Vaccines will be administered on a first-come, first-serve basis, from 11:00 a.m. to 3:00 p.m., or until the supply is depleted on September 21, World Rabies Day, thanks to 250 vaccines provided by the World Rabies Organization and Pfizer Animal Health.

DOVER (March 18, 2021) – The Delaware Division of Public Health (DPH) is advising Sussex County residents, who live or spend time near the area of Bayard Avenue and Philadelphia Street in Rehoboth Beach, of a positive case of rabies in a fox. One individual, a non-Delaware resident, was potentially exposed to the fox in the residential neighborhood. The […]

DOVER (March 31, 2022) – The Delaware Division of Public Health (DPH) is advising Sussex County residents, who live or spend time near the areas of Burbage and Jones roads, and Burbage Road and Route 374 in Frankford, of a positive case of rabies in a fox. The fox did not have any known contact with humans, […]

DOVER (June 29, 2022) – The Delaware Division of Public Health (DPH) is advising Kent County residents who live or spend time near the area of Smyrna Landing Road in Smyrna that a positive case of rabies in a stray cat has been reported. Two individuals were potentially exposed to the stray cat in the residential neighborhood. The […]

The Delaware Division of Public Health (DPH) is announcing its first reported rabies case of 2023. DPH received a report last week of a human and their pet dog who had been exposed to a potentially rabid groundhog in a residential neighborhood located near Bringhurst Woods Park on Washington St., off Carr Road. The groundhog was tested for rabies and the results came […]

A recent study published in iEmerging Infectious Diseases,/i reveals that medlinkdeforestation/medlink in Costa Rica heightens the vulnerability

On Wednesday, July 16 sometime between 2:30-3 p.m., MST, a bat landed on a visitor while she was standing in front of the Tusayan Museum, just west of the Desert View Visitors’ Center within Grand Canyon National Park. https://www.nps.gov/grca/learn/news/2-bats-positive-rabies.htm

A bat recently removed from an area along the Colorado River within Grand Canyon National Park has tested positive for rabies. https://www.nps.gov/grca/learn/news/bat-rabies-october-2014.htm

Grand Canyon National Park has received confirmation that a bat collected at Phantom Ranch on August 31, 2018 tested positive for rabies. The rabies positive bat did not come in contact with any visitors. All individuals who have had physical contact with a bat have been advised to seek medical attention and be assessed for appropriate medical treatment. https://www.nps.gov/grca/learn/news/bat-positive-for-rabies-in-grand-canyon-natl-park-09-14-2018.htm

Grand Canyon National Park has received confirmation that two bats collected along the Colorado River in the park last month tested positive for rabies. The rabies-positive bats, both Canyon Bats, were deceased at the time of collection and did not come in contact with any visitors or staff. https://www.nps.gov/grca/learn/news/bats-found-in-grand-canyon-national-park-test-positive-for-rabies-20190912.htm

Health officials in El Paso County recently confirmed rabies in a skunk, the third positive test for the disease this year in the county.

Rabies is the archytypical zoonotic disease, and only by vaccination in animals will we prevent infections in people. In two podcasts linked to our latest clinical review "The prevention and management of rabies"​ we'll be discussing how we can get there. In this podcast Sarah Cleaveland, professor of comparative epidemiology at the University of...

Delaware's Division of Public Health (DPH) is warning Sussex County residents who live in the residential area of Camp Arrowhead Road between Marsh Island Golf Club and Angola Road of a positive case of rabies in a fox that bit a human and a dog earlier this week.

Delaware's Division of Public Health (DPH) is warning Hockessin residents in the Highland Meadows area (from Brackenville Road to Sharpless Road) of a positive case of rabies in a raccoon that came into contact with two dogs recently. The raccoon was captured and brought to the DPH Lab, where test results on Friday, Aug. 3, 2018, confirmed it had rabies.

The Delaware Division of Public Health (DPH), and Department of Agriculture (DDA) are asking residents to increase efforts to prevent exposure to rabies after the death of a Kent County woman from the disease. The woman, who lived west of Felton, is the second Delawarean to contract, and subsequently pass away from, the disease. The first was a young boy from Newport, who passed away in 1941 after being bitten by a stray dog.

DOVER (Sept. 13, 2018) – Delaware’s Division of Public Health (DPH) is advising Sussex County residents who live in the residential area of Mount Joy Road between Townsend and Cannon roads in Millsboro of a positive case of rabies in a stray cat that came into contact with a human recently. The victim was bitten […]

Delaware’s Division of Public Health (DPH) is advising Kent County residents who live in the area of Still Road between Pony Track and Mahan Corner roads near Sandtown of a positive case of rabies in a fox that came into contact with a human recently. The fox attacked a chicken on the victim’s property and then bit the individual’s leg. The individual has begun treatment for rabies exposure.

Delaware's Division of Public Health (DPH) is advising Ocean View residents who reside in the Plantation Park community of a positive case of rabies in a feral kitten that came into contact with a human.

The nuclear factor kappa B (NF-B) is a potent transcription factor, activation of which typically results in robust proinflammatory signaling and triggering of fast negative feedback modulators to avoid excessive inflammatory responses. Here, we report that infection of epithelial cells, including primary porcine respiratory epithelial cells, with the porcine alphaherpesvirus pseudorabies virus (PRV) results in the gradual and persistent activation of NF-B, illustrated by proteasome-dependent degradation of the inhibitory NF-B regulator IB and nuclear translocation and phosphorylation of the NF-B subunit p65. PRV-induced persistent activation of NF-B does not result in expression of negative feedback loop genes, like the gene for IBα or A20, and does not trigger expression of prototypical proinflammatory genes, like the gene for tumor necrosis factor alpha (TNF-α) or interleukin-6 (IL-6). In addition, PRV infection inhibits TNF-α-induced canonical NF-B activation. Hence, PRV infection triggers persistent NF-B activation in an unorthodox way and dramatically modulates the NF-B signaling axis, preventing typical proinflammatory gene expression and the responsiveness of cells to canonical NF-B signaling, which may aid the virus in modulating early proinflammatory responses in the infected host.

IMPORTANCE The NF-B transcription factor is activated via different key inflammatory pathways and typically results in the fast expression of several proinflammatory genes as well as negative feedback loop genes to prevent excessive inflammation. In the current report, we describe that infection of cells with the porcine alphaherpesvirus pseudorabies virus (PRV) triggers a gradual and persistent aberrant activation of NF-B, which does not result in expression of hallmark proinflammatory or negative feedback loop genes. In addition, although PRV-induced NF-B activation shares some mechanistic features with canonical NF-B activation, it also shows remarkable differences; e.g., it is largely independent of the canonical IB kinase (IKK) and even renders infected cells resistant to canonical NF-B activation by the inflammatory cytokine TNF-α. Aberrant PRV-induced NF-B activation may therefore paradoxically serve as a viral immune evasion strategy and may represent an important tool to unravel currently unknown mechanisms and consequences of NF-B activation.

South Carolina health department announces a human rabies case sourced from a bat.

Caused by the Rabies lyssavirus, rabies is a viral infection that affects the brain and spinal cord of all mammals, including dogs, cats, monkeys, bats and humans. The dog has been and still is the primary cause of rabies in India