Multiple sclerosis is curable if recognised as Lyme disease. The cause is a cyst-forming bacterium, Borrelia Burgdorferi, which causes lesions that degrade brain and spinal cord tissue.

Secaucus, NJ — Lyme disease is becoming more common outside the Northeast and more prevalent in the United States overall, a recent study by lab services provider Quest Diagnostics shows.

One serious risk of outdoor work is Lyme disease, which is spread when individuals are bitten by infected ticks. Initial symptoms of the disease include fever, headache, fatigue and skin rash.

Although spending time in nature can reduce stress and generally improve health and well-being, insects like mosquitoes and ticks also pose a risk.

Although spending time in nature can reduce stress and generally improve health and well-being, insects like mosquitoes and ticks also pose a risk.

As warmer weather brings people outdoors and potentially in contact with ticks, the Delaware Division of Public Health (DPH) is recognizing Lyme Disease Awareness Month this May. According to DPH’s Office of Infectious Disease Epidemiology, Lyme disease is the most common tick-borne disease in Delaware, with over 300 cases reported each year. Lyme disease is spread […]

A new test spots Lyme disease faster than the existing go-to approach and, if approved, could reduce the risk of complications

Ticks that are able to transmit Lyme disease are more abundant in deciduous oak forests than pine forests, according to a study conducted in Belgium, which provides an example of how landscape can influence human health. To help prevent tick attacks and the incidence of Lyme disease, the researchers suggest increased efforts are needed to raise public awareness of control measures, such as protective clothing and repellants.

What is Lyme disease? Here's where you are more likely to get it and the symptoms to look for if you're concerned.

Children with Lyme and septic arthritis of the knee may present similarly, although septic arthritis requires prompt treatment initiation to avoid joint destruction. Clinicians must make initial management decisions without Lyme serology and bacterial culture results.

Our clinical prediction rule accurately identified patients at low risk for septic arthritis in a Lyme disease–endemic area. In the appropriate clinical context, low-risk patients may be spared invasive testing such as diagnostic arthrocentesis. (Read the full article)

While many Delawareans couldn’t be happier to see spring’s arrival and winter’s departure, the Division of Public Health (DPH) is warning residents that with warm weather comes ticks, fleas, mosquitoes and increased chances of vector-borne diseases. Whether staying home or traveling in the coming months, DPH wants to remind Delawareans of the risk of these diseases, which include Lyme disease, Zika, and West Nile Virus, and to share prevention tips.

DOVER  – Lyme disease is the most common vector-borne disease in the United States with approximately 20,000 new cases reported each year. Delaware is among the top 10 states in the United States with the highest incidence rates. In 2018, the Division of Public Health (DPH) reported 520 confirmed and probable cases in the state. […]

Title: Study Debunks Lyme Disease-Autism Link
Category: Health News
Created: 4/30/2013 12:35:00 PM
Last Editorial Review: 5/1/2013 12:00:00 AM

ABSTRACT

A bioinformatics approach was employed to identify transcriptome alterations in the peripheral blood mononuclear cells of well-characterized human subjects who were diagnosed with early disseminated Lyme disease (LD) based on stringent microbiological and clinical criteria. Transcriptomes were assessed at the time of presentation and also at approximately 1 month (early convalescence) and 6 months (late convalescence) after initiation of an appropriate antibiotic regimen. Comparative transcriptomics identified 335 transcripts, representing 233 unique genes, with significant alterations of at least 2-fold expression in acute- or convalescent-phase blood samples from LD subjects relative to healthy donors. Acute-phase blood samples from LD subjects had the largest number of differentially expressed transcripts (187 induced, 54 repressed). This transcriptional profile, which was dominated by interferon-regulated genes, was sustained during early convalescence. 6 months after antibiotic treatment the transcriptome of LD subjects was indistinguishable from that of healthy controls based on two separate methods of analysis. Return of the LD expression profile to levels found in control subjects was concordant with disease outcome; 82% of subjects with LD experienced at least one symptom at the baseline visit compared to 43% at the early convalescence time point and only a single patient (9%) at the 6-month convalescence time point. Using the random forest machine learning algorithm, we developed an efficient computational framework to identify sets of 20 classifier genes that discriminated LD from other bacterial and viral infections. These novel LD biomarkers not only differentiated subjects with acute disseminated LD from healthy controls with 96% accuracy but also distinguished between subjects with acute and resolved (late convalescent) disease with 97% accuracy.

