetermined number of laser pulses is measured; once that number of pulses is exceeded, the energy from the pulse immediately preceding the most recent predetermined number of pulses is dropped from the running total, so that the running total is from the most recent predetermined number of pulses. If the running total of the EUV energy exceeds a target dose, the next pulse is caused to not hit a droplet. This avoids the unwanted side effects of various prior art solutions, such as needing to miss many droplets in a row, or requiring the laser pulses to be shortened or reduced in power as in other prior art solutions.

Seattle police say Leo Driver, 32, walked into the department's East Precinct and confessed to killing his girlfriend, Elisabeth Wright, in March 2015. Her death had originally been attributed to an accidental overdose.

Dr. Susy Hota, the Medical Director for Infection Prevention and Control at University Health Network in Toronto joins Dr. Brian Goldman to answer 10 questions on COVID-19.

Dr. Goldman talks to 'the germ guy', Jason Tetro. They cover: How to don and doff a mask. The best material for making masks. Should a mask cover your nose? Can hospitals clean masks?  Should you worry about take-out food? Should you share homemade food? Does heat kill the virus on food? Do you need to disinfect every item from the store? Is it safe to handle money? What about pin pads?  Do gloves protect you from anything? 

Dr. Goldman answers questions about the coronavirus from kids across Canada, with the help of Tai Poole, host of the CBC podcast Tai Ask Why, and Matt Galloway, host of CBC Radio's The Current

A mother alleges her newborn baby needed emergency help after being given a life-threatening dose of insulin at a Queensland public hospital.

Clown doctors in Outback Australia medicate paediatric patients with a regular dose of humour.

The Daily Planet team from the Discovery Channel Canada is hip. They highlight cool new technologies and explore interesting people, places and things. So, when their FutureTech team wanted to get a first-hand look at the New Mobile Workplace, they came to IBM.

The Country Singer From Pittsburgh, PA Has Released The First Single From Her Forthcoming Full Length, Set For Late 2019 Release On MTS Records.

IBM y Red Hat, líder mundial de software de nube de código abierto, anunciaron un acuerdo en el que IBM adquirirá todas las acciones comunes emitidas y en circulación de Red Hat por USD$190.00 por acción en efectivo, lo que representa un valor total para la empresa de aproximadamente USD$34 mil millones.

Patient Jessica Ellision recalled how she broke down and sobbed Monday when she finally received her medication after a three-hour wait — much of it in the crowded hallway where she feared the other patients might be infected. “It was so intense and so stressful, and you feel like you worked so hard not to be sick, but this is it now — this is how it happens,” said Ellison, 39, of the Bronx.

A Texas grand jury has been hearing evidence that could form the basis for criminal charges related to the opioid overdose death of Angels pitcher Tyler Skaggs.

THANKFULLY, the Government is still encouraging us to get out and exercise - as long as we keep the two-metre distance rule.

As many as 75,000 Americans could die because of drug or alcohol misuse and suicide as a result of the coronavirus pandemic, according to an analysis conducted by the national public health group Well Being Trust.

The play is the theater program's way of countering anti-drug programs that haven't worked — the kind where adults shake fingers at students.

Senate candidate Luke Messer airs a new TV ad. It's refreshing because it doesn't demean the opposition and doesn't aim to anger primary voters.

(Oregon State University) Clinical trial data behind drug dose recommendations for elevated cholesterol and chronic obstructive pulmonary disease illustrate how larger doses may not be worth the extra costs for many types of patients.

Calculation of radiation dosimetry in targeted nuclear medicine therapies is traditionally resource-intensive requiring multiple post-therapy SPECT acquisitions. An alternative approach is to take advantage of existing pharmacokinetic data from these smaller cohorts to enable dose computation from a single post-treatment scan in a manner that may be applied to a much broader patient population. Methods: In this work, a technical description for simplified dose estimation is presented and applied to assessment of ¹⁷⁷Lu-PSMA-617 therapy (Prostate-Specific Membrane Antigen) for metastatic prostate cancer. By normalizing existing time-activity curves to a single measurement time, it is possible to calculate a mean and range of time-integrated activity values which relate to radiation absorbed dose. To assist with accurate pharmacokinetic modelling of the training cohort, a method for contour-guided image registration was developed. Results: Tissue-specific dose conversion factors for common post-treatment imaging times are reported along with a characterization of added uncertainty in comparison to a traditional serial imaging protocol. Single time point dose factors for tumor were determined to be 11.0, 12.1, 13.6, and 15.2 Gy per MBq/mL at image times of 24, 48, 72, and 96 hours, respectively. For normal tissues, parotid gland factors were 6.7, 9.4, 13.3, and 19.3 Gy per MBq/mL and kidneys were 7.1, 10.3, 15.0, and 22.0 Gy per MBq/mL at those times. Tumor dose estimates were most accurate using delayed scanning at times beyond 72 hours. Dose to healthy tissues is best characterized by scanning patients in the first two days of treatment owing to the larger degree of tracer clearance in this early phase. Conclusion: The work demonstrates a means for efficient dose estimation in ¹⁷⁷Lu-PSMA-617 therapy. By providing methods to simplify and potentially automate radiation dosimetry we hope to accelerate the understanding of radiobiology and development of dose-response models in this unique therapeutic context.