Menu labels depicting physical activity calorie equivalents may lead to ordering of fast food meals totaling fewer calories for adults. The effects of physical activity calorie equivalent labeling on parents’ fast food decisions for their children have not been examined.

Parents shown menus with any type of caloric content label may order fast food meals totaling fewer calories for their children. Menu labels showing physical activity equivalents may be more likely to influence parents to encourage their children to exercise. (Read the full article)

Resistance to amoxicillin-clavulanate, a widely used beta-lactam/beta-lactamase inhibitor combination antibiotic, is rising globally, yet susceptibility testing remains challenging. To test whether whole-genome sequencing (WGS) could provide a more reliable assessment of susceptibility than traditional methods, we predicted resistance from WGS for 976 E. coli bloodstream infection isolates from Oxfordshire, UK, comparing against phenotypes from the BD Phoenix (calibrated against EUCAST guidelines). 339/976 (35%) isolates were amoxicillin-clavulanate resistant. Predictions based solely on beta-lactamase presence/absence performed poorly (sensitivity 23% (78/339)) but improved when genetic features associated with penicillinase hyper-production (e.g. promoter mutations, copy number estimates) were considered (sensitivity 82% (277/339); p<0.0001). Most discrepancies occurred in isolates with peri-breakpoint MICs. We investigated two potential causes; the phenotypic reference and the binary resistant/susceptible classification. We performed reference standard, replicated phenotyping in a random stratified subsample of 261/976 (27%) isolates using agar dilution, following both EUCAST and CLSI guidelines, which use different clavulanate concentrations. As well as disagreeing with each other, neither agar dilution phenotype aligned perfectly with genetic features. A random-effects model investigating associations between genetic features and MICs showed that some genetic features had small, variable and additive effects, resulting in variable resistance classification. Using model fixed-effects to predict MICs for the non-agar dilution isolates, predicted MICs were in essential agreement (±1 doubling dilution) with observed (BD Phoenix) MICs for 691/715 (97%) isolates. This suggests amoxicillin-clavulanate resistance in E. coli is quantitative, rather than qualitative, explaining the poorly reproducible binary (resistant/susceptible) phenotypes and suboptimal concordance between different phenotypic methods and with WGS-based predictions.

The human diseases caused by the fungal pathogens Cryptococcus neoformans and C. gattii are associated with high indices of mortality, and toxic and/or cost-prohibitive therapeutic protocols. The need for affordable antifungals to combat cryptococcal disease is unquestionable. Previous studies suggested benzimidazoles as promising anti-cryptococcal agents combining low cost and high antifungal efficacy, but their therapeutic potential has not been demonstrated so far. In this study, we investigated the antifungal potential of fenbendazole, the most effective anti-cryptococcal benzimidazole. Fenbendazole was inhibitory against 17 different isolates of C. neoformans and C. gattii at a low concentration. The mechanism of anti-cryptococcal activity of fenbendazole involved microtubule disorganization, as previously described for human parasites. In combination with fenbendazole, the concentrations of the standard antifungal amphotericin B required to control cryptococcal growth were lower than those required when this antifungal was used alone. Fenbendazole was not toxic to mammalian cells. During macrophage infection, the anti-cryptococcal effects of fenbendazole included inhibition of intracellular proliferation rates and reduced phagocytic escape through vomocytosis. Fenbendazole deeply affected the cryptococcal capsule. In a mice model of cryptococcosis, the efficacy of fenbendazole to control animal mortality was similar to that observed for amphotericin B. These results indicate that fenbendazole is a promising candidate for the future development of an efficient and affordable therapeutic tool to combat cryptococcosis.

Durlobactam (DUR, also known as ETX2514) is a novel β-lactamase inhibitor with broad activity against Ambler class A, C, and D β-lactamases. Addition of DUR to sulbactam (SUL) in vitro restores SUL activity against clinical isolates of Acinetobacter baumannii. The safety and pharmacokinetics (PK) of DUR alone and with SUL and/or imipenem/cilastatin (IMI/CIL) were evaluated in healthy subjects. This was a randomized, placebo-controlled study. In Part A, subjects including an elderly cohort (DUR 1 g) received single ascending doses of DUR 0.25-8 g. In Part B, multiple ascending dose of DUR 0.25-2 g were administered every 6 hours (q6h) for 29 doses. In Parts C and D, the drug-drug interaction (DDI) potential, including safety, of DUR (1 g) with SUL (1 g) and/or IMI/CIL (0.5/0.5 g) was investigated after single and multiple doses. Plasma and urine concentrations of DUR, SUL, and IMI/CIL were determined. Among 124 subjects, DUR was generally safe and well tolerated either alone or in combination with SUL and/or IMI/CIL. After single and multiple doses, DUR demonstrated linear dose proportional exposure across the studied dose ranges. Renal excretion was a predominant clearance mechanism. No drug:drug interaction potential was identified between DUR and SUL and/or IMI/CIL. SUL-DUR, 1 g (of each component) administered q6h with a 3 hour IV infusion, is under development for the treatment of serious infections due to A. baumannii.