IMPORTANCE Lyme disease (LD), caused by Borrelia burgdorferi, is the most common tick-borne infectious disease in the United States. We examined gene expression patterns in the blood of individuals with early disseminated LD at the time of diagnosis (acute) and also at approximately 1 month and 6 months following antibiotic treatment. A distinct acute LD profile was observed that was sustained during early convalescence (1 month) but returned to control levels 6 months after treatment. Using a computer learning algorithm, we identified sets of 20 classifier genes that discriminate LD from other bacterial and viral infections. In addition, these novel LD biomarkers are highly accurate in distinguishing patients with acute LD from healthy subjects and in discriminating between individuals with active and resolved infection. This computational approach offers the potential for more accurate diagnosis of early disseminated Lyme disease. It may also allow improved monitoring of treatment efficacy and disease resolution.

The spirochete Borrelia burgdorferi sensu lato is the causative agent of Lyme disease (LD). The spirochetes produce the CspZ protein that binds to a complement regulator, factor H (FH). Such binding downregulates activation of host complement to facilitate spirochete evasion of complement killing. However, vaccination with CspZ does not protect against LD infection. In this study, we demonstrated that immunization with CspZ-YA, a CspZ mutant protein with no FH-binding activity, protected mice from infection by several spirochete genotypes introduced via tick feeding. We found that the sera from CspZ-YA-vaccinated mice more efficiently eliminated spirochetes and blocked CspZ FH-binding activity than sera from CspZ-immunized mice. We also found that vaccination with CspZ, but not CspZ-YA, triggered the production of anti-FH antibodies, justifying CspZ-YA as an LD vaccine candidate. The mechanistic and efficacy information derived from this study provides insights into the development of a CspZ-based LD vaccine.

Lyme borreliosis is a tick-borne disease caused by the Borrelia burgdorferi sensu lato complex. Bio-Rad Laboratories has developed a fully automated multiplex bead-based assay for the detection of IgM and IgG antibodies to B. burgdorferi. The BioPlex 2200 Lyme Total assay exhibits an improved rate of seropositivity in patients with early Lyme infection. Asymptomatic subjects from endemic and nonendemic origins demonstrated a seroreactivity rate of approximately 4% that was similar to other commercial assays evaluated in this study. Coupled to this result was the observation that the Lyme Total assay retained a high first-tier specificity of 96% while demonstrating a relatively high sensitivity of 91% among a well-characterized CDC Premarketing Lyme serum panel. The Lyme Total assay also performs well under a modified two-tier algorithm (sensitivity, 84.4 to 88.9%; specificity, 98.4 to 99.5%). Furthermore, the new assay is able to readily detect early Lyme infection in patient samples from outside North America.

If you’re looking for a Lyme disease vaccine, you can choose from among several—for your dog. A vaccine for humans hasn’t been available for years and few companies have tried to fill that void. Valneva has advanced its Lyme vaccine candidate to mid-stage clinical testing, and the company now has the help of drug giant […]

Pfizer partners with Valneva to progress Phase II-stage vaccine candidate for Lyme disease.

Caused by Borrelia burgdorferi and transmitted by the bite of infected Ixodes ticks, Lyme disease if left untreated can cause serious neurologic, cardiac, and/or rheumatologic complications

Lyme disease is very common in certain regions of the country and is caused by the spirochete Borrelia bergdorferi. Lyme disease is transmitted by tick bites and in this podcast we review the discovery of Lyme disease, its major clinical features, and how to diagnose and treat it, as told by Dr Alan Steere, Dr Lyndon Hu, and Dr Paul Auerwerter.

Related article: Review of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis