The police said that unlike other drug busts of this scale, the shipment was intended for the local market, and had a street value of €20 million. Four Maltese men have been arrested in connection with the bust

Ronald Whelan faces extradition over an alleged plot to import 100kg of high-purity Colombian cocaine.

UK Border Force find 25kg of cocaine in a Darlington man's suitcase after he flies in from Mexico.

The post Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder was curated by information for practice.

STIMULANTS: Cocaine, Amphetamin, Ecstasy, Alcohol, Tobacco, Caffeine

Scientists identified traces of the drug in the brain tissue of two individuals buried in the crypt of a hospital in Milan

The use of cocaine only took off in Europe during the 19th century, after the drug was chemically isolated from coca leaves, but new evidence suggests much earlier use

Title: cocaine
Category: Medications
Created: 8/15/2022 12:00:00 AM
Last Editorial Review: 8/15/2022 12:00:00 AM

Previous studies demonstrated that sigma receptor (R) antagonists alone fail to alter cocaine self-administration despite blocking various other effects of cocaine. However, R antagonists when combined with dopamine transporter (DAT) inhibitors substantially decrease cocaine self-administration. To better understand the effects of this combination, the present study examined the effects of R antagonist and DAT inhibitor combinations in male rats discriminating cocaine (10 mg/kg, i.p.) from saline injections. The DAT inhibitors alone [(–)-2-β-carbomethoxy-3-β-(4-fluorophenyl)tropane 1,5-naphthalenedisulfonate monohydrate (WIN 35,428) and methylphenidate] at low (0.1-mg/kg) doses that were minimally active failed to shift the dose-effect function for discriminative-stimulus effects of cocaine to the left more than 2-fold. At 0.32 mg/kg the DAT inhibitors alone shifted the cocaine dose-effect function leftward 24- or 6.6-fold, respectively. The R antagonists (BD1008, BD1047, and BD1063) failed to fully substitute for cocaine, although BD1008 and BD1047 substituted partially. At 10 mg/kg, BD1008, BD1047, or BD1063 alone shifted the cocaine dose-effect function leftward less than 6.0-fold. In combination with 0.1 mg/kg WIN 35,428, the 10 mg/kg doses of R antagonists shifted the cocaine dose-effect function from 12.3- to 36.7-fold leftward, and with 0.32 mg/kg WIN 35,428 from 14.3- to 440-fold leftward. In combination with 0.1 mg/kg methylphenidate, those R antagonist doses shifted the cocaine dose-effect function from 5.5- to 55.0-fold leftward, and with 0.32 mg/kg methylphenidate from 10.5- to 48.1-fold leftward. The present results suggest that dual DAT/R inhibition produces agonist-like subjective effects that may promote decreases in self-administration obtained in previous studies.

A driver tried to throw NZ$50,000 worth of cocaine out of his van while police were chasing him but ended up with cocaine all over the inside of the vehicle after forgetting to actually open the window.A photo of the man's expensive...

The Sydney District Court today sentenced two men to a combined 17.5 years imprisonment over a 2018 seizure of almost 115 kilograms of cocaine.

A joint operation between the Australian Border Force, ACT and NSW police has discovered about 384kg of cocaine inside a second-hand excavator bound for a regional NSW business. (Supplied: Australian Border Force)

Police seize more than $140 million worth of cocaine stashed in the arm of an excavator that was destined for a business in a small NSW town.

Two men on trial over a 700kg cocaine importation racket used encrypted mobile phones to help arrange for the drugs to be sailed from Tahiti to Australia, a court hears.

A court has heard Border Force and NSW and federal police officers formed a human chain to unload hundreds of bricks of cocaine from a catamaran linked to an international drug syndicate.

A man who denied knowing anything about $245 million worth of drugs onboard a catamaran he skippered from Tahiti faces life in jail after being found guilty of the crime.

MORNING BRIEFING: Former Newcastle Knights star Jarrod Mullen is charged over his alleged role in a cocaine ring in the Hunter region and Australia's country music industry is in shock after singer and producer Glen Hannah dies.

City Girls and Lil Baby perform three of their hit songs.

City Girls and Lil Baby perform three of their hit songs.

Rockville, Maryland : National Institute on Drug Abuse, 1984.

Rockville, Maryland : National Institute on Drug Abuse, 1985.