Seasonal and pandemic influenza causes 650,000 deaths annually in the world. The emergence of drug-resistance to specific anti-influenza drugs such as oseltamivir and baloxavir marboxil highlights the urgency of novel anti-influenza chemical entity discovery. In this study, we report a series of novel thiazolides derived from an FDA-approved drug nitazoxanide with antiviral activity against influenza and a broad range of viruses. The preferred candidates 4a and 4d showed significantly enhanced anti-influenza potentials with 10-fold improvement, compared with nitazoxanide, and were effective against a variety of influenza subtypes including oseltamivir-resistant strains. Notably, the combination using of compounds 4a/4d and oseltamivir carboxylate or zanamivir displayed synergistic antiviral effect against oseltamivir-resistant strain. Mode of action analysis demonstrated that compounds 4a/4d acted at the late phase of viral infection cycle through inhibiting viral RNA transcription and replication. Further experiments showed that treatment with compounds 4a/4d significantly inhibited influenza virus infection in human lung organoids, suggesting the druggability of the novel thiazolides. In-depth transcriptome analysis revealed a series of up-regulated cellular genes that may contribute to the antiviral activities of 4a/4d. Together, our study pointed the optimization direction of nitazoxanide as anti-influenza drug, and discovered two novel-structured candidates 4a/4d with relatively broad-spectrum antiviral potential.

Ahead of Matchday 7, UEFA.com looks at some obvious selections and some lesser-owned options.

Ahead of Matchday 8, UEFA.com looks at some obvious #UCLfantasy selections and those who could cause a surprise.

Researchers in Penn State’s College of Engineering, College of Agricultural Sciences and College of Medicine say direct LTP treatment and plasma-activated media are effective treatments against bacteria found in liquid cultures and have devised a way to create plasma directly in liquids.

Internal rate of return: remember that candidates must be sifted through the funnies sieve first.

The Sustainable Growth table offers it a most intriguing set of rankings to mull.

Using AI and machine learning capabilities, the system can be further trained to respond like a professional.

Lifestyle, as an industry, has a lot of potential. There are challenges that keep me motivated as this industry goes through evolution in terms of practices and business methods.

Conversational commerce, as it is more popularly known, is any form of online communication that takes place during an e-commerce purchase.

Agricultural entrepreneurs who want to produce certain foods in their on-farm kitchens can receive food safety training and become certified under Delaware law at an upcoming workshop. The eight-hour Food Safety for Entrepreneurs program will be Saturday, Feb. 28, 8 a.m. to 4:30 p.m. at the Department of Agriculture offices near Camden, 2320 South DuPont Highway.

Agricultural entrepreneurs who want to produce certain foods in their on-farm kitchens can receive food safety training and become certified under Delaware law at an upcoming workshop.

Agricultural entrepreneurs who want to produce certain foods in their on-farm kitchens can receive food safety training and become certified under Delaware law at an upcoming workshop.

Agricultural entrepreneurs who want to produce certain foods in their on-farm kitchens can receive food safety training and become certified under Delaware law at an upcoming workshop jointly sponsored by the University of Delaware Cooperative Extension and the Delaware Department of Agriculture. The eight-hour “Food Safety for Entrepreneurs” program presented by Dr. Sue Snider of the University of Delaware will take place Saturday, March 25, at the Delaware Department of Agriculture, from 8 a.m. to 4:30 p.m.

NEW CASTLE (Oct. 23, 2018) – Department of Health and Social Services (DHSS) Secretary Dr. Kara Odom Walker, a board-certified family physician, is reassuring Delawareans that a proposed change to the public charge rule by the U.S. Department of Homeland Security does not affect current eligibility for health care and social services in Delaware, and […]

Updated Information: DPH Announces Potential Exposure at Two Additional Food Establishments and Updated Timeline DOVER – The Division of Public Health (DPH) announced today that employees and patrons of Buffalo Wild Wings located at 540 W. Main St., Middletown, may have been exposed to the hepatitis A virus between March 31 and April 10, 2019. When […]

he Division of Public Health (DPH) is providing updated information regarding a potential Hepatitis A exposure at a Buffalo Wild Wings food establishment in Middletown, which was announced on Thursday, April 11, 2019.

The Delaware Division of Public Health (DPH) is actively taking steps to prepare for community spread of the coronavirus disease known as COVID-19, as well as providing information to Delawareans about the actions they can take now to make preparations. To date, no one in Delaware has tested positive for COVID-19.

Budget 2019: NEP has potential to overhaul the system

Figures by the World Travel & Tourism Council (WTTC) show the industry contributing $8.8 trillion to the global economy in 2018 with over 319 million jobs supported worldwide. Tourism can be a major contributor to the Indian economy given the right mix of policies and infrastructure.

Novalead’s technology has a track record of successfully discovering repurposed drug candidates with its lead drug candidate currently being in Phase 3 trials in India, for diabetic foot ulcers.

Europe can potentially generate 100 times the current amount of energy generated, and produce enough power to power the world until 2050, if it were to maximize land use for onshore wind capacity.

