When it comes to education, the 49th state faces its own challenges, some of which are unique to Alaska and some that it shares with other rural states. This series explores how cultural and geographic barriers, teacher shortages, historical developments, and more have shaped schooling in Alaska.

[London] (at the Historic Gallery, 87 Pall Mall) : Pub.d by Mr Stone.

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LIKE many of your readers, I would imagine, I am a fairly enthusiastic armchair football supporter with no real club affiliation.

NEIL Mackay (“Johnson? Sturgeon? When it comes to coronavirus they are both the same”, The Herald, May 5) lambasts Nicola Sturgeon and Boris Johnson for both taking an almost identical approach in their fight against Covid-19, somehow implying that this is in itself a fault.

READING about the Brooks family and their foraging for food (“Family serves a dinner-time treat ... Japanese Knotweed crumble”, The Herald, May 2) provoked very happy memories of another forager-par-excellence; Rosalind Burgess, the Skye weaver, cook, and writer of an excellent book on how to use the things you grow and forage.

IT is good to see that one of your readers, R Russell Smith, has been enjoying our wildlife and fresh air, having “walked over fields and alongside the burn close to home, enjoying the sunshine and company of lambs gambolling” (Herald letters, May 5).

YOU report (HeraldScotland, May 5) that Professor Neil Ferguson, one of the UK government’s key advisers on the current lockdown restrictions, has resigned after breaching the government (and his own) strong advice on the need for social distancing.

LIKE many people with a wee bit of time on their hands at the moment, I enjoy a morning walk along the cycle track between Elderslie and Castlehead, a nice enough stroll, if you like litter that is; and I mean, really like litter.

BEING a full-time, voluntary, unpaid carer, since November 2018, for my wife, who has dementia, I would like to ask a question of the Scottish Government, especially Jeane Freeman, the health secretary.

THE Herald has reported (May 6) on another economically and socially “lost generation” of children and young people due to Covid-19.

EUGENE Cairns (Herald Letters, May 6) feels that a fitting tribute to our NHS heroes would be to name hospitals and wards after those who have died in our service during the pandemic crisis.

Bacteria of the genus Campylobacter are major foodborne pathogens which have become increasingly resistant to clinically important antimicrobial agents (1)....

The currently unfolding coronavirus pandemic threatens health systems and economies worldwide....

Exploring different ways of minimising linezolid toxicity without compromising efficacy is a major quest in the treatment of drug resistant tuberculosis (TB)....

To commemorate the 250th anniversary of the publication of his “Letters From a Pennsylvania Farmer” and the role John Dickinson played in setting the stage for the American Revolution, the Delaware Department of State has launched a new website, de.gov/johndickinson, and a slate of special programming to take place over the coming months.

The celebration of the life and works of Delaware statesman and “Penman of the Revolution” John Dickinson continues into the New Year with programs slated to explore his legacy and honor his contributions to the history of the state and the nation.

The celebration of the life and works of Delaware statesman John Dickinson comes to a close with a special program featuring Gov. John Carney and an annual wreath-laying at the graveside of the “Penman of the Revolution.”

Brian Waller questions the lack of political will when it comes to preventable deaths across Asia and sub-Saharan Africa, while Tony Haynes reveals how artists can explore attitudes to disease

Neil Singh’s powerful long read (Cholera and coronavirus: why we must not repeat the same mistakes, 1 May) tellingly compares the way in which the world is reacting to Covid-19 with how it has handled cholera, especially in developing countries. He states: “There is no biological or environmental reason why cholera can’t be eradicated … It is not the knowhow that is lacking, but rather the political will.”

Exactly the same conclusion can be reached in respect of the 5 million-plus children under five who are dying every year. According to the World Health Organization, many of these early child deaths are preventable or can be easily treated, but there is nothing remotely like the effort being put into this as in the response to Covid-19. Might the reason for that inaction be that more than 80% of these deaths involve children in central and south Asia, and sub-Saharan Africa?
Brian Waller
Otley, North Yorkshire

The English High Court, in the recent case Kairos Shipping Limited v. Enka & Co LLC & Others (Atlantic Confidence) [2013] EWHC 1904 (Comm), considered whether or not a tonnage limitation fund may be constituted by provision of a P&I club...

ISLAMABAD: Prime Minister Imran Khan on Friday issued red-letter to 16 ministries over delay in implementation of the cabinet’s decisions.This is the second time the PM’s office has issued the red-letter, which is a warning and a sign of displeasure. Last year, secretaries of 27...

