Erlangen : F. Enke, 1874-1875.

Leipzig : W. Engelmann, 1865.

Hannover : Hahn, 1869.

Berlin : J. Springer, 1887.

Berlin : C. Nohring, 1868.

Wien : Urban & Schwarzenberg, 1879.

Darmstadt : C.W. Leske, 1850.

London : Swan Sonnenschein, 1898.

Nearly 45 percent of children in rural McDowell County, West Virginia do not live with their parents and many are being raised by grandparents.

A major difficulty of solving continuous POMDPs is to infer the multi-modal distribution of the unobserved true states and to make the planning algorithm dependent on the perceived uncertainty. We cast POMDP filtering and planning problems as two closely related Sequential Monte Carlo (SMC) processes, one over the real states and the other over the future optimal trajectories, and combine the merits of these two parts in a new model named the DualSMC network. In particular, we first introduce an adversarial particle filter that leverages the adversarial relationship between its internal components. Based on the filtering results, we then propose a planning algorithm that extends the previous SMC planning approach [Piche et al., 2018] to continuous POMDPs with an uncertainty-dependent policy. Crucially, not only can DualSMC handle complex observations such as image input but also it remains highly interpretable. It is shown to be effective in three continuous POMDP domains: the floor positioning domain, the 3D light-dark navigation domain, and a modified Reacher domain.

Where a service connects to the network. In a service oriented architecture, any single network interaction involves two endpoints: one to provide a service, and the other to consume it. In web services, an endpoint is specified by a URI.

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The NDP health critic says comments Premier Doug Ford made this week calling out medical officers of health for not getting enough COVID-19 testing done are uncalled for.

Advanced preliminary release for Q4 2019 quarterly data on credit-to-GDP gaps covering 44 economies have been updated. These time-series data show the difference between the credit-to-GDP ratio and its long-run trend, which can serve as an early warning indicator of financial crises. As input, the data used are the credit-to-GDP ratio as published in the BIS database of total credit to the private non-financial sector. The credit series capture total borrowing by the private non-financial sector (ie households and non-financial corporations) from all sources.

Apple's next release in the AirPods family could be its long-rumored over-ear headphones, a leaker claims, with the larger personal audio accessory tipped to have the name "AirPods Studio."

This law is going to make a mess sooner rather than later.

There is an urgent need for new, potent anti-tuberculosis (TB) drugs with novel mechanisms of action that can be included in new regimens to shorten the treatment period for TB. After screening a library of carbostyrils, we optimized 3, 4-dihydrocarbostyril derivatives and identified OPC-167832 as having potent anti-tuberculosis activity. The minimum inhibitory concentrations of the compound for Mycobacterium tuberculosis ranged from 0.00024 to 0.002 μg/mL. It had bactericidal activity against both growing and intracellular bacilli, and the frequency of spontaneous resistance for Mycobacterium tuberculosis H37Rv was less than 1.91 x 10^-7. It did not show antagonistic effects with other anti-TB agents in an in vitro checkerboard assay. Whole genome and targeted sequencing of resistant isolates to OPC-167832 identified the decaprenylphosphoryl-β-D-ribose 2'-oxidase (DprE1), an essential enzyme for cell wall biosynthesis, as the target of this compound, and further studies demonstrated inhibition of the DprE1 enzymatic activity by OPC-167832. In a mouse model of chronic TB, OPC-167832 showed potent bactericidal activities starting at a dose of 0.625 mg/kg. Further, it exhibited significant combination effects in 2-drug combinations with delamanid, bedaquiline, or levofloxacin. Finally, 3-4 drug regimens comprised of delamanid and OPC-167832 as the core along with bedaquiline, moxifloxacin, or linezolid showed superior efficacy in reducing bacterial burden and preventing relapse compared to the standard treatment regimen. In summary, these results suggest that OPC-167832 is a novel and potent anti-TB agent and regimens containing OPC-167832 and new or repurposed anti-TB drugs may have the potential to shorten the duration of treatment for TB.

With iOS 13.1 and iPadOS, Apple adds an Audio Sharing feature that lets you share with a friend what you're listening to on your Apple AirPods or select Beats headphones.

When was the last time you opened these Windows apps?

Tired of tangled cords? Cut yourself some slack and switch to Bluetooth headphones. Whether you're looking for earbuds, on-ears, or to go completely wire-free, start with the best wireless headphones we've tested.