Southeast Asia is poised for a long-overdue and much-needed boom in solar.

Building solar and wind energy projects on potentially contaminated lands can be a golden opportunity, both effective and cost-effective, for developers. The 120-acre Reilly Tar & Chemical Corporation Superfund site was recently redeveloped with a utility-scale solar farm and is a prime example of the reuse potential inherent in thousands of Superfund sites, brownfields, retired power plants, and landfills.

Biogas is a resource that has enormous potential in Spain and beyond. Biogas technologies convert organic wastes into renewable energy, clean transport fuel, and nutrient-rich natural fertiliser, reducing greenhouse gas emissions and improving energy and food security and air quality. A recent study commissioned by Naturgy, Spain’s largest natural gas distributor, showed a potential for 26,684 gigawatt hours (GWh) of biogas in the country, enough to cover the energy demand of 40% of Spain’s households.

The addition of hydropower generating capacity to an irrigation network in northern Japan is one step closer to completion. Several sites have been identified for the installation of VLH turbines, with a total capacity of 1.433 MW.

One or two new runners for the units at the 355-MW Brazeau Power Station in Alberta, Canada, would allow owner TransAlta Corp. to better optimize revenue and provide valuable ancillary services. Modeling of the various upgrade options allowed the utility to arrive at the most valuable solution.

There are a total of about 530,000 potentially feasible pumped hydro energy storage sites worldwide, with a total storage potential of about 22 million GWh. These astonishing numbers come from a report recently released by Professor Andrew Blakers and other researchers with Australian National University’s RE100 Group.

Power infrastructure in the East African countries of Uganda, Kenya, Tanzania and Rwanda is inherently connected to their economic growth. As urbanisation and industrialisation fuel the need for electricity in cities, the demand for electricity in East Africa is expected to grow at approximately 5.3 percent per year until 2020. To meet these requirements, generation capacity would have to increase by 37.7 percent in Uganda, 96.4 percent in Kenya, 75.3 percent in Tanzania and 115 percent in Rwanda. The government, in conjunction with development partners, must build a more favourable business environment to facilitate growth.

If all energy production channels were employed, the United States has sufficient resources to eliminate all coal, gasoline and diesel combustion in all demand sectors and replace them with natural gas, wind and solar electricity firmed and shaped with both grid-scale and distributed energy storage. I believe that we can reach a zero-air-pollution, coal-free, crude-import free, all-electric low-cost energy future. We have energy rhetoric and technology to get there; do we have leadership and will?

The annual outlook issue of Renewable Energy World magazine is our attempt to predict what will happen within the renewable energy industry over the course of the year. To do this, we went straight to the top of major renewable energy companies, asking CEOs and presidents to tell us where they are devoting their company resources in order to capitalize on some of the market growth that they expect to see in 2015.

The global strategy for mitigating climate change is no secret. Most countries have embarked on an initiative to transition to clean energy sources. According to a study by scientists from the universities of Oxford and Utrecht, we will almost certainly pass a point of no return for dealing with global warming if governments worldwide don’t transition away from fossil fuels, such as coal and natural gas, towards renewable energy by 2035. This would mean that renewables would need to see their total share of power generation increase by at least two percent per year.

Building solar and wind energy projects on potentially contaminated lands can be a golden opportunity, both effective and cost-effective, for developers. The 120-acre Reilly Tar & Chemical Corporation Superfund site was recently redeveloped with a utility-scale solar farm and is a prime example of the reuse potential inherent in thousands of Superfund sites, brownfields, retired power plants, and landfills.

Africa’s renewable energy capacity is expected to quadruple to about 120 gigawatts by 2030 if investors dedicate “substantial flows” of funds to the region, the InternationalRenewable Energy Agency said.

Billionaire Rubens Ometto’s Cosan SA has the potential to triple its power generation by burning sugar-cane leftovers if the government offers power-purchase contracts for biomass producers.

You may recall the recent case of Golden Ocean Group Ltd v Salgaocar Mining Industries PVT Ltd [2011] EWHC 56 (Comm) in which it was argued that a valid guarantee had been given as a result of a chain of emails exchanged between two parties. At...

UK goes into ‘Lockdown’ The current lockdown arises as a result of The Health Protection (Coronavirus, Restrictions) (England) Regulations 2020. Broadly, this legislation restricts the movement of people to ‘essential journeys&rsqu...

Part 2 of 4 (a) For Users/Consumers Simply put, OTT services are low or free of charge services. Its known that online video traffic is on the growth due to simple accessibility and cheapness. Consumers’ hopes are also evolving as they are exp...

Contenders to replace Theresa May as Conservative leader continue to clash over the prospect of a no-deal Brexit and how it could be achieved. In the meantime, the chemicals sector continues to attempt to mitigate the major ramifications it could ha...

As celebrities reveal details about their charitable giving during the COVID-19 pandemic, some feel it could be the start of a new attitude to donating ...

The NBA says some players can voluntarily return to their team practice facilities starting Friday, with some very specific conditions and only in places where ...