ISLAMABAD: Prime Minister Imran Khan on Friday issued red-letter to 16 ministries over delay in implementation of the cabinet’s decisions.This is the second time the PM’s office has issued the red-letter, which is a warning and a sign of displeasure. Last year, secretaries of 27...

ISLAMABAD: Prime Minister Imran Khan on Friday issued red-letter to 16 ministries over delay in implementation of the cabinet’s decisions.This is the second time the PM’s office has issued the red-letter, which is a warning and a sign of displeasure. Last year, secretaries of 27...

In our computational study, we use molecular simulations to substantiate a hypothetical mechanism for glycosidic bond cleavage in the presence of a single catalytic acid at the active site of the mutant D10N HiCel45A. In addition to discussing this plausible mechanism from the context of structurally related MltA lytic transglycosylase and subfamily C GH45s, we also suggest the implications of the plausible mechanism for our current understanding of the action of expansins and lytic transglycosylases. As correctly pointed out by Professor Cosgrove (1), there is large body of evidence, a significant portion of which was regrettably not discussed in our paper, that suggests that expansins are incapable of lytic action on polysaccharide substrates. Whereas these insights do not change the results or the conclusions of our article, we would like to thank Professor Cosgrove for these additional insights. In particular, our main point with respect to expansins is that our results suggest the possibility that expansins are capable of nonhydrolytic lytic activity. Our intention was not to suggest this was the mechanism of expansins, but that it should be considered based on our results and the similarity of the active sites.The molecular mechanisms of how expansins enable cell wall expansion remains to be fully understood. Whereas our proposed mechanism resulting in the formation of the 1,6-anhdro product might be found in expansins and might contribute to the mode of action of expansins, we would like to emphasize that the intent of this study was only to suggest this as a...

From their simulations of endoglucanase Cel45A, Bharadwaj et al. (1) propose that structurally related expansins and MltA may cut glycan backbones without generating reducing ends. This is tenable for MltA, a peptidoglycan lytic transglycosylase whose action produces nonreducing 1,6-anhydro products, but is untenable for expansins.Expansins loosen plant cell walls and induce wall expansion. Contrary to the assertion by Bharadwaj et al., the conclusion that expansins are not lytic is not merely based on lack of new reducing ends but is supported by multiple (negative) tests for polysaccharide cleavage that do not rely on detection of reducing ends. At least eight studies with three divergent groups of expansins document this point. For instance, α-expansin did not reduce the viscosity of various wall polysaccharide solutions, an endolytic assay that does not rely on measuring reducing ends (e.g. see Ref. 2 and other studies).Walls treated with α-expansin did not release saccharide fragments, measured by pulsed amperometric detection, which can detect nonreducing saccharides (3).In the case of β-expansins, protein treatments did not cleave the backbones of a wide range of dye-coupled cross-linked wall polysaccharides; nor did they cleave backbones of polysaccharides extracted from plant cell walls, measured by gel permeation chromatography (4).For five microbial expansins, tests with a range of dye-coupled cross-linked polysaccharides likewise did not detect lytic activity (e.g. see Ref. 5). Thus, extensive published evidence argues against lytic action by expansins, as proposed by Bharadwaj (1), and attempts to identify 1,6-anhydro products seem unlikely to succeed.

Shannon's said: “OCRO HLI RGWR NMIELWIS”

The speed limit on Spadina Crescent from Avenue H to Windsor Street should be reduced to 40km per hour, writes Don Greer.

I fear that once the restrictions are lifted, people will forget and life will continue as it had before, writes Terri Sleeva.

Coronavirus: the symptoms Follow our live updates here

The Duke of Cambridge and his stepmother the Duchess of Cornwall have both written to Captain Tom Moore, 99, to congratulate him on smashing his NHS fundraising target.

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The post Letters From the May 18/25, 2020, Issue appeared first on The Nation.

Saturday, May 9: Some odd musical instruments, the Official Plan and the pandemic -- you can write to us too, on these or any topics, at: letters@ottawacitizen.com

For the first in our new series of letters capturing tales and thoughts during lockdown, Amira Hashish finds comfort in her neighbour's act of kindness...

For the next instalment of our new series of letters capturing tales and reflections during lockdown, Zoe Paskett finds the family traditions she once resisted have become the highlight of her week

In the latest instalment in our series of thoughts and reflections during lockdown, Suzannah Ramsdale reassesses what's actually important