Whether you're looking for sleek AirPods or big over-ear models, these are the best headphones and earbuds we've tested, with advice for finding just the right pair for you.

Noise cancellation removes unwanted sounds. The best noise-cancelling headphones let you block out the world around you to enjoy your music...or the sweet sound of silence.

It's no secret that music is a great motivator for working out. Before you lace up your kicks and head out to the track, trail, or treadmill, check out the best wireless headphones we've tested for powering your run.

Not a fan of the bulk that comes with over-the-ear headphones? Whether you call them earbuds, earphones, or in-ear headphones, check out the best in-ear models we've tested.

A good gaming headset delivers rich sound to really get you into the game and an integrated microphone so you can trash talk your opponents. These are the best gaming headphones we've tested.

Enterprises and small to midsize businesses (SMBs) require rock-solid endpoint security. The challenge is determining the right features to best keep exploits at bay. We put the leading solutions to the test to find the best options for your business.

Statewide flu totals in Delaware decreased for the third week in a row, according to the Division of Public Health (DPH). During the week ending March 10, DPH reports 290 laboratory-confirmed flu cases, down from the prior week’s total of 381 confirmed cases. The latest numbers increase the total number of influenza cases for the season to 7,433. DPH is also reporting one additional flu-related death, a 62-year-old female from New Castle County with multiple underlying health conditions, bringing the number of flu-related deaths for the 2017-2018 flu season to 31.

The Delaware Division of Public Health (DPH) is investigating a mumps outbreak among attendees of a February Hispanic dance festival in New Castle County. Officials have confirmed three cases of the mumps, all involving attendees of a social dance (Baile Mejicano or Mexican Dance) that took place at the Chase Center on the Riverfront in Wilmington on Feb.10, 2018. DPH is recommending that anyone who attended the dance, contact their primary care physician to determine if they may have contracted mumps and if they and their family or close contacts need to receive vaccination against mumps.

The Division of Public Health (DPH) is advising parents and teachers to be aware of a recent trend among youth known as “JUULing.” JUUL is a brand of e-cigarette that looks similar to a flash drive and can be charged in the USB port of a computer. JUULs can be appealing to youth for a variety of reasons. Pods come in a variety of fruit and candy flavors, the devices can be difficult to distinguish from a real flash drive, and the vapor dissipates quickly instead of hanging in the air like a smoke trail. This has caused concern among school administrators across the country as youth have taken to “JUULing” on school property, even in class.

The Delaware Division of Public Health (DPH) is advising Delawareans of a multistate outbreak of E. coli infections linked to chopped romaine lettuce from the Yuma, Arizona, growing region. The lettuce could be contaminated with Shiga toxin-producing Escherichia coli O157:H7 and could make people sick. To date, there have been no confirmed cases reported in Delaware, but DPH urges consumers to take precautions to prevent illness.

While many Delawareans couldn’t be happier to see spring’s arrival and winter’s departure, the Division of Public Health (DPH) is warning residents that with warm weather comes ticks, fleas, mosquitoes and increased chances of vector-borne diseases. Whether staying home or traveling in the coming months, DPH wants to remind Delawareans of the risk of these diseases, which include Lyme disease, Zika, and West Nile Virus, and to share prevention tips.

The Division of Public Health (DPH) announced today that over 600 individuals may have been exposed to someone with active tuberculosis (TB) at the ManorCare Health Services Foulk Road facility during a nine-month period in 2017. Consistent with routine Division TB protocols, the agency is sending out letters to former residents and staff of the facility who may have been exposed to the infected individual between January and September 2017. DPH is also following up with phone calls to provide information on free testing and treatment at one of its three clinics in Newark, Dover, and Georgetown.

The Division of Public Health is continuing its efforts to encourage former residents and employees of the ManorCare Health Services Foulk Road facility in Wilmington, between January and September 2017, to be tested for tuberculosis (TB). DPH opened a call center on Tuesday, May 29, 2018, to follow up with individuals who had been sent a letter and answer any questions, as well as to field questions from the public. As the number of incoming calls has decreased significantly since the opening, DPH is announcing that the call center will cease operations at 4:00 p.m., Friday, June 1, 2018.

The Division of Public Health (DPH) will host a two-day, exercise on Tuesday, June 19, and Wednesday, June 20, at Sussex Central High School, Georgetown. The purpose is to test the division’s ability to operate a shelter for residents who may be displaced or unable to occupy their homes in the event of a disaster.