Prenatal cocaine exposure is associated with the trajectories of childhood behavior problems. Exposure effects may also be related to maternal use of other substances during pregnancy, and risk factors other than prenatal exposure may augment the detrimental cocaine effects.

The balance between cumulative risk and protective indexes predicts behavior outcomes, independent of prenatal drug exposure. A high protective index even with a high level of risks can mitigate the detrimental effects of drug exposure on behavior problem trajectory. (Read the full article)

Title: Not Just Opioids: Deaths Tied to Cocaine, Meth Are Soaring, Too
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM

The initial response to an addictive substance can facilitate repeated use: That is, individuals experiencing more positive effects are more likely to use that drug again. Increasing evidence suggests that psychoactive cannabinoid use in adolescence enhances the behavioral effects of cocaine. However, despite the behavioral data, there is no neurobiological...

A person who has ingested cocaine will excrete a compound that can be detected from a single fingerprint, even if they have washed their hands

Follow our live Covid-19 updates HERE Coronavirus: The symptoms

Three people have been arrested after a staggering 190kg of cocaine worth about £19 million was found hidden in lorries carrying toys and paper at the Port of Dover.

Two men have been charged after a £3 million cocaine haul was uncovered in a purpose-built smuggling lorry in Dover.

The EastEnders actor has discussed his struggle with addiction

An alleged cocaine drug ring spanning two states is uncovered by New South Wales and South Australian police, leading to the arrests of five people.

Rene Oswald Cobar, a Guatemalan national, and Luis Angel Gonzalez-Largo, a Colombian national, were each sentenced today to 235 months in prison on federal drug charges. Cobar and Gonzalez-Largo were sentenced by U.S. District Judge James C. Mahan for the District of Nevada. Cobar and Gonzalez-Largo were indicted on May 5, 2004, in the District of Nevada for conspiracy to distribute cocaine.

Christian Fernando Borda and Alvaro Alvaran-Velez, two narcotics traffickers aligned with the Autodefenses Unidas de Colombia (AUC), were found guilty today in U.S. District Court of conspiring to import ton-quantities of cocaine into the United States.

Colombian drug trafficker Carlos Ojeda-Herrera pleaded guilty today before U.S. District Judge Ellen S. Huvelle in the District of Columbia to conspiring and attempting to transport shipments of 700- 800 kilograms of cocaine from Isla de Margarita, off the coast of Venezuela, to vessels waiting on the high seas to transport the drugs to Florida.

U.S. District Judge Gloria M. Navarro sentenced Jose Lopez-Buelna, aka “Miguel,” 51, to 20 years in prison, and Erik Dushawn Webster, 47, to 25 years in prison.

Edison Burgos-Montes, of Puerto Rico, was convicted after a two-month jury trial of cocaine possession with intent to distribute and killing a government witness.

Whenever we talk about the production of cocaine fueling rainforest destruction, or the electricity consumption of indoor marijuana growing, many commenters decry that it is prohibition that causes these negative impacts, not the drug itself. There is,

Drugs traffickers hit by coronavirus-induced slowdown and seizures, says UN agency

Glamorous party girl Monique Belovukovic, 21, was driving her black Mercedes through Sydney's Surrey Hills when she was pulled over by highway patrol officers.

The former EastEnders star, 48, was crowned the winner of the 2018 series of the show and revealed getting into the kitchen helped him to change his habit.

Officers from Devon and Cornwall Police stopped the driver on the M5 and when they got to the cab they discovered the inside was covered in white powder.

Republic of Ireland international Daryl Murphy has admitted to taking cocaine on a night out that led to him being banned by the Football Association.

A Sydney man who flaunted his extravagant lifestyle on social media is now facing life in prison for plotting to bring $150million dollars of cocaine into Australia. 

Vera Zinger, 23, was pulled over by police in Barangaroo near Sydney's CBD, on November 29 where officers allegedly found four bags containing 2kg worth of drugs and $2,150 in cash.

Charlene Friend, 44, met Prince in 1989 and dated him for two years. While she never personally saw Prince take drugs, she says says his half-brother told her he subsisted on a 'cocaine diet'.

The Australian Border Force found the huge haul at the Sydney Container Examination Facility after an X-ray was conducted on the construction item in June.

Days after Walmart pulled a controversial sweater featuring a cartoon Santa Claus doing cocaine with the tagline 'Let It Snow' from its website, the infamous novelty item has now become a best-seller.