Free HIV testing will be offered through the Division of Public Health (DPH) at two Delaware state service centers on Wednesday, June 27, 2018, in observance of National HIV Testing Day. The Centers for Disease Control and Prevention (CDC) recommends that everyone between the ages of 13 and 64 get tested for HIV at least once as part of routine health care.

The Delaware Division of Public Health (DPH) is seeking input from Delawareans on a draft version of a statewide assessment identifying the primary health needs of First State residents.

As many Delawareans head outside for Fourth of July festivities, the Division of Public Health (DPH) encourages Delaware residents to prepare for extreme heat early this week and prevent heat-related illness as temperatures rise. Temperatures are expected to reach the mid-90s through Tuesday, with the heat index values as high as 105 degrees.

The Delaware Division of Public Health (DPH) recommends that residents take steps to keep family, friends, and pets safe during Fourth of July gatherings.

The Delaware Division of Public Health (DPH) has advised the operator of Broadkiln Beach Water Company located in Sussex County to issue a boil water notice to customers after water samples collected from the system tested positive for the presence of E-coli bacteria on Friday, July 20. Because the Broadkiln Beach Water Company shares a connection with PrimeHook Water Company, anyone who uses drinking water from either system should not drink the water without boiling it first.

The Division of Public Health (DPH) is announcing the state’s second human case of West Nile Virus (WNV) in 2018. WNV, a mosquito-borne illness, can become serious, and DPH reminds people to take precautions to avoid mosquito bites.

The Division of Public Health (DPH) is investigating an outbreak of pertussis, commonly known as whooping cough, in Kent County. Whooping cough is a highly contagious disease transmitted by coughing or sneezing, or coming in direct contact with respiratory secretions of infected persons. The most common symptom is uncontrollable coughing spells often followed by a characteristic “whoop” sound. The disease can cause severe illness in infants and young children.

The Delaware Division of Public Health (DPH), and Department of Agriculture (DDA) are asking residents to increase efforts to prevent exposure to rabies after the death of a Kent County woman from the disease. The woman, who lived west of Felton, is the second Delawarean to contract, and subsequently pass away from, the disease. The first was a young boy from Newport, who passed away in 1941 after being bitten by a stray dog.

Division of Public Health (DPH) officials are concerned about the increasing number of cases of West Nile Virus (WNV) in humans this year. DPH is announcing that WNV is confirmed in a 73-year-old New Castle County man, who has been hospitalized since late August. This is the third case of WNV confirmed in humans in the last month. The first case involved a 60-year-old Sussex County man, and the second a 68-year-old New Castle County man. Additionally, DPH is awaiting results from the Centers for Disease Control and Prevention (CDC) in a fourth potential case of the disease. Last week, the Delaware Department of Agriculture announced two cases of WNV in horses.

The Division of Public Health (DPH) is announcing two laboratory-confirmed cases of influenza, just three weeks before the official start of the 2018-2019 flu season, which begins September 30.

Officials pushing vaccination message after flu spreads statewide and first flu-related hospitalization is confirmed  DOVER (Sept. 19, 2018) — While the “official” start of flu season is still two weeks away, the Division of Public Health (DPH) is urging residents not to wait to get vaccinated. Four cases of the flu now have been confirmed, […]

The Division of Public Health (DPH) invites parents with children from birth to 5 years old to participate in its first Books, Balls and Blocks event, which will take place from 1:00 to 4:00 p.m., Saturday, October 13, at the Route 9 Library and Innovation Center in New Castle, Delaware.

The Delaware Division of Public Health (DPH) is reporting the state's first laboratory-confirmed case of influenza in a child for the 2018-2019 flu season. The case involves a 5-year-old from Sussex County. This brings the total number of flu cases this season to six, as of Oct. 5, 2018.

Increasing access to the overdose-reversing medication naloxone has been a key priority for the Delaware Department of Health and Social Services (DHSS) as state and local partners work together to develop solutions to address the opioid epidemic. In support of that, the Department’s Division of Public Health (DPH) is announcing sustained funding for naloxone for first responder agencies statewide.

The Delaware Division of Public Health (DPH) is advising Delawareans of a multistate outbreak of Listeria infections linked to deli ham. Several companies have recalled ham products that could be contaminated with Listeria monocytogenes bacteria and could make people